Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83766-88-5, name is 2-(tert-Butoxy)pyridine, the common compound, a new synthetic route is introduced below. name: 2-(tert-Butoxy)pyridine

Carboxylic acid (0.2 g, 1.64 mmol), tert-butoxypyridine (0.33 g, 2.21 mmol) and boron trifluoride diethyl etherate (0.31 g, 2.21 mmol) in dry PhCH3 (2 mL) were added to a 20-ml vial. The reaction mixture was then allowed to stir at room temperature for 30 min before quenching with anhydrous NaHCO3. The reaction mixture was diluted with ethyl acetate (30 mL), then washed with water (20 mL), followed by brine (20 mL). The organic layer was dried over anhydrous sodium sulfate and carefully concentrated under reduced pressure. The resulting residue was then purified by flash column chromatography on silica gel with 0:4 to 1:4 dichloromethane/hexane as eluent to yield the desired product 5a as a colorless oil.

The synthetic route of 83766-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; La, Minh Thanh; Kim, Hee-Kwon; Tetrahedron; vol. 74; 27; (2018); p. 3748 – 3754;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63237-88-7, name is Pyrazolo[1,5-a]pyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. Safety of Pyrazolo[1,5-a]pyridine-2-carboxylic acid

To a stirred solution of pyrazolo[1,5-a]pyridine-2-carboxylic acid (2.01 g, 12.4 mmol) in 65 mL of dry tetrahydrofuran (THF) cooled at 0 C, under nitrogen, were slowly added 31 mL (62.1 mmol) of a 2 M solution of borane dimethyl sulfide in toluene. After 30 min. at room temperature, the solution was heated at 65 ºC for 5 h, and then cooled to 0 ºC to add 15 mL of water. After addition of 8 mL of 6N solution of HCl, the mixture was refluxed for 2 h. Finally, the organic solvent was removed under reduced pressure, 40 mL of methanol were added and concentrated. The residue was solved in ethyl acetate, and washed with aqueous NaOH 10% solution and water. The organic layers were dried (Na2SO4) and concentrated to afford 1.42 g (77%) of pyrazolo[1,5-a]pyridin-2-ylmethanol as a colorless oil.

The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; Diaz-Fernandez,Jose-Luis; Cuberes-Altisent,Mª Rosa; EP2631236; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 56826-61-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56826-61-0, name is (2-Methylpyridine-3-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-(2-((2-methylpyridin-3-yl)methyl)benzofuran-5- yl)acetamidea) 2-methylnicotinaldehydeTo a stirred solution of (2-methylpyridin-3-yl)methanol (200 mg, 1.6 mmol) in CH2CI2 (10 mL) was added M11O2 (200 mg, 2.3 mmol). The reaction mixture was refluxed overnight under N2. The solid was removed by filtration and the filtrate was concentrated. The resultant residue was purified by flash chromatography (50% EtO Ac/petroleum ether) to afford the title compound (120 mg, 60%) as a colorless liquid. LCMS-P1 : 122.0 [M+H]+; Rt: 0.344 min.

According to the analysis of related databases, 56826-61-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 83766-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83766-88-5, name is 2-(tert-Butoxy)pyridine, molecular formula is C9H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Carboxylic acid (0.2 g, 1.64 mmol), tert-butoxypyridine (0.33 g, 2.21 mmol) and boron trifluoride diethyl etherate (0.31 g, 2.21 mmol) in dry PhCH3 (2 mL) were added to a 20-ml vial. The reaction mixture was then allowed to stir at room temperature for 30 min before quenching with anhydrous NaHCO3. The reaction mixture was diluted with ethyl acetate (30 mL), then washed with water (20 mL), followed by brine (20 mL). The organic layer was dried over anhydrous sodium sulfate and carefully concentrated under reduced pressure. The resulting residue was then purified by flash column chromatography on silica gel with 0:4 to 1:4 dichloromethane/hexane as eluent to yield the desired product 5a as a colorless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 83766-88-5, 2-(tert-Butoxy)pyridine.

Reference:
Article; La, Minh Thanh; Kim, Hee-Kwon; Tetrahedron; vol. 74; 27; (2018); p. 3748 – 3754;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

557.8g 2,3,6-trichloropyridine, which is obtainedby the chlorination, 123.5g triethylamine, 8.4g palladium-carbon and 1673g toluene are added to a reactorfor one time, then heated to 60?80C, and hydrogen gasis introduced to proceed hydrogenating. When pH valueof the reaction solution reaches 4?8, stopping introduci After the aforementioned reaction solution wascooled to room temperature, 420g water is added for dissolvingtriethylamine hydrochloride. Then the reactionsolution is filtered, and the cake which is palladium carbonwashed by 30g water and 30g toluene can be recycled.The filtrate is allowed to stand stratification, andthen the toluene layer is extracted by 200g hydrochloricacid at least three times after the water was separated.The extracted solution can be recycled for the next batchwith replenishing 2,3,6-trichloropyridine and toluene. Thehydrochloride layers are combined and diluted by 1630gwater after extraction, and then solid is crystallized. Thesolid is washed by 100g water (the waste water can berecycled for extraction) after filtration, then wet 2,3-dichloropyridine is given. Dry product of 2,3-dichloropyridineis given by drying the wet product. Finally, 387.7gproduct is totally gained when the waste water is recycled,and the yield is 85.7%, the purity is greater than orequal to 99.5%.

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Lianhe Chemical Technology Co., Ltd.; Jiangsu Lianhe Chemical Technology Co., Ltd; WANG, Ping; FAN, Xiaobin; ZHANG, Juntao; YE, Fangsheng; EP2687510; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 135900-33-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.135900-33-3, name is 6-(Trifluoromethoxy)pyridin-3-amine, molecular formula is C6H5F3N2O, molecular weight is 178.11, as common compound, the synthetic route is as follows.

[0289] Quinoline-7-carboxylic acid (70 mg, 0.404 mmol, 1.0 eq) and 6- (trifluoromethoxy)-pyridin-3-amine (79 mg, 0.44 mmol, 1.1 eq) were dissolved in 1 mL of DMF and the resulting mixture was cooled down to 0 C. HATU (168 mg, 0.44 mmol, 1.1 eq) and DIPEA (0.144 mL, 0.808 mmol, 2.0 eq) were added at 0 C, and then the reaction mixture was allowed to warm up to room temperature and stirred at room temperature for 4 hrs. The progress of the reaction was monitored by LCMS and TLC. Upon completion, the reaction mixture was poured into ice-cold water. The formed solid was filtered, washed and dried in vacuo to give 20 mg of the desired compound 126 as a pale-yellow solid in 15% yield. 1H NMR (400 MHz, CDC13): delta 9.03-9.02 (dd, J = 2.8 Hz, 1.6 Hz, 1H), 8.57 (s, 1H), 8.48 (s, 1H), 8.46-8.45 (d, J = 2.8 Hz, 1H), 8.26 (s, 1H), 8.24 (brs, 1H), 8.09-8.12 (dd, J = 8.8 Hz, 1.6 Hz, 1H), 8.0-7.97 (d, J = 8.8 Hz, 1H), 7.56-7.52 (dd, J = 8.4 Hz, 4.4 Hz, 1H), 7.12-7.10 (d, J = 8.8 Hz, 1H). 99.15% purity by LCMS; m/z =334.19 [M+H]+.

Statistics shows that 135900-33-3 is playing an increasingly important role. we look forward to future research findings about 6-(Trifluoromethoxy)pyridin-3-amine.

Reference:
Patent; ACTAVALON, INC.; DNEPROVSKAIA, Elena, V.; HOLZWARTH, Michael, S.; RYCHNOVSKY, Scott, D.; (184 pag.)WO2018/85348; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628691-93-0, name is 2-Chloro-3-fluoroisonicotinic acid, the common compound, a new synthetic route is introduced below. Computed Properties of C6H3ClFNO2

Example 125: 3-(4-Bromo-2-fluoro-phenylamino)-2-chloro-isonicotinic acid; 2-Chloro-3-fluoro-isonicotinic acid (200mg, 1.14mmol) and 4-bromo-2-fluoroaniline (217mg, 1.14mmol) were added to 5ml of dry THF and the mixture was cooled to -78 0C. LiHMDS (1 M in THF, 4.0ml) was added and the mixture was allowed to warm to room temperature over night. Solid ammonium hydrochloride (1g) was added and after 1h the mixture was filtered and the volatiles were removed in vacuo. The crude material was purified by flash-chromatography using a gradient of 0-12% methanol (containig 0.5% EPO formic acid) in DCM as eluent to give 213mg (0.617mmol; 54% yield) of pure desired carboxylic acid product. LC-MS (method IiI): rt = 4.42min; m/z [M+H]+ 386/388.

The synthetic route of 628691-93-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2006/45514; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 116855-08-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116855-08-4, name is 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Step 5 To a solution of 1H-pyrazole[3,4-b]pyridine-3-carboxylic acid (XIII) (0.39 g, 2.4 mmol) in dry MeOH (10 mL) was added concentrated H2SO4 (4 drops) and refluxed for 6 h under nitrogen. The solution was cooled and the solvent was evaporated under vacuum. The residue was partitioned between DCM and saturated aqueous NaHCO3 solution. The organic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified on a flash silica gel column (100% DCM?3:97 MeOH:DCM) to produce methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate (XIV) as a white solid (382 mg, 2.16 mmol, 90% yield). 1H NMR (CDCl3) delta ppm 4.08 (s, 3H), 7.38 (m, 1H), 8.63 (dd, J=8.10 Hz, J=1.51 Hz, 1H), 8.72 (dd, J=4.62 Hz, J=1.41 Hz, 1H); ESIMS found for C8H7N3O2 m/z 178.2 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 116855-08-4, 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid.

Reference:
Patent; Samumed, LLC; KC, Sunil Kumar; Wallace, David Mark; Cao, Jianguo; Chiruta, Chandramouli; Hood, John; (264 pag.)US2016/68550; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 72587-18-9, name is 2-Chloro-5-(trifluoromethyl)pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H4ClF3N2

[0276] [B] N- (2-Chloro-5- (trifluoromethyl) pyridin-3-yl) acetamide [0277] [0278] A mixture solution of 2-chloro-5- (trifluoromethyl) pyridin-3-amine (75 g, 381.6 mmol) and Ac2O (82.5 mg, 808.1 mmol) in pyridine (200 mL) was stirred at 80 for 16 h. After cooling to room temperature, it was diluted with EtOAc (500 mL), washed with water and brine. The organic layer was dried over anhy. Na2SO4, filtered, and concentrated in vacuo to give a crude product, which was first purified by silica gel flash chromatography (petroleum etherEtOAc 51) and then crystallization in petroleum ether (100 mL) to afford the title compound (65 g, mixture of mono-and bis-Ac protected product, 73yield) as white solids. MS239.0 [M+H] +.N- (2-Methyl-5- (trifluoromethyl)pyridin-3-yl) acetamide[0280][0281]To a mixture of N- (2-chloro-5- (trifluoromethyl) pyridin-3-yl) acetamide and N-acetyl-N- (2-methyl-5- (trifluoromethyl) pyridin-3-yl) acetamide (35 g 146.7 mmol) K2CO3(62.2 g 450 mmol) methyl boroxine (50in ether 70 g 278.8 mmol) and X-phos (14.4 g 43mmol) in MeCN (250 mL) and water (150 mL) was added Pd (OAc)2(3.4 g 15.1 mmol) And the resulting reaction mixture was stirred at 100 for 16 h. After cooling to room temperature The reaction was diluted with EtOAc (300 mL) washed with water (300 mL) and brine (300 mL) . The organic layer was dried over anhy. Na2SO4 filtered and concentrated in vacuo to give a crude product which was then purified by silica gel flash chromatography (petroleum etherEtOAc51) to afford the title compound (20 g 57yield) as a gray solid. MS 219.0 [M+H]+.1H NMR (400MHz CHCl3-d1) delta 8.62 (s 1H) 8.54 (s 1H) 7.11 (br 1H) 2.60 (s 3H) 2.28 (s 3H) .

With the rapid development of chemical substances, we look forward to future research findings about 72587-18-9.

Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; TAN, Xuefei; WANG, Lisha; CUMMING, John Graham; LIU, Yongfu; WU, Jun; LI, Dongbo; SHEN, Hong; SHI, Tianlai; (179 pag.)WO2017/133657; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1122-43-6 ,Some common heterocyclic compound, 1122-43-6, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Description 143-(2-Fluoro-4-nitrophenoxy)- 14)2,6-Dimethyl-pyridin-3-ol (3.0 g, 24.35 mmol) and cesium carbonate (15.87 g, 48.71 mmol) were added to a solution of 3,4-difluoronitrobenzene (3.87 g, 24.35 mmol) in DMF (30 ml). The mixture was heated at 140 0C for 2 hours. After cooling to room temperature it was filtered through diatomaceous earth and the solvent evaporated in vacuo. The crude product was purified by column chromatography (silica gel; 2 % methanol/DCM as eluent) to yield intermediate D14 (5.88 g, 92 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-43-6, its application will become more common.

Reference:
Patent; ORTHO-McNEIL-JANSSEN PHARMACEUTICALS, INC.; ADDEX PHARMA S.A.; WO2009/33702; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem