Tag: M.W:100-200

Reference of 10128-72-0, Adding some certain compound to certain chemical reactions, such as: 10128-72-0, name is Methyl 3-hydroxyisonicotinate,molecular formula is C7H7NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10128-72-0.

Example A; 3, N-Dihydroxy-isonicotinamide To a stirred suspension of methyl 3-hydroxy-isonicotinate (176 g; 1.15 mol) in water/ice (50/50,1700 mL), was added hydroxylamine hydrochloride (127.9 g; 1.84 mol). The temperature fell to-5 C and then aqueous NAOH solution (454 mL, 28% w/v) was added dropwise keeping the temperature below 5 C during the addition. Hereafter the reaction mixture was stirred at ambient temperature for 1.5 h followed by heating to 60 C. At this temperature the pH was adjusted to 5.4 by the addition of aqueous hydrochloric acid (10 M) at which point a heavy precipitate forms. The reaction mixture was then stirred at ambient temperature followed by cooling to 5 C. THE pH was then adjusted to 4.0 by the addition of aqueous hydrochloric acid (10 M), and then was stirred whilst cold for 1,5 h. The crystals were filtered off, rinsed with water (3 x 100 mL), dried on the filter and then dried further at reduced pressure and 40 C overnight to give 3, N-dihydroxy-isonicotinamide (169.3 g, 96%; HPLC purity 98%) as a white solid. NMR data : H-NMR (DMSO-d6,250 MHz) 8 = 7.55 (1H, d, J=6 Hz); 8.11 (1H, d, J=6 Hz); 8.32 (1H, s); 9.56 (1H, s, broad peak); 11.50 (1H, s, broad peak) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10128-72-0, Methyl 3-hydroxyisonicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; H. LUNDBECK A/S; WO2005/23820; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13958-86-6, 5-Methylpyridine-3,4-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Methylpyridine-3,4-diamine, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Methylpyridine-3,4-diamine

Aquo composite of 7-methyl-1H-[1,2,3]triazolo[4,5-c]pyridinium nitrate was obtained from 5-methylpyridine-3,4-diamine. 19 mmol (2.4 g) of this substrate were dissolved in 75 mL of water and 3 mL of concentrated H2SO4 acid was added. This solution was cooled to 0 C and then a solution made from 15 mL of water and 30 mmol (2.1 g) of NaNO2 was added dropwise. The mixture was stored at room temperature for 0.5 h, vaporized to its half volume and neutralized with KHCO3. After filtration 1.9 g of powder (melting point 260 C with its decomposition) was obtained. The yield of this synthesis was 73%. The obtained composite was recrystallized from a small amount of water. It is well soluble in water and alcohol but hardly soluble in benzene and chloroform. The transformation process of the cationic unit of the composite is described in Scheme 1 [53].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13958-86-6, 5-Methylpyridine-3,4-diamine, and friends who are interested can also refer to it.

Reference:
Article; Dymi?ska, Lucyna; Sheweshen, Khalil Salem M.; G?gor, Anna; Lorenc, Jadwiga; Hanuza, Jerzy; Journal of Molecular Structure; vol. 1133; (2017); p. 9 – 17;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1074-98-2, name is 3-Methyl-4-nitropyridine 1-oxide, molecular formula is C6H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H6N2O3

Step 2: A solution of 3-methyl-4-nitropyridine /V-oxide (30.0g, 195 mmol) and 10% Pd-C (6.0 g) in EtOH (450 mL) was stirred at rt under H2 (5 bar) for 36 h. The RM was filtered through a pad of celite and the volatiles were removed under reduced pressure to yield the desired compound (20.0 g, 95%).

With the rapid development of chemical substances, we look forward to future research findings about 1074-98-2.

Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 127356-38-1, 2-Methoxy-5-nitropyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 127356-38-1, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Methoxy-5-nitropyridin-4-amine

Step 3: Synthesis of 6-methoxypyridine-3,4-diamine Aq. conc. HCl (1 ml, 32.9 mmol) was diluted with water. To the solution was added tin (II) chloride (0.448 g, 2.365 mmol), followed by 2-methoxy-5-nitropyridin-4-amine (0.1 g, 0.591 mmol). The mixture was heated to 60 C. for 18 h. The reaction mixture was cooled to room temperature, then basified using 10% NaOH solution. The mixture was extracted with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resultant crude compound was triturated with 10% ethyl acetate in Pet-ether to afford 6-methoxypyridine-3,4-diamine (0.06 g, 0.366 mmol, 62.0% yield) as a solid. 1H NMR (400 MHz, DMSO-d6): delta ppm 7.21 (s, 1H), 5.83 (s, 1H), 5.39 (b s, 2H), 4.04 (b s, 2H), 3.62 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127356-38-1, its application will become more common.

Reference:
Patent; Sun, Li-Qiang; Zhao, Qian; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshim, Pulicharla; Gillis, Eric P.; Scola, Paul Michael; US2014/127156; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 188637-63-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 188637-63-0 as follows.

To a mixture of A214.2 (14.3 g, 76.5 mmol) and pyridine (14.3 mL) in anhydrous tetrahydrofuran (250 mL) was added acetic anhydride (14.3 mL), and the reaction mixture was stirred for 3 hr at room temperature. The solvent was removed under reduced pressure, and the oily residue was diluted with dichloromethane, washed with water, washed with a saturated aqueous solution of sodium bicarbonate, and dried over anhydrous sodium sulfate. Concentration followed by drying under reduced pressure afforded 16.3 g (93%) of A214.3 as an off-white solid. The compound had an HPLC retention time = 0.987 min. (Column: Chromolith SpeedROD 4.6 x 50 mm – 4 min.; Solvent A = 10% MeOH, 90% H2O, and 0.1% TFA; Solvent B = 90% MeOH, 10% H2O, and 0.1% TFA) and a LC/MS M+1 = 229.10 and 231.10.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,188637-63-0, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/122137; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 886365-46-4, name is 5-Chloro-3-methylpyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below., Recommanded Product: 5-Chloro-3-methylpyridine-2-carboxylic acid

Example 170 Synthesis of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-methylpicolinamide The titled compound was synthesized by procedure and steps analogous to those described in Method Y, Example 163 above, but using 5-chloro-3-methyl-pyridine-2-carboxylic acid (Frontier Scientific, Inc) in step 10. MS m/z=463.0 [M+H]+. Calculated for C19H16ClF5N4O2: 462.8 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.68 (br. s., 3H) 1.94 (t, J=12.52 Hz, 1H) 2.78 (br. s., 4H) 3.99-4.15 (m, 1H) 7.03 (br. s., 1H) 7.66 (br. s., 1H) 8.11 (br. s., 1H) 8.39 (br. s., 1H) 10.06 (br. s., 1H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 886365-46-4, 5-Chloro-3-methylpyridine-2-carboxylic acid.

Reference:
Patent; MINATTI, Ana Elena; LOW, Jonathan D.; ALLEN, Jennifer R.; CHEN, Jian; CHEN, Ning; CHENG, Yuan; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; TAMAYO, Nuria A.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; US2014/249104; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 121643-44-5, 2-Methoxy-3-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 121643-44-5, blongs to pyridine-derivatives compound. Recommanded Product: 121643-44-5

2. 3-Trifluoromethyl-pyridin-2-ol EPO Heat a mixture of 2-methoxy-3-trifluoromethyl-pyridine (1.0 g, 5.6 mmol) and 30% HBr in acetic acid (5 mL) at reflux for 1 hour. Cool the mixture and remove the volatiles by rotary evaporation. Add ether and collect the precipitate by filtration. Air-dry to give the title compound as the hydrogen bromide salt.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,121643-44-5, 2-Methoxy-3-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; NEUROGEN CORPORATION; WO2006/42289; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59290-81-2, name is 2-Methyl-5-nitro-3-pyridinecarboxylic acid, molecular formula is C7H6N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Methyl-5-nitro-3-pyridinecarboxylic acid

A mixture of intermediate C (14 mg, 0.06 mmol), oxalyl chloride (0.3 mmol) and a catalytical amount of DMF in 1 ml DCM was stirred at r.t. for 1.5 hr. After evaporation to dryness, the resulting acid chloride was coupled with compound 17 (0.05 mmol) in 0.5 ml DCM in presence of DIEA (44 mul, 5 eq.). The reaction mixture was stirred at r.t. overnight before concentration to dryness. Preparative HPLC purification gave 28.3 mg of the product as the TFA salt. (Calculated mass: 552.6, observed mass: 552.8).

With the rapid development of chemical substances, we look forward to future research findings about 59290-81-2.

Reference:
Patent; KEMIA, INC.; WO2007/56016; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 700811-29-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 700811-29-6, name is 2-Chloro-4-hydrazinopyridine. A new synthetic method of this compound is introduced below.

A microwave reaction vessel was charged with 1.34 g of (2-Chloro-pyridin-4-yl)-hydrazine (7.48 mmol, 1.1 equiv) and 2.00 g of N-cyano-N’-(4-acetamidophenyl)-O-phenylisourea (6.80 mMol, 1 equiv). The solids were dissolved in 40 mL of NMP and 8 mL of DIEA. The sealed vessel was warmed to 220 C. for 6 min via microwave irradiation. Upon cooling, the resulting solution was poured into 200 mL of saturated sodium bicarbonate. The precipitate was collected and washed with 3×100 mL of water. After azeotropic drying (3×50 mL of acetonitrile) the dark yellow solid (2.0 g, 5.80 mMol, 85% yield) was used without further purification. 1H NMR (500 Mhz, DMSO-d6) delta 9.68 (1 H, s), 9.00 (1 H, s), 8.40 (1 H, d), 7.67 (2 H, m), 7.50 (2 H, d), 7.40 (2 H, d), 6.95 (2 H, s), 2.0 (3 H, s) ppm. LCMS: 2.16 minutes/343.95 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,700811-29-6, 2-Chloro-4-hydrazinopyridine, and friends who are interested can also refer to it.

Reference:
Patent; Salituro, Francesco; Ledeboer, Mark; Ledford, Brian; Wang, Jian; Pierce, Albert; Duffy, John; Messersmith, David; US2006/63756; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99368-68-0, name is 6-Chloro-5-(trifluoromethyl)pyridin-3-amine, molecular formula is C6H4ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 99368-68-0

The crude 6-chloro-5- (trifluoromethyl) pyridin-3-amine 5(crude 1.3 g, 6.61 mmol) was dissolved in pyridine (10 ml), then 4-dimethylaminopyridine (DMAP) (50 mg) was added. di -t- butyl dicarbonate(2.17g) was added dropwise, and the mixture was stirred for 4 hours at 22 . Toluene (20ml) was added, all solvent was removed under reducedpressure. The residue was filtered through a plug of silica gel (hexane/ ethyl acetate 2: 1), to obtain t- butyl N-6- chloro-5- (trifluoromethyl)pyridin-3-yl carbamate 6.

With the rapid development of chemical substances, we look forward to future research findings about 99368-68-0.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; JUNG, MICHAEL E; SAWYERS, CHARLES L; OUK, SAMEDY; TRAN, CHRIS; WONGVIPAT, JOHN; (40 pag.)JP2016/11315; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem