Tag: M.W:100-200

Application of 19524-06-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

CuI (95 mg, 0.50 mmol), (Ph3P)2PdCl2 3(174 mg, 0.25 mmol), Na ascorbate (98 mg, 0.50 mmol) and 4-bromopyridinehydrochloride 22 (970 mg, 5.0 mmol) wereplaced in a flask, which was degassed and filled with Ar. Pri2NH (10 mL) andTHF (10 mL) were added. The mixture was stirred at 40°C for 30 min. Me3SiC?CH (532 mg, 5.0 mmol) was added and themixture was stirred at 40°C for 10 h. Evaporation and chromatography (petroleumether / EtOAc 5:1 ? 3:1) gave 20l (767mg, 89percent) as a pale buff oil (lit.7 yellow liquid); 1H NMR(CDCl3) d 0.27 (9 H, s, SiMe3), 7.29 (2 H, d, J = 4.4 Hz, 3,5-H2) 8.55 (2 H, d, J = 4.4 Hz, 2,6-H2); 13C NMR (CDCl3)d -0.002 (SiMe3),100.24 (ethyne 2-C), 102.31 (ethyne 1-C), 126.16 (3,5-C2), 131.52(4-C), 150.03 (2,6-C2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19524-06-2, 4-Bromopyridine hydrochloride.

Reference:
Article; Kumpan, Katerina; Nathubhai, Amit; Zhang, Chenlu; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Haikarainen, Teemu; Lehtioe, Lari; Threadgill, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3013 – 3032;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 944401-65-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.944401-65-4, name is 5-Bromo-6-fluoropyridin-2-amine, molecular formula is C5H4BrFN2, molecular weight is 191, as common compound, the synthetic route is as follows.

Synthesis of 5-cyclopropyl-6-fluoropyridin-2-amine. A solution of 5-bromo-6-fluoropyridin-2-amine (3.0 g, 15.8 mmol), cyclopropylboronic acid (2.04 mg, 23.7 mmol), Pd(OAc)2 (354 mg, 1.58 mmol), PCy3 (886.2 mg, 3.16 mmol) and K3PO4(6.7 g, 31.6 mmol) in dioxane/H2O (30 mL/3 mL) was stirred at 100 C. for 16 h. Then the reaction mixture was diluted with H2O (50 mL) and extracted with EtOAc (100 mL*3). The combined organic layers were dried over Na2SO4 and concentrated to give the desired compound 5-cyclopropyl-6-fluoropyridin-2-amine (yellow oil, 2.2 g). ESI-MS [M+H]+: 153.2.

Statistics shows that 944401-65-4 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-6-fluoropyridin-2-amine.

Reference:
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113118-81-3, name is 5-Bromonicotinaldehyde, molecular formula is C6H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 113118-81-3

[0641] To a solution of 5-bromonicotinaldehyde (XXXVII) (2.0 g, 10.8 mmol, 1 eq) in MeOH (20 mL) was added NaB (2.4 g, 64.9 mmol, 6 eq) and the reaction mixture was stirred at room temperature for 3 h. The mixture was concentrated in vacuo and the residue was diluted in water (15 mL), the aqueous phase was extracted with DCM (10 mL x 3). The combined organic layers were dried over MgSO/t, filtered and concentrated in vacuo to afford (5-bromopyridin-3- yl)methanol (XLIV) (1.8 g, 9.57 mmol, 90.0% yield) as a colorless oil. TiNMR iCDC , 500 MHz) delta ppm 4.73 (s, 2H), 7.90 (s, 1H), 8.47 (s, 1H), 8.57 (s, 1H). ESIMS found for C6H6BrNO mlz 188.0 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 113118-81-3.

Reference:
Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; MARAKOVITS, Joseph Timothy; BOLLU, Venkataiah; HOOD, John; (293 pag.)WO2017/23988; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54221-96-4, name is 6-Methoxypicolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H7NO2

General procedure: The mixture of benzaldehyde (3a) (1 mL, 0.010 mol), 2 (2.45 g,0.010 mol) and triethyl phosphite (4) (3.4 mL, 0.020 mol) was placed in a round bottomed flask. To this mixture, 37percent nano-BF3*SiO2 (0.30g) was added and the mixture was irradiated in the ultrasonicator at ambient temperature for about 10 minutes. The progress of the reaction was monitored by TLC (EtOAc/nhexane7:3). After completion of the reaction as checked byTLC, the reaction mixture was cooled to room temperature. CH2Cl2 (15 mL) was added to the reaction content and stirred for 10 min. The catalyst nano-BF3*SiO2 was separated by filtrationas residue, washed with CH2Cl2 (2 × 10 mL) and the residue was dried under vacuum at 100°C to be utilized in further studies. The combined organic layer was washed with water (15 mL), dried over anhydrous Na2SO4 and concentrated under vacuum at 50°C to obtain crude 5a. Pure 5a was obtained by column chromatography (EtOAc/n-hexane 7:3). The same procedure was used for the preparation of the remaining compounds 5b-k.

With the rapid development of chemical substances, we look forward to future research findings about 54221-96-4.

Reference:
Article; Ravikumar; Mohan; Subramanyam, Ch.; Rao, K. Prasada; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 193; 6; (2018); p. 400 – 407;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 38533-61-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38533-61-8, name is 2-Chloro-6-methoxy-3-nitropyridine, molecular formula is C6H5ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 2-chloro-6-methoxy-3-nitropyridine (20.85 g, 110.57 mmol) in concentrated hydrochloric acid (37%) (171 mL, 5528.49 mmol) was stirred at 90 0C for 3 hours and allowed to cool to ambient temperature. The suspension was adjusted to pH 5 with 2M NaOH and the aqueous mixture was then continually extracted with EtOAc (250 mL). The organics were concentrated to afford a yellow solid which was filtered off and washed with Et2theta (200 mL). The solid was stirred in EtOAc (200 mL) and the green insoluble solid filtered off. Both filtrates were combined and dried (MgSO4) before concentrating to yield as 6-chloro-5-nitropyridin-2-ol a yellow solid (14.7 g, 84.22 mmol, 76 %).1R NMR (400 MHz, DMSOd6) delta 6.52 (IH, d), 8.26 (IH, d), no OH peak observed, m/z 173 (M-H)”

According to the analysis of related databases, 38533-61-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/24821; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 36052-24-1 , The common heterocyclic compound, 36052-24-1, name is Methyl 6-aminonicotinate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 15 (1.0 equiv., 3.94 mmol, 0.600 g) was added portion wise to a suspension OfLiAlH4 (3.00 equiv., 11.83 mmol, 0.449 g) in dry THF (17 ml) at 00C. The reaction mixture was stirred at room temperature overnight. Excess LiAlH4 was destroyed by addition of methanol (while cooling on ice), the reaction mixture was filtered over Celite and the filtrate concentrated under reduced pressure. The crude product was purified by column chromatography (dichloromethane / methanol 75:25) to give 6-amino-3-pyridinemethanol (16) (0.330 g, yield = 67%) as a white solid. 1H NMR (delta, CD3OD): 4.43 (2H, s), 6.58 (IH, d, J = 8.5 Hz), 7.48 (IH, dd, J = 8.5, ~ 2 Hz) 7.86 (IH, d, J ~ 2 Hz)

The synthetic route of 36052-24-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tibotec Pharmaceuticals Ltd.; WO2007/113290; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5346-38-3, Pyridine-2-carbothioamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5346-38-3, blongs to pyridine-derivatives compound. Computed Properties of C6H6N2S

Pyridinecarbothioamides 26-28 (1 eq.) and dichloroacetone(1 eq.) were dissolved in toluene (1 M) and heated to reflux (110 C).After completion of the reaction, the mixture was cooled to roomtemperature and extracted with EtOAc (3 times) and the organiclayer was washed (brine), dried (MgSO4), filtered and concentratedin vacuo. The product was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5346-38-3, its application will become more common.

Reference:
Article; Louvel, Julien; Guo, Dong; Soethoudt, Marjolein; Mocking, Tamara A.M.; Lenselink, Eelke B.; Mulder-Krieger, Thea; Heitman, Laura H.; Ijzerman, Adriaan P.; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 681 – 691;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Picolinaldehyde

2-Pyridylbenzaldehyde (10.7 g, 0.1 mol), malonic acid (25.5 g, 0.25 mol) was added to a 100 ml round bottom flask.30 ml of pyridine was added as a solvent, magnetically stirred, and after all of it was dissolved, 1.6 g of piperidine was injected into the system.The oil bath was heated to 65 C and reacted for 3 h.The reaction was followed by thin layer chromatography, and after the reaction was completed, the reaction solution was cooled to 0-5 C.Pour into a mixture of ice and water containing concentrated hydrochloric acid (12 mol / l, 50 ml), a large amount of white solids precipitated, suction filtration,The desired 2-pyridine acrylic acid was obtained in a molar yield of 78%.

With the rapid development of chemical substances, we look forward to future research findings about 1121-60-4.

Reference:
Patent; Danyang Ning David Fang To Detect Co., Ltd.; Wei Qian; (4 pag.)CN109748851; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 76469-41-5 ,Some common heterocyclic compound, 76469-41-5, molecular formula is C5H2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6.65 g of the compound obtained in Step 3 and 4.6 ml of hydrazine monohydrate were added to 100 ml of n-propanol. The resulting mixture was refluxed for 6 hours, and distilled under a reduced pressure to remove the solvent. The residue thus obtained was dissolved in 80 ml of chloromethane, washed with water, and dried over anhydrous magnesium sulfate. The resulting organic layer was concentrated under a reduced pressure to obtain 6.20 g (yield: 85.6%) of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 76469-41-5, 2,3,5-Trifluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Park, Tae-Ho; Zhao, Long-Xuan; Lee, Sang-Ho; US2006/47124; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 34392-85-3, Adding some certain compound to certain chemical reactions, such as: 34392-85-3, name is 3-Amino-2-chloro-6-methoxypyridine,molecular formula is C6H7ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34392-85-3.

Bring a solution of 2-chloro-6-methoxy-3-nitro-pyridine (2. 8 g, 0. 018 mol) in 75% H2SO4 (15 mL) to 0C using an ice bath. Slowly add a solution of NaN02 in water (5 mL) to the reaction mixture and stir for 30 minutes. Add three molar equivalents of CuCI in concentrated HCl and stir for 15 minutes. Heat the mixture at 80C for 30 minutes. Pour onto ice, extract the aqueous with ethyl acetate, dry the organic layer (NA2SO4) and concentrate under reduced pressure. Purify using flash column chromatography (hexanes to 10% ethyl acetate/hexanes eluent) to afford the title compound.

According to the analysis of related databases, 34392-85-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem