Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 23612-36-4, 3-Bromo-1H-pyrrolo[3,2-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 23612-36-4, blongs to pyridine-derivatives compound. Product Details of 23612-36-4

To a mixture of Intermediate 1 (1.80 g, 9.14 mmol) in DCM (60 mL) was added di-tert-butyl dicarbonate (2.18 g, 10.0 mmol) followed by 4-dimethylaminopyridine (122 mg, 1.00 mmol). After 80 min the solution was diluted with DCM (20 mL) and washed with 0.1 M HCl (25, 10 mL) and brine. The organic layer was dried (Na2SO4), filtered and evaporated to yield the title compound as a light yellow solid (2.47 g, 90%). MS (ESI+) m/z=299 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23612-36-4, its application will become more common.

Reference:
Patent; PROXIMAGEN LIMITED; Evans, David; Carley, Allison; Stewart, Alison; Higginbottom, Michael; Savory, Edward; Simpson, Iain; Nilsson, Marianne; Haraldsson, Martin; Nordling, Erik; Koolmeister, Tobias; US2013/102587; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1133879-69-2, Adding some certain compound to certain chemical reactions, such as: 1133879-69-2, name is 3-Fluoro-5-vinylpyridine,molecular formula is C7H6FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1133879-69-2.

A mixture of carboline 2 (1 mmol), vinylpyridine 3a (1 mmol), CsF (0.1 g), hydroquinone(0.02 g), and DMSO (1.5 mL) was heated with stirring for 6 h at 150-160 C and then concentrated in vacuo (3 Torr). The residue was extracted with CH2Cl2, and the solution was concentrated. The product was isolated by chromatography on silica gel(260 mesh) using MeOH-CHCl3, 1 : 10, as the eluent. Yield 2.6 g (80%). M.p. 103-104 C. 1H NMR (CDCl3), delta: 2.44 (s, 3 H,Me); 2.49-2.56 (m, 5 H, CH2 and MeN); 2.72 (t, 2 H, CH2, 3JH,H = 6.1 Hz); 3.01 (t, 2 H, CH2, 3JH,H = 6.0 Hz); 3.65 (s, 2 H, CH2); 4.20 (t, 2 H, CH2, 3JH,H = 6.0 Hz); 6.88 (dt, 1 H, CHPy, 3JH,F = 9.1 Hz, 4JH,H = 1.9 Hz); 6.98 (d, 1 H, CHInd, 3JH,H = 8.4 Hz); 7.10 (d, 1 H, CHInd, 3JH,H = 8.4 Hz); 7.20 (s, 1 H, CHInd); 8.11 (t, 1 H, CHPy, 4JH,H = 1.9 Hz); 8.32 (d, 1 H, CHPy, 4JH,H = 1.9 Hz). 13C NMR (CDCl3), delta: 21.2, 22.5, 32.8, 43.6, 45.4, 51.4, 52.1, 107.6, 108.1, 117.5, 122.1, 122.8 (d, CPy(4), 2JC,F = 18 Hz); 125.9, 128.0, 132.5, 134.0, 135.6 (d, CPy(3), 3JC,F = 3 Hz); 136.1 (d, CPy(6), 2JC,F = 23 Hz); 145.5 (d, CPy(2), 3JC,F = 4 Hz); 156.4, 161.5 (d, CPy(5), 1JC,F = 257 Hz). 19F NMR (CDCl3), delta: -47.5 (d, 3JF,H = 9.1 Hz). Rf 0.46 (CHCl3-MeOH,10 : 1). Found (%): C, 74.41; H, 6.68; N, 12.79. C20H22FN3. Calculated (%): C, 74.28; H, 6.86; N, 12.99.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1133879-69-2, 3-Fluoro-5-vinylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Aksinenko, A. Yu.; Bachurin, S. O.; Maleev, G. V.; Nebogatikov, V. O.; Shevtsova, E. F.; Ustyugov, A. A.; Vasil?eva, N. A.; Vikharev, Yu. B.; Russian Chemical Bulletin; vol. 69; 4; (2020); p. 781 – 786; Izv. Akad. Nauk, Ser. Khim.; 4; (2020); p. 781 – 786,6;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31181-88-1, name is 5-Fluoropicolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 5-Fluoropicolinaldehyde

a) 2-Ethynyl-5-fluoro-pyridineTo a mixture of 5-fluoro-2-formylpyridine (1.10 g, 9.0 mmol) in MeOH (38 mL) was added potassium carbonate (2.44 g, 0.018 mol) followed by a solution of (l-diazo-2-oxo-propyl)- phosphonic acid dimethyl ester (2.03 g, 11 mmol) in MeOH (12 mL). The mixture was stirred at room temperature for 90 min, then extracted with diethylether. The organic layers were then washed with sodium hydrogen carbonate solution (1 M) and brine, dried over sodium sulfate, filtered and evaporated at to give the title compound (1.01 g, 78%) as a light brown liquid. MS: m/e = 121.0 [M]+.

With the rapid development of chemical substances, we look forward to future research findings about 31181-88-1.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HERNANDEZ, Maria-Clemencia; LUCAS, Matthew C.; THOMAS, Andrew; WO2012/62687; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1071727-78-0 ,Some common heterocyclic compound, 1071727-78-0, molecular formula is C9H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6,7-Dihydro-5H-[1]pyrindin-7-ylamine: 5,6-Dihydro-[1]pyrindin-7-one O-methyl-oxime (4.1 g, 25.28 mmol) and Pd/C (150 mg) were mixed in TFA and then resulting reaction mixture was hydrogenated under 50 psi for 14 hours. Filtration via celite and concentration afforded the desired title amine. Spectroscopic data: 1H NMR (300 MHz, CDCl3) delta 1.89-2.02 (m, 1H), 2.46-2.58 (m, 1H), 2.89-3.01 (m, 2H), 4.62-4.73 (m, 1H), 7.30-7.37 (m, 1H), 7.77 (d, J=7.62 Hz, 1H), 8.35-8.50 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1071727-78-0, (Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Allergan, Inc.; US2008/255239; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 131747-55-2, name is 2-Fluoro-3-(hydroxymethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Fluoro-3-(hydroxymethyl)pyridine

Step (ii)A solution of (2-fluoropyridin-3-yl)methanol (400mg, 3.1mmol), methanesulfonyl chloride (0.37mL, 4.7mmol) and triethylamine (0.88mL, 6.30mmol) in dichloromethane (lOmL) was stirred at rt for 16h. The mixture was then diluted with dichloromethane and washed with H20, then brine. The organic phase was collected, dried (MgS04) and concentrated in vacuo to give (2-fluoropyridin-3-yl)methyl methanesulfonate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 131747-55-2, 2-Fluoro-3-(hydroxymethyl)pyridine.

Reference:
Patent; CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew; WO2011/48082; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 98353-08-3 ,Some common heterocyclic compound, 98353-08-3, molecular formula is C8H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5-ethoxypicolinic acid (14.36 mg, 0.086 mmol) in DMF (1 mL)was added HATU (33 mg, 0.086 mmol). The reaction mixture was stirred at rt for 5 mm, followed by addition of (R)- 1 -(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethanamine (18 mg, 0.066 mmol) Intermediate 40L and N-methylmorpholine (0.032 mL, 0.264 mmol). The resulting mixture was stirred at rt for 2 h. The reaction mixture was concentrated in vacuo and the residue was dissolved in MeOH, filtered, and purified via preparativeHPLC to give Example 163 (16 mg, 0.03 8 mmol, 57% yield). LC-MS Anal. Calc?d for C25H28FN302 421.22, found [M+H] 422.3. T = 1.63 mm (Method I). ?H NMR (500MHz, DMSO-d6) oe: 8.81 (d, J=4.4 Hz, 1H), 8.36 (d, J=9.6 Hz, 1H), 8.26 (d, J2.4 Hz, 1H), 8.07 (dd,J9.1, 5.8 Hz, 1H), 7.99-7.85 (m, 2H), 7.73-7.59 (m, 1H), 7.55-7.39 (m, 2H),4.39 (d, J6.6 Hz, 1H), 4.14 (q, J6.9 Hz, 2H), 3.71 – 3.52 (m, 1H), 1.94 – 1.52 (m, 9H),1.34 (t, J=6.9 Hz, 3H), 1.19 (d, J6.4 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 98353-08-3, 5-Ethoxypicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FLEXUS BIOSCIENCES, INC.; BECK, Hilary Plake; JAEN, Juan Carlos; OSIPOV, Maksim; POWERS, Jay Patrick; REILLY, Maureen Kay; SHUNATONA, Hunter Paul; WALKER, James Ross; ZIBINSKY, Mikhail; BALOG, James Aaron; WILLIAMS, David K.; MARKWALDER, Jay A.; SEITZ, Steven P.; CHERNEY, Emily Charlotte; ZHANG, Liping; SHAN, Weifang; GUO, Weiwei; HUANG, Audris; (231 pag.)WO2016/73774; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13602-82-9, Adding some certain compound to certain chemical reactions, such as: 13602-82-9, name is N-(2-Chloropyridin-4-yl)acetamide,molecular formula is C7H7ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13602-82-9.

A mixture of 10 g (59 mmol) N~(2-chloropyridin-4-yl)acetamide (commercially available), 9.8 g (17.6 mmol) pulverized KOH and 4.1 ml (6.4 mmol) methyl iodide in 60 ml acetone was stirred at room temperature for 2 h. After evaporation of all volatiles the residue was taken up in water and extracted with ethyl acetate. The combined organic layers were dried with MgSQ4 and evaporated to yield 7.1 g (66%) of the title compound as off-white solid. MS: (m/e): 345.2 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13602-82-9, N-(2-Chloropyridin-4-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63718; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 801303-22-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 801303-22-0, name is 2-Amino-5-fluoronicotinonitrile. A new synthetic method of this compound is introduced below.

To a solution of furan (16.6 mmol) in 50 mL THF at -78 C was slowly added 17 mmol n-BuLi (6.8 mL of a 2.5 M solution in hexanes). The solution was transferred to an ice water bath, and allowed to stir for 1.5 hours. The furanyllitium solution was returned to the -78 C bath prior to the addition of 2-amino-5-fluoronicotinonitrile (570 mg, 4.16 mmol) dissolved in 15 mL THF. The combined mixture was then returned to the 0 C ice water bath. After 30 minutes at 0 C the reaction was quenched with NH4CI (aq) and the organic layer washed several times with water, dried (MgS04), and concentrated under vacuum to yield 800 mg product, MS (M+H) = 206, H NMR (300 MHz, DMSO-D6) # ppm 6.69 (dd, J=3.39, 1.88 Hz, 1 H) 6.94 (d, J=3.39 Hz, 1 H) 7.30 (s, 2 H) 7.67 (dd, J=9.80, 3.01 Hz, 1 H) 7.96 (d, J=1.51 Hz, 1 H) 8.12 (d, J=3.01 Hz, 1 H) 10.85 (s, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,801303-22-0, 2-Amino-5-fluoronicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; WO2005/111001; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 59942-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59942-87-9, name is Pyrazolo[1,5-a]pyridin-2(1H)-one, molecular formula is C7H6N2O, molecular weight is 134.1353, as common compound, the synthetic route is as follows.

To a solution of pyrazolo[1,5-a]pyridin-2-ol (120 mg, 0.89 mmol) in 4 mL of anhydrous DMF, were added K2CO3 (270 mg, 1.95 mmol), 4-(2-chloroethyl)morpholine hydrochloride (183 mg, 0.98 mmol) and Nal (134 mg, 0.89 mmol) and the mixture heated to 80 ºC for 18 h under nitrogen. The solvent was evaporated under reduced pressure and the residue poured into a mixture of EtOAc and water, to afford after drying and evaporation of organic layers, 112 mg of an oil that was purified by silica gel flash chromatography with EtOAc/MeOH (9:1) as eluent to afford 57 mg of 4-(2-(pyrazolo[1,5-a]pyridin-2-yloxy)ethyl)morpholine. 40 mg (0.43 mmol) of anhydrous oxalic acid in 0.5 mL of acetone were added to a solution of 98 mg of 4-(2-(pyrazolo[1,5-a]pyridin-2-yloxy)ethyl)morpholine base oil in 0.5 mL of acetone.

Statistics shows that 59942-87-9 is playing an increasingly important role. we look forward to future research findings about Pyrazolo[1,5-a]pyridin-2(1H)-one.

Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; Diaz-Fernandez,Jose-Luis; Cuberes-Altisent,Mª Rosa; EP2631236; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 213193-32-9, Adding some certain compound to certain chemical reactions, such as: 213193-32-9, name is 5-Acetyl-2-methoxypyridine,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 213193-32-9.

To a solution of 111-2 (5 g, 33 mmol) in 20 mL of EtOH was added aq. HBr (48%, 60 mL), the reaction mixture was heated to reflux overnight. After being cooled to rt., the mixture was neutralized by addition of saturated aq. NaHCO3, extracted with EtOAc (100 mLx3). The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated to supply crude 111-3 (3 g, 65% yield) as white solid.

According to the analysis of related databases, 213193-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INTERMUNE, INC.; RAMPHAL, Johnnie, Y.; BUCKMAN, Brad, Owen; EMAYAN, Kumaraswamy; NICHOLAS, John, Beamond; SEIWERT, Scott, D.; WO2015/153683; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem