Tag: M.W:100-200

Related Products of 65873-72-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 65873-72-5 as follows.

STR17 2 g of Raney nickel are added to 10.9 g (0.08 mol) of 6-methoxypyridine-3-aldehyde in 100 ml of ethanol, and the mixture is subsequently hydrogenated at 75 C. and 50 bar hydrogen pressure for 3 hours. For working up, the catalyst is filtered off and the filtrate is concentrated in vacuo. 11.1 g (100% of theory) of 2-methoxy-5-hydroxymethylpyridine are obtained as an oil which can be purified by distillation, of boiling point 85 C. to 88 C. at 0.6 mbar.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65873-72-5, its application will become more common.

Reference:
Patent; Bayer Aktiengesellschaft; US4990622; (1991); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 100367-55-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100367-55-3, name is 5-Nitropicolinonitrile, molecular formula is C6H3N3O2, molecular weight is 149.11, as common compound, the synthetic route is as follows.

Step B: 5-Aminopicolinonitrile (21) [00384] A mixture of 5-nitropicolinonitrile (20, step A) (3 g, 20 mmol), Zn (6.5 g, 100 mmol) and H4C1 (10 g, 185 mmol) in EtOH (40 mL) was stirred for at room temperature for 2 h. The reaction was diluted with DCM (150 mL) and filtered; filtrate was concentrated and purified by silica gel column chromatography with petroleum ether/ ethyl acetate (3 : 1) to give the product (1 g, 42%) as a yellow solid. LC-MS: (M + H)+ 120.0

The chemical industry reduces the impact on the environment during synthesis 100367-55-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NEW YORK UNIVERSITY; UNIVERSITY OF ALBANY; SCHMIDT, Ann, Marie; RAMASAMY, Ravichandran; SHEKHTMAN, Alexander; RAI, Vivek; MANIGRASSO, Michaele, B.; (179 pag.)WO2017/184547; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1116136-63-0 ,Some common heterocyclic compound, 1116136-63-0, molecular formula is C7H4ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Into a 250 ml 3-necked roundbottom flask, was placed a solution of 5-chloro-3-nitro-1H- pyrrolo[3,2-b]pyridine (1.1 g, 5.56 mmol, 1.00 equiv) in 1,4-dioxane (30 ml). To this was added HCl (6mol/L) (15 ml, 90 mmol, 16.00 equiv). This was followed by the addition of a solution of Fe (2.5 g, 44.64 mmol, 8.00 equiv) in MeOH (50 ml). The resulting solution was allowed to react, with stirring, for 3 hours while the temperature was maintained at reflux in a bath of oil. A filtration was performed. The filtrate was concentrated by evaporation under vacuum using a rotary evaporator. The resulting solution was diluted with H2O. Adjustment of the pH to 7-8 was accomplished by the addition of Na2CO3. The resulting solution was extracted three times with 100 ml of EtOAc and the organic layers combined and dried over Na2SO4 and concentrated by evaporation under vacuum using a rotary evaporator. This resulted in 1.3 g (crude) of 5-chloro-1H-pyrrolo[3,2-b]pyridin-3-amine as a black solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1116136-63-0, its application will become more common.

Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2009/23844; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89809-65-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89809-65-4, name is Methyl 6-Cyanopyridine-3-carboxylate, molecular formula is C8H6N2O2, molecular weight is 162.1454, as common compound, the synthetic route is as follows.

To a solution of methyl 5-(3-chlorobenzyl)pyridin-2-amine (0.262 g, 1 .2 mmol) in toluene (7 ml_) was added trimethylaluminum (0.6 ml_,1 .2 mmol, 2 M in toluene) at room temperature under argon. The reaction mixture was stirred at room temperature for 1 h before a solution of methyl 6-cyanonicotinate (0.162 g, 1 mmol) in toluene (2 ml_) was added. Reaction mixture was stirred at 100 0 C for 2 h under argon. The reaction solution was cooled to room temperature and quenched with methanol (5 ml_) and 1 N hydrochloric acid aqueous (5 ml_). The volatiles were concentrated, and the aqueous phase was extracted with dichloromethane (1 00 ml_ x 2). The combined organic layers were washed with brine (1 00 ml_), dried over sodium sulfate, filtered and concentrated. The crude sample was dissolved in minimal A/,A/-dimethylformamide and purified v/a prep-HPLC (Boston C18 21 *250 mm 10 pm column. The mobile phase was acetonitrile/0.01 % aqueous trifluoroacetic acid) to give A/-(5-(3-chlorobenzyl)pyridin-2-yl)-6-cyanonicotinamide (70 mg, 0.20 mmol, 20.8%) as a white solid. 1 H NMR (500 MHz, Dimethylsulfoxide-c/g) d 1 1 .33 (s, 1 H), 9.22 (d, J = 1 .3 Hz, 1 H), 8.53 (dd, J = 4.3, 2.5 Hz, 1 H), 8.36 (d, J = 2.0 Hz, 1 H), 8.20 (d, J = 8.0 Hz, 1 H), 8.12 (d, J = 8.5 Hz, 1 H), 7.75 (dd, J = 4.3, 2.5 Hz, 1 H), 7.35 – 7.32 (m, 2H), 7.28-7.23 (m, 2H), 3.99 (s, 2H); LCMS (ESI) m/z: 349.0 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 89809-65-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; YUMANITY THERAPEUTICS, INC.; LE BOURDONNEC, Bertrand; LUCAS, Matthew; OZBOYA, Kerem; PANDYA, Bhaumik; TARDIFF, Daniel; TIVITMAHAISOON, Parcharee; WRONA, Iwona; (475 pag.)WO2019/183587; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 403-45-2, name is 6-Fluoronicotinic acid, the common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Fluoronicotinic acid

A mixture of 6-fluoro-nicotinic acid (2.07g, 14.7mmol), K2CO3 (4.48g, 32.4mmol) and MeI (3.2Og, 22.5mmol) in DMF (6OmL) was stirred for 16h at rt. After dilution with H2O (5OmL), the reaction mixture was extracted with EtOAc (5OmL) and the extract washed successively with saturated NaHCO3 solution (2OmL), brine (2 x 2OmL) and dried (MgSO4). Filtration and evaporation of the solvent gave the product as an orange solid (1.79g, 78%). 1H (CDCl3) 8.53 (IH, s), 8.12 (IH, m), 6.77 (IH, dd), 3.67 (3H, s)

The synthetic route of 403-45-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JAMES BLACK FOUNDATION; WO2007/135350; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 52378-63-9, Adding some certain compound to certain chemical reactions, such as: 52378-63-9, name is (3-Aminopyridin-2-yl)methanol,molecular formula is C6H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52378-63-9.

(i) A solution sodium nitrite (2.38 g.) in water (10 ml.) was added dropwise to a stirred mixture of 3-amino-2-hydroxymethylpyridine (4.8 g.) in aqueous hydrobromic acid (48%, 10 ml) and water (5 ml) at 0-5 C. This solution of the diazonium salt was added to a hot solution of cuprous bromide (2.5 g.) in 60% hydrobromic acid and following cessation of nitrogen evolution the mixture was heated on the steam bath for 0.5 hours, diluted with water and saturated with hydrogen sulphide. Filtration, concentration to low bulk and extraction with chloroform yielded 3-bromo-2-hydroxymethyl-pyridine (4.8 g.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52378-63-9, (3-Aminopyridin-2-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4025527; (1977); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52311-20-3, 2-Amino-4-ethoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4-ethoxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4-ethoxypyridine

4-Ethoxy-pyridin-2-ylamine (15 g, 109 mmol) is dissolved in HOAc (100 mL) and cooled to 0 C. Bromine is added dropwise with vigorous stirring. The mixture is allowed to stir at RT for 30 minutes at which point a precipitate forms. The mixture is stirred for 30 min and the solids collected by filtration, washed with EtOAc in dried in a vacuum oven to give 5-bromo-4-ethoxy-pyridin-2-ylamine hydrobromide (23.3 g, 78.2 mmol).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52311-20-3, 2-Amino-4-ethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; Boehringer Ingelheim International GmbH; LIU, Pingrong; MILLER, Craig Andrew; YU, Maolin; ZHANG, Zhonghua; (93 pag.)US2018/72717; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 139585-48-1, name is 2-Chloro-5-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H6ClNO

Carboxylic acid XIIIAcid XIII-I5 ‘-Methoxy-3,4,5,6-tetrahydro-2H- [ 1 ,2 ‘] bipyridinyl-4-carboxylic acida) 5′-Methoxy-3,4,5,6-tetrahydro-2H-[l,2’]bipyridinyl-4-carboxylic acid ethyl esterTo a stirred solution of piperidine-4-carboxylic acid ethyl ester (0.52 g, 3.34 mmol) and 2- chloro-5-methoxy-pyridine in 10 mL of toluene was added (13 mg, 0.057 mmol) of Pd(II) acetate, (17 mg, 0.027 mmol) of BINAP and tBuOK (0.44 g, 3.90 mmol). The mixture was heated at 1200C for two hours, concentrated under vacuo and the residue was directly purified on column chromatography (SiO2, EtOAc/Hept 1 :2) yielding 0.17 g (24 %) of the title compound as a light yellow oil. ES-MS m/e: 265.3 (M+H+).

With the rapid development of chemical substances, we look forward to future research findings about 139585-48-1.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; JABLONSKI, Philippe; KNUST, Henner; NETTEKOVEN, Matthias; PATINY-ADAM, Angelique; RATNI, Hasane; RIEMER, Claus; WO2011/23626; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1254073-41-0, name is 5-Fluoropicolinohydrazide, the common compound, a new synthetic route is introduced below. Recommanded Product: 1254073-41-0

The title compound was prepared in an analogous method to that described in E1 11. To a solution of 4-[(2-chlorophenyl)carbonyl]-2-piperazinone (I4) (225 mg, 0.943 mmol) in Dichloromethane (5 ml) stirred under argon at room temp was added solid triethyloxonium tetrafluoroborate (179 mg, 0.943 mmol). The reaction mixture was stirred at RT for 2 hr. Solid 5-fluoro-2-pyridinecarbohydrazide (I24) (161 mg, 1.037 mmol) was added and the reaction mixture stirred at RT for 18 hr. The solvent was evaporated in vacuo, and the residue dissolved in n-butanol (5 ml) and stirred at 120 0C for 4 hr. The reaction mixture was cooled to room temperature and partitioned between Dichloromethane (~ 25 ml) and saturated brine (~ 25 ml). The aqueous phase was extracted wih Dichloromethane (2 x 25 ml) and the combined organic extracts washed with saturated brine (~ 25 ml), dried over sodium sulphate, and evaporated in vacuo to afford the crude product as a yellow oil. This was dissolved in 1 :1 MeOH:DMSO and purified by Open Access Mass Directed AutoPrep on Sunfire C18 column using Acetonitrile Water with a Formic acid modifier. The solvent was evaporated in vacuo and the residue dried overnight in a vacuum oven at 40 0C to give the required product as a white powder in 126.4 mg.LCMS: 2 minute run in MeCN. MH+ m/z = 358.03; RT = 0.80-0.82 min.

The synthetic route of 1254073-41-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 167837-43-6, Adding some certain compound to certain chemical reactions, such as: 167837-43-6, name is (E)-3-(6-Aminopyridin-3-yl)acrylic acid,molecular formula is C8H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 167837-43-6.

e) 3-(6-amino-pyridin-3-yl)-N-(3-cyano-lH-indol-2-yhnethyl)-N-methyl-acrylamide; EDC (250 mg, 1.3 mmol) was added to a solution of (£)-3-(6-Amino-pyridin-3-yl)- acrylic acid (172 mg, 1.05 mmol), 2-methylaminomethyl-lH-indole-3-carbonitrile (186 mg, 1.0 mmol), HOBf H2O (135 mg, 1.0 mmol) and DPEA (510 muL, 3.0 mmol) in dry DMF (4 mL). After 3 days of stirring, the mixture was diluted with water (50 mL) at 100C. The resulting precipitate was filtered, washed with water and dried to afford the title compound (277 mg, 84%). 1H NMR (300 MHz, DMSO-d6, delta): 12.1 (m, IH), 8.16 (s, IH), 7.84 (s, IH), 7.5 (m, 3H), 7.2 (m, 2H), 6.97 (m, IH), 6.44 (s, 2H), 5.08 and 4.88 (rotamers, 2s, 2H), 3.22 and 2.96 (rotamers, 2s, 3H). MS (ESI): m/e 332 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 167837-43-6, (E)-3-(6-Aminopyridin-3-yl)acrylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2007/53131; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem