Tag: M.W:100-200

Application of 1124-64-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1124-64-7, name is 1-Butylpyridinium Chloride. This compound has unique chemical properties. The synthetic route is as follows.

1Butylpyridinium chloride [BPy][Cl] (0.2580 g, 1.46 mmol) wasdissolved in 15 mL of methanol and to this solution the ionexchange resin Amberlyst A26 (OH-) (9.13 mL, 7.3 mmol) wasadded and it was kept in stirring for 1 h in order to exchange thechloride to the hydroxide form. The resin was filtered and washedwith methanol. To the resultant filtrate, H3PMo12O40 (0.973 g,0.53 mmol) in methanol was slowly added, a yellow precipitateimmediately formed and the mixture was stirred at room temperaturefor 1 h. The product was filtered, washed several times withmethanol and dried in the oven at 80 C overnight (1.05 g, 89%). 1H NMR (400.13 MHz, DMSO d6, 25C) delta = 9.10 (d, J = 4.0 Hz,2H), 8.63 (t, J = 8.0 Hz, 1H), 8.19 (t, J = 8.0 Hz, 2H), 4.63(t, J = 8.0 Hz, 2H), 1.95 (m, J = 8.0 Hz, 2H), 1.31 (m, 2H), 0.94(t, J = 8.0 Hz, 3H) ppm. 31P NMR (162 MHz, CD3CN, 25 C)delta = -2.09 ppm. Selected FTIR (cm-1, KBr): 3124 (w), 3080 (w),3063 (w), 2963 (w), 2929 (w), 2869 (w), 1632 (s), 1581(w), 1485 (s), 1462 (m), 1384 (w), 1316 (w), 1278 (w), 1209 (w),1168 (m), 1063 (vs), 956 (vs), 878 (s), 795 (s), 682 (s), 644 (w),594 (w), 504 (m). Anal. Calc. for (C9H14N)3PMo12O40 (2230.87): C,15.04; H, 1.88; N, 1.87; Found: C, 14.76; H, 1.85; N, 1.87

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-64-7, 1-Butylpyridinium Chloride.

Reference:
Article; Mirante, Fatima; Gomes, Neide; Corvo, Marta C.; Gago, Sandra; Balula, Salete S.; Polyhedron; vol. 170; (2019); p. 762 – 770;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Picolinic acid

General procedure: A mixture of o-phenylendiamine (1 eq) and the corresponding picolinic acid (1 eq), and 5-20 eq of polyphosphoric acid was stirred in an oil bath at 170 C for 4 h. The mixture was cooled to 100 C and then poured into rapidly stirred water. The pH was adjusted to 7 with NaHCO3. The solid was collected by filtration, and recrystallized from EtOAc to afford the corresponding products with 60-80% yields.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98-98-6, Picolinic acid.

Reference:
Article; Jia, Jianhuan; Jiang, Chenglin; Zhang, Xiaojing; Jiang, Yongwen; Ma, Dawei; Tetrahedron Letters; vol. 52; 43; (2011); p. 5593 – 5595;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1597-32-6, name is 2-Amino-6-fluoropyridine, molecular formula is C5H5FN2, molecular weight is 112.11, as common compound, the synthetic route is as follows.HPLC of Formula: C5H5FN2

General procedure: A dried glass reaction tube equipped with a magnetic stir bar was charged with 1 (106 mg, 0.5 mmol), 2 or 4 (141.2 mg, or 207 mg,1.5 mmol), I2 (254 mg, 1 mmol) in DCE (10 mL); stirred at 100 C for30 min. The solvent was evaporated under vacuum, and washed with saturated sodium thiosulfate solution, water, brine. The organic layer was dried over anhydrous Na2SO4, filtered, and concentrated to give the crude product, which was purified through flash column chromatography (ethyl acetate in petroleum ether) to give the desired product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1597-32-6, 2-Amino-6-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Article; Guo, Yanchun; Wang, Yuexiu; Xue, Han; Cao, Shuxia; Zhao, Yufen; Tetrahedron; vol. 75; 11; (2019); p. 1481 – 1491;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 871836-51-0 , The common heterocyclic compound, 871836-51-0, name is 4-Chloro-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10152] A mixture of tert-butyl 4-chloro-1H-pyrazolo[4,3- c]pyridine (30.6 mg, 0.2 mmol) and E-001 (68 mg, 0.2 mmol) was heated at 1000 C. overnight. MeOH (2 mE) was added and the resultant was purified by Prep-TEC (ethyl acetate petroleum ether=11) to give D-01-02 (50 mg, 54.5percent) as a yellow oil.

The synthetic route of 871836-51-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. Hoffmann-La Roche AG; Savira pharmaceuticals GmbH; European Molecular Biology Laboratory; Schulz-Gasch, Tanja; Weikert, Robert; Neidhart, Werner; Buschmann, Helmut; Szolar, Oliver; Wolkerstorfer, Andrea; Handler, Norbert; Roch, Franz-Ferdinand; Cusack, Stephen; (69 pag.)US2016/2227; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13534-97-9, 6-Bromopyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 6-Bromopyridin-3-amine, blongs to pyridine-derivatives compound. Application In Synthesis of 6-Bromopyridin-3-amine

To a solution of 6-bromopyridin-3-amine (4.0 g, 23.25 mmol) in DCM (60 mL) was added pyridine (5.51 g, 69.75 mmol) and 3-chloropropanoyl chloride (3.515 g, 27.9 mmol) at 0°C and allowed to stir at RT for 12. The reaction mixture was diluted with DCM (200 mL) and washed with water (100 mL) and brine solution (100 mL). (0601) The separated organic layer was dried over anhydrous NBISOA, filtered and concentrated under reduced pressure to afford the title compound (4.5 g, 73percent) as a brown colour liquid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13534-97-9, 6-Bromopyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; ORYZON GENOMICS, S.A.; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; SALAS SOLANA, Jorge; (129 pag.)WO2018/219478; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19798-77-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19798-77-7, name is 4-Amino-3-chloropyridine. A new synthetic method of this compound is introduced below.

To a (100 ml_) round bottom flask was added 2-(5-iodo-3-methyl- 4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7(4H)-yl)acetic acid (1.2 g, 3.60 mmol), HATU (1.370 g, 3.60 mmol) and 4-amino-3-chloropyridine (0.695 g, 5.40 mmol). N,N- dimethylformamide (DMF) (Volume: 7 mL) was added. The mixture was stirred at room temperature for 2 hrs after which an additional amount HATU (0.5 eqv) was added until reaction was judged complete by LCMS. A mixture of EtOAc/Hexanes (50 ml, 1 :4) was added and the crude mixture stirred for an additional 5 minutes. The top layer was decanted and the resulting mixture was treated with 50 mL of water. The resulting precipitate was filtered, dried under vacuum at 45-50C to afford the desired product (1.582g, 95% yield); LCMS [M+H]+ 444.99.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 894074-85-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.894074-85-2, name is Ethyl 2-chloro-5-methylnicotinate, molecular formula is C9H10ClNO2, molecular weight is 199.63, as common compound, the synthetic route is as follows.

A mixture of ethyl 2-chloro-5-methylnicotinate (14.7 g) , 2, 2′ -azobis (isobutyronitrile) (1.31 g) , N- bromosuccinimide (17.1 g) and carbon tetrachloride (200 ml) was heated at 900C for 5 hours. After an aqueous saturated sodium chloride solution (100 ml) was added to the reaction mixture, this was extracted with ethyl acetate, and the ethyl acetate layer was washed with an aqueous saturated sodium chloride solution, dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate-hexane) to obtain the desired product (10.5 g) as an oil. 1H-NMR (CDCl3) delta 1.4 – 1.5 (3H, m) , 4.3-4.5 (4H, m) , 7.97 (IH, d) , 8.19 (IH, d) .

The chemical industry reduces the impact on the environment during synthesis 894074-85-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2006/64944; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 22245-83-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22245-83-6, name is 3-(Trifluoromethyl)pyridin-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

5-iodo-3-trifluoromethyl-2-pyridinol C 800C, 2h I>80%[0070] 3-trifluoromethyl-2-pyridinol (25 g, 153.3 mmol) is dissolved in anhydrousCH3CN (150 rnL) and DMF (150 rnL). N-iodosuccinimide (34.5 g, 153 mmol) is then added. The reaction mixture is stirred at 80 0C for 2 hours and cooled to room temperature. Aqueous 1 M NaHCO3 (150 mL) is then added to the cooled mixture. After stirring for 5 min, the solvents are evaporated to dryness. Water is added and the aqueous phase is extracted (x2) with dichloromethane. The organic phase is then evaporated and the desired product is recrystallized in water to afford 36.2 g (81 %) of a white powder.[0071] 1H NMR (500 MHz, CDCl3) delta 7.85 (d, J= 2.3, IH); 7.98 (d, J= 2.3, IH),13.41 (br s, IH); 13C NMR (250 MHz CDCl3) delta 63.0, 121.4 (q, JC-F= 272.3 Hz), 122.2 (q, JC- F= 31.6 Hz), 144.4, 148.1 q, (JC-F= 5.0 Hz), 160.1.

According to the analysis of related databases, 22245-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; WO2008/119015; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74764-17-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74764-17-3, name is N1-(Pyridin-2-yl)ethane-1,2-diamine. This compound has unique chemical properties. The synthetic route is as follows.

Step 6 (3S)-8-Amino-9-fluoro-2,3-dihydro-7-oxo-3-phenylmethyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid A mixture of (3S)-8-Amino-9,10-difluoro-2,3-dihydro-7-oxo-3-phenylmethyl-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (76.9 mg, 0.207 mmol), 2-(2-pyridylamino)ethylamine (41.8 mg, 0.303 mmol), and triethylamine (42.1 muL, 0.302 mmol) in DMSO (1.5 mL) was stirred at 100 C. for 3 h. The reaction mixture was poured into ice-water and the resulting precipitates were collected by filtration. Recrystallization of the filtered precipitates from CH2Cl2-EtOH gave (3S)-8-amino-9-fluoro-2,3-dihydro-7-oxo-3-phenylmethyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (55.4 mg, 55%) as a yellow powder. 1H NMR (400 MHz, CDCl3) delta 2.98-3.09 (2H, m), 3.71 (2H, br), 3.82 (2H, br), 3.97 (1H, d, J=11.0 Hz), 4.20 (1H, t, J=7.9 Hz), 4.33 (1H, d, J=11.0 Hz), 4.71 (1H, br), 5.75 (1H, br), 6.25 (2H, br), 6.44 (1H, d, J=7.9 Hz), 6.60 (1H, dd, J=6.7, 5.5 Hz), 7.11 (2H, d, J=6.7 Hz), 7.31-7.43 (4H, m), 8.07 (1H, s), 8.69 (1H, dd, J=5.5, 1.5 Hz), 15.1 (1H, s). HRESIMS (+): 490.19342 (calcd for C26H25FN5O4, 490.18906). [alpha]D27-204 (c 0.313, CHCl3).

According to the analysis of related databases, 74764-17-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cociorva, Oana; Li, Bei; Szardenings, Katrin; Fukuda, Yasumichi; Nomura, Masahiro; Seto, Shigeki; Yumoto, Kazuhiro; Okada, Kyoko; Nakamura, Ayako; US2007/254866; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 84249-14-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.84249-14-9, name is 2-Amino-4-bromopyridine, molecular formula is C5H5BrN2, molecular weight is 173.0106, as common compound, the synthetic route is as follows.

To a solution of 4-bromopyridin-2-amine (5.0 g, 29.07 mmol) in dichloromethane (50 mL) cooled to 0 C was added pyridine (3.5 mL, 43.4 mmol) and the solution was stirred for 10 min. Acetyl chloride (2.1 mL, 29.5 mmol) was added. The reaction mixture was allowed to stir at 0 C for 30 min. Then the reaction mixture was allowed to warm to RT and stirred for 1 h. The reaction mixture was diluted with brine (50 mL). The aqueous layer was extracted with dichloromethane (3 x 200 mL). The organic layer was dried over Na2S04, filtered and concentrated under reduced to afford the title compound (4.1 g, 19.2 mmol, 66%> yield) as a light yellow solid. LCMS (ESI) m/e 215.0 [(M+H)+, calcd for C7H8BrN20, 215.0]; LC/MS retention time (method F): tR = 1.53 min.

Statistics shows that 84249-14-9 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4-bromopyridine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DZIERBA, Carolyn Diane; BRONSON, Joanne J.; MACOR, John E.; DASGUPTA, Bireshwar; NARA, Susheel Jethanand; VRUDHULA, Vivekananda M.; PAN, Senliang; HARTZ, Richard A.; RAJAMANI, Ramkumar; (199 pag.)WO2016/22312; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem