Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Amino-2-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Amino-2-(trifluoromethyl)pyridine

Example 4; 5-amino-l-(3-(pyrrolidin-l-ylmethyl)benzyl)-7-(trifluoromethyl)pyrMdionePreparation of 2-chloro-6-(trifluoromethyl)pyridin-3-amine (19)[000396] To a solution of 6-(trifluoromethyl)pyridin-3-amine (18) (1 equiv) (commercially available) in CH3CN (0.25M) was added N-cholorosuccinimide (1 equiv) and stirred at 80 C for 2 hours. The mixture was then cooled down to room temperature and concentrated en vaccuo. The residue was purified by Combi-Flash using 0-20% EtOAc in hexane to afford 2-chloro-6- (trifluoromethyl)pyridin- 3 – amine (19).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; IRM LLC; CORTEZ, Alex; LI, Yongkai; LIAO, Xuebin; WU, Tom Yao-Hsiang; ZHANG, Xiaoyue; WO2011/57148; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74784-70-6, Adding some certain compound to certain chemical reactions, such as: 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine,molecular formula is C6H5F3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74784-70-6.

Example 100 [6-TRIFLUOROMETHYL-2- [4- (3-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL]-3H-] [IMIDAZO [4, 5-B] PYRIDINE,] trifluoroacetic acid salt. (a) [3-NITRO-5-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE.] To a 250-mL, round-bottomed flask was added [5-TRIFLUOROMETHYL-PYRIDIN-] 2-ylamine (8.3 g, 51.2 mmol, Matrix Scientific) and H2SO4 (49 mL). The resulting mixture was cooled to [0 C,] and [HN03] (8.2 mL) was added dropwise. The mixture was heated to [80 C] for [48] h, cooled to room temperature and added dropwise into a vigorously stirred ice-water (500 mL). After the addition, the mixture was basified to pH 9 with [1 ON NAOH] and extracted with EtOAc (2 x [500] mL). The combined organic extracts were dried over [MGS04] and filtered. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with [ETOAC/HEXANE] (1: 2) to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 208 (M+1).

According to the analysis of related databases, 74784-70-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61889-48-3, name is 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride, the common compound, a new synthetic route is introduced below. Computed Properties of C7H7Cl2NO

Recombinant E. coli HB101 (pNTFPG) accession number FERM BP-7117 (April 11, 2000, International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken 305-8566 Japan) was inoculated in 50 ml of 2xYT medium, which was sterilized in a 500 ml Sakaguchi flask, and cultured by shaking at 37C for 18 hours. After 2 mg of NAD+ and 2.8 g of glucose were added to 40 ml of the obtained culture solution, 2 g of 3-(2-chloro-acetyl)pyridine hydrochloride was added over 5 hours while adjusting the pH to 6.5 at 30C and then agitation was conducted for 2 hours. After the reaction was finished, the reaction solution was extracted by ethyl acetate and concentrated under reduced pressure to obtain 1.6 g of yellow oily matter, which is the title compound. The chemical purity and optical purity were analyzed in the same manner as in Example 1. The chemical purity was 96.5 % and the optical purity was 99.0 %ee

The synthetic route of 61889-48-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KANEKA CORPORATION; EP1454899; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73027-79-9, name is 4,6-Dichloronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dichloronicotinic acid

The solution of Example 146a (3.0 g, 19.2 mmol, 1.0 eq) in POCl3(30 mL) was stirred for 4 h at 100oC. After the reaction completed, it was concentrated under vacuo to give crude product (3.0 g, crude) which was used to next step without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 73027-79-9, 4,6-Dichloronicotinic acid.

Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; KALDOR, Stephen W.; (0 pag.)WO2020/86616; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105596-61-0, name is Ethyl 2-methoxyisonicotinate, molecular formula is C9H11NO3, molecular weight is 181.19, as common compound, the synthetic route is as follows.Recommanded Product: Ethyl 2-methoxyisonicotinate

A solution of ethyl 2-methoxy-pyridine-4-carboxylate (0.93 g, 5 mmol) in ether (5 ml) was added to lithium aluminium hydride (0.3 g, 8 mmol) in ether (10 ml) cooled to 5 C. and the mixture stirred for 2 hours. Water was added, the mixture was filtered through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was extracted with ethyl acetate and the combined extracts were washed with brine, dried (MgSO4) and the solvent removed by evaporation to give 4-hydroxymethyl-2-methoxypyridine (0.64 g, 89%) as a yellow oil. 1 H NMR Spectrum: (CDCl3) 3.86(s, 3H); 4.62(s, 2H); 6.65(s, 1H); 6.76(d, 1H); 8.05(d, 1H) MS – ESI: 140 [MH]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,105596-61-0, Ethyl 2-methoxyisonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Zeneca Limited; Zeneca Pharma S.A.,; US5962458; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-00-9, name is Pyridine-2,3-dicarboxylic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

A solution of pyridine-2,3-dicarboxylic acid (0.5 g, 3 mmol) and NaOH (0.24 g, 6 mmol) in water (25 mL) was added dropwise with stirring at 60 C to a solution of CdSO4·8/3H2O (0.77 g, 3 mmol) in water (25 mL). A precipitate immediately formed and stirring was continued for 4 h at 50 C. The addition of the 2-meim ligand (0.49 g, 6 mmol) in water (10 mL) to the precipitate mixture resulted in a clear solution. The mixture was stirred for 2 h at 60 C and then cooled to room temperature. The crystals that formed were filtered, washed with 10 mL of water, and dried in air. The crystals were collected for 1 in 69.3% yield. Anal. Calc. for C11H9CdN3O4: C, 36.74; H, 2.52; N, 11.68. Found: C, 36.67; H, 2.71; N, 11.52%.

The synthetic route of 89-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Semerci, Fatih; Ye?ilel, Okan Zafer; Soylu, Mustafa Serkan; Keskin, Seda; Bueyuekguengoer, Orhan; Polyhedron; vol. 50; 1; (2013); p. 314 – 320;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6000-50-6, 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride, blongs to pyridine-derivatives compound. Safety of 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride

To a solution of 6-(4-aminophenyl)-4-(quinolin-7-yl)pyridazin-3(2H)-one, (800 mg, 2.54 mmol), in tetrahydrofuran, 160 mL, was added 4-nitrophenyl carbonochloridate (615 mg, 3.05 mmol). The reaction mixture was heated at 60 C for 5 hours and concentrated under vacuum. The residue was dissolved in N,N-dimethylformamide, 20 mL and added to 2,3- dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride (588 mg, 2.54 mmol) and N,N- diisopropylethylamine, (2.21 mL, 12.7 mmol) in dichloromethane (60 mL) and stirred at r.t. for 16 hours. The precipitate was collected by filtration, washed with water and dried to give the desired product, 850 mg (98% purity, 65% yield over two steps).PRODUCTS: (1029) LC-MS (Method 3): Rt = 0.32 min; MS (ESIpos): m/z = 461 [M+H]+ 1H-NMR (400 MHz, DMSO-D6) delta [ppm]: 4.79-4.81 (m, 4H), 7.41 (d, 1H), 7.54-7.57 (m, 1H), 7.68-7.71 (m, 2H), 7.91-7.93 (m, 2H), 8.03-8.05 (m, 1H), 8.15-8.17 (m, 1H), 8.31 (s, 1H), 8.38-8.40 (m, 1H), 8.46-8.48 (m, 1H), 8.58-8.60 (m, 2H), 8.74 (s, 1H), 8.93-8.94 (m, 1H).

The synthetic route of 6000-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; BOeHNKE, Niels; BERGER, Markus; SOMMER, Anette; HAMMER, Stefanie; FERNANDEZ-MONTALVAN, Ernesto, Amaury; STELTEN-LUDWIG, Beatrix; GUeNTHER, Judith; MAHLERT, Christoph; GREVEN, Simone; SARKER, Abul, Basher; TAIT, Michael; (451 pag.)WO2019/149637; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 53939-30-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53939-30-3, name is 5-Bromo-2-chloropyridine, molecular formula is C5H3BrClN, molecular weight is 192.44, as common compound, the synthetic route is as follows.

EXAMPLE 2 N-(2,5-difluorobenzyl)-3-[4-(4-methylpiperazin-l-yl)phenyl][l ,2,4]triazolo[4,3-a]pyridin amine5 -Bromo-2-hydrazinylpyridine (2-2) Hydrazine (1,633 mL, 52.0 mmol) was mixed with a stirred, room temperature of 5-bromo-2- chloropyridine (2000 mg, 10.39 mmol) in dioxane (13 mL). The reaction mixture was stirred for 110 C for overnight. The reaction mixture was quenched with aqueous sodium hydrogen carbonate (saturated, 50 mL). The reaction mixture was extracted with EtOAc (3 x 30mL). The combined organic fractions were washed with brine (saturated, 40 mL), dried and filtered. The solvent was evaporated under reduced pressure to provide the title compound; MS (ES) m/z M calc’d; 188, found: 188.

The chemical industry reduces the impact on the environment during synthesis 53939-30-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; GREEN, Ahren; LI, Yiwei; STACHEL, Shawn; WO2012/125667; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 115473-15-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115473-15-9 as follows.

A reaction flask equipped with a stirrer, a condenser and a thermometer was charged with Intermediate II-214.9 g,This was dissolved in 40 ml of trichloromethane, 15.0 g of triethylamine was added under stirring,9.5 g of 5,6,7,7a-tetrahydrothieno [3,2-c] pyridin-2 (4H) -one hydrochloride were added portionwise to the reaction system,After completion of the dropwise addition, the reaction was continued at 0 C for 3 hours (the plate showed complete reaction).The reaction solution was washed with 3 x 20 ml of water, the chloroform layer was separated,Dried over anhydrous sodium sulfate, filtered, evaporated to dryness under reduced pressure,To give 12.0 g of a pale yellow solid product (HPLC: 98.9%),

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115473-15-9, its application will become more common.

Reference:
Patent; Tianjin Institute of Pharmaceutical Research; LIU, DENG KE; MU, SHUAI; LIU, YING; NIU, DUAN; TAN, CHU BING; ZHOU, ZHI XING; LIU, CHANG XIAO; (22 pag.)CN103896962; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 19733-96-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19733-96-1, name is 2-(6-Methylpyridin-3-yl)acetic acid, molecular formula is C8H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 4 Preparation of 2-(6-methylpyridin-3-yl)N-p-tolylamide 2-methylpyridinylacetic acid was dissolved in 150ml of DMF, added with DIEA 40ml, p-toluidine 10.2g, HOBt 18g, and stirred for 15min, then added with EDC.HCl 21g, after addition, the reaction was performed at room temperature for 12h. Then, water 800ml was added for dilution, stirred, insoluble solid appeared, after stirring for 2h, suction filtrated, washed with water to obtain off-white powder solid, dired to obtain 2-(6-methylpyridin-3-yl)N-p-tolylamide 12g, yield was about 68%. 1H-NMR(400MHz,DMSO-d6) delta 2.19(3H,s,CH3); 2.39(3H,s, CH3); 3.56(2H,s, CH2); 7.06-7.04(2H,d, ArH); 7.15-7.17(1H,d, ArH); 7.40-7.42(2H,d, ArH); 7.55-7.57(1H,dd,ArH); 8.32(1H,d,ArH); 10.07(1H,s, NH).

According to the analysis of related databases, 19733-96-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A.; EP2417973; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem