Tag: M.W:100-200

Electric Literature of 87674-21-3, Adding some certain compound to certain chemical reactions, such as: 87674-21-3, name is 1-(3-Fluoropyridin-4-yl)ethanone,molecular formula is C7H6FNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87674-21-3.

[0378] 3-Fluoro-l-(2-bromo-4-pyridinyl)ethanone Hydrobromide (169). l-(3- Fluoro-4-pyridinyl)ethanone (168) (880 mg, 6.33 mmol) was dissolved in glacial acetic acid (20 mL) and treated with bromine (0.36 mL, 7.0 mmol) followed by HBr/AcOH (30% w/v, 1.4 mL, 7.0 mmol) at 5-10 0C. The reaction mixture was stirred at 20 0C for 3 h, it was then diluted with Et2O (100 mL) and the precipitate was filtered off, washed with Et2O and dried under high vacuum to afford the crude bromoketone 169 (1.65 g) as a pale yellow solid that was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 52311-50-9, Adding some certain compound to certain chemical reactions, such as: 52311-50-9, name is 2-Chloro-4-ethoxypyridine,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52311-50-9.

Solid 2-chloro-4-ethoxypyridine (100 g 0.63 mol) was added to H2SO4(500 mL) slowly. Then 1-bromopyrrolidine-2 5-dione (124.2 g 0.70 mol) was added into above mixture at rt. The mixture was stirred at 80 for 3 h. TLC (PE/EA 101 Rf 0.5) showed the reaction was finished. The reaction mixture was poured into ice-water (2 L) and extracted with EA (1 L x 3) . The organic layer was washed with saturated Na2CO3solution (1 L x 2) dried over Na2SO4and concentrated. The residue was purified on silica column chromatography (PE/EA 601-301) . All fractions found to contain product by TLC (PE/EA 101 Rf 0.5) were combined and concentrated to yield 5-bromo-2-chloro-4-ethoxypyridine (60.9 g 0.26 mol 40yield) 1HNMR(400 MHz CD3OD) delta 8.31 (s 1H) 7.14 (s 1H) 4.32-4.10 (m 2H) 1.58-1.35 (m 3H) ES-LCMS m/z 237 (M+2)

According to the analysis of related databases, 52311-50-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1254473-66-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1254473-66-9, name is 1-(3,5-Dichloropyridin-4-yl)ethanol. A new synthetic method of this compound is introduced below.

A solution of 1- (3,5-dichloropyridin-4-yl) ethanol (II) (6 g, 31.24 mmol) in dichloromethane (DCM, 50 ml) was added portionwise over 10 min. PCC, 10.1 g, 46.86 mmol) at room temperature for 10 h.The insoluble matter was removed by filtration, and the residue was washed three times with DCM. The combined organic layers were concentrated to a crude product.Purification by silica gel column chromatography (petroleum ether: ethyl acetate = 20: 1) gave 5.10 g of colorless, turbid oil; Yield 85%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1254473-66-9, its application will become more common.

Reference:
Patent; Sichuan University; Wu, Yong; Hai, Li; Lei, Fan; Li, XiaoCen; (7 pag.)CN103819396; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 917364-11-5, Adding some certain compound to certain chemical reactions, such as: 917364-11-5, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid,molecular formula is C8H10N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 917364-11-5.

Example 91N-((ls,4s)-4-(2-(3′-(((3S,5R)-3,5-dimethylpiperazin-l-yl)methyl)-4′-hydroxybiphenyl-3- yloxy)-5-fluoronicotinamido)cyclohexyl)-5,6,7,8-tetr ahydroimidazo [ 1 ,2-a] pyridine-2- carboxamide To a solution of 5,6,7, 8-tetrahydroimidazo[l,2-a]pyridine-2-carboxylic acid (28.4 mg, 0.17 mmol) in acetonitrile (5 niL) was added DIPEA (0.057 niL, 0.34 mmol) and HATU (65.1 mg, 0.17 mmol). The mixture was allowed to stir at RT for 10 min before a solution of N-((ls,4s)- 4-aminocyclohexyl)-2-(3′-(((3S,5R)-3,5-dimethylpiperazin-l-yl)methyl)-4′-hydroxybiphenyl- 3-yloxy)-5-fluoronicotinamide (100 mg, 0.17 mmol) in acetonitrile (5 mL) with DIPEA (0.057 mL, 0.34 mmol) was added and the mixture stirred at RT for 30 mins. The reaction mixture was diluted in EtOAc (10 mL), washed with water, brine, dried (MgSO4) and evaporated to give a foam. This was purified by preparative HPLC to afford the title compound as a white solid. Yield: 31 mg1H NMR (400 MHz, CD3OD) delta 8.42 (d, J= 6.9 Hz, IH), 8.11 – 8.06 (m, 2H), 7.75 (s, IH), 7.57 – 7.42 (m, 4H), 7.38 (s, IH), 7.15 – 7.08 (m, IH), 6.92 (d, J= 8.5 Hz, IH), 4.16 – 4.07 (m, 5H), 3.98 – 3.89 (m, IH), 3.62 – 3.52 (m, 2H), 3.44 (d, J= 12.8 Hz, 2H), 2.95 (t, J= 6.2 Hz, 2H), 2.67 (t, J= 12.6 Hz, 2H), 2.10 – 1.64 (m, 12H), 1.32 (d, J= 6.7 Hz, 6H). MS: [M+H]+=696.4 (calc=696.3673) (MultiMode+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 917364-11-5, 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 61494-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61494-55-1, name is 2-(2-Chloropyridin-3-yl)acetic acid, molecular formula is C7H6ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of diisopropyl amine (1.65 mL, 1 1.7 mmol) in anthydrous THF (10 mL) cooled to -15C was added n-butyl lithium (2.5 M in hexanes, 4.80 mL, 12.0 mmol) slowly between -10C and 0C. The resultant mixture was stirred at room temperature for 15 minutes before being cooled to 0C. The solution of LDA thus formed was added to a rapidly stirred suspension of 2-(2-chloropyridin-3-yl)acetic acid (1.00 g, 5.8 mmol) in anhydrous THF( 20 mL ) at 0C. Upon complete addition of the LDA solution the resultant bright yellow suspension was stirred at 0C for 15 minutes. A solution of (3-fluoro-4- isothiocyanatophenyl)(methyl)sulfane (1.63 g, 8.2 mmol) in anhydrous THF (10 mL) was then added to the reaction mixture and heated to 65C for 18 hours. The reaction mixture was cooled to room temperature and the volatiles removed in vacuo. The resultant brown gum was redissolved in THF, cooled to 0C and 10% aq acetic acid 10 mL added slowly. Acetonitrile (5 mL) was added slowly until a yellow solid developed, the solid was isolated by filtration and washed with ether and acetonitrile to give the title compound as a yellow solid (546mg, 20%). LC/MS: [M+l] 335. ‘HNMR ( 300 MHz, DMSO-d6): d 8.34 ( d, J=8.1 Hz, 1 H ), 7.85-8.20 ( m, 1H ), 7.61 ( t, J = 8.6 Hz, 1H ), 7.39-7.30 ( m, 2H ), 7.21 (d, J = 9.2 Hz, 1H ), 2.52 (s, 3H).

According to the analysis of related databases, 61494-55-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NFLECTION THERAPEUTICS, INC.; KINCAID, John; NEWSAM, John; KISAK, Edward; WOOTTON, Michael; KUSHWAHA, Avadhesh; (364 pag.)WO2020/106304; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 166331-65-3, Adding some certain compound to certain chemical reactions, such as: 166331-65-3, name is 2-Chloro-6-isopropylnicotinic acid,molecular formula is C9H10ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 166331-65-3.

Preparation Example 10 2-Chloro-6-isopropylnicotinic acid (312 g), palladium carbon(10%) (16.0 g) and ethanol-water (6:1) (2000 mL) were stirred under a hydrogen atmosphere at room temperature for 3 days. The reaction solution was filtrated, and the filtrate was concentrated under reduced pressure. Ethyl acetate and a small amount of ethanol were added to the residue, and the precipitated solid was collected by filtration. The solid was added to cooled 1N-aqueous sodium hydroxide solution (1130 mL) and, after dissolution, the precipitated solid was collected by filtration. This was dissolved in chloroform, and dried over magnesium sulfate. The solvent was evaporated, the residual solid was suspended in hexane and collected by filtration to give 6-isopropylnicotinic acid (152 g) as white powder crystals. 1H-NMR(CDCl3)delta: 1.37(6H,d,J=6.9Hz), 3.29(1H,sept,J=6.9Hz), 7.38(1H,d,J=8.1Hz), 8.40(1H,dd,J=2.1,8.1Hz), 9.33(1H,d,J=2.1Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 166331-65-3, 2-Chloro-6-isopropylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mitsubishi Pharma Corporation; EP1852431; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 72617-82-4, 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 72617-82-4, blongs to pyridine-derivatives compound. name: 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine

EXAMPLE 3 N-[2-(2,2,2-Trifluoroethoxy)-5-pyridyl]-1,3-dithietan-2-imine 8.8 g (0.048 mol) 2-(2,2,2-Trifluoroethoxy)-5-aminopyridine and 3.50 g (0.046 mol) carbon disulphide were combined. Over 5 minutes, 4.65 g (0.046 mol) triethylamine was added, dropwise. The reaction mixture was then stirred at 70 C. for 1 hour. After this 50 ml diethyl ether was added at room temperature. The resulting crystals were separated and dried. 12.0 g (70.6% of theory) triethylammonium N-[2-(2,2,2-trifluoroethoxy)-5-pyridyl]dithiocarbamate was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,72617-82-4, its application will become more common.

Reference:
Patent; Schering Aktiengesellschaft; US4897415; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6515-09-9, Adding some certain compound to certain chemical reactions, such as: 6515-09-9, name is 2,3,6-Trichloropyridine,molecular formula is C5H2Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6515-09-9.

In a 1000 mL autoclave, 50 g of 2,3,6-trichloropyridine and 150 g of toluene were added; 150 g of water and 30 g of triethylamine were added.Then add 5% palladium carbon 2g, control hydrogen pressure 8 ~ 10atm, temperature 10 ~ 15 C, reaction for 8 hours,The HPLC monitoring of the control material (2,3,6-trichloropyridine) was <10% and the reaction was stopped. The reaction solution is filtered, palladium carbon is recovered, the filtrate is separated into liquid, triethylamine is recovered in the aqueous phase, the organic phase is concentrated under reduced pressure, toluene is recovered, and the residue is subjected to vacuum distillation.Product 2,3-dichloropyridine ~32.5g,Yield ~ 80% (theory: 40.56g). According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular. Reference:
Patent; Shanghai Yaben Chemical Co., Ltd.; Lin Zhigang; Jiang Yueheng; Cai Tong; (4 pag.)CN107778221; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 709652-82-4, name is 2-Amino-5-bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 709652-82-4

PREPARATION 16 PREPARATION OF (Z)-2-AMiNO-5-BROMO-N’-HYDROXYNicoTiNiMiD AMIDE A solution of 2-amino-5-bromopyridine-3-carbonitrile (2.00 g, 10.1 mmol), hydroxylamine hydrochloride (1.06 g, 15.3 mmol) and 24 mL of triethylamine in 40 mL of ethanol was refluxed for 3 h. The resulting mixture was poured into ice cold water to afford a white solid. The solid was separated by filtration and washed with water. The filtrate was extracted with ethyl acetate and the organic layers were combined, dried over anhydrous sodium sulfate and filtered. The filtrate was evaporate to afford a white solid which was combined with the white solid obtained earlier to afford (Z)-2-amino-N’-(benzoyloxy)-5-bromonicotinimidamide in quantitative yield (2.30 g). 1H NMR (400 MHz, OMSO-d6):S9.95 (s, 1H), 7.96 (d, J= 2.4 Hz, 1H), 7.89 (d, J= 2.4 Hz, 1H), 7.20 (br s, 2H), 5.93 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 709652-82-4.

Reference:
Patent; SIGNALCHEM LIFESCIENCES CORPORATION; ZHANG, Zaihui; WO2015/81257; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60588-81-0, name is (3-Chloropyridin-2-yl)methanol, molecular formula is C6H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H6ClNO

Synthesis of 3-chloro-2-(chloromethvDpyridine (32 31 To a solution of compound 31 (300 mg, 2.1 mmol) in DCM (4 mL) was added DIE A (539 mg, 4.2 mmol) at 0 C, then MsCl (263 mg, 2.3 mmol) was added dropwise at 0 C. The mixture was stirred at room temperature for 3h. Water was added, and the mixture was extracted with DCM, washed with sat. NaHCO and brine, dried over a?.S04, filtered, concentrated under reduced pressure to give compound 32 (240 mg, 69 %) as a yellow oil.

With the rapid development of chemical substances, we look forward to future research findings about 60588-81-0.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; BECKWITH, Jonathan Roger; DUTTON, Rachel; ESER, Markus; LANDETA, Cristina; BLAZYK, Jessica L.; MEEHAN, Brian M.; HATAHET, Feras; BOYD, Dana; WO2015/143164; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem