Tag: M.W:100-200

Related Products of 113124-09-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 113124-09-7, name is 5,6-Dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

13,0 g of trifluoromethane sulfonic acid was added dropwise to a mixture of 0,91 g (7,0 mmol)2,3-dimethylpyridi ne-5-carbonitrile and 2,0 g (9,0 mmol) I -(2-fluorophenyl)-2-(2-pyridyl)propan-2-olin 40 ml dichloroethane at 0 – 5C. After 2 days at room temperature the reaction mixture was poured onto sodium carbonate solution, the organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic extracts were extracted withsodium hydrogen carbonate and water, evaporated and the residue was purified via MPLC with water/acetonitrile mixtures to yield 0,11 g (4 %) of the title compound as a light yellow oil. 1H.NMR (CDCI3, 6 in ppm): 8,7 (s, 1H); 8,6 (d, 1H); 7,8 (m, 2H); 7,6 (m, 1H); 7,3-7,1 (m, 4H);3,4 (d, IH); 3,3, (d, IH); 2,6 (s, 3H); 2,4 (s, 3H); 1,6 (s, 6H).*HPLCMS: Rt = 0,743 mm; M+H = 346,1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 113124-09-7, 5,6-Dimethylnicotinonitrile.

Reference:
Patent; BASF SE; MUELLER, Bernd; CAMBEIS, Erica; LOHMANN, Jan Klaas; ESCRIBANO CUESTA, Ana; WOLF, Antje; FEHR, Marcus; RIEDIGER, Nadine; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; WINTER, Christian; (151 pag.)WO2018/54721; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2,5-Pyridinedicarboxylic acid

To a mixture containing Cu(ClO4)2·6H2O (0.190 g, 0.5 mmol) and tris(3-aminopropyl)amine, trpn (0.0.094 g, 0.5 mmol) dissolved in MeOH (20 mL), an aqueous solution (5 mL) of pyridine-2,5-dicarboxylic acid disodium salt (0.053 g, 0.25 mmol) was added. The solution was then heated on a steam-bath for 10 min, filtered through celite and the resulting blue solution was allowed to stand at room temperature. The crude solid, which separated was collected by filtration. Crystallization of the product from H2O afforded tiny blue crystals suitable for X-ray analysis. These were collected by filtration, washed by propan-2-ol, Et2O and dried in air (overall yield: 0.150 g, 82% based on Cu(ClO4)2·6H2O). Characterization: C32H54Cl2Cu3N10O16 (1096.37 g/mol): Calcd: C, 35.06; H, 4.96; N, 12.78. Found: C, 34.88; H, 5.01; N,12.63%. Selected IR bands (ATR, cm1): 3323 (m), 3285 (m) nu(NeH) stretching; 2934 (w), 2889 (w) nu(CeH) stretching; 1594 (s), 1436 (vs)[nu(C]O+C]C+C]N)]; 1070 (vs, b) nu(CleO). UV-Vis (H2O): lambdamax, nm (epsilonmax M-1 cm-1 per Cu atom)=562 (sh), 679 (85), 906 (sh).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Louka, Febee R.; Haq, Sabriah J.; Guidry, Hollie R.; Williams, Bailey R.; Henary, Maher M.; Fischer, Roland C.; Torvisco, Ana; Massoud, Salah S.; Mautner, Franz A.; Inorganica Chimica Acta; vol. 500; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 139022-25-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.139022-25-6, name is Imidazo[1,2-a]pyridine-6-carboxylic acid, molecular formula is C8H6N2O2, molecular weight is 162.15, as common compound, the synthetic route is as follows.

To a stirred solution of compound D (2.5 g,15.4 mmol, 1 eq) in DMF (50 mL) were added compound E (2.3g, 23.1 mmol, 1.5 eq), triethylamine (15.6 g, 154.3 mmol, 10 eq) and T3P (-50% in ethyl acetate, 14.8 g, 23.1 mmol, 1.5 eq) at 23 C and the resulting mixture was heated at 120 C for 18 h. The reaction mixture was cooled to RT, quenched with water and the organic components were extracted with 10% methanol/ CH2CI2. The organic layer was concentrated in vacuo and the crude material was purified by flash chromatography (Combiflash) using 100-200 mesh silica gel eluting with 10% MeOH/ CH2CI2 to obtain the compound F (600 mg, 20%) as off white solid. (0302) [0292] lH NMR (400 MHz, OMSO-d6) delta 9.03 (s, 1 H), 8.06 (s, 1 H), 7.64 (m, 1 H), 7.59 (d, / = 8 Hz, 1 H), 7.47-7.44 (m, 1 H), 3.61 (s, 3 H), 3.32 (s, 3 H); (0303) [0293] LCMS : m/z = 206.2 [M+H], RT = 0.54 minutes; (Program Rl , Column W).

Statistics shows that 139022-25-6 is playing an increasingly important role. we look forward to future research findings about Imidazo[1,2-a]pyridine-6-carboxylic acid.

Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott, K.; PRIESTLEY, Tony; KUNDU, Mrinalkanti; SAHA, Ashis; NATH, Suvadeep; (126 pag.)WO2018/64135; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 109-09-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-09-1, name is 2-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, as common compound, the synthetic route is as follows.

Synthesis of pyridin-2-yl-hydrazine (2): To a stirredsolution of 1 (20 g, 0.176 mol, 1 equiv) in hydrazine hydrate (200 mL, 10 vol) was stirred at 100 C for 48 h. When TLC (8:2 EtOAc and methanol) showed complete consumption of the starting material, the reaction mixture was diluted with water (200 mL) and extracted with ethyl acetate (5 × 500 mL), dried over Na2SO4 evaporated to dryness under reduced pressure to afford 2 (15.0 g, 78 %) as a red oil; 1H NMR (300 MHz,CDCl3): delta 8.14 (1H, d, J = 3 Hz, Ar-H), 7.51-7.45 (1H, m, Ar-H), 6.71-6.66 (2H, m, Ar-H), 5.78 (1H, brs, -NH), 3.81 (2H,brs, -NH2); LCMS calculated for C5H7N3: 109.13; Found 110.1,[M+H]+

The chemical industry reduces the impact on the environment during synthesis 109-09-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Gandikota, N. Murthy; Bolla, R. Sekhar; Viswanath, I. V. Kasi; Bethi, Sridharreddy; Asian Journal of Chemistry; vol. 29; 9; (2017); p. 1920 – 1924;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H5F3N2

(1) Pyridine (2.9 mL) was added to a solution of 2-trifluoromethyl-5-aminopyridine (1.95 g) in chloroform (15 mL), the mixture was cooled in ice, and phenyl chloroformate (1.8 mL) was added thereto. The resulting mixture was stirred at room temperature overnight, and the reaction mixture was concentrated under reduced pressure. The residue was washed with isopropyl ether to afford phenyl[6-(trifluoromethyl)pyridin-3-yl]carbamate (2.16 g). (ESI pos.) m/z: 283 ([M+H]+)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD; Moriya, Minoru; Ohta, Hiroshi; Yamamoto, Shuji; Abe, Kumi; Araki, Yuko; Sun, Xiang-Min; Wakasugi, Daisuke; US2013/331571; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 104408-23-3 ,Some common heterocyclic compound, 104408-23-3, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

STR93 (Process (a) 16.9 g (0.1 mole) of ethyl ethoxymethylenecyanoacetate and 17.8 g (0.1 mole) of 3,5-dichloro-pyrid-2-ylhydrazine in 150 ml of ethoxyethanol are stirred at 80 C. for 5 hours and then at 120 C. for a further 2 hours. For working up, the solvent is removed in vacuo. 29.6 g (98% of theory) of 5-amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole of melting point 98-101 C. are obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,104408-23-3, its application will become more common.

Reference:
Patent; Bayer Aktiengesellschaft; US4772312; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6602-32-0, 2-Bromo-3-hydroxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Bromo-3-hydroxypyridine, blongs to pyridine-derivatives compound. Quality Control of 2-Bromo-3-hydroxypyridine

Diethyl azodicarboxylate (95 mL, 0.6 mol) was added dropwise to a stirred mixture of 2-bromo-3- hydroxypyridine (97 g, 0.55 mol), 3-buten-l-ol (47.7 mL, 0.55 mol), and PPh3 (175.3 g, 0.66 mol) in THF (970 mL) at 0C under a N2 atmosphere. The reaction mixture was warmed to 50C in an oil bath and stirred for 17.5 h. Reaction progress was monitored by TLC (15% EtOAc in hexane, UV active). The reaction mixture was cooled to ambient temperature and diluted with saturated NaHC03 solution (500 n L). The aqueous solution was extracted with EtOAc (1 L). The organic layer was dried over Na2S04 (200 g), and concentrated. The residual product was purified by column chromatography using 60-120 mesh, eluting with 5% EtOAc in hexane to afford the title compound as a pale yellow oil. MS (ESI) m/z; 228 (MH+).

The synthetic route of 6602-32-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NANT HOLDINGS IP, LLC; NANTWORKS, LLC; TAO, Chunlin; WANG, Qinwei; SOON-SHIONG, Patrick; (94 pag.)WO2017/24315; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1603-41-4, name is 2-Amino-5-methylpyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 1603-41-4

3.40 mL of 50% sulfuric acid (v / v) was added to a 25 mL reaction flask followed by the addition of 1.00 g (10 mmol) of 2-amino-5-methylpyridine (Compound 1), the ice salt bath was cooled to below 10 C, After a few minutes, the reaction solution became milky white; and then slowly slowly adding 1.72 g (25 mmol) of a mixture of NaNO2 and 3 mL of H2O to form a brownish-colored irritating odor gas, and the reaction solution Into a pale yellow, with 10% dilute sulfuric acid to adjust the pH to 7-8, reflux stirring reaction about 20min, spin off most of the water, to which the appropriate amount of 300 mesh silica gel, spin dry, into the glass sand core funnel, The ester was filtered and the filtrate was spin-dried to obtain the crude product (Compound 3) which was used in the next step without purification.

The synthetic route of 1603-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sichuan University; Yin, Shu-Fan; Li, Yong; Cao, Tingting; Yang, Ziyao; (16 pag.)CN105998016; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55717-45-8, Adding some certain compound to certain chemical reactions, such as: 55717-45-8, name is 6-Bromopyridin-3-ol,molecular formula is C5H4BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55717-45-8.

2-Bromo-5-hydroxypyridine (5 mmol) is dissolved in DMF (10 ml) and NaH (1.4 eq., 60% suspension in liquid paraffin) is added. After 30 min iodomethane (2 eq.) is added and the reaction solution is stirred 3 days. The reaction solution is pored into water and extracted with methyl-tert-15 butyl ether. The combined organic layers are dried over MgSO4 and the solvent is removed in vacuo. 2-Bromo-5-methoxy-pyridine is obtained as yellow oil in a yield of 79 %; HPLC (method C): 1.49 min; LC-MS (method A): 1.16 min, 187.95 (M+H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55717-45-8, 6-Bromopyridin-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; WO2009/46784; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 499-51-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 499-51-4 as follows.

A mixture of 205 4-hydroxypyridine-2,6-dicarboxylic acid 18a (10 g, 54.6 mmol), 206 phosphorus pentachloride (56 g, 272 mmol) and 179 chloroform (30 mL) was heated to 80 C. and stirred for three days. The mixture was cooled to room temperature and added slowly with 31 methanol (20 mL). The obtained mixture was stirred at room temperature for 2 h, basified with a solution of 118 sodium bicarbonate and extracted with dichloromethane (50 mL). The organic phase was combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography to give the target 207 compound dimethyl 4-chloropyridine-2,6-dicarboxylate 18b (8 g, white solid). Yield: 64%. MS m/z (ESI): 230[M+1]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,499-51-4, its application will become more common.

Reference:
Patent; Beijing Innocare Pharma Tech Co., Ltd.; CHEN, Xiangyang; GAO, Yingxiang; US2019/185472; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem