Tag: M.W:100-200

Related Products of 55676-21-6 ,Some common heterocyclic compound, 55676-21-6, molecular formula is C7H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 1-(2-chloropyridin-3-yl)ethanone (B-2) (6 g, 38.6 mmol) and hydrazine (85%, 9.1 g, 154.4 mmol) in pyridine (80 mL) was stirred under reflux overnight. The mixture was cooled to room temperature, concentrated, diluted with water (80 mL) and then extracted with ethyl acetate (100 mL*3). The combined organic layers were washed with brine, dried over Na2S04, and concentrated under vacuo. The resulting residue was used for the next step without furtuer purification. MS (m/z): 134 (M+1 )+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; WO2011/79804; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 106984-91-2, name is 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, molecular formula is C6H5NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 6-Oxo-1,6-dihydropyridine-3-carbaldehyde

A solution of 6-hydroxynicotinaldehyde SM 1(192mg, 4 mmol) and (S)-1-cyclopropylethanamine (170 mg, 2 mmol) in DCM (5 mL) and EtOH (5 mL) was added NaBH3CN(620 mg, 10 mmol), then stirred at RT for 16 h. The resulting reaction mixture was quenched withwater and extracted with DCM, dried and evaporated, purified by combiflash (methanol:DCM =1:20) to give compound 1(300mg, 78%). LC-MS: m/z = 193.1 [M+H]

With the rapid development of chemical substances, we look forward to future research findings about 106984-91-2.

Reference:
Patent; ABBVIE INC.; MICHAELIDES, Michael; HANSEN, Todd; DAI, Yujia; ZHU, Guidong; FREY, Robin; GONG, Jane; PENNING, Thomas; CURTIN, Michael; MCCLELLAN, William; CLARK, Richard; TORRENT, Maricel; MASTRACCHIO, Anthony; KESICKI, Edward A.; KLUGE, Arthur F.; PATANE, Michael A.; VAN DRIE, John H. Jr.; JI, Zhiqin; LAI, Chunqiu C.; WANG, Ce; (1190 pag.)WO2016/44770; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 26452-80-2 ,Some common heterocyclic compound, 26452-80-2, molecular formula is C5H3Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step B Preparation of 2,4-dichloro-3-pyridine Carboxaldehyde Under nitrogen, a solution of 1.6 g of 2,4-dichloropyridine in 5 mL dry tetrahydrofuran (THF) was added to a solution of 6 mL of lithium diisopropyl amide in 25 mL of THF at -70 C., followed by stirring at this temperature for 3 hours. Then 1 mL of dry N,N-dimethylformamide was added at -70 C. followed by stirring at this temperature for 1 hour. Then 25 mL of saturated ammonium chloride solution was added and the reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with 25 mL of water and extracted with ethyl acetate (2*). The combine organic phases were distilled under vacuum to give solids that were dissolved in 5 mL of methylene chloride and filtered through silica gel, eluding with 100% methylene chloride. Removal of the solvent under vacuum provided the title intermediate as a solid. 1H NMR (CDCl3; 300 MHz) delta7.41 (d, 1H, J is 5.3 Hz), 8.42 (d, 1H, J is 5.2 Hz), 10.5 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26452-80-2, its application will become more common.

Reference:
Patent; Neubert, Timothy Donald; Piotrowski, David Walter; Walker, Michael Paul; US2004/44040; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5350-93-6, name is 6-Chloropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. name: 6-Chloropyridin-3-amine

Reference Example 134 6-Chloropyridin-3-ylsulfonyl chloride Under ice-cooling, thionyl chloride (12 mL) was added dropwise over 1 hr to water (70 mL) and the mixture was stirred at room temperature for 12 hr to give a sulfur dioxide-containing solution. Under ice-cooling, 5-amino-2-chloropyridine (5.0 g) was added to concentrated hydrochloric acid (40 mL) and the mixture was stirred. An aqueous solution (12.5 mL) of sodium nitrite (2.88 g) was added dropwise while keeping the inside temperature at not higher than 5°C, and the mixture was further stirred for 15 min. The reaction mixture was gradually added at 5°C to the above-mentioned sulfur dioxide-containing solution added with cuprous chloride (70 mg). Under ice-cooling, the mixture was further stirred for 30 min. The precipitate was collected by filtration, and washed with water and ethanol to give the title compound (yield 4.79 g, 58percent). 1H-NMR (CDCl3)delta: 7.60-7.63 (1H, m), 8.24-8.27 (1H, m), 9.03-9.04 (1H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5350-93-6, 6-Chloropyridin-3-amine.

Reference:
Patent; Takeda Pharmaceutical Company Limited; Kajino, Masahiro; Hasuoka, Atsushi; Tarui, Naoki; Takagi, Terufumi; EP2336107; (2015); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13362-28-2, name is 2-Amino-4-pyridinecarboxylic acid, molecular formula is C6H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-Amino-4-pyridinecarboxylic acid

Methanol solution (1.8L) of 2-aminoisonicotinic acid (207g, 1.5mol) was added to thionyl chloride (238g, 2mol) at 50C by dropping. The solution was stirred for 5 more hours at the same temperature. Then, the solvent was removed under reduced pressure, and saturated aqueous solution of sodium carbonate was added to the residue to be basic of pH=9-10. After extracting the mixed solution by using dichloromethane (3*300ml), organic layer was collected and dried by using anhydrous sodium sulfate. The solvent was concentrated to obtain methyl 2-aminoisonicotinate (189g, 83%) (Compound 2) of yellow solid. [0518] 1H-NMR (d6-DMSO, 300MHz): delta3.96 (S, 3H) ; 7.14 (d, 1H); 7.49(br, 1H); 8.07(d, 1H); 8.18 (br, 2H, NH).

With the rapid development of chemical substances, we look forward to future research findings about 13362-28-2.

Reference:
Patent; Shin Nippon Biomedical Laboratories, Ltd.; SUZUKI, Nobuyuki; YAMASHITA, Hidetoshi; (156 pag.)EP3018125; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17874-79-2 ,Some common heterocyclic compound, 17874-79-2, molecular formula is C8H7NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-(methoxycarbonyl)pyridine-2-carboxylic acid (100 mg, 0.55 mmol) was dissolved in acetonitrile (1 mL). Triethylamine (0.230 mL, 1.66 mmol) and O-benzotriazol-1-yl- tetramethyluronium hexafluorophosphate (314 mg, 0.83 mmol) were added. The reaction mixture was stirred at rt for 5 min. 3,3,3-trifiuoropropylamine hydrochloride (83 mg, 0.55 mmol) was added and the reaction mixture was stirred at ambient temperature for 2h. The solvent was removed in vacuo and the crude was partioned between ethyl acetate and IM sodium hydroxide. The organic layer was dried over magnesium sulfate and concentrated in vacuo. The crude was purified by column chromatography using a gradient of ethyl acetate in heptane yieded 38 mg (25%) of the title compound as a white solid; 1H NMR (400 MHz, DMSOtZ6) delta ppm 9.17 (t, 1 H), 9.11 (d, 1 H), 8.48 (dd, 1 H), 8.18 (d, 1 H), 3.92 (s, 3 H), 3.53 – 3.60 (m, 2 H), 2.54 – 2.66 (m, 2 H); MS (ESI) m/z 277 [M+H+], m/z 275 [M-H+];

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17874-79-2, 5-(Methoxycarbonyl)picolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WO2008/130320; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 13466-38-1, Adding some certain compound to certain chemical reactions, such as: 13466-38-1, name is 5-Bromopyridin-2-ol,molecular formula is C5H4BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13466-38-1.

(i) 5-bromo-l-ethylpyridin-2(lH)-onePotassium tert-butoxide (328 mg) was added to 5-bromopyridin-2(lH)-one (509 mg) in dimethoxyethane (15 mL) at 20C under an atmosphere of nitrogen and stirred for 30 min. Potassium carbonate (283 mg) and iodoethane (0.236 mL) were added to the reaction mixture and the resulting suspension was stirred at 95C for 3 h. The reaction mixture was cooled and filtered, evaporated to dryness and redissolved in dichloromethane, and washed with 0.1M hydrochloric acid. The organic layer was dried over magnesium sulfate, filtered and evaporated to afford an oil which was purified by chromatography on silica eluting with 30 to 50% ethyl acetate in z’sohexane. Pure fractions were evaporated to dryness to afford the subtitled compound (367 mg).1H NMR (500 MHz, DMSO) delta 8.04 (d, IH), 7.50 (dt, IH), 6.35 (d, IH), 3.88 (q, 2H), 1.19 (t, 3H). m/e (APCI+) 204 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13466-38-1, 5-Bromopyridin-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FORD, Rhonan; KINCHIN, Elizabeth; MATHER, Andrew; METE, Antonio; MILLICHIP, Ian; STANIER, Andrew Geoffrey; WO2011/154677; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 677728-92-6, name is 2-Fluoropyridine-5-carbaldehyde. A new synthetic method of this compound is introduced below., Quality Control of 2-Fluoropyridine-5-carbaldehyde

Intermediate 8.2- ^S-formylpyridm-2-ylV3-azaspi- |’5.51undecan-9-yl)aSodium bicarbonate (2.70 g, 5 equiv), 2-fluoropyridine-6-carboxaldehyde (0.80 g, 1 equiv) and the hydrochloride salt of 3-azaspiro[5.5]undec-9-ylacetic acid (1.59 g, 1 equiv) were stirred at 80 C in NMP (12 mL) for 5 hours. The mixture was cooled to room temperature, acidified with 1 M HCl (25 mL, 4 equiv), diluted with water, and extracted with dichloromethane. The combined organic layers were concentrated in vacuo and purified by silica gel chromatography (0% acetone:dichloromethane to 50% acetoneidichloromethane) to give the pure aldehyde as a white solid: [ H]+ m/z 317.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 677728-92-6, 2-Fluoropyridine-5-carbaldehyde.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CERNAK, Timothy, A.; BALKOVEC, James, M.; NARGUND, Ravi, P.; REITER, Maud; SPERBECK, Donald, M.; DYKSTRA, Kevin, D.; YU, Yang; DREHER, Spencer; MALONEY, Kevin, M.; WU, Zhicai; DEVITA, Robert, J.; VERRAS, Andreas; WO2012/9217; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1003-68-5, name is 5-Methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below., Quality Control of 5-Methylpyridin-2(1H)-one

General procedure: The coupling reaction was performed as follows: in a typical process, 5-methyl-2-(1H)-pyridone(1 mmol), aryl halide (1 mmol), base (2 mmol) and solvent (5 mL) were added to an oven-dried tube containing 5% (based on copper) MOF catalyst or copper salt. The mixture was stirred at desired temperature for 2 h. After being cooled to room temperature, the catalyst was filtrated and washed with ethyl acetate. The products were isolated by a series 1500 preparative high performance liquid chromatography system (SSI, Charlotte, NC, USA) equipped with a UV-VIS detector, using a Kromasil C18 column (50 x 250 mm) and gradient elution with a H2O (A)-acetonitrile (B) the mobile phase. The gradient program was 0 min, 10% B; 20 min, 35% B. The flow rate of mobile phase was 40 mL/min, and the detection wavelength was 220 nm. Fractions were collected and evaporated to afford the pure products.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1003-68-5, 5-Methylpyridin-2(1H)-one.

Reference:
Article; Long, Wei; Qiu, Wenge; Guo, Chongwei; Li, Chuanqiang; Song, Liyun; Bai, Guangmei; Zhang, Guizhen; He, Hong; Kuznetsov, Maxim L.; Molecules; vol. 20; 12; (2015); p. 21178 – 21192;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1427-06-1, name is Methyl 6-fluoropyridine-3-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Methyl 6-fluoropyridine-3-carboxylate

( (2S) -5- (4- (trifluoromethyl) phenyl) piperidin-2-yl) methanol (294 mg, 1.13 mmol) , methyl 6-fluoropyridine-3-carboxylate (198 mg, 1.28 mmol) and K 2CO 3 (489 mg, 3.54 mmol) were dissolved in DMSO (3 mL) . The mixture was stirred for 24 h at an oil-bath temperature of 50 . The reaction mixture was cooled to room temperature, and to the mixture was added saturated NaCl solution (50 mL) , and the mixture was extracted with EtOAc (40 mL×2) . The combined organic layers were dried over anhydrous Na 2SO 4, and concentrated in vacuo to give a crude product, which was purified by silica-gel column chromatography (eluent: PET/EtOAc (v/v) = 5: 1) to give colorless oil (166 mg, 37%) . [2165] MS (ESI, pos. ion) m/z = 395.3 [M+1] +.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1427-06-1, Methyl 6-fluoropyridine-3-carboxylate.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHONG, Xue; WANG, Feng; LI, Xuke; HE, Wei; PAN, Wei; HUANG, Jiuzhong; ZHANG, Yingjun; ZHENG, Changchun; (0 pag.)WO2020/11147; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem