Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 4966-90-9, 4-Hydroxy-6-methyl-3-nitropyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 4966-90-9, blongs to pyridine-derivatives compound. Product Details of 4966-90-9

Step A: A stirred solution of 4-hydroxy-6-methyl-3-nitro-2-pyridone (2.24 g, 13.2 mmol) in POCl3 (13 mL) was refluxed overnight. The excess POCl3 was removed under vacuum and ice was added to the black residue. The resulting slurry was carefully neutralized (pH 7) by addition of conc. NH4OH. The resulting slurry was poured through filter paper, washing the solid with cold water. The solid was dried under vacuum at 50 C. overnight to give crude 2,4-dichloro-6-methyl-3-nitropyridine, 2.12 g (78%) as black crystals.

The synthetic route of 4966-90-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Vanderbilt University; Fesik, Steve; Waterson, Alex; Burns, Michael; Sun, Qi; Phan, Jason; Salovich, James M.; Abbott, Jason R.; Little, Andrew; (159 pag.)US10501421; (2019); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 36953-37-4 ,Some common heterocyclic compound, 36953-37-4, molecular formula is C5H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium chloro(difluoro)acetate (5.26 g, 34.5 mmol) and potassium carbonate (0568) (3.57 g, 25.8 mmol) were added to a solution of 4-bromopyridin-2(1 /-/)-one (3.00 g, 17.2 mmol) in /V,/V-dimethylformamide (30 mL), and the reaction mixture was stirred at 95 C for 2 hours. Water (100 mL) was added, and the resulting mixture was extracted with ethyl acetate (3 x 50 mL). The combined organic layers were washed sequentially with water (200 mL) and with saturated aqueous sodium chloride solution (150 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Silica gel chromatography (Eluent: 15: 1 petroleum ether / ethyl acetate) afforded the product as a pale yellow oil. Yield: 1 .5 g, 6.7 mmol, 39%. 1H NMR (400 MHz, CDCI3) delta 8.04 (d, J=5.5 Hz, 1 H), 7.44 (t, JHF=72.6 HZ, 1 H), 7.27 (dd, J=5.4, 1 .6 Hz, 1 H), 7.12 (br d, J=1 .5 Hz, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36953-37-4, its application will become more common.

Reference:
Patent; PFIZER INC.; ZHANG, Lei; BUTLER, Christopher Ryan; BECK, Elizabeth Mary; BRODNEY, Michael Aaron; BROWN, Matthew Frank; MCALLISTER, Laura Ann; LACHAPELLE, Erik Alphie; GILBERT, Adam Matthew; (170 pag.)WO2018/2760; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 13602-82-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13602-82-9, name is N-(2-Chloropyridin-4-yl)acetamide. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4.6 g (27 mmol) N-(2-chloropyridin-4-yl)acetamide (commercially available) and 5.2 g (41 mmol) l-(2-propyl-)-pirhoerazine in 2 ml DMF was heated to 150 0C for 4 h. Purification of the crude mixture with flash column chromatography on silica eluting with a gradient formed from DCM (1% NEt3) and methanol yielded after evaporation of the product fractions 3.38 g (47%) of the title compound as white solid. MS: (m/e): 263.4 (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13602-82-9, N-(2-Chloropyridin-4-yl)acetamide.

Reference:
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63718; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 10167-97-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10167-97-2, name is 2-Amino-5-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5-methoxypyridin-2-amine (15.0 g) in methanol (40 mL) and water (20 mL) was added 2-chloroacetaldehyde (25.0 g) and sodium bicarbonate (10.2 g). The mixture was stirred under reflux for 2 hours, and then concentrated. The residue was partionedbetween EA and aq. NaH CO3 solution. The organic layer was concentrated and purified by column chromatography to afford 6-methoxyimidazo[1 ,2-a]pyridine (15.0 g).

According to the analysis of related databases, 10167-97-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHEN, Weichun; IGBOKO, Ebere F; LIN, Xichen; LU, Hongfu; REN, Feng; WREN, Paul Bryan; XU, Zhongmiao; YANG, Ting; ZHU, Lingdong; WO2015/181186; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 824-51-1, 6-Methyl-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C8H8N2, blongs to pyridine-derivatives compound. Formula: C8H8N2

PREPARATION 124 5-Bromo-2-(6-methyl-1 H-pyrrolo[2,3-b]pyridin-1 -yl)benzonitrile The title compound of Preparation 58 (0.05 g, 0.38 mmol) was dissolved in 1 ml dimethylformamide. Potassium carbonate (0.105 g, 0.76 mmol) and 5-bromo-2- fluorobenzonitrile (0.1 14 g, 0.57 mmol) were added and the reaction mixture was stirred at 150 C for 3h. The mixture was allowed to cool to room temperature and was partitioned between ethyl acetate and water. The organic layer was washed with water, dried over sodium sulphate, filtered and concentrated under reduced pressure. The residue was purified using the Isolera Purification System (ether-hexane gradient, 0: 100 rising to 100:0) to give 0.1 10 g (0.35 mmol, 93%) of the title compound as a yellow solid. Purity 99%. UPLC/MS (3 min) retention time 1 .84 min. LRMS: m/z 312 (M+1 ).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,824-51-1, 6-Methyl-1H-pyrrolo[2,3-b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta; WO2013/10880; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 58481-17-7, Methyl 2-(hydroxymethyl)isonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 2-(hydroxymethyl)isonicotinate, blongs to pyridine-derivatives compound. name: Methyl 2-(hydroxymethyl)isonicotinate

Under ice-cooling, sodium hydride (187 mg, 60%, dispersed in liquid paraffin) was added to a solution ofmethyl 2-(hydroxymethyl)isonicotinate (650 mg) in N,N-dimethyl formamide (8.0 mL), followed by stirringfor 15 minutes. Methyl iodide (740 muL) was added thereto, followed by stirring for 1 hour. Ethyl acetate wasadded thereto, then, the organic layer was washed with a saturated aqueous sodium chloride solution, anddried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the obtainedresidues were purified by silica gel column chromatography (hexane:ethyl acetate=9:1?1:1), wherebymethyl 2-(methoxymethyl)isonicotinate (370 mg) was obtained as a colorless oily material

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58481-17-7, Methyl 2-(hydroxymethyl)isonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; FUJIFILM Corporation; KUBO, Yohei; ANDO, Makoto; TANAKA, Hidehiko; OSAKA, Shuhei; MATSUMOTO, Takuya; NAKATA, Hiyoku; TERADA, Daisuke; NITABARU, Tatsuya; (379 pag.)US2016/168139; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1192813-41-4, Adding some certain compound to certain chemical reactions, such as: 1192813-41-4, name is 2-(Difluoromethoxy)-5-nitropyridine,molecular formula is C6H4F2N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1192813-41-4.

Step B: 6-(Difluoromethoxy)pyridin-3-amine To 2-(difluoromethoxy)-5-nitropyridine (4.7 g, 24.7 mmol) in degassed methanol (100 mL) was added 10% palladium on carbon (500 mg, 0.47 mmol) and the reaction was hydrogenated at atmospheric pressure for 1 hour. To this was added acetic acid (2.83 mL, 49.4 mmol) and the reaction was filtered through Celite and concentrated in vacuo to afford 6-(difluoromethoxy)pyridin-3-amine (6.33 g, 25.9 mmol, 105% yield) as an olive green liquid. 1H NMR (400 MHz, MeOD-d4) delta ppm 7.60 (d, J=2.76 Hz, 1H), 7.37 (s, 0.5H), 7.15 (dd, J=8.66, 2.89 Hz, 1H), 7.00 (s, 0.5H), 6.71 (d, J=8.78 Hz, 1H).

According to the analysis of related databases, 1192813-41-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bristol-Myers Squibb Company; US2009/270405; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4966-90-9, name is 4-Hydroxy-6-methyl-3-nitropyridin-2(1H)-one, molecular formula is C6H6N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

Part A 2,4-Dichloro-6-methyl-3-nitropyridine 4-hydroxy-6-methyl-3-nitropyridone, (18.67 g, 0.11 mol) was heated at reflux with diethylaniline (19 mL, 0.12 mol) in POCl3 (85 mL) for 3 h. After cooling it was poured into ice/water (800 mL), allowed to react for 2.5 h and extracted with EtOAc (3*400 mL). The combined organic extracts were washed with NaHCO3 (200 mL), brine (200 mL), dried (MgSO4) and stripped in vacuo. The residue was dissolved in EtOAc (100 mL) and passed through a glass funnel packed with 1 in silica gel and 1 in celite. The filtrate was stripped in vacuo to give the product. NMR (CDCl3) 7.30 (s, 1H), 2.61 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 4966-90-9.

Reference:
Patent; Dupont Pharmaceuticals Company; US6107301; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 138588-22-4, Adding some certain compound to certain chemical reactions, such as: 138588-22-4, name is 3-(Pyridin-2-yl)-1,2,4-thiadiazol-5-amine,molecular formula is C7H6N4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 138588-22-4.

3-Pyridin-2-yl-[l,2,4]thiadiazo{-5-ylamine (50 mg, 0.28 mmol) was dissolved in 1 mL of anhydrous tetrahydrofuran, to which solution was added p-methoxyphenyl isocyanate (36 muEpsilon, 0.28 mmol). The mixture was stirred at 50 C overnight. Precipitation formed which was filtered and rinsed with methanol to yield a white solid (47,9 mg, 52%). NMR (400 MHz, DMSO-ifc) delta ppm 3.74 (s, 3 H) 6.81 – 7.06 (m, 2 H) 7.32 – 7.46 (m, 2 H) 7.46 – 7.57 (m, 1 H) 7.83 FontWeight=”Bold” FontSize=”10″ 8.06 (m, 1 i n 8.19 i d. ./ 7.S6 Hz, 1 H) 8.60 · 8.90 (m, 1 H) 9.12 (s, 1 I I ) 1 1.49 (s, 1 H); LCMS (M/Z): M+H ” 328.

According to the analysis of related databases, 138588-22-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCYNEXIS INC.; LIU, Hao; SLIGAR, Jessica, Marie; SPEAKE, Jason, Daniel; MOORE, Joseph, A., III; BECK, Brent, Christopher; WO2015/73797; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 88569-83-9, 2-Methoxy-6-(methylamino)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Methoxy-6-(methylamino)pyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2-Methoxy-6-(methylamino)pyridine

Preparation 4 Ethyl 6-iodo-7-methoxy-1-methyl-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate 6-Methoxy-N-methyl-2-pyridinamine (17.24 g, 124 mmol) is dissolved in DMF (160 mL) and cooled to 0 C. followed by the addition of NIS (28 g, 124 mmol, 1 equiv), at a rate which keeps the reaction temperature below 10 C. The reaction is then allowed to warm to room temperature and stirred for 1 h. The reaction is distilled to dryness in vacuo and the residue is dissolved in CH2Cl2 and passed through a silica plug eluding with heptane/EtOAc (9/1) affording 32 g of crude 5-iodo-6-methoxy-N-methyl-2-pyridinamine. The crude 5-iodo-6-methoxy-N-methyl-2-pyridinamine is dissolved in diethyl ethoxymethylenemalonate (32 mL) and the mixture is heated at 140 C. for 2 h, then cooled to room temperature and passed through a silica plug eluding with heptane/EtOAc (19/1, 0/1). The product is then dissolved in Eaton’s reagent (132 mL) and heated at 100 C. for 40 min, cooled to rt and poured into Na2CO3. The basic aqueous layer is then extracted with CH2Cl2 (3*), washed with water, and brine, dried (MgSO4), filtered and concentrated in vacuo. The residue is purified by silica gel chromatography (heptane/EtOAc, 4/1, 1/1, CH2Cl2/MeOH 19/1) the desired product is then triturated with MeOH to afford 7.9 g (16%) of ethyl 6-iodo-7-methoxy-1-methyl-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate. Physical characteristics are as follows: 1H NMR (CDCl3) delta 9.04, 8.52, 4.41, 4.13, 3.91, 1.43; IR (diffuse reflectance) 2491, 2427, 2350, 2282, 2242, 1678, 1632, 1613, 1579, 1384, 1309, 1275, 1227, 1106, 804, cm-1; MS (EI) m/z 388, 344, 343, 317, 316, 185, 159, 86, 84, 51; Anal calcd for C13H13IN2O4: C, 40.23; H, 3.38; N, 7.22. Found: C, 40.20; H, 3.40; N, 7.16.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,88569-83-9, 2-Methoxy-6-(methylamino)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Vaillancourt, Valerie A.; Thorarensen, Atli; US2002/19413; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem