Tag: M.W:100-200

Related Products of 14150-94-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14150-94-8, name is 1-Methyl-3,5-dinitro-1H-pyridin-2-one. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of the dinitropyridone 1 (50 mg, 0.25 mmol) in ethanol (10 mL), 4-phenyl-3-buten-2-one (4a) (36.5 mg, 0.25 mmol) and NH4OAc (578 mg, 7.5 mmol) were added, and the resultant mixture was heated at 65 C for 24 h. After removal of the solvent, the residue was washed with benzene (3 × 10 mL) to remove unreacted ketone 4a and treated with column chromatography on silica gel (eluent: hexane/ethyl acetate =95/5) to afford 5-nitro-2-(2-phenylethenyl)pyridine (5a) (41 mg, 0.18 mmol, 72%) as a yellow powder. The reactions of the dinitropyridone 1 with other ketones 4b-f or 10a-c were performed in a similar way.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14150-94-8, 1-Methyl-3,5-dinitro-1H-pyridin-2-one.

Reference:
Article; Le, Song Thi; Asahara, Haruyasu; Nishiwaki, Nagatoshi; Chemistry Letters; vol. 44; 6; (2015); p. 776 – 778;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1206977-80-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1206977-80-1 as follows.

[0098] As shown in step 3-ii of Scheme 3, an excess of sodium metal was dissolved into 20 mL anhydrous methanol and 2-chloro-3-(difluoromethoxy)pyridine (2.O g, 11.1 mmol ) in anhydrous methanol was added. The reaction mixture was stirred in a sealed vessel at 1000C for 6 hours. The volatiles were removed under reduced pressure and the residue was partitioned between EtOAc and brine. The brine was extracted with EtOAc and the combined organics were dried over Na2SO4, filtered, and the volatiles removed under reduced pressure. The product was purified by silica gel chromatography (DCM) to yield 3-(difluoromethoxy)- 2-methoxypyridine as a colorless oil (Compound 1007, 1.1 g, 56% yield: ESMS (M+H) 176.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1206977-80-1, its application will become more common.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; BANDARAGE, Upul, Keerthi; COTTRELL, Kevin; DAVIES, Robert; KRUEGER, Elaine; LEDEBOER, Mark; LEDFORD, Brian; LE TIRAN, Arnaud; LIAO, Yusheng; MESSERSMITH, David; WANG, Tiansheng; XU, Jinwang; WO2010/96389; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62150-45-2, name is 4-Bromopyridine-2-carbonitrile. A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Bromopyridine-2-carbonitrile

Step 1. 5-Chloro-3,4′-bipyridine-2-carbonitrile A degassed mixture of 4-bromopyridine-2-carbonitrile (0.99 g, 5.4 mmol, Synthonix), (5-chloropyridin-3-yl)boronic acid (0.847 g, 5.38 mmol, Aldrich), CsF (2.4 g, 16 mmol), and 4-(di-tert-butylphosphino)-N,N-dimethylaniline-dichloropalladium (2:1) (0.38 g, 0.54 mmol, Aldrich) in 1,4-dioxane (10 mL) and water (3 mL) was heated to 90-105° C. for 2.5 hours. The reaction mixture was filtered and the volume was reduced via rotary evaporation. The mixture was diluted with water and extracted with EtOAc. The combined organic extracts were washed sequentially with water and brine, dried over sodium sulfate, filtered, and concentrated. The resulting solid was triturated with MTBE (5 mL). The solid product was isolated by filtration and air dried. Yield: 0.95 g, 82percent. LCMS (M+H)+: 216.0/218.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62150-45-2, 4-Bromopyridine-2-carbonitrile.

Reference:
Patent; Incyte Corporation; Sparks, Richard B.; Shepard, Stacey; Combs, Andrew P.; Buesking, Andrew W.; Shao, Lixin; Wang, Haisheng; Falahatpisheh, Nikoo; (158 pag.)US2017/190689; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6959-47-3, 2-(Chloromethyl)pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Chloromethyl)pyridine hydrochloride, blongs to pyridine-derivatives compound. Recommanded Product: 2-(Chloromethyl)pyridine hydrochloride

The ligand L1 was synthesized via previously reported procedure[23]. A solution of potassium carbonate (2.55 g, 18.45 mmol)in 10 mL water was dropwise added to the aqueous solution of 2-(chloromethyl)-pyridine hydrochloride (1.5 g, 9.15 mmol in10 mL). After about 30 min. of stirring at room temperature, thereaction mixture was extracted with dichloromethane(3 20 mL). The combined organic extracts were dried over anhydroussodium sulfate. The solution was filtered and the solvent wasremoved under vacuum. The resulted residue was then dissolvedin dichloromethane (10 mL). The dichloromethane solution of 2-chloromethyl-pyridine was added dropwise to a solution of N,N0-dimethylethylenediamine (0.471 mL, 5.34 mmol) in dichloromethane(15 mL). After this addition, 10 mL of aqueous sodiumhydroxide (1 M) was added slowly and the reaction mixture wasstirred for next 60 h at room temperature. After stirring was finished,another fraction of sodium hydroxide (10 mL, 1 M) wasadded rapidly. The reaction mixture was extracted with dichloromethane(3 25 mL) and combined organic portion was dried overanhydrous sodium sulfate. Evaporation of solvent led to isolationof the ligand L1 as a dark orange oil. (1.13 g, Yield 79%) 1H NMR(500 MHz, Methanol-d4) d 7.27 (m, 2H, pyridine ring), 7.50 (d,2H, pyridine ring), 7.76 (m, 2H, pyridine ring), 8.45 (d, 2H, pyridinering), 3.68 (s, 4H, -N-CH2-Py), 2.63 (s, 4H, -CH2-CH2-), 2.26 (s, 6H,N-CH3). IR (cm1): 2945, 2789, 1589, 1569, 1472, 1432, 1360,1304, 1146, 1090, 1031, 994, 635, 614, 418.

The synthetic route of 6959-47-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Singh, Nirupama; Niklas, Jens; Poluektov, Oleg; Van Heuvelen, Katherine M.; Mukherjee, Anusree; Inorganica Chimica Acta; vol. 455; (2017); p. 221 – 230;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 85838-94-4, name is tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C10H17NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C10H17NO2

To a solution of tert-butyl5,6-dihydropyridine-1(2H)-carboxylate (0.3627 g, 1.979 mmol) in CH2Ch (5 ml) at ooc was5 added a solution of mCPBA (0.53 g, 3.07 mmol) in CH2Cb (5 ml). The resulting reactionmixture was allowed to warm to rt and stirred over the weekend. The reaction was partitionedbetween EtOAc and 5% Na2S20 3. After separation of layers, the organic layer was washed withsat. NaHC03. brine, dried over anhydrous MgS0 4, filtered and concentrated to give the titlecompound as colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 85838-94-4.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CHOBANIAN, Harry; PIO, Barbara; GUO, Yan; DING, Fa-Xiang; DONG, Shuzhi; WALSH, Shawn, P.; JIANG, Jinlong; KIM, Dooseop; WO2015/95097; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5345-47-1, name is 2-Aminonicotinic acid. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

Example 7 Synthesis of Compound 33 General Method for the SYNTHESIS of Compounds 26-44 [0096] This example illustrates Reaction Scheme IV. Preparation OF IVA : [0097] 2-Amino NICOTINIC acid (SOG, 0. 362 mole) was dissolved in 500ml methanol and treated with thionyl chloride (66MOL, 107. 6g, 0. 905MOLLE) dropwise over 30 min. Reaction mixture was heated to reflux for 3 days. Removed solvent under vacuum, residue taken up in chloroform, washed with 5% HCl (50ml), 10% sodium bicarbonate (50ml), water, and chloroform layer dried over sodium sulfate (ANH). Removed solvent to give 27G product (49. 1 % yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5345-47-1, 2-Aminonicotinic acid.

Reference:
Patent; SCIOS INC.; WO2005/32481; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19798-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-80-2, name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 4-chloropyridin-2-amine (8 g, 62.2 mmol) in acetonitrile (600 mL) at rt was added NBS (11.08 g, 62.2 mmol) in portions and the reaction was stirred for 14 h. The reaction mixture was concentrated under reduced pressure. The residue was reconstituted in ethyl acetate and water. The organics were extracted with ethyl acetate (3*50 mL). The combined organic layers were washed with water (100 mL), brine (100 mL), and dried over sodium sulphate. The organics were concentrated under reduced pressure to afford 5-bromo-4-chloropyridin-2-amine as yellow solid (13 g, 99% yield) that was used without further purification in the next step. LCMS (ESI) m/e 207.0 [(M+H)+, calcd for C5H5BrClN2 206.9]; LC/MS retention time (method B): tR=0.8 min; 1H NMR (400 MHz, CDCl3) delta 8.17 (s, 1H), 6.63 (s, 1H), 4.59 (s, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-80-2, 4-Chloropyridin-2-amine.

Reference:
Patent; Bristol-Myers Squibb Company; Vrudhula, Vivekananda M.; Pan, Senliang; Rajamani, Ramkumar; Macor, John E.; Bronson, Joanne J.; Dzierba, Carolyn Diane; Nara, Susheel Jethanand; Karatholuvhu, Maheswaran Sivasamban; US2013/237555; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 27048-04-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27048-04-0, name is 6-Chloro-3-nitropyridin-2-amine, molecular formula is C5H4ClN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-amino-6-chloro-3-nitropyridine (1, 5.7 g, 32.8 mmol), water (4.5 mL), c-H2SO4 (1.26 mL) and H5IO6 (1.59 g) was stirred for 15 min at 95 C. Iodine (3.6 g) was added in portions. The reaction mixture was stirred for 1 h at 95 C., cooled to room temperature, poured into sat. aqueous sodium thiosulfate solution and extracted with ethyl acetate. The organic layer was dried (Na2SO4), filtered and concentrated. The residue was purified by silica gel column chromatography (Hex/EtOAc=3/2) to give compound 2 (8.7 g, 29.1 mmol, 88%). 1H NMR (DMSO-d6, 300 MHz) delta8.62 (s, 1H), 8.26 (brs, 2H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27048-04-0, 6-Chloro-3-nitropyridin-2-amine.

Reference:
Patent; Benner, Steven A; Hoshika, Shuichi; (37 pag.)US10059737; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5435-54-1, name is 3-Nitropyridin-4-ol. A new synthetic method of this compound is introduced below., Safety of 3-Nitropyridin-4-ol

To a suspension of 3-nitropyridin-4-ol (4.342 g, 31 mmol) in toluene (60 mL) was added POCl3 (11.6 mL, 124.4 mmol) at 0 C. The resulting mixture was warmed to room temperature, then heated to 110 C. for 14 hours. After cooling to room temperature, the solvent was removed in vacuo and the residue was poured into ice, and basified with saturated aqueous NH4Cl solution. The mixture was extracted with EtOAc (40 mL×2). The combined organic layers was washed with water, brine, dried (MgSO4) and concentrated to a brown oil, which solidified on standing. (3.68 g, 75% yield).1H NMR (DMSO-d6): delta ppm 9.23 (s, 1H), 8.80 (d, J=5.4 Hz, 1H), 7.91 (d, J=5.4 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5435-54-1, 3-Nitropyridin-4-ol.

Reference:
Patent; ARDEA BIOSCIENCES; US2007/244164; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6959-47-3, 2-(Chloromethyl)pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(Chloromethyl)pyridine hydrochloride, blongs to pyridine-derivatives compound. Quality Control of 2-(Chloromethyl)pyridine hydrochloride

A mixture of 4 (0.8 g, 5.0 mmol), sodium carbonate (2.4 g, 22.6 mmol) and 2-pyridylmethyl chloride hydrochloride (1.8 g, 10.9 mmol) in 15 mL of dry ethanol was refluxed for 12 h under N2, and then evaporated. The residue was dissolved in 50 mL of aqueous solution of sodium hydroxide and extracted with dichloromethane (3 × 30 mL). Then the organic layer was dried over potassium carbonate and evaporated. The residue was separated by silica gel flash chromatography using EtOAc as eluent to give N-(2-(bis(2-pyridylmethyl)amino)ethyl)carbamic acid tert-butyl ester 5 (1.5 g, 91%) as yellow viscous oil. 1H NMR (400 MHz, CDCl3): delta 8.52 (d, 2H, J = 4.8 Hz), 7.60 (ddd, 2H, J = 7.2 Hz), 7.39 (d, 2H, J = 7.6 Hz), 7.12 (m, 2H), 5.82 (s, 1H), 3.85 (s, 4H), 3.21(m, 2H), 2.67 (t, 2H, J = 5.6 Hz), 1.43 (s, 9H) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6959-47-3, 2-(Chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Article; Yan, Liwei; Ye, Zhongbin; Peng, Chunxiang; Zhang, Shihong; Tetrahedron; vol. 68; 12; (2012); p. 2725 – 2727;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem