Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 1092286-30-0, 5-Chloro-2-methyl-3-pyridinecarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1092286-30-0, blongs to pyridine-derivatives compound. Recommanded Product: 1092286-30-0

5-Chloro-2-methylnicotinoyl chloride5-Chloro-2-methyl-nicotinic acid (4.15 g, 24.2 mmol) was placed in a flask with DCM (100 ml) and oxalyl chloride (3.68 g, 29 mmol). DMF (200muIota) was added and the reaction mixture was stirred at RT for 1 hour (gas evolution). The mixture was filtered and the solvent was removed in vacuo to afford the title product which was used without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1092286-30-0, 5-Chloro-2-methyl-3-pyridinecarboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; BEATTIE, David; BRUCE, Ian; COLSON, Anny-Odile; CULSHAW, Andrew James; SHARP, Thomas; WO2011/95450; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 75893-75-3, 6-Cyclopropylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 75893-75-3, blongs to pyridine-derivatives compound. Formula: C9H9NO2

Step-6: Synthesis of N-[3-bromo-2-[[tert-butyI(dimethyl)siIyl]oxymethyl]phenyl]-6- cyclopropyl-pyridine-3-carboxamide: To a solution of 6-cyclopropylpyridine-3-carboxylic acid (0.5 g, 3.06 mmol), 3-bromo-2-[[tert- butyl(dimethyl)silyl]oxymethyl]aniline (1.16 g, 3.67 mmol) and HOBt (0.495 g, 3.67 mmol) in DCM (15 mL) was added NMM (0.5 mL, 4-59 mmol) and EDCI.HCl (0.876 g, 4.59 mmol). The reaction mixture was stirred at room temperature for 16 h. After completion of the reaction (as indicated by TLC), water (10 mL) was added to it and extraction was carried out using DCM (50 mL x 2). The combined organic layers were washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue was purified using column chromatography (Si02, 10% ethyl acetate in hexanes) to afford title compound (0.5 g, 35%). LCMS: m/z 461.2 (M + 1)+. NMR (400 MHz, CDC13) delta 0.15 (s, 6H), 0.87 (s, 9H), 1.05-1.10 (m, 2H), 1.1 1-1.51 (m, 2H), 2.06-2.16 (m, 1H), 5.1 1 (s, 2H), 7.19-7.23 (aromatics, 2H), 7.33 (d, J = 8.0 Hz, 1H), 8.03 (dd, J = 8.0, 2.0 Hz, 1H), 8.33 (d, J = 8.0 Hz, 1H), 8.99 (d, J = 2.0 Hz, lH), 9.99 (s, lH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75893-75-3, its application will become more common.

Reference:
Patent; ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; SINGH, Umesh; WO2013/157021; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 824-51-1, Adding some certain compound to certain chemical reactions, such as: 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine,molecular formula is C8H8N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 824-51-1.

To a solution of 6-methyl-1H-pyrrolo[2,3-b]pyridine (500 mg) in dichloroethane (6 mL) were added aluminumchloride (1.09 g) and acetyl chloride (0.40 mL), and then the mixture was stirred at room temperature for 1.5hours. The reaction solution was poured into aqueous saturated sodium hydrogen carbonate solution, andextracted with chloroform. The organic layer was washed with saturated saline, dried over magnesium sulfate,and then concentrated under reduced pressure. The resulting residue was triturated with isopropyl ether to give1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone [REx(8-1)] (481 mg) as a yellow powder.APCI-MS m/z: 175[M+H]+.

According to the analysis of related databases, 824-51-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Shanghai Pharmaceuticals Holding Co., Ltd.; IIJIMA, Toru; SUGAMA, Hiroshi; KAWAGUCHI, Takayuki; SHEN, Jingkang; XIA, Guangxin; XIE, Jianshu; EP2687518; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 133928-73-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 133928-73-1, name is 2-Chloro-3-methyl-4-pyridinecarboxylic Acid. A new synthetic method of this compound is introduced below.

[01652] Step 4: Synthesis of methyl 2-chl hylpyridine-4-carboxylate[01653] To a stirred solution of 2-chloro-3-methylpyridine-4-carboxylic acid (780 mg, 4.5 mmol) in anhydrous DMF (5.0 ml), was added potassium carbonate (1 .25 g, 9.1 mmol), followed by methyl iodide (0.42 ml, 6.8 mmol) dropwise. A further 4 ml of DMF was added and the reaction mixture was stirred at room temperature under nitrogen for 18.5 hours. The solvent was removed in-vacuo and the residue was then partitioned between CI b b (20 ml) and water (20 ml). The layers were separated and the aqueous layer was extracted with CH2C12 (3 x 15 ml). The combined organic layers were washed with water (2 x 30 ml), brine (40 ml), dried (MgS0 ), filtered and concentrated in-vacuo. The residue was purified by column chromatography (l Og SNAP cartridge, Isolera, 0-6% ethyl acetate:heptanes) to give the title compound (591 mg, 59%) as a colourless oil. LC-MS 84%, m/z = 185.9, 1 87.9; NMR (500 MHz, Chloroform-d) delta ppm 8.33 (d, J=5.04 Hz, 1 H) 7.54 (d, J=5.04 Hz, 1 H) 3.95 (s, 3 H) 2.60 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,133928-73-1, 2-Chloro-3-methyl-4-pyridinecarboxylic Acid, and friends who are interested can also refer to it.

Reference:
Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 886365-46-4, name is 5-Chloro-3-methylpyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

Thionyl chloride (71 mu, 962 muiotaetaomicron) is added to a mixture of 5-chloro-3-methyl-pyridine-2- carboxylic acid (150 mg, 874 muiotaetaomicron), toluene (1 ml) and DMF (20 mu). The mixture is heated to 60C for 1 hour. The mixture is concentrated in vacuo and the crude product used directly without further purification.

The synthetic route of 886365-46-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; REISER, Ulrich; WO2015/25018; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 58602-02-1, 2,6-Difluoro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 58602-02-1, blongs to pyridine-derivatives compound. name: 2,6-Difluoro-3-nitropyridine

Step A 2,6-difluoro-3-nitropyridine (14.68g,91.8mmol) was added to a mixture of DL-alanine ethyl ester hydrochloride (14.09g 92mmol) and potassium carbonate (25.3g, 183mmol) in acetonitrile (200ml) and the mixture stirred for 2 hours at room temperature. The reaction mixture was poured into water and extracted several times with ethyl acetate; the combined extracts were dried (MgSO4) and the solvent removed in vacuo leaving a viscous orange-yellow residue which solidified on standing. The solid was triturated with hexane and the solvent removed from the hexane soluble fraction leaving ethyl DL-2-[6-fluoro-3-nitropyridyl-2-amino]propionate as a yellow solid m.p. 49-51 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58602-02-1, its application will become more common.

Reference:
Patent; Imperial Chemical Industries PLC; US5133798; (1992); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1075-62-3 ,Some common heterocyclic compound, 1075-62-3, molecular formula is C7H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 25 mL round bottom flask, 5-(methoxymethylene)-2,2-dimethyl-i,3-dioxane- 4,6-dione (6.06 g, 32.5 mmol) was added to a stirred mixture of N-(6-aminopyridin-2- yl)acetamide (4.10 g, 27.1 mmol) in EtOH (5 ml) at room temperature. After the reaction mixture was stirred at 80C for 3 hr, it was cooled down to room temperature and then concentrated under vacuum to give the title compound as a solid. LCMS (ESI) calc?d for C,4H,5N305 [M+i ]: 306,found: 306; ?H NMR (300 MHz, CDC13): oei i.18(s, 1H), 9.27 (d, J= 4.2 Hz, 1H), 8.06 (d, J= 8.4 Hz, 1H), 7.90 (s,1H),7.77-7.72(m,1H), 6.73 (d, J= 7.8 Hz, 1H),2.26 (s,3H), 1.76 (s,6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1075-62-3, N-(6-Aminopyridin-2-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BENNETT, Frank; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; SCOTT, Jack D.; TANG, Haiqun; ZHAO, Zhiqiang; HUANG, Yuhua; HUNTER, David; YANG, Dexi; ZHANG, Zhibo; FU, Jianmin; BAI, Yunfeng; ZHENG, Zhixiang; ZHANG, Xu; YOUNG, Katherine; XIAO, Li; (580 pag.)WO2016/206101; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 483324-01-2, 2-Chloro-4-(pyridin-3-yl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H6ClN3, blongs to pyridine-derivatives compound. Formula: C9H6ClN3

Preparation of 4-pyridin-3-yl-pyrimidin-2-ylamine lll-b In a sealed tube, a solution of lll-a (1 .18 g, 6.16 mmol) in 30percent NH4OH (12 mL) was heated at deltaOmicron ‘ for 16h. After cooling, the precipitate was isolated by filtration, washed with water and dried under vacuum to give the title compound lll-b as a beige solid (925 mg, 87 percent). H NMR (400 MHz, DMSO-d6) delta 9.23 (d, J = 2.1 Hz, 1 H), 8.69 (dd, J = 4.7, 1 .3 Hz, 1 H), 8.43 – 8.38 (m, 1 H), 8.36 (d, J = 5.1 Hz, 1 H), 7.53 (dd, J = 8.0, 4.8 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.76 (s, 2H).

The synthetic route of 483324-01-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AB SCIENCE; MOUSSY, Alain; BENJAHAD, Abdellah; SCHALON, Claire; PEZ, Didier; CHEVENIER, Emmanuel; SANDRINELLI, Franck; MARTIN, Jason; PICOUL, Willy; WO2014/202763; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 696-42-4, 5-Fluoronicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H3FN2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H3FN2

General procedure: (Reference Example 35) 5-[4-(5-Amino-1H-pyrazol-3-yl)piperidin-1-yl]pyridine-3-carbonitrileThe title compound (0.167 g, yield: 37%) was obtained through reaction in the same way as the method described in Reference Example 34 using 5-fluoropyridine-3-carbonitrile (0.204 g, 1.67 mmol) instead of 3,6-dichloropyridazine. 1H-NMR (400 MHz, DMSO-d6) delta: 11.13 (1H, brs), 8.59 (1H, d, J = 3 Hz), 8.28 (1H, d, J = 2 Hz), 7.78 (1H, dd, J = 3 Hz, 2 Hz), 5.20 (1H, brs), 4.45 (2H, brs), 3.94-3.87 (2H, m), 2.93-2.85 (2H, m), 2.73-2.64 (1H, m), 1.94-1.87 (2H, m), 1.65-1.55 (2H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,696-42-4, 5-Fluoronicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Daiichi Sankyo Company, Limited; KOBAYASHI, Hideki; OHKAWA, Nobuyuki; TAKANO, Daisuke; KUBOTA, Hideki; ONODA, Toshio; KANEKO, Toshio; ARAI, Masami; TERASAKA, Naoki; EP2862861; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1020253-14-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1020253-14-8, name is 6-Chloro-5-fluoronicotinonitrile, molecular formula is C6H2ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: 6-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)-5-fluoronicotinonitrile (0252) 44 3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)azetidin-3-ol hydrochloride (3c, 200 mg, 0.4 mmol), 84 6-chloro-5-fluoronicotinonitrile (74.8 mg, 0.48 mmol), 23 potassium carbonate (247 mg, 4.0 mmol) and 8 DMF (2 mL) were combined and the mixture was heated at 80 C. for 3 hrs in a sealed tube. 31 Water (20 mL) was added and the resulting mixture was extracted with EtOAc (50 mL×3), the combined organic phases were washed with brine (20 mL), dried over Na2SO4, filtered, and concentrated in vacuo. Silica gel column chromatography gave the desired 85 product.

According to the analysis of related databases, 1020253-14-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gilead Sciences, Inc.; Blomgren, Peter A.; Currie, Kevin S.; Farand, Julie; Gege, Christian; Kropf, Jeffrey E.; Xu, Jianjun; (35 pag.)US2017/355693; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem