Tag: M.W:100-200

Related Products of 83766-88-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83766-88-5, name is 2-(tert-Butoxy)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

Carboxylic acid (0.2 g, 1.64 mmol), tert-butoxypyridine (0.33 g, 2.21 mmol) and boron trifluoride diethyl etherate (0.31 g, 2.21 mmol) in dry PhCH3 (2 mL) were added to a 20-ml vial. The reaction mixture was then allowed to stir at room temperature for 30 min before quenching with anhydrous NaHCO3. The reaction mixture was diluted with ethyl acetate (30 mL), then washed with water (20 mL), followed by brine (20 mL). The organic layer was dried over anhydrous sodium sulfate and carefully concentrated under reduced pressure. The resulting residue was then purified by flash column chromatography on silica gel with 0:4 to 1:4 dichloromethane/hexane as eluent to yield the desired product 5a as a colorless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 83766-88-5, 2-(tert-Butoxy)pyridine.

Reference:
Article; La, Minh Thanh; Kim, Hee-Kwon; Tetrahedron; vol. 74; 27; (2018); p. 3748 – 3754;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7546-50-1, name is 2-(2-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid. A new synthetic method of this compound is introduced below., name: 2-(2-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid

The 2-methyl-7-azaindole-3-acetic acid (3)[11] (10 mmol) were esterified in a classical manner with methanol and cat-alytic amount of con H2SO4 under reflux for 7 h. After com-pletion, the reaction mixture was cooled and solvent methanol was removed under reduced pressure. The residue was then poured onto crushed ice and extracted repeatedly with ethyl acetate. The ethyl acetate layer was washed with saturated sodium bicarbonate solution followed by water. The ethyl acetate layer was dried over sodium sulphate and distilled off under reduced pressure. The solid product ob-tained was filtered, washed with cold ethyl acetate and dried.Yield: 82 %; m.p. 182-184 C; IR (KBr, cm-1): 3154 (NH), 2952 (CH), 1730 (C=O), 1626, 1586, 1558; 1H NMR (400 MHz, CDCl3) delta / ppm: 2.55 (s, 3H, CH3), 3.70 (s, 3H, CH3), 3.73 (s, 2H), 7.07-7.10 (m, 1H, ArH), 7.88 (d, J = 4.0 Hz, 1H, ArH), 8.25 (d, J = 4.0 Hz, 1H, ArH), 12.03 (s, 1H, NH), 13C NMR (75 MHz, CDCl3): 21.83, 30.11, 51.97, 102.41, 115.39, 121.56, 126.35, 134.29, 140.64, 148.32, 172.29; ESI-MS: m / z 205.0 (M+1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7546-50-1, 2-(2-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid.

Reference:
Article; Dongare, Sakharam B.; Bandgar, Babasaheb P.; Bhale, Pravin S.; Shringare, Sadanand N.; Chavan, Hemant V.; Croatica Chemica Acta; vol. 92; 1; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176526-00-4, name is 2-(Pyridin-4-yl)benzaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-(Pyridin-4-yl)benzaldehyde

General procedure: A mixture of 4-hydroxycoumarine 1 (162 mg, 1 mmol), thearomatic aldehydes 2a-l (1 mmol; 106, 185, 141, 175, 131, 122,136, 120, 151, 96, 107, and 112 mg, respectively), 6-amino-1,3-dimethyluracil 3 (155 mg, 1 mmol), and Fe3O4TiO2 NPs(0.02 g), in H2O (2 mL) were stirred at ambient temperaturefor 2-3 h (see Table 2). After completion of the reactionas indicated by thin layer chromatography (eluent/ethyl acetate-petrol = 3:1), the reaction mixture was dilutedwith DMF (1 mL) and the catalyst was recovered from thereaction mixture by simply using an external magnet. Forreuse, the catalyst was washed with EtOH and dried in airat ambient temperature for several hours. The remainingsolution was diluted with H2O (1 mL), to yield the pureproducts by recrystallization from this solution.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 176526-00-4, 2-(Pyridin-4-yl)benzaldehyde.

Reference:
Article; Fakheri-Vayeghan, Sakineh; Abdolmohammadi, Shahrzad; Kia-Kojoori, Reza; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 73; 8; (2018); p. 545 – 551;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 197376-47-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 197376-47-9, name is Ethyl 6-Chloropyridine-3-acetate, molecular formula is C9H10ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of lithium bis(trimethylsilyl)amide in THF (1 M, 14 mL, 14.0 mmol) was added to a solution of ethyl 2-(6-chloropyridin-3-yl)acetate (2.5 g, 12.5 mmol) in THF at -78 C under nitrogen. After stirred at -78 C for 2 h, methyl iodide (1.94 g, 13.7 mmol) was added. The mixture was stirred at 20 C for another 8 h. Worked up, concentrated and purified with silica gelcolumn chromatography, eluting with 0%-40% EA/PE, to give the title compound (1.5 g, 83% purity in LCMS, yield 46%) as yellow oil. MS (ES+) C10H12C1N02 requires: 213, 215, found:214, 216 [M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 197376-47-9, Ethyl 6-Chloropyridine-3-acetate.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; BROOIJMANS, Natasja; BRUBAKER, Jason, D.; FLEMING, Paul, E.; HODOUS, Brian, L.; KIM, Joseph, L.; WAETZIG, Josh; WILLIAMS, Brett; WILSON, Douglas; WILSON, Kevin, J.; (347 pag.)WO2017/181117; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 163658-33-1, (6-Ethylpyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 163658-33-1, blongs to pyridine-derivatives compound. Recommanded Product: 163658-33-1

EXAMPLE 3 N-[1-(6-ethyl-2-pyridylmethyl)piperidin-4-yl]-2-cyclopentyl-2-hydroxy-2-phenylacetamide STR7 To a solution of 22 mg of 6-ethyl-2-pyridine-methanol in 3 ml of ethyl acetate, 0.1 ml of triethylamine and 50 mul of methanesulfonylchloride were added at room temperature, followed by 30 minutes’ stirring at the same temperature. Saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture, followed by an hour’s stirring. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The extract was combined with the organic layer, washed with saturated saline solution, dried over anhydrous magnesium sulfate and removed of the solvent by reduced pressure distillation. The residue was dissolved in 3 ml of N,N-dimethylformamide, and to the solution 32 mg of N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide as obtained in Step (2) of Example 2, 12 mg of sodium bromide and 85 mg of potassium carbonate were added, followed by 4 hours’ stirring at room temperature. The reaction mixture was poured into water and extracted with diethyl ether. The extract was sequentially washed with water and saturated saline solution, dried over anhydrous magnesium sulfate and removed of the solvent by reduced pressure distillation. The residue was purified by preparative thin layer chromatography [Kieselgel 60F254, Art 5744 (Merck), chloroform/methanol=12/1] to give 14.5 mg of the title compound as a white solid. FAB-MS (m/e, (C26 H35 N3 O2 +H)+) 422 1 H-NMR(CDCl3) delta: 1.15-1.34 (1H, m), 1.29 (3H, t, J=7.5 Hz), 1.38-1.92 (11H, m), 2.17-2.30 (2H, m), 5 2.70-2.89 (2H, m), 2.81 (2H, q, J=7.5 Hz), 2.97-3.22 (2H, m), 3.63 (2H, s), 3.67-3.81 (1H, m), 6.35 (1H, brd, J=7.7 Hz), 7.04 (1H, d, J=7.3 Hz), 7.21 (1H, d, J=7.9 Hz), 7.24-7.40 (3H, m), 7.53-7.65 (3H, m)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,163658-33-1, (6-Ethylpyridin-2-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Banyu Pharmaceutical Coaltd; US6130232; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3998-90-1, name is Methyl 2-chloro-6-picoline-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C8H8ClNO2

A mixture of methyl 2-chloro-6-methyl-pyridine-4-carboxylate (1.8 g, 10 mmol) and 10% palladium-on-charcoal catalyst (200 mg) in methanol (100 ml) was stirred under hydrogen at 5 atmospheres pressure. The catalyst was removed by filtration and the volatiles removed from the filtrate by evaporation. The residue was treated with 10% aqueous sodium hydroxide solution and extracted with ether (3*30 ml). The combined extracts were dried (MgSO4) and the solvent removed by evaporation to give methyl 2-methyl-pyridine-4-carboxylate (800 mg, 53%) as an oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3998-90-1, Methyl 2-chloro-6-picoline-4-carboxylate.

Reference:
Patent; Zeneca Limited; Zeneca Pharma S.A.,; US5962458; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 7471-05-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7471-05-8, name is 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine, molecular formula is C8H9N3, molecular weight is 147.1772, as common compound, the synthetic route is as follows.

General procedure for dehydrogenation of imidazolines with NaIO4 catalyzed by [Mn(TPP)Cl]: All of the reactions were carried out at room temperature under air in a 25 mL flask equipped with a magnetic stirrer bar. A solution of NaIO4 (2 mmol) in H2O (10 mL) was added to a mixture of 2-imidazolines (1 mmol), [Mn(TPP)Cl] (0.05 mmol) in CH3CN (5 mL). The progress of reaction was monitored by TLC (eluent: EtOAc/MeOH 4:1). After the reaction was completed, water (30 mL) was added and the corresponding imidazoles were extracted with CH2Cl2 (2 x 20 mL). The imidazole derivatives were obtained after evaporation of solvent. IR and 1H NMR spectral data confirmed the identities of the products.

The chemical industry reduces the impact on the environment during synthesis 7471-05-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kargar, Hadi; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Nameni, Iman; Bioorganic and Medicinal Chemistry Letters; vol. 21; 7; (2011); p. 2146 – 2148;,
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Pyridine | C5H5N – PubChem

Synthetic Route of 61494-55-1, Adding some certain compound to certain chemical reactions, such as: 61494-55-1, name is 2-(2-Chloropyridin-3-yl)acetic acid,molecular formula is C7H6ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61494-55-1.

PREPARATIVE EXAMPLE 1 STR50 A stirred mixture of 5 grams(g) (0.029 mole) of 2-chloro-3-pyridineacetic acid, 9.4 g (0.058 mole) of 3-trifluoromethylaniline and 50 mg of p-toluenesulfonic acid in 15 mL of n-pentanol is heated for 24 hours from 130 to 140 C. After the solvent is removed at reduced pressure, the resulting solid residue is triturated with water, filtered, and recrystallized from isopropylacetate to afford 6 g of pure product of Formula A with melting point 133-134 C. (75% yield). By essentially the same method using aniline, 1,3-dihydro-1-phenyl-2H-pyrrolo[2,3-b]pyridine-2-one is prepared, m.p. 120-121 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61494-55-1, 2-(2-Chloropyridin-3-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Schering Corporation; US5023265; (1991); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 59944-76-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59944-76-2, name is Thieno[2,3-b]pyridine-2-carboxylic acid, molecular formula is C8H5NO2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Thieno[2,3-b]pyridin-2-yl-carbamic acid tert-butyl ester (147-D) A solution of compound 147-C (0.36 g, 2.00 mmol), N,N-diisopropylethylamine (0.385 mL, 2.21 mmol) and diphenyl phosphoryl azide (0.536 mL, 2.41 mmol) in t-butanol (3.6 mL) was heated at reflux for 16 h. The solvent was evaporated in vacuo, the residue dissolved in dichloromethane, washed with 1 N NaOH, brine, dried with Na2SO4, filtered, and evaporated to afford a residue. Flash column chromatography (SiO2) eluting with dichloromethane afforded compound 147-D as a white solid (0.25 g, 50%). 1H-NMR (CDCl3): delta 1.55 (s, 9H), 6.60 (s, 1H), 7.20 (dd, 1H), 7.80 (d, 1H), 8.40 (d, 1H); MS: m/z 251.2 (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59944-76-2, Thieno[2,3-b]pyridine-2-carboxylic acid.

Reference:
Patent; Branum, Shawn T.; Colburn, Raymond W.; Dax, Scott L.; Flores, Christopher M.; Jetter, Michele C.; Liu, Yi; Ludovici, Donald; Macielag, Mark J.; Matthews, Jay M.; McNally, James J.; Reaney, Laura M.; Russell, Ronald K.; Qin, Ning; Teleha, Christopher; Wells, Kenneth M.; Youells, Scott C.; Youngman, Mark A.; US2012/190674; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 63071-12-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63071-12-5, name is (6-Methoxypyridin-2-yl)methanol, molecular formula is C7H9NO2, molecular weight is 139.15, as common compound, the synthetic route is as follows.

To a 100-mL round-bottomed flask was added 6-methoxy-2- pyridinyl)methanol (1.1 g, 7.91 mmol), triphenylphosphine (2.28 g, 8.70 mmol, Aldrich, St. Louis, MO) and tetrabromomethane (0.84 mL, 8.70 mmol, Aldrich, St. Louis, MO) in DCM (20 mL). The reaction mixture was stirred at 0 C for 2 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with 10% EtOAc/hexanes to give 2-(bromomethyl)-6- methoxypyridine (1.33 g) as a colorless oil.

The chemical industry reduces the impact on the environment during synthesis 63071-12-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael David; BO, Yunxin; BRYAN, Marian C.; CROGHAN, Michael; FOTSCH, Christopher Harold; HALE, Clarence Henderson; KUNZ, Roxanne Kay; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis Dale; POON, Steve Fong; STEC, Markian Myroslaw; ST. JEAN, David, Joseph, Jr.; TAMAYO, Nuria A.; TEGLEY, Christopher Michael; YANG, Kevin Chao; WO2012/27261; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem