Tag: M.W:100-200

Synthetic Route of 165547-79-5, Adding some certain compound to certain chemical reactions, such as: 165547-79-5, name is 4-Chloro-3-nitro-2(1H)-pyridinone,molecular formula is C5H3ClN2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 165547-79-5.

To a suspension of 4-chloro-3-nitro-2-pyridone (1.0 g, 5.7 mmol) and silver carbonate (1.9 g, 6.9 mmol) in hexane (17 mL) was added Mel (0.72 mL, 11.5 mmol). The rxn mixture was heated to 80C for 1h and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc to give the title compound as white solid. LC-MS: tR=0.82 min 1H NMR (400 MHz, DMSO-d6) 5: 8.41 (d, J = 5.6 Hz, 1 H), 7.50 (d, J = 5.6 Hz, 1 H), 4.02 (s, 3 H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 165547-79-5, 4-Chloro-3-nitro-2(1H)-pyridinone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (188 pag.)WO2019/141803; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 39658-41-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39658-41-8, name is Ethyl 6-aminonicotinate, molecular formula is C8H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: To a stirred solution of lithium aluminium hydride (73 mg, 1.93 mmol) in tetrahydrofuran was slowly added solution of ethyl 6-aminonicotinate (80 mg, 0.48 mmol) in tetrahydrofuran at 0 C. under nitrogen. The reaction mixture was stirred at 0 C. for 30 minutes then at room temperature for 3 h. The mixture was quenched at 0 C. with 1N HCl until pH is 3 then basified with sodium carbonate solution until pH is 7. Then the mixture was filtered using celite to remove LAH residue and it was dissolved in ethylacetate and washed with saturated sodium carbonate solution. The organic layer was dried over MgSO4 and filtered. The filtrate was removed in vacuo. The crude condition of (6-aminopyridin-3-yl)methanol (30 mg, crude) was obtained in 50% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39658-41-8, Ethyl 6-aminonicotinate.

Reference:
Patent; Gruenenthal GmbH; FRANK, Robert; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo; US2013/29961; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13466-35-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13466-35-8, name is 3-Chloro-2-hydroxypyridine, molecular formula is C5H4ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Equipped with a thermometer,Mechanical agitation,Add 150 grams of 1,2-dichloroethane to a 500-mL four-necked flask with a reflux condenser,26.0 g (0.2 mol) of 3-chloro-2-hydroxypyridine (IV) prepared in Example 3,52.0 grams (0.25 moles) of phosphorus pentachloride,Stir the reaction at 60-65 for 10 hours,Then slowly pour the remainder into 200 grams of ice water,Stir well,Then 40wt% sodium hydroxide aqueous solution neutralizes the pH value to 7-8,Layered,Use 1,2-dichloroethane three times for the water layer,50 grams each time,Combine the organic phase,Wash with 30 grams of saturated saline,Then dry with 5 grams of anhydrous sodium sulfate,The solvent was removed by rotary evaporation to obtain 28.1 g of 2,3-dichloropyridine (I), Yield 94.9%, gas phase purity 99.9%.

According to the analysis of related databases, 13466-35-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Qi Yuxin; Zhang Mingfeng; Ju Lizhu; Wang Quanlong; (9 pag.)CN110818621; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 56673-34-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56673-34-8, name is 3-Bromo-6-mercaptopyridine, molecular formula is C5H4BrNS, molecular weight is 190.06, as common compound, the synthetic route is as follows.

B8. 5-Bromo-pyridine-2-sulfonyl chloride; 2.0 g of 5-bromo-pyridine-2-thiol (compound C2) are dissolved in 40 ml of carbon tetrachloride and 8 ml of water. Subsequently, the suspension is cooled in an ice bath and chlorine gas is passed into the reaction mixture for 20 min (flow: 35 ml/min). Thereafter, nitrogen is passed into the yellow solution to remove excess chlorine. Subsequently, the mixture is diluted with 150 ml of dichloromethane and extracted with 50 ml of brine. The organic layer is separated, dried using Na2SO4, filtered with suction, and evaporated to dryness to afford 2.70 g of the title compound as light yellow needles. M. p. 8O0C. GC-MS: 254.8/256.8/258.8 (77:100:25; M+). TLC: Rf = 0.84 (dichloromethane/ethanol 20:1 parts by volume).

Statistics shows that 56673-34-8 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-6-mercaptopyridine.

Reference:
Patent; ALTANA Pharma AG; WO2007/39578; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 54231-35-5, 3-Fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 54231-35-5, blongs to pyridine-derivatives compound. Recommanded Product: 54231-35-5

Step 1: A mixture of 3-fluoro-2-nitropyridine (3 g, 21.1 mmol) and K2CO3 (5.8 g, mmol) in MeOH (30 mL) was refluxed for lh and then cooled to room temperature. The mixture was filtered and the filtrate evaporated to give crude 32-2 as a yellow oil. LC-MS: m/z = 155.1 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54231-35-5, 3-Fluoro-2-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1075-62-3, N-(6-Aminopyridin-2-yl)acetamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of N-(6-Aminopyridin-2-yl)acetamide, blongs to pyridine-derivatives compound. Safety of N-(6-Aminopyridin-2-yl)acetamide

A. N-(2-Dimethylaminoethyl)-N-(6-amino-2-pyridyl)acetamide The title compound is obtained by following the procedure of part A of Example 13 but substituting an equivalent weight of N-(6-amino-2-pyridyl)acetamide for N-(5-methyl-2-pyridyl)acetamide. The product has b.p. 140-178/0.6 mm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1075-62-3, N-(6-Aminopyridin-2-yl)acetamide, and friends who are interested can also refer to it.

Reference:
Patent; Merck & Co., Inc.; US4203988; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 102645-33-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 102645-33-0 as follows.

This aldehyde was dissolved in 100 ml of 2-propanol, mixed with 13.8 g of hydroxylamine hydrochloride and 20 drops of concentrated HCl and heated on a steambath for 1 hour. The mixture was then poured onto 200 g of ice, stirred well and filtered leaving a solid residue. The solid was vacuum dried to give 22.8 g (85%) of the desired 2,5-dichloro-4-pyridinecarboxaldehyde oxime STR6 m.p. 173-174 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,102645-33-0, its application will become more common.

Reference:
Patent; The Dow Chemical Company; US4558134; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5006-66-6, 6-Oxo-1,6-dihydropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H5NO3, blongs to pyridine-derivatives compound. COA of Formula: C6H5NO3

step A) methyl 5-bromo-6-methoxynicotinate Bromine (0.60 mL) was added to a solution of 6-hydroxynicotinic acid (1.02 g) in acetic acid (5 mL) and the mixture was stirred at 60C for 16 hr. The solvent was evaporated under reduced pressure and the residue was dissolved in phosphorus oxychloride (5 mL). Phosphorus pentachloride (3.05 g) was added and the mixture was stirred at 100C for 2 hr. The solvent was evaporated under reduced pressure, and the residue was dissolved in methanol (5 mL), and the mixture was refluxed for 2 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was dissolved in methanol (10 mL). A methanol solution (28%, 2.2 mL) of sodium methoxide was added and the mixture was stirred at room temperature for 2 hr. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.18 g) as white crystals. 1H NMR (400 MHz, CDCl3) delta3.92 (3H, s), 4.08 (3H, s), 8.40 (1H, d, J = 1.8 Hz), 8.75 (1H, d, J = 1.6 Hz).

The synthetic route of 5006-66-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; MIWATASHI, Seiji; SUZUKI, Hideo; OKAWA, Tomohiro; MIYAMOTO, Yasufumi; YAMASAKI, Takeshi; HITOMI, Yuko; HIRATA, Yasuhiro; EP2816032; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35590-37-5, name is 5-Bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H3BrN2

To a degassed solution of 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)aniline (1.0 equiv.), 5-bromonicotinonitrile (1.1 equiv.) and Na2CO3 (5 equiv., 2M aq. sln) was added PdCl2(dppf).CH2Cl2 adduct (0.15 equiv.). This mixture was heated to 120 C for 15 min in the microwave and cooled to room temperature. Water was added, the phases were separated and the water mixture was extracted with ethyl acetate. The organic phases were pooled, dried with MgSO4 and the volatiles removed in vacuo to give 5-(5-amino-2- methylphenyl)nicotinonitrile in 99% yield. LCMS (m/z) (M+H) = 210.0, Rt = 0.43 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 35590-37-5, 5-Bromonicotinonitrile.

Reference:
Patent; NOVARTIS AG; BARSANTI, Paul Andrew; BURGER, Matthew T.; LOU, Yan; NISHIGUCHI, Gisele A.; POLYAKOV, Valery Rostislavovich; RAMURTHY, Savithri; SUBRAMANIAN, Sharadha; TAFT, Benjamin R.; TANNER, Huw Rowland; WAN, Lifeng; (180 pag.)WO2016/38583; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.953780-40-0, name is Methyl 5-fluoro-6-methoxynicotinate, molecular formula is C8H8FNO3, molecular weight is 185.15, as common compound, the synthetic route is as follows.SDS of cas: 953780-40-0

A mixture of methyl 5-fluoro-6-methoxynicotinate (3.5 g, 18.9 mmol) and KOH (4.2 g, 61.5 mmol) in MeOH (70 ml) was stirred at room temperature for 5 h. After concentration, the residue was dissolved in water, and the obtained solution was washed with ether. The aqueous phase was acidified to pH = 1 with dilute hydrochloric acid, and extracted with ether, and the combined organic layers were washed with brine, dried over Na2SO4 and concentrated under vacuum to afford S-fluoro–methoxynicotinic acid (3.2g, 98%) as a white solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,953780-40-0, Methyl 5-fluoro-6-methoxynicotinate, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2007/120729; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem