Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.159783-22-9, name is 3,5-Difluoropyridin-4-amine, molecular formula is C5H4F2N2, molecular weight is 130.1, as common compound, the synthetic route is as follows.Recommanded Product: 159783-22-9

EXAMPLE 25 Compounds FQ-FR By proceeding as in Example 24 but using 4-amino-3,5-difluoropyridine instead of 4-amino-3,5-dichloropyridine, and using 3-cyclopentyloxy-4-(methylthio)benzoyl chloride and 4-(methylthio)-3-(tetrahydro-3-furyloxy)benzoyl chloride, there are prepared: N-(3,5-difluoropyrid-4-yl)-3-cyclopentyloxy-4-(methylthio)benzamide is synthesised; m.p. 174-5C. [Elemental analysis: C,59.4; H,5.1;; N,7.6; S,8.3%; calculated: C,59.3; H,5.0; N,7.7; S,8.3%]; and N-(3,5-difluoropyrid-4-yl)-4-(methylthio)-3-(tetrahydro-3-furyloxy)benzamide.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,159783-22-9, 3,5-Difluoropyridin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; RHONE-POULENC RORER LIMITED; EP741707; (1998); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 94220-38-9

EXAMPLE 24 7-(3,4-Dichloroanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (24) STR37 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (1.5 g) and 3,4-dichloroaniline (1.45 g) were heated under reflux in ethanol (90 ml) for 48 h. The solvent was removed in vacuo to yield a yellow solid which was suspended in water and the pH adjusted to 7.8. The solid was filtered off, washed with water, and dried to yield the 7-(3,4-dichloroanilino)-compound (2.27 g, 87%) which was recrystallized from ethanol (charcoal) to yield a white amorphous solid m.p. 273 (dec.). (Found: C, 53.1; H, 3.5; N, 19.3; Cl, 24.1. C13 H10 N4 Cl2 requires C, 53.3; H, 3.45; N, 19.1; Cl, 24.2%), numax. 3400-2250 (N-H), 1630, 1580, 1530, 1410, 1400, 1310, 1135, 955, 850, 810 cm-1, delta (CF3 COOH) 2.76 (3H, s, 5-CH3), 6.86 (1H, s, 6-H), 7.49 (3H, m, aromatic protons), 8.46 (1H, s, 3-H), 9.47 (2H, s, N? H2), total proton count 10.

With the rapid development of chemical substances, we look forward to future research findings about 94220-38-9.

Reference:
Patent; Beecham Group, p.l.c.; US4559348; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 59942-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59942-87-9, name is Pyrazolo[1,5-a]pyridin-2(1H)-one, molecular formula is C7H6N2O, molecular weight is 134.1353, as common compound, the synthetic route is as follows.

52a. Synthesis of 4,5,6,7-tetrahydropyrazolo[1 ,5-a]pyridin-2-ol A solution of pyrazolo[1 ,5-a]pyridin-2-ol (7.5 g, 0.056 mol) in 280 mL of AcOH was hydrogenated over 2.5 g of 10 wt % Pd/C dry powder for 20 h under atmospheric pressure of hydrogen. After 72 h, the suspension was filtered over decalite and concentrated under vacuum to afford an orange residue that was suspended in hot IPA and stirred for 15 min, then cooled to 0 5C and filtered to afford 4.84 g of a cream colored solid. The filtrate was concentrated under vacuum, and recrystallyzed from EtOAc to afford additional 2.62 g (global 96%). 1 H NMR (CDCI3) delta ppm: 5.32 (s, 1 H), 3.91 (t, J = 6.1 Hz, 2H), 2.69 (t, J = 6.3 Hz, 2H), 2.06 – 1 .91 (m, 2H), 1 .86 – 1 .69 (m, 2H).

Statistics shows that 59942-87-9 is playing an increasingly important role. we look forward to future research findings about Pyrazolo[1,5-a]pyridin-2(1H)-one.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ FERNANDEZ, Jose Luis; CUBERES ALTISENT, Mª Rosa; WO2013/124341; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 75358-90-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75358-90-6 as follows.

To a nitrogen flushed solution of Description 34 (14.27 g, 81 mmol) and conc. HC1 (15 ml) was added 10% Palladium on carbon (2 g), and the resulting mixture hydrogenated at 50 psi until HPLC and MS indicated complete conversion (approx 2 days). The catalyst was removed by filtration and the filtrate evaporated to give the title compound (17.55 g, 100%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75358-90-6, its application will become more common.

Reference:
Patent; Merck Sharp & Dohme Limited; WO2004/46133; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 197376-47-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 197376-47-9, name is Ethyl 6-Chloropyridine-3-acetate. A new synthetic method of this compound is introduced below.

To a solution of ethyl 2-(6-chloropyridin-3-yl)acetate (1.1 g, 5.51 mmol) in dimethylformamide was added slowly sodium hydride (242 mg, 6.06 mmol) at 0 C, followed by iodomethane (821 mg, 5.79 mmol). The mixture was stirred at same degree for 1 hour, and then quenched with water. The resulting mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over MgS04 and concentrated under reduced pressure to afford crude which was purified by column chromatography to afford ethyl 2-(6-chloropyridin-3-yl)propanoate (790 mg, 67 %).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,197376-47-9, Ethyl 6-Chloropyridine-3-acetate, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2013/13817; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 77555-27-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 77555-27-2, name is 2-(Pyridin-2-ylthio)ethanol. A new synthetic method of this compound is introduced below.

A solution of 0.2 g (0.55 mmol) of the product from example 11, Step C and 0.1 g (0.66 mmol) of the product from Example 23, step A in toluene (20 ml) was refluxed for 16 hours. The reaction mixture was partitioned between water and ethyl acetate. The combined organic layers were successively washed with water (25 ml x 2) and brine (25 ml x 2), dried over anhydrous sodium sulphate and evaporated under vacuo. The solid residue was purified by column chromatography over silica gel using 60 % ethyl acetate in hexane as the eluent to afford 0.1 g of the title compound as a yellow solid. ¹H NMR (400 MHz, DMSOd6) 8 3 – 3.11 (2H, t), 3.28 (2H, t), 3.55 – 3.56 (4H, t), 3.72 – 3.75 (4H, t), 6.92 – 6.95 (1H, d), 7.11 – 7.14 (1H, d), 7.35 – 7.37 (1H, d), 7.51 – 7.59 (3H, m), 7.62 – 7.67 (2H, m), 7.99 – 8.03 (3H, m), 8.08 – 8.14 (1H, m), 8.43 – 8.45 (1H, d), 9.08 – 9.13 (1H, d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,77555-27-2, its application will become more common.

Reference:
Patent; TORRENT PHARMACEUTICALS LTD; WO2005/97746; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 19235-89-3 ,Some common heterocyclic compound, 19235-89-3, molecular formula is C6H3ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A teflon capped vial was charged with 4-amino-3- fluorophenol (0.291 g, 2.29 mmol) and anhydrous DMF (2.3 mL). The resultant solution was de-gassed in vacuo and backfilled with argon (3x). The vial was treated with sodium te/ -butoxide (0.27 g, 2.41 mmol) under argon and quickly capped. The reaction mixture was stirred at RT for lh. After addition of 4-chloropicolinonitrile (0.317 g, 2.29 mmol) and K2CO3 (0.174 g, 1.26 mmol), the vial was de-gassed again and heated in a 90 C oil bath overnight. The reaction mixture was diluted with EtOAc (60 mL) and washed with brine (25 mL). The aqueous phase was back-extracted with EtOAc (50 mL). The combined organic layers were washed with brine (25 mL), dried (MgSO^, concentrated in vacuo and purified by chromatography to afford 4-(4-amino-3- fluorophenoxy)picolinonitrile (0.162 g, 31% yield) as a colorless oil. FontWeight=”Bold” FontSize=”10″ H NMR (DMSO- d6) delta 8.56 (d, J = 5.6 Hz, 1H), 7.62 (d, J = 2.0 Hz, 1H), 7.14 (dd, J = 6.0 , 2.8 Hz, 1H), 7.03 (dd, J = 1 1.6, 2.4 Hz, 1H), 6.88-6.77 (m, 2H), 5.25 (s, 2H); MS (ESI) m z: 230.0 (M+H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19235-89-3, 4-Chloropyridine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.; WO2013/36232; (2013); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1097839-70-7, Adding some certain compound to certain chemical reactions, such as: 1097839-70-7, name is 5-Methoxy-2-methyl-1H-pyrrolo[2,3-c]pyridine,molecular formula is C9H10N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1097839-70-7.

A solution of 5-methoxy-2-methyl-lH-pyrtauolo[2,3-c]pyridine (530mg, 3.3mmol), Cs2CO3 (3eq) and methyl (2R)-2-[3-(bromomethyl)-4-chlorophenoxy]propanoate (1.2eq) in DMF (2OmL) was stirred at 25 C for 8 hours. The reaction mixture was diluted with EtOAc, washed with water (2x) and satd NH4Cl (Ix). The organic layer was dried over Na2SO4 and concentrated. Purification via flash chromatography eluding with a gradient of 0 to 100% EtOAc/hexanes provided methyl (2R)-2-{4-chloro-3-[(5-methoxy-2-methyl-lH-pyrrolo[2,3- c]pyridin-l-yl)methyl]phenoxy}propanoate as a yellow syrup.1H NMR (500 MHz, CDCl3): delta 8.02 (s, IH), 7.25 (d, IH), 6.82 (s, IH), 6.68 (dd, IH), 6.25 (s, IH), 5.76 (d, IH), 5.26 (s, 2H), 4.36 (q, IH), 3.91 (s, 3H), 3.54 (s, 3H), 2.31 (s, 3H), 1.42 (d, 3H).

According to the analysis of related databases, 1097839-70-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2009/5672; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 113293-70-2, 2,6-Dichloroisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

EXAMPLE 7G 2,6-dichloro-4-(dimethoxymethyl)pyridine To a solution of EXAMPLE 7F (2 g, 1 1.4 mmol) in methanol (10 mL) and toluene (10 mL) was added methyl orthoformate (2.4 g, 22.9 mmol) and p-toluenesulfonic acid (98 mg, 0.57 mmol) and the mixture was heated at reflux for 2 hours. After concentration, the residue was diluted with dichloromethane and was washed with saturated aqueous sodium carbonate and brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to give the title compound.

The synthetic route of 113293-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1079054-78-6, name is 5-Amino-6-methylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1079054-78-6

l,l’-Thiocarbonyldiimidazole (368 mg, 1.96 mmol, 95 mass%) and then hydrochloric acid in dioxane (0.89 mL, 3.6 mmol, 4 mol/L) were added to a solution of 5-amino-6-methylpicolinonitrile (250 mg, 1.78 mmol, 95 mass%) in DCM (8.9 mL) under air. The reaction was stirred at r.t. for 24.5 hours before being concentrated in vacuo and purified by flash column chromatography on silica (gradient elution with 0% to 100% EtOAc in isohexanes) to give the title compound (176 mg, 56 % Yield). LCMS [M+H]+ 176, RT 0.93 minutes (Method 7).

With the rapid development of chemical substances, we look forward to future research findings about 1079054-78-6.

Reference:
Patent; UCB BIOPHARMA SRL; CHOVATIA, Prafulkumar Tulshibhai; CONNELLY, Rickki Lee; FRANKLIN, Richard Jeremy; HASLETT, Gregory William; HENRY, Alistair James; MADDEN, James; NEUSS, Judi Charlotte; NORMAN, Timothy John; PHILPS, Oliver; PITT, William Ross; RAMPALAKOS, Konstantinos; SELBY, Matthew Duncan; SELVARATNAM, Suganthan; TRANI, Giancarlo; ZHU, Zhaoning; (768 pag.)WO2019/243550; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem