Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68325-15-5, name is 3-Chloro-4-cyanopyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-Chloro-4-cyanopyridine

3-EthoxyisonicotinonitrileSodium ethoxide (53 mg, 0.74 mmol) was added to a 0C solution of 3-chloro-4-cyanopyridine (100 mg, 0.72 mmol) in DMF (1 mL). The mixture was stirred at 0C for 30 mm and at rt for 2h, then the mixture was concentrated in vacuo. To the residue Et20 was added, and the salts were filtered off. The filtrate was concentrated in vacuo to yield the title compound as a white solid. LC-MSA: tR= 0.67 mm; [M(35Cl)+H]= 149.06.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 68325-15-5, 3-Chloro-4-cyanopyridine.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2014/141065; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 571189-49-6 ,Some common heterocyclic compound, 571189-49-6, molecular formula is C10H16N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The mixture of intermediate d (0.5mmol), intermediate e (0.55mmol), Pd(OAc)2 (0.05mmol), X-phos or Xantphos (0.15mmol), Cs2CO3 (1.25mmol) and 1,4-dioxane or DME were refluxed under argon atmosphere for 1 h-4 h. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography to produce title compound A or B.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 571189-49-6, 5-(4-Methylpiperazin-1-yl)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Hao; Wang, Jin; Shen, Ying; Wang, Hui-Yan; Duan, Wei-Ming; Zhao, Hong-Yi; Hei, Yuan-Yuan; Xin, Minhang; Cao, Yong-Xiao; Zhang, San-Qi; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 221 – 237;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 19798-77-7 ,Some common heterocyclic compound, 19798-77-7, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of substituted acetylsalicyloyl chlorides (0.022 mol) in anhydrous chloroform (100 mL) was added triethylamine (0.023 mol) at 4 C. After the mixture was stirred for 5-15 min and then substituted 4-amino pyridinewas added portion wise in the ice bath. After warmed to room temperature, the solution was stirred for 24-48 h and then quenched by 1 mL of 1 M hydrochloric acid. The reaction mixture was extracted with 10 % hydrochloric acid (50, 30and 30 mL) and the combined aqueous was basified to pH 7-9 with cooled saturated sodium bicarbonate solution. The yellow precipitation was filtered producing the crude products. After recrystallized in ethanol, the products were isolated as pure form in more than 85 % yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19798-77-7, 4-Amino-3-chloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dian, He; Zhou, De-Bin; Mou, Jian-Ping; Yang, Zhu-Qing; Zhong, Jia; Ding, Xiao-Quan; Li, Chong; Wang, Xiao-Hong; Zhang, Jian-Gang; Asian Journal of Chemistry; vol. 26; 21; (2014); p. 7269 – 7275;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 7356-60-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7356-60-7, name is Nicotinimidamide hydrochloride, molecular formula is C6H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-(3,5-Dibromophenyl)-1-(4-pyridin-3-ylphenyl)-acetone 3-(3,5-Dibromo-phenyl)-1-(4-pyridin-3- Yl-phenyl)-propanone (34 g, 76.73 mmole), 3-Amidinopyridinium chloride (18.02 g, 11.43 mmole),Potassium phosphate (57g, 268.56mmole),And 340 ml of xylene was placed in a reaction flask and heated to maintain a reflux of 140 C.After the reaction is completed, the temperature is lowered to 90 C.After adding 100 ml of deionized water and stirring for 5 minutes, the water layer was removed.After concentrating the organic layer until the solid precipitates,The solid was washed with ethyl acetate and filtered to give a white solid.After drying, 22 g of white solid 4-(3,5-dibromophenyl)-2-pyridin-3-yl-6-(4-pyridin-3-ylphenyl)-pyrimidine (4-(3, 5-Dibromo-phenyl)-2-pyridin-3-yl-6-(4-pyridin-3-yl-phenyl)-pyrimidine),The yield was 52.69%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7356-60-7, Nicotinimidamide hydrochloride.

Reference:
Patent; E-ray Optoelectronics Technology Co Ltd; Huang, Heh Lung; Guo, Huang Ming; Chao, Teng Chih; Lin, Chi Jen; Chang, Min Jong; (53 pag.)TW2019/30287; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 10201-73-7, 2-Amino-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H8N2O, blongs to pyridine-derivatives compound. COA of Formula: C6H8N2O

General procedure: To the solution of Acid SM-IX (70 mg, 0.20 mmol, 100 mol-%) in dry DMF (2 ml) under nitrogen atmosphere was added i-hydroxybenzotriazole hydrate (HOBt) (60 mg, 0.45 mmol, 220 mol-%), i-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride (EDCI) (86 mg, 0.45 mmol, 220 mol-%) and 3- amino-6-methoxypyridazine (51 mg, 0.41 mmol, 200 mol-%). The reaction mix-ture was stirred at + 50 C for 3.5 hours. Water (3 ml) was added to the reaction mixture. The solid precipitate was filtered and washed several times with water and finally with heptane to yield 56 mg of crude product. Purification was done by flash chromatography. Amount of product compound 3 was 36 mg.1H-NMR (200 MHz, DMSO-d6): 0.98 (5, 3H), 1.20-2.47 (m, 16H),2.60-2.97 (m, 2H), 3.98 (5, 3H), 6.89-7.06 (m, 1H), 7.08-7.21 (m, 2H), 7.25 (d,1H), 8.26 (d, 1H), 10.94 (brs, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10201-73-7, 2-Amino-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; FORENDO PHARMA LTD; HIRVELAe, Leena; HAKOLA, Marjo; LINNANEN, Tero; KOSKIMIES, Pasi; STJERNSCHANTZ, Camilla; (182 pag.)WO2018/224736; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 86604-79-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 86604-79-7, name is 2,3,5-Trimethyl-4-nitropyridine 1-oxide. This compound has unique chemical properties. The synthetic route is as follows.

The 2,3,5-trimethyl-4-nitropyridine1-oxide (13.4 g, 73.6 mmol) obtained in the step (11c) was added to acetyl chloride (80 ml, 1,125 mmol) at -30 C. in a nitrogen atmosphere. The mixture was stirred at -30 C. to room temperature for 4 hours and 20 minutes. After the reaction mixture was concentrated, the residue was subjected to silica gel column chromatography (NH silica gel: 300 g, elution solvent: heptane, heptane/ethyl acetate=50/50, ethyl acetate, ethyl acetate/methanol=10/1) to obtain fractions containing a pure product of the title compound and fractions containing a crude product of the title compound. The fractions containing a crude product of the title compound was concentrated. The residue was suspended in ethyl acetate and the resulting precipitate was collected by filtration, washed with ethyl acetate and diethyl ether to obtain the title compound (Lot A, 1.58 g) as a white solid. The filtrate was concentrated. The residue was dissolved in chloroform and washed with a saturated aqueous solution of sodium hydrogen carbonate, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was suspended in diethyl ether. The resulting precipitate was collected by filtration, washed with diethyl ether to obtain the title compound (Lot B, 2.69 g) as a pale brown solid. The fractions containing a pure product of the title compound were concentrated. The residue was dissolved in chloroform, washed with a saturated aqueous solution of sodium hydrogen carbonate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain the title compound (Lot C, 6.56 g) as a pale white solid. The yield of the obtained title compounds of 3 lots was 85.7% in total. Lot A: 1H NMR(400 MHz, DMSO-d6) deltappm; 2.24(3H, s), 2.35(3H, s), 2.39(3H, s), 8.25(1H, s). Lot B: 1H NMR(400 MHz, DMSO-d6) deltappm; 2.24(3H, s), 2.35(3H, s), 2.39(3H, s), 8.25(1H, s). Lot C: 1H NMR(400 MHz, DMSO-d6) deltappm; 2.24(3H, s), 2.35(3H, s), 2.39(3H, s), 8.25(1H, s).

According to the analysis of related databases, 86604-79-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai Co., Ltd.; US2007/10542; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20265-35-4, name is 2-Methoxy-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H6N2O3

Method 4 Synthesis of 7-methoxy-1H-pyrrolo[2,3-c]pyridine (Intermediate 5) A solution of R-4 (500 mg, 3.24 mmol) in anhydrous THF (20 mL) is cooled to -78° C. and vinylmagnesium bromide (9.73 mL of a 1 M solution in THF, 9.73 mmol) added. The reaction is stirred at -20° C. for 6 h then quenched with saturated aqueous NH4Cl solution and extracted with EtOAc. The organic phase is concentrated in vacuo and the crude material purified by flash chromatography (SiO2, 2percent to 10percent MeOH in DCM) to give the title intermediate I-5 (100 mg) m/z 148.9 [M+H].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 20265-35-4, 2-Methoxy-3-nitropyridine.

Reference:
Patent; BARTOLOZZI, Alessandra; CHEN, Zhidong; DINES, Jonathon Alan; LO, Ho Yin; LOKE, Pui Leng; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee M.; US2013/196967; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94220-45-8, name is 5-Chloro-1H-pyrazolo[4,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H4ClN3

10786] To a suspension of sodium hydride (94 mg, 2.3 mmol, 60% in mineral oil) in DMF (4.0 mE) was added dropwise a solution of 5-chioro-1 H-pyrazolo[4,3-b]pyridine (0.30 g, 2.0 mmol, J&W Pharmlab) in DMF (1.0 mE). The mixture was stirred for 10 minutes, then benzyl bromide (0.244 mE, 2.05 mmol, Aldrich) was added. Afier 70 minutes, the mixture was quenched by the addition of water and the product was extracted with EtOAc. The combined extracts were washed with water, followed by brine, dried over sodium sulfate, filtered, and concentrated. Flash chromatography, eluting with a gradient from 0-20% EtOAc in hexanes afforded two isomeric products: Peak 1 (first to elute, 1-ben- zyl-5-chloro-1 H-pyrazolo[4,3-b]pyridine): 0.21 g, 44% yield. Peak 2 (second to elute, 2-benzyl-5-chloro-2H-pyra- zolo[4,3-b]pyridine): 0.10 g, 21% yield.Peak 1 (first to elute, 1-benzyl-5-chloro-1H-pyrazolo[4,3-b] pyridine): ?H NMR (500 MHz, CDC13) oe 8.19 (d, J=0.8 Hz, 1H), 7.56 (dd, J=8.8, 0.7 Hz, 1H), 7.38-7.27 (m, 3H), 7.22 (d,J=8.8 Hz, 1H), 7.18 (dd, J=7.7, 1.5 Hz, 2H), 5.59 (s, 2H);LCMS (M+H): 244.1, 246.1.Peak 2 (second to elute, 2-benzyl-5-chloro-2H-pyrazolo[4,3-b]pyridine): ?H NMR (500 MHz, CDC13) oe 8.07 (d, J=0.8 Hz,1H), 8.00 (dd, J=9.0, 0.8 Hz, 1H), 7.41-7.33 (m, 3H), 7.29(dd, J=7.6, 1.7 Hz, 2H), 7.19 (d, J=9.0 Hz, 1H), 5.60 (s, 2H);LCMS (M+H): 244.1, 246.1.

With the rapid development of chemical substances, we look forward to future research findings about 94220-45-8.

Reference:
Patent; Incyte Corporation; Rodgers, James D.; Shepard, Stacey; Wang, Haisheng; Shao, Lixin; US2015/175604; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 56026-36-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate. A new synthetic method of this compound is introduced below.

To a methanol (16 mL)-acetic acid (20 mL) solution of methyl 6-hydroxymethylnicotinate (1.16 g, 6.94 mmol), 10% palladium/carbon (580 mg) was added. Then, the reaction solution was stirred for 12 hours at room temperature under a 4 atmospheres (0.4 MPa)-hydrogen atmosphere, the reaction solution was filtered with Celite. The solvents of the filtrate were removed under reduced pressure to give desired piperidine derivative. The product was used for the following reaction without further purification. In a 200 mL recovery flask, to an acetonitrile (46 mL) solution of the piperidine derivative obtained in the reaction described above, a 37% formalin aqueous solution (1.24 mL) and sodium triactoborohydride (3.97 g, 18.7 mmol) were added. The reaction mixture was stirred for 30 minutes at room temperature. After adding 20% potassium carbonate aqueous solution 20 mL, the product was extracted with chloroform/methanol solution (9/1, 50 mL) six times. The combined organic layer was dried with sodium sulfate, and the solvents were removed under reduced pressure. The residue was purified with aminosilica gel column chromatography (chloroform/methanol=9/1) to give crystalline methyl 6-hydroxymethyl-1-methypiperidine-3-carboxylate (1.02 g; total yield of two steps, 79%). (0449) LCMS (M+H=188)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56026-36-9, its application will become more common.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; SUMITOMO DAINIPPON PHARMA CO., LTD.; FUSANO, Akira; KOBAYASHI, Tomonori; SAITO, Yasuhiro; KANAI, Toshio; (55 pag.)US2016/221948; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13091-23-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13091-23-1, name is 4-Chloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 4-chloro-3-nitropyridine (1.0 equiv.) and piperidine (2.0 equiv.) in ethanol, at a concentration of 0.5 M, was stirred at rt for 48 hours at which time the ethanol was removed in vacuo. The residue was partitioned between EtOAc (300 mL) and Na2CO3 (Sat) (75 mL), was washed further with H2O (50 mL), NaCl(Sat ) (50 mL), was dried over MgSO4, was filtered and the volatiles were removed in vacuo yielding 3- nitro-4-(piperidin-l-yl)pyridine (95%). LCMS (m/z): 207.7 (MH+); LC Rt = 1.60 min. 1H NMR (CDCl3): delta 8.80 (s, IH), 8.31 (d, J=5.7, IH), 6.84 (d, J=6.3, IH), 3.18-3.21 (m, 4H), 1.64-1.78 (m, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13091-23-1, 4-Chloro-3-nitropyridine.

Reference:
Patent; NOVARTIS AG; WO2009/109576; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem