Tag: M.W:100-200

Related Products of 84249-14-9, Adding some certain compound to certain chemical reactions, such as: 84249-14-9, name is 2-Amino-4-bromopyridine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84249-14-9.

To a stirred solution of 2-amino-4-bromopyridine (1.0 g, 5.78 mmol) in 1,4-dioxane (2 ml) was added K3PO4 (2.45 g, 11.56 mmol) and l,r-bis(di-tert-butylphosphino)ferrocene (0.168 g, 0.29 mmol) at rt. The reaction was purged with nitrogen for 30 min before adding phenylboronic acid (1.05 g, 8.67 mmol) and Pd(OAc)2 (0.065 g, 0.29 mmol) at rt. The reaction mixture was heated at 80C for 16 h. The resulting reaction mixture was cooled to rt, poured into water (50 ml) and extracted with EtOAc (3 x 25 ml). The combined organic phase was washed with water (25 ml). The organic phase was separated, dried over Na2S04, filtered and concentrated under reduced pressure. The crude material was purified by flash chromatography (62% EtOAc in hexane) yielding 4-phenylpyridin-2-amine (0.42 g, 2.47 mmol). LCMS: Method C, 1.47 min, MS: ES+ 171.14; NMR (400 MHz, DMSO-d6) delta ppm 7.96 (d, J=5.2 Hz, 1 H), 7.63 – 7.65 (m, 2 H), 7.41 – 7.52 (m, 3 H), 6.77 (dd, J=1.6 Hz, 5.2 Hz, 1 H), 6.69 (d, J=1.2 Hz, 1 H), 6.00 (s, 2 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 84249-14-9, 2-Amino-4-bromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MISSION THERAPEUTICS LIMITED; GIBSON, Karl Richard; JONES, Alison; KEMP, Mark Ian; MADIN, Andrew; STOCKLEY, Martin Lee; WHITLOCK, Gavin Alistair; WOODROW, Michael D.; (109 pag.)WO2017/141036; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74115-12-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74115-12-1, name is 5-Chloro-3-hydroxypyridine, molecular formula is C5H4ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

7-((Difluoromethyl)sulfonyl)-4- fluoro-2,3-dihydrospiro[indene-l ,2′-[l,3]dioxolane] (3.0 g, 9.7 mmol) was combined with 5- chloropyridin-3-ol (1.89 g, 14.6 mmol) and sodium bicarbonate (2.45 g, 29.2 mmol) then the solids were suspended in N-methylpyrrolidinone (28.5 mL). The mixture was heated to 90 C for 14 hours then stirred at ambient temperature for 34 hours. The reaction mixture was diluted with ethyl acetate and water and the layers were separated. The aqueous was washed with ethyl acetate and the combined organic layers were washed five times with water, saturated NaCl, dried over Na2S04 and concentrated in vacuo to a cream-colored solid (4.36 g). LCMS ESI (+) m z (Mu+Eta) 418, 420.

According to the analysis of related databases, 74115-12-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PELOTON THERAPEUTICS, INC.; DIXON, Darryl, David; GRINA, Jonas; JOSEY, John, A.; RIZZI, James, P.; SCHLACHTER, Stephen, T.; WALLACE, Eli, M.; WANG, Bin; WEHN, Paul; XU, Rui; YANG, Hanbiao; WO2015/35223; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1232431-75-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1232431-75-2, name is 4-Bromopyridine-2,3-diamine. This compound has unique chemical properties. The synthetic route is as follows.

2,3-diamino-4-bromopyridine (320 mg, 1.7 mmol)Mix with 20 ml of dimethyl oxalate, warm to reflux and stir for 3-4 hours.After the reaction solution was cooled, the resulting solid was filtered off.The solid was dispersed in 15 ml of N,N-dimethylformamide.Add 1 g of activated carbon, raise the temperature to reflux, and filter it hot after 1 hour.1 ml of water was added to the filtrate and allowed to stand for 1 hour.The precipitated white solid is filtered and washed with water.95% ethanol wash,Ethyl acetate wash to give 8-bromo-5-azaquinoxaline-2,3-dione white solid(332 mg, yield 80.6%).

According to the analysis of related databases, 1232431-75-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Jiao Tong University; Wang Yongxiang; Fu Lei; Xie Dongsheng; Lu Jun; (37 pag.)CN103435561; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 79055-62-2, name is 2-Chloro-5-methylpyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 79055-62-2

Step A: Preparation of 2′-chloro-4-hydroxy-6,5′-dimethyl-[1,4′]bipyridinyl-2-one To a screw top vial with rubber septa inset was added 2,2-dimethyl-6-(2-oxo-propyl)-[1,3]dioxin-4-one, prepared as described in Organic Letters, 11(21), 4910-4913; 2009, (500 mg, 2.7 mmol) and 2-chloro-5-methyl-pyridin-4-ylamine (575 mg, 4 mmol, 1.5 eq). The mixture was dissolved in anhydrous 1,4-dioxane (10 mL). Once the mixture was homogeneous the vial was placed on a stirrer/hot plate preset to 90° C. The reaction vessel was heated at this temperature for 3.5 h. The reaction vial was removed from heat and analyzed by HPLC which showed that the reaction was >95percent complete. The vial was placed back on the hot plate. To the heated mixture was added H2SO4 (250 muL) and the reaction was heated for 1 h. The reaction vial was removed from the heat and after cooling to ambient temperature, the dioxane was removed by passing a stream of air over the top of the open vial to give a brown residue. Water (?4 mL) was added to the vial, and the mixture was stirred for 30 min. The resulting tan solid was filtered off with washing from additional water and the diethyl ether to give the desired product (531 mg, 57percent based on being the sulfate salt) as a tan solid which by HPLC was ?95percent pure: MS (ES) m/e 250 (M+H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 79055-62-2, 2-Chloro-5-methylpyridin-4-amine.

Reference:
Patent; Hockerman, Susan L.; Monahan, Joseph B.; Selness, Shaun R.; US2014/364442; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 88912-27-0, name is 3-Chloroisonicotinic acid, molecular formula is C6H4ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H4ClNO2

Reference Production Example 26To a mixture of 0.58 g of WSC and 5 ml of pyridine 5ml, 0.48 g of 3- chloroisonicotinic acid was added. The reaction mixture was stirred at room temperature for 25 minutes. To the reaction mixture, 0.75 g of 2-amino-4-(heptafluoroisopropyl)phenol was added and was stirred while heating at 60C for three hours. The reaction mixture was cooled to room temperature, the 0.24 g of 3-chloroisonicotinic acid and 0.29 g of WSC was added and stirred while heating at 60C for 1.5 hours and then at 80C for 1.3 hours. The mixture reaction was cooled to room temperature, and then concentrated under reduced pressure. Then, water was added to the residue, followed by extraction with ethyl acetate twice. The combined organic layers were washed with a saturated sodium chloride solution, was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.90 g of 3-chloro-N-[2- hydroxy-5-(heptafluoroisopropyl)phenyl]isonicotinamide.1H-NMR (DMSO-d6) delta: 10.19 (br s, 1H), 8.75 (s, 1H), 8.63 (d, J=4.9 Hz, 1H), 8.36 (d, J=1.9 Hz, 1H), 7.65 (d, J=4.9 Hz, 1H), 7.32 (dd, J=8.8, 2.0 Hz, 1H), 7.12 (d, J=8.8 Hz, 1H)

With the rapid development of chemical substances, we look forward to future research findings about 88912-27-0.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; OTSUKI, Junko; WO2011/49223; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14432-12-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14432-12-3, name is 4-Amino-2-chloropyridine. A new synthetic method of this compound is introduced below.

NaHMDS (9 mL, 2 M, 18 mmol) was added dropwise to a solution of 2-chloro-4-aminopyridine (1.0 g, 7.8 mmol) in dry tetrahydrofuran (30 mL) at 0C under N2. After continuously stirred for 30 min, a solution of ditertbutyl dicarbonate (3.75 g, 17 mmol) in dry tetrahydrofuran was added. The reaction mixture was stirred overnight at room temperature, and then poured into saturated ammonium chloride solution. The mixture was extracted with ethyl acetate, and the organic layer was washed by saturated brine, concentrated under vacuum to remove the solvent.The resulting residue was purified by column chromatography (petroleum ether :ethyl acetate = 8:1) to afford the title compound (923 mg, 36 %). 1H NMR (CDCl3): delta 8.39 (1H, d, J = 5.2 Hz), 7.19 (1H, d, J = 1.6 Hz), 7.05 (1H, dd, J = 1.6 Hz, 5.2 Hz), 1.47 (18H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14432-12-3, its application will become more common.

Reference:
Patent; Li, Yuliang; WANG, Huting; ZHU, Yan; WANG, Zhe; ZHANG, Hui; ZHAO, Ruiyu; HUANG, Yuanyuan; WANG, He; PENG, Yong; LUO, Hong; XIAO, Dengming; CAO, Shousong; HAN, Yongxin; EP2862571; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 101990-70-9, 5-(Chloromethyl)-2-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 101990-70-9, blongs to pyridine-derivatives compound. Product Details of 101990-70-9

To a stirred solution of compound 2 (400 mg, 1.79 mmol) in DMF (4 mL) at 0 C, was added NaH (90 mg of a 60% dispersion in mineral oil, 2.25 mmol). The mixture was warmed to RT and stirred for 20 mm. The mixture was cooled to 0 C, and a solution of 5-(chloromethyl)-2- methoxypyridine (310 mg, 1.97 mmol) in DMF (1 mL) was added. The mixture was allowed to warm to RT and stirred for a further 16 h. The mixture was partitioned between water (50 mL)and EtOAc (30 mL). The organic layer was separated and the aq. layer re-extracted with additional EtOAc (30 mL). The combined organic layers were dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure. The residue was purified (silica gel; eluting with 0-100% EtOAc in hexanes), to afford compound 3 (580 mg, 85%) as a colorless oil. LCMS Mass: 345.0 (M+1).

The synthetic route of 101990-70-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin, W.; HUTCHINSON, John, Howard; (185 pag.)WO2017/3862; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 81167-60-4, 4-(tert-Butyl)-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 81167-60-4, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 2-chloro-4-terbutylpyridine (1.79 g, 10.5 mmol), 2,6-difluoro-3-pyridylboronic acid (2.6 g, 16.4 mmol), Pd(PPh3)4 (400 mg, 0.35 mmol), 2M aqueous solution of potassium carbonate (25 ml, 50 mmol) and 1,4-dioxane (80 ml) was deaerated by bubbling nitrogen through the mixture for 15 minutes. The mixture was stirred at 70C (bath) for 15 hours. The mixture was evaporated to a volume of approximately 30 ml. The residue was extracted with hexane (2 X 30 mL). The organic layers were washed with brine (20 mL) and dried over MgS04. After the evaporation of the solvent the product was purified by column chromatography (silicagel, ethyl acetate/hexane 1/2) and dried in high vacuum at room temperature. Yield 2.3 g, 88 %.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81167-60-4, its application will become more common.

Reference:
Patent; CAMBRIDGE DISPLAY TECHNOLOGY LIMITED; SUMITOMO CHEMICAL COMPANY LIMITED; STEUDEL, Annette; KOZHEVNIKOV, Valery; WO2014/9716; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5470-22-4, name is 4-Chloropicolinic acid, molecular formula is C6H4ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 4-Chloropicolinic acid

A mixture of 4-chloropicolinic acid (10.0 g, 63.4 mmol), thionyl chloride (40 ml) and a catalytic amount of DMF were heated at 80 C for 3 h. Then the reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was dissolved in 30 ml of CH2Cl2 in an ice-bath, then added to a 25% aqueous solution of ammonia (60 ml) at a rate which kept the internal temperature below 7 C with constant stirring. After 1 h, the precipitate was filtrated, washed with water (3 × 50 ml) and dried in vacuo to afford compound 2 (9.2 g, 93% yield) as a yellow solid, mp 161-162 C; 1H NMR (DMSO-d6, 400 MHz): delta 7.74-7.76 (dd, J = 1.8 and 5.3 Hz, 1H), 7.80 (br s, 1H), 8.03 (d, J = 1.8 Hz, 1H), 8.20 (br s, 1H), 8.62 (d, J = 5.3 Hz, 1H); ESI-MS m/z: 157[M+H]+; Anal. Calcd for C6H5ClN2O (%): C 46.03, H 3.22, N 17.89; Found: C 45.98, H 3.27, N 17.94.

With the rapid development of chemical substances, we look forward to future research findings about 5470-22-4.

Reference:
Article; Zhan, Wenhu; Li, Yanyang; Huang, Weiping; Zhao, Yanjin; Yao, Zhenglin; Yu, Shanyou; Yuan, Shoujun; Jiang, Falong; Yao, Shan; Li, Shuxin; Bioorganic and Medicinal Chemistry; vol. 20; 14; (2012); p. 4323 – 4329;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13534-97-9, name is 6-Bromopyridin-3-amine, molecular formula is C5H5BrN2, molecular weight is 173.0106, as common compound, the synthetic route is as follows.COA of Formula: C5H5BrN2

To a solution of 3-amino-6-bromopyridine (1.1 g, 6.4 mmol) in THF (7 mL)-MeOH (7 mL) at RT was added phenylboronic acid (1.60 g, 12.8 mmol), PXPd (69 mg, 0.13 mmol), followed by K2CO3 (3.54 g, 25.6 mmol). The reaction mixture was stirred at 70° C. in a preheated oil bath for 16 h. After cooling to RT, the reaction mixture was poured into water (10 mL), and the resultant mixture was extracted with EtOAc (3.x.40 mL). The combined organic layers were washed with saturated NaCl, dried (Na2SO4), filtered and concentrated. The resulting residue was purified by silica gel (40 g) column chromatography eluting with a gradient of EtOAc (30-100percent) in hexane to give the title compound as an off-white solid (940 mg, 86percent). LC/MS (method A): retention time=1.28 min, (M+H)+=171.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13534-97-9, 6-Bromopyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; Sun, Chongqing; Ewing, William R.; Huang, Yanting; US2006/154955; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem