Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106984-91-2, name is 6-Oxo-1,6-dihydropyridine-3-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 106984-91-2

To a stirred solution of 5-3 (O.lg, 0.3mMol) and triethylamine (0.08mL, 0.5mMol) in NMR (ImL) was added 17-2 (0.03g, 0.3mMol) and acetic acid (0.03mL, 0.5mMol), followed by sodium triacetoxyborohydride (0.12g, 0.5mMol). After stirring overnight at room temperature, the reaction was filtered through a syringe filter and purified on a Cl 8 reverse phase HPLC to yield 17-3 as the HCl salt. Mass (M+l) calculated: 473.2085 observed: 473.2092.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106984-91-2, 6-Oxo-1,6-dihydropyridine-3-carbaldehyde.

Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 19337-97-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19337-97-4, name is trans-3-(3-Pyridyl)acrylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Compound 1-3 (1.3 g, 3 mmol) was dissolved in dichloromethane (10 ml)Trifluoroacetic acid (2 ml) was added,The reaction was carried out at room temperature for 2 hours, and the solvent was distilled off under reduced pressure to give a brown oil. The oil was dissolved in dichloromethane (20 ml)N, N-diisopropylethylamine (1.6 ml, 9 mmol) was added successively,Trans-3 (3-pyridyl) allyl acid(448 mg, 3 mmol),EDCI (1.7 g, 9 mmol),DMAP (73 mg, 0.6 mmol), reacted at room temperature for 4 hours,Saturated ammonium chloride (20 ml) was added and extracted with dichloromethane (20 ml x 3). The combined organic layers were dried over anhydrous sodium sulfate and filtered. The solvent was evaporated under reduced pressure and subjected to column chromatography to give Compound 1 ((E) -N- 3- (2-amino-6- (cyclopropylamino) pyrimidin-4-yl) phenyl) -5- (3- (pyridin-3-yl) acrylamido) pentanamide) (0.9 g, %).

According to the analysis of related databases, 19337-97-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Guangzhou Bio-pharmaceutical And Health Institute; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; China Pharmaceutical University; Jiang Sheng; Tu Zhengchao; Zhu Jidong; Yao Hequan; Yao Yiwu; Tan Xiaochu; Gu Shoulai; Qiu Yatao; (30 pag.)CN106928192; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 113118-81-3 ,Some common heterocyclic compound, 113118-81-3, molecular formula is C6H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of methyltriphenylphosphine bromide (3.16 g, 8.87 mmol) in tetrahydrofuran (20 ml.) is added sodium hexamethyldisilazane (1 M solution in THF, 9.67 ml_, 9.67 mmol) dropwise. The reaction mixture is stirred at room temperature for 30 min, whereupon 5-bromo-pyridine-3-carbaldehyde (1.5 g, 8.06 mmol) is added. The reaction mixture is allowed to stir at room temperature for 1 h. The mixture is concentrated and the residue is purified by silica gel flash chromatography (heptane- ethyl acetate, 7:3) to afford 3-bromo-5-vinyl-pyridine as a colorless oil. MS (ESI) m/z 185.91 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113118-81-3, its application will become more common.

Reference:
Patent; NOVARTIS AG; WO2009/156462; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1480-87-1 ,Some common heterocyclic compound, 1480-87-1, molecular formula is C5H3FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a flask charged with toluene (37.3 mL) were added trans-N-boc- 1 ,4- cyclohexanediamine (2.00 g, 9.33 mmol), potassium carbonate (1.290 g, 9.33 mmol) and 2-fluoro-3-nitropyridine (commercially available from Matrix Scientific, Columbia, SC) (1.326 mL, 9.33 mmol). The resulting bright yellow solution was heated overnight at 120C leading to conversion to the desired product as the primary species along with a more polar impurity according to LC-MS. The mixture was diluted with water, transferred to a separatory funnel and extracted with EtOAc (2x). The combined organic layers were dried with Na2S04, filtered, and dried under reduced pressure providing a bright yellow solid which was triturated with DCM providing tert-butyl ((lr,4r)-4-((3-nitropyridin-2-yl)amino)cyclohexyl)carbamate (1.51 g, 4.49 mmol, 48.1 % yield) as a bright yellow solid. lH NMR (400 MHz, DMSO-d6) delta = 8.49 (dd, J = 1.8, 4.5 Hz, 1 H), 8.41 (dd, J= 1.8, 8.4 Hz, 1 H), 8.06 (d, J= 7.7 Hz, 1 H), 6.79 – 6.69 (m, 2 H), 4.13 – 4.00 (m, J= 3.9, 7.4, 7.4, 1 1.3 Hz, 1 H), 3.29 – 3.20 (m, 1 H), 2.01 – 1.92 (m, 2 H), 1.82 (d, J= 10.6 Hz, 2 H), 1.55 – 1.41 (m, 2 H), 1.38 (s, 9 H), 1.35 – 1.21 (m, 2 H). m/z (ESI) 281.2 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1480-87-1, its application will become more common.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin; GUNAYDIN, Hakan; GUZMAN PEREZ, Angel; HUA, Zihao; HUANG, Hongbing; HUANG, Xin; MARTIN, Matthew, W.; PATEL, Vinod; WO2013/134079; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 183208-35-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.183208-35-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, molecular weight is 197.03, as common compound, the synthetic route is as follows.

Example 4: Synthesis of 5-Pyridin-3-yl-lH-pyrrolo[2,3-b] pyridine 20 and related compounds.[0137] 5-Pyndin-3-yl-l H-pyrrolo[2,3-b]py?dine 20 was synthesized in one step from 5-bromo-lH- pyrrolo[2,3-b]pyridme 1 as described m Scheme 6Scheme 6Step 1 – Preparation of5-Pyndiotan-3-yl-LH-rhoyrrolo[2,3-b]pyndiotane (20)[0138] To 5-bromo-7-azaindole (1, 1 00 g, 5 08 mmol) m water (13 0 mL) and acetonitnle (36 mL) were added pyridine-3-boronic acid (19, 1 0 g, 8 1 mmol), potassium carbonate (1 79 g, 0 0130 mol) and Tetrakis(tnphenylphosphine)palladmm(0) (50 0 mg, 0 043 mmol) under an atmosphere of nitrogen The reaction mixture was heated to 170 0C overnight. The reaction mixture was poured into water and extracted with ethyl acetate The organic layer was washed with brine, dried over sodium sulfate, and concentrated The residue was purified with silica gel column chromatography elutmg with 25% ethyl acetate in hexane to provide a light yellow solid (20, 820 mg, 82%) 1

The chemical industry reduces the impact on the environment during synthesis 183208-35-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PLEXXIKON, INC.; WO2008/80001; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6231-18-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6231-18-1, name is 2,6-Dimethoxypyridine. A new synthetic method of this compound is introduced below.

General procedure: To a stirred cooled (0 C) solution of 2,2,6,6-tetramethylpiperidine (1.0 mL, 6.0 mmol) in THF (5 mL) were added BuLi (1.6 M hexanes solution, 6.0 mmol) and, 5 min later, FeBr2 (0.43 g, 2.0 mmol). The mixture was stirred for 15 min at 0 C before introduction of the substrate (2.0 mmol). After 2 h at room temperature, the electrophile (6.0 mmol) was added. The mixture was stirred for 1 h before addition of H2O (10 mL) and extraction with EtOAc (3×20 mL). The combined organic layers were dried over MgSO4, filtered, and concentrated under reduced pressure.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6231-18-1, 2,6-Dimethoxypyridine, and friends who are interested can also refer to it.

Reference:
Article; Nagaradja, Elisabeth; Chevallier, Floris; Roisnel, Thierry; Jouikov, Viatcheslav; Mongin, Florence; Tetrahedron; vol. 68; 14; (2012); p. 3063 – 3073;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109-09-1, name is 2-Chloropyridine. A new synthetic method of this compound is introduced below., name: 2-Chloropyridine

General procedure: 2-Chloropyridines were dissolved in EtOH and hydrazine hydrate added. The solution was heated in a thick walled sealed vial for 72h at 55 C, concentrated under a stream of nitrogen and purified by silica gel chromatography, (hexanes/ethylacetate).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-09-1, 2-Chloropyridine.

Reference:
Article; Finlay, Heather J.; Jiang, Ji; Caringal, Yolanda; Kover, Alexander; Conder, Mary Lee; Xing, Dezhi; Levesque, Paul; Harper, Timothy; Hsueh, Mei Mann; Atwal, Karnail; Blanar, Michael; Wexler, Ruth; Lloyd, John; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1743 – 1747;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 138-60-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.138-60-3, name is 4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid, molecular formula is C7H5NO5, molecular weight is 183.1183, as common compound, the synthetic route is as follows.

4-hydroxypyridine-2,6-dicarboxylic acid monohydrate(5.0 g, 27.3 mmol) and o-phenylenediamine (6.49 g,58.7 mmol) were suspended in phosphoric acid (85%,55 mL). The mixture was kept at around 200 C for 6 hwith vigorous stirring. After cooling to room temperature,the mixture was poured into ice-water (300 mL), and thewhite color precipitate was filtered off and added to hot 10%aqueous Na2CO3solution (350 mL). The resulting light bluesolid was filtered off and added to hot methanol saturatedwith Na2CO3.The suspending solution was filtered off anddiluted with water (100 mL) and acidified with 15% hydrochloricacid to pH 1. The white precipitate was filtered offand extracted several times with boiling methanol. The collectedextracts were evaporated until precipitation began.The color-less product was filtered and dried under vacuum;yield: 4.0 g (48%); light-yellow color solid.

The chemical industry reduces the impact on the environment during synthesis 138-60-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Tsutsumi, Mayu; Kobayashi, Fumiya; Ohtani, Ryo; Nakamura, Msaaki; Hayami, Shinya; Journal of Inclusion Phenomena and Macrocyclic Chemistry; vol. 94; 3-4; (2019); p. 183 – 188;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89937-77-9, Adding some certain compound to certain chemical reactions, such as: 89937-77-9, name is Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate,molecular formula is C7H7NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89937-77-9.

To a mixture of crude IS (2 g, 13.1 mmol), phenylboronic acid (1.93 g, 15.7 mmol), TEA (2.64 g, 26.1 mmol), Py (2.07 g, 26.1 mmol) in DCM (20 mL) is added Cu(OAc)2 (3.56 g, 19.6 mmol). After reacting at room temperature overnight under oxygen, the mixture is filtered, concentrated, and purify by silica gel column chromatography (MeOH:DCM = 1 :50) to give 16 as a yellow solid (2.3 g, 77% yield), (MS: | VI · H | 230.1)

According to the analysis of related databases, 89937-77-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14667-47-1 ,Some common heterocyclic compound, 14667-47-1, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of methyl 2-amino-4-chlorobenzoate (300 mg, 1.6 mmol) and ethyl 2-phenoxyacetate (320 mg, 1.8 mmol) in anhydrous THF (9 mL) was added KHMDS (4.8 mL, 1.0 M in THF, 4.8 mmol) in one portion with vigorous stirring under a nitrogen atmosphere. The reaction mixture was stirred at rt until completion of the reaction (10 min) then MeOH was added. The reaction mixture was concentrated under reduced pressure and the resulting residue was taken up in water and acidified with 1 N HCl until precipitation occurred. The precipitate was filtered, washed with EtOH then dried to give 7-chloro-4-hydroxy-3-phenoxyquinolin-2(1H)-one (Table 2, entry 1) as a pale pink powder (449 mg, 92%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14667-47-1, its application will become more common.

Reference:
Article; Toum, Jerome; Moquette, Alexandre; Lamotte, Yann; Mirguet, Olivier; Tetrahedron Letters; vol. 53; 15; (2012); p. 1920 – 1923;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem