Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 13296-04-3, 4-(Pyridin-4-yl)aniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13296-04-3, blongs to pyridine-derivatives compound. COA of Formula: C11H10N2

EXAMPLE 163BA mixture of EXAMPLE 163A (298.8 mg), 4-pyridin-4-yl-phenylamine (124.9 mg), palladium(II) acetate (7 7 mg), 4,5-bis(diphenylphosphino)~9,9-dimethylxanthene (25 6 mg), cesium carbonate (0.46 g), and dioxane (5 mL) were heated in a microwave at 16O0C for 40 minutes The solvent was removed and the residue purified by flash chioniatography on silica gel using 15% methanol/dichloromethane to provide the title compound (141 6 mg, 36%) as a tan powder

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13296-04-3, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; WO2007/140233; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83766-88-5, name is 2-(tert-Butoxy)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 83766-88-5

Carboxylic acid (0.2 g, 1.64 mmol), tert-butoxypyridine (0.33 g, 2.21 mmol) and boron trifluoride diethyl etherate (0.31 g, 2.21 mmol) in dry PhCH3 (2 mL) were added to a 20-ml vial. The reaction mixture was then allowed to stir at room temperature for 30 min before quenching with anhydrous NaHCO3. The reaction mixture was diluted with ethyl acetate (30 mL), then washed with water (20 mL), followed by brine (20 mL). The organic layer was dried over anhydrous sodium sulfate and carefully concentrated under reduced pressure. The resulting residue was then purified by flash column chromatography on silica gel with 0:4 to 1:4 dichloromethane/hexane as eluent to yield the desired product 5a as a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 83766-88-5.

Reference:
Article; La, Minh Thanh; Kim, Hee-Kwon; Tetrahedron; vol. 74; 27; (2018); p. 3748 – 3754;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 122306-01-8, Adding some certain compound to certain chemical reactions, such as: 122306-01-8, name is (6-Bromopyridin-3-yl)methanol,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122306-01-8.

SOCI2 (1.26 g, 10.6 mmol, 2 eq) was added drop wise to a stirred solution of compound 77 (1 g, 5.3 mmol, 1 eq) in CHCb (10 mL) at 0 C. The mixture was stirred for 4 h at room temperature. After LC-MS indicated completion, the mixture was poured into ice-water and adjusted pH = 7-8 with saturated NaHCCb, extracted with DCM (10 mL X 3). The combined organic layers was washed with brine (5 mL X 3) and dried over NaiSCU, filtered and concentrated to afford the crude product (870 mg, crude), which was used in next step directly. NMR (300 MHz, CDCb): delta 8.39 (d, J= 1.5 Hz, 1 H), 7.64 – 7.60 (m, 1 H), 7.52 (d, J= 8.1 Hz 1 H), 4.56 (s, 1 H). LCMS: (M+H)+ = 205.9, 207.9.

According to the analysis of related databases, 122306-01-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BEIJING XUANYI PHARMASCIENCES CO., LTD.; SONG, Yuntao; CHEN, Xiaoqi; (188 pag.)WO2019/35008; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 780800-73-9, name is (3-Isopropylpyridin-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of (3-Isopropylpyridin-2-yl)methanol

To a vigorously stirred solution of (3-isopropyl-pyridin-2-yl)-methanol (26 g, 170 mmol) in CH2Cl2 (575 mL) was added MnO2 (105 g, 1.20 mol) under N2. The mixture was stirred for 18 h then filtered through a celite pad and concentrated in vacuo. Purification by column chromatography on silica gel (EtOAc/hexanes, 1:3) afforded 3-isopropyl-pyridine-2-carbaldehyde (15.65 g, 61%) as an orange oil. 1H NMR (CDCl3) delta 1.26 (d, 6H, J=7.0 Hz), 4.17 (sep, 1H, J=6.6 Hz) 7.45 (dd, 1H, J=7.9, 4.4 Hz), 7.84 (d, 1H, J=7.9 Hz), 8.56 (dd, 1H, J=4.4, 1.3 Hz), 10.2 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 780800-73-9, (3-Isopropylpyridin-2-yl)methanol.

Reference:
Patent; Chen, Gang; Crawford, Jason; Skerlj, Renato; US2005/154201; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 59146-67-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59146-67-7, name is 5,6-Dimethylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

5,6-Dimethyl-2-pyridinecarbonitrile 1 -oxide; To a solution of 5,6-dimethyl-2-pyridinecarbonitrile (3.68 g, Ref: Guay et al., Bioorg. Med. Chem. Letters, 8 (5), 453. (1998)) in chloroform (25 ml) was added dropwise a solution of m-chloroperbenzoic acid (7.35 g) in chloroform (75 ml) and the solution stirred at ambient temperature for 40 hours. Sodium sulphite (2.4 g) was added and the mixture stirred for 1 hour, filtered and the solid washed with dichloromethane. The filtrate was washed with saturated sodium bicarbonate (50 ml) and water (50 ml), dried (MgSO4) and concentrated in vacuo. The residue was recrystallised from ether to afford the title compound (3.44 g, 83%) as a white solid. LC/MS [MH+] = 149, RT = 1.30 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59146-67-7, 5,6-Dimethylpicolinonitrile.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/66968; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 107867-51-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107867-51-6, name is 5-(Trifluoromethyl)pyridine-2,3-diamine, molecular formula is C6H6F3N3, molecular weight is 177.1272, as common compound, the synthetic route is as follows.

Step C: 2-(chloromethyl)-6-(trifluoromethyl)-3H-imidazo[4,5-]pyridine To a DCM 2mL suspension of 5~(trifluoromethyl)rhoyridine-2,3 -diamine (454mg, 2.56mmol) was added 2~Chloro-l,l ,l-triethoxy-ethane (504mg, 2.56mmol). The mixture was heated to 1000C for 20 mill using a microwave reactor and resulting solid was suspended in 1 :1 DCM:hexanes (5mL) and gently sonicated. The precipitate was collected by suction filtration to give the title compound (324mg). LC/MS: m/z 236(M+H). 1H-NMR (500MHz, d6-DMSO): delta 4.98 (s, 2H), 8.42(d, 1H), 8.72 (d, 1H).

The chemical industry reduces the impact on the environment during synthesis 107867-51-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK & CO., INC.; WO2009/152072; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53554-20-4, name is 6-Amino-2-chloronicotinonitrile, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 6-Amino-2-chloronicotinonitrile

[00227j Step 1: 6-Amino-2-chloronicotinonitrile (0.100 g, 0.65 1 mmol) was taken in a sealed tube and dissolved in dioxane (3 mL) and NMP (0.2 mL). To that was added (R)pyrrolidin-3-ol (0.05 7 g, 0.651 mmol) and NMP (0.2 mL) and the set up was heated at 150 C for 18 h. The solvents were evaporated from the reaction mixture and the crudewas dissolved in water and made basic by adding NaHCO3 and was extracted with DCM(3 x 15 mL). The combined organic layer were dried and evaporated to get the product(80 mg, 42% yield) which was directly in the next reaction. LCMS 205.2 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 53554-20-4.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; DUNCIA, John V.; HYNES, John; NAIR, Satheesh K.; PITTS, William J.; KUMAR, Sreekantha R.; GARDNER, Daniel S.; MURUGESAN, Natesan; PAIDI, Venkatram Reddy; SANTELLA, Joseph B.; SISTLA, Ramesh; WU, Hong; WO2014/74675; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1137-67-3, 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, blongs to pyridine-derivatives compound. Recommanded Product: 2-(Pyridin-3-yl)-1H-benzo[d]imidazole

A solution of CoCl2¢6H2O (0.25 g, 1.05 mmol), 3-PBIM(0.2 g, 1.03 mmol), 1,3-H2BDC (0.2 g, 1.2 mmol), and H2O(15 mL) was stirred under ambient condition. The mixturewas then sealed in a Teflon-lined steel vessel and heated at170C for three days. After slow cooling to room temperature, the resulting product was obtained (yield: 55%). Anal.Calcd. for C64H56Co2N12O14: C, 57.58; N, 12.59; H, 4.23%.Found: C, 58.13; N, 12.87; H, 4.54%. IR (KBr pellet, cm1):3450 s, 3050 s, 1870 m, 1615 s, 1565 w, 1535 m, 1500 m, 1478m, 1448 m, 1371 m, 1270 s, 1145 m, 1130 m, 1060 s, 1018 s,970 s, 880 m, 840 s, 770 m, 745 s, 705 m, 695 m, 593 m, 565 m.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1137-67-3, 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Quanzheng; Xia, Changkun; Lu, Hongdian; Jiang, Rui; Zhang, Xueke; Wang, Xinghan; He, Longzhong; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 46; 4; (2016); p. 543 – 547;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 90395-45-2, name is 1-(4-(Pyridin-3-yl)phenyl)ethanone. A new synthetic method of this compound is introduced below., Recommanded Product: 1-(4-(Pyridin-3-yl)phenyl)ethanone

1-(4-Pyridin-3-ylphenyl)-ethanone (75 g, 380.26 mmole), 3-bromobenzaldehyde (3-bromo) -benzaldehyde) (67g, 362.16mmole), add 1340 ml of ethanol to the reaction flask, and finally add sodium tert-butoxide (52.7 g, 543.23 mmole) at room temperature. After the reaction is complete, add 200 ml. The mixture was filtered with deionized water, and the solid was filtered, washed with deionized water and methanol. The solid was then stirred with 100 ml of deionized water and 200 ml of methanol for 30 minutes. The solid was dried twice to obtain 78 g of pale yellow solid. 3-(3-Bromophenyl)-1-(4-pyridin-3-ylphenyl)-propanone (3-(3-Bromo-phenyl)-1-(4-pyridin-3-yl-phenyl)- Propanone), yield 88.7%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 90395-45-2, 1-(4-(Pyridin-3-yl)phenyl)ethanone.

Reference:
Patent; E-ray Optoelectronics Technology Co Ltd; Huang, Heh Lung; Guo, Huang Ming; Chao, Teng Chih; Lin, Chi Jen; Chang, Min Jong; (53 pag.)TW2019/30287; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 856851-48-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.856851-48-4, name is 2-Chloro-5-ethoxypyridine, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.

2-Chloro-5-ethoxy-pyridine (23 mg, 0.134 mmol) was dissolved in 2 ml dioxane. To this solution was added under argon 1,3-bis-(2,6-diisopropylphenyl)-imidazolinium chloride (12 mg,0.028 mmol), Pd2dba3 (12 mg, 0.013 mmol), compound (II) (56 mg, 0.143 mmol) and NaOtBu (20 mg, 0.21 mmol). The mixture was heated under argon at 100 C. for 6 hours. After cooling, the reaction was diluted with ethylacetate, washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by Prep TLC using 5% methanol in dichloromethylene to afford 23 mg of 6-Dimethylamino-2-{3-[5-(5-ethoxymethyl-pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-hydroxymethyl-phenyl}-3,4-dihydro-2H-isoquinolin-1-one (31% yield).

The chemical industry reduces the impact on the environment during synthesis 856851-48-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Berthel, Steven; Firooznia, Fariborz; Fishlock, Daniel; Hong, Jun-Bae; Lou, Yan; Lucas, Matthew; Owens, Timothy D.; Sarma, Keshab; Sweeney, Zachary Kevin; Taygerly, Joshua Paul Gergely; US2010/222325; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem