Tag: M.W:100-200

Application of 1040682-68-5, Adding some certain compound to certain chemical reactions, such as: 1040682-68-5, name is 1H-Pyrrolo[3,2-c]pyridine-4-carbonitrile,molecular formula is C8H5N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1040682-68-5.

To a solution of lH-pyrrolo[3,2-c]pyridine-4-carbonitrile (60.0 mg, 0.42 mmol , 1.0 eq), NIS (52.0 mg, 0.46 mmol, 1.1 eq) in DCM (4.0 mL) was stirred at rt for 2 h. After the reaction was complete, water was added, and the mixture was extracted with EA. The organic layer was washed with water, dried over Na2S04, filtered and concentrated. The resulting residue was purified by column chromatography (EA/PE = 1/1, v/v) to provide 3-iodo-lH-pyrrolo[3,2-c]pyridine-4-carbonitrile (160 mg, 97%).

According to the analysis of related databases, 1040682-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (346 pag.)WO2018/11628; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 23100-12-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23100-12-1, name is 6-Chloronicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: Preparation of tert-butyl 4-((6-chloropyridin-3-yl)methyl)piperazine-1-carboxylate To a solution of 6-chloronicotinaldehyde (0.5 g, 2.68 mmol) and tert-butyl piperazine-1-carboxylate (0.6 g. 3.22 mmol) in DCE was added acetic acid (0.1 mL) and the reaction was stirred for 2 h at RT. Then NaBH(OAc)3 (1.7 g, 8.1 mmol) was added to the reaction portion-wise at RT. The reaction was stirred at RT for 16 hours. The reaction mixture was then concentrated. The crude material was dissolved in water and basified to pH 8-9 using saturated aqueous NaHCO3 solution. The mixture was extracted with EtOAc (2*25 mL). The combined organic layers were washed with water and brine, dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by preparative HPLC to afford tert-butyl 4-((6-chloropyridin-3-yl)methyl)piperazine-1-carboxylate (300 mg, 31% yield).

According to the analysis of related databases, 23100-12-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; DALES, Natalie; GORMISKY, Paul; KERRIGAN, John Ryan; SHU, Lei; (159 pag.)US2019/77773; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 956010-87-0, name is 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

To compound 12 (50 mg, 0.27 mmol) and 2-aminophenol (35 mg, 0.32 mmol) was added a 1N aqueous sodium hydroxide solution (0.75 mL), and the mixture was heated in a microwave oven to 150 C for 10 min. It was then diluted with water and extracted twice with ethyl acetate. 4N HCl solution was added (pH 4), and the mixture was extracted again with ethyl acetate. The combined organic layers were dried over sodium sulfate, and the solvent was evaporated. The residue was purified by preparative HPLC to yield 52 mg (82%) of the title compound as a tan solid. 1H NMR (400 MHz, DMSO-d6): delta 7.44-7.52 (m, 3H), 7.89 (t, J=8.4Hz, 2H), 8.71 (d, J=4.4Hz, 1H), 8.76 (d, J=8.1Hz, 1H), 14.42 (br s, 1H). 13C NMR (125 MHz, DMSO-d6): delta 111.0, 113.3, 118.9, 119.8, 125.0, 125.8, 130.4, 131.9, 141.1, 149.5, 150.1, 152.3, 157.4. HRMS m/z calcd for C13H8N4O: 236.0698; found: 236.0698.

With the rapid development of chemical substances, we look forward to future research findings about 956010-87-0.

Reference:
Article; Schirok, Hartmut; Griebenow, Nils; Fuerstner, Chantal; Dilmac, Alicia M.; Tetrahedron; vol. 71; 34; (2015); p. 5597 – 5601;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53636-70-7, name is 6-Methyl-2,3-pyridinedicarboxylic acid, molecular formula is C8H7NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 53636-70-7

In a 100 ml round-bottomed flask 6-methyl-2,3-pyridinedicarboxylic acid (10 g, 55.2 mmol) and acetic anhydride (26 ml, 276 mmol) were added and heated at 100 C. under nitrogen for 5 hours. After this time the volatiles were removed under vacuum to give the title compound D40 (8.2 g) as a slightly brown solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 8.41 (d, 1H), 7.82 (d, 1H), 2.73 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 53636-70-7.

Reference:
Patent; ALVARO, Giuseppe; Amantini, David; Castiglioni, Emiliano; Di Fabio, Romano; Pavone, Francesca; US2010/144760; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 188577-68-6, Adding some certain compound to certain chemical reactions, such as: 188577-68-6, name is 4,5-Dichloropyridin-2-amine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 188577-68-6.

A mixture of 4,5-dichloropyridin~2-amine (300 mg, 1.84 mmol) and morpholine (480 mg, 5.52 mmol) in DMA (3.6 mL) was heated at 2000C for 60 minutes by microwave irradiation. The mixture was purified by ion exchange chromatography on SCX-II acidic resin (2 g) eluting with methanol, then 2M ammonia-methanol. The basic fractions were combined and solvent was evaporated. Flash chromatography on silica, eluting with ethyl acetate – hexane (1:1) gave 5-chloro-4-morpholinopyridin-2-amine as a colourless solid (347 mg, 88%).1H NMR (500 MHz, (CD3)2CO) delta 3.07-3.09 (4H, m), 3.76-3.78 (4H, m), 5.39 (2H, s), 6.20 (1 H, s), 7.78 (1 H, s). LCMS (3) Rt 2.60 min; m/z (ESI+) 252 (MK+).

According to the analysis of related databases, 188577-68-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; WO2009/44162; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 131747-53-0, (6-(Trifluoromethyl)pyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 131747-53-0, blongs to pyridine-derivatives compound. Recommanded Product: 131747-53-0

TEA (1.4 g, 1.9 mL, 14 mmol) was added dropwise to 0 C(6-trifluoromethyl-pyridin-2-yl) -methanol(1.61 g,9.09 mmol) in DCM (20 mL) was added MsCl (1.2 g, 11 mmol) under nitrogen,The reaction was then continued at 0 C. The reaction mixture was concentrated under reduced pressure, then saturated aqueous sodium bicarbonate (40 mL)Dichloromethane (50 mL x 3)The organic phase was dried over anhydrous Na2SO4 and the concentrated crude product was isolated by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 7 /3) to give 2.2 g of a yellow solid, yield: 95%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,131747-53-0, (6-(Trifluoromethyl)pyridin-2-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Quality Control of 6-Methyl-1H-pyrrolo[2,3-b]pyridine

Azaindole 98 (55 mg, 0.42 mmol) was dissolved in 2 ml anhydrous dimethylformamide under nitrogen. Sodium hydride (60% dispersion in oil, 22 mg, 0.54 mmol) was added and the mixture was stirred for 45 min at room temperature. Bromide 10c (180 mg, 0.50 mmol) dissolved in 2 ml anhydrous dimethylformamide was added and the mixture was stirred for 3 h. The mixture was poured over ice-water and was extracted three times with ether. The combined organics were dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure to give crude 109 (170 mg) as a yellow oil. Used as such without further purification. Purity 90%. NMR spectrum not recorded. UPLC/MS (3 min) retention time 1.97 min. LRMS: m/z 411 (M+1).

The synthetic route of 824-51-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Esteve, Cristina; Ferrer, Manel; Forns, Pilar; Gonzalez, Jacob; Lopez, Sara; Roberts, Richard S.; Sevilla, Sara; Vidal, Bernat; Vidal, Laura; Vilaseca, Pere; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 102 – 133;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: TCP A (333 mg), complex (1.71 mol%) and solvent (3 mL) are added to each reactor, followed byNEt3 (446 microL). The reactor is purged with nitrogen (3 times) and hydrogen (3 times) thenhydrogenated at 5 bar and various reactor temperatures for 60 mins in a Biotage Endeavor. 40 pL aliquot of each reaction mixture is added to 1 mL MeCN and analysed by normal HPLC method. HPLC areas are converted to concentration (pmol/mL) from the gradients equations in the multipoint external standard.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6515-09-9, 2,3,6-Trichloropyridine.

Reference:
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; MORTIMER, Danny Lee; (19 pag.)WO2017/85476; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 102074-19-1, (5-Methylpyridin-3-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H9NO, blongs to pyridine-derivatives compound. Computed Properties of C7H9NO

Step 2. 5-methyl-3-pyridinecarboxaldehyde. A mixture of 5-methyl-3-pyridinemethanol (106 mg, 0.86 mmol) and activated MnO2 (376 mg) in methylenechloride (10 mL) was stirred at room temperature overnight. The black solid of MnO2 was removed by filtration. The filtrate was concentrated in vacuo to yield the title compound as an oil (100 mg, 85%). 1H NMR (CDCl3): 10.10 (s, 1H), 8.89 (s, 1H), 8.68 (s, 1H), 7.98 (s, 1H), 2.45 (s, 3H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,102074-19-1, (5-Methylpyridin-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Cytovia, Inc.; EP1230232; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 89510-90-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89510-90-7, name is 2-Chloro-5-fluoro-4-pyridinamine. A new synthetic method of this compound is introduced below.

A microwave vial charged with 2-Chloro-5-fluoropyridin-4-amine (500 mg, 3.41 mmol) and (S)-3-Methylmorpholine (3102 pi, 27.3 mmol) was heated in the microwave at 210 C for 52 hours. The crude product was concentrated onto celite and purified on the Biotage (reverse phase silica gel) eluting with 0-50% ACN/H2O. The desired fractions were collected, concentrated and dried under high vacuum at RT to afford (S)-5-fluoro-2-(3- methylmorpholino)pyridin-4-amine (2.94 mmol, 86 % yield) as a sticky brown solid. 1 H NMR (500MHz, DMSO-d6) d = 7.70 (d, J=3.1 Hz, 1 H), 5.96 (d, J=6.4 Hz, 1 H), 5.85 (s, 2H), 4.1 1 – 4.05 (m, 1 H), 3.87 (dd, J= 3.5, 1 1 .1 Hz, 1 H), 3.68 – 3.64 (m, 1 H), 3.61 – 3.56 (m, 1 H), 3.51 (dd, J=2.1 , 12.8 Hz, 1 H), 3.43 (dt, J=3.1 , 1 1 .6 Hz, 1 H), 2.92 (dt, J= 3.7, 12.4 Hz, 1 H), 1 .02 (d, J= 6.6 Hz, 3H); LCMS (m/z): 212.4 [M+1 ]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89510-90-7, 2-Chloro-5-fluoro-4-pyridinamine, and friends who are interested can also refer to it.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem