Tag: M.W:100-200

Related Products of 1480-87-1 ,Some common heterocyclic compound, 1480-87-1, molecular formula is C5H3FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 0.3 g (2.44 mmol) 1(1R)-1-(3-methylisoxazol-5-yl)ethanol in THF 2.45 mL (1 M in THF; 2.45 mmol) LiHMDS is added drop wise. After 30 minutes of stirring 0.3 g (2.04 mmol) 2-fluoro-3-nitro-pyridine is added. The mixture is stirred over night. The mixture is diluted with 1 N HCl and water and neutralized with NH3. EtOAc is added and the organic layer is separated, washed with brine, dried and evaporated to furnish 3-methyl-5-[(1R)-1-[(3-nitro-2-pyridyl)oxy]ethyl]isoxazole. A mixture of 0.5 g (2.09 mmol) 3-methyl-5-[(1R)-1-[(3-nitro-2-pyridyl)oxy]ethyl]isoxazole and acetone are cooled to 5 C. and 87 ml (17.4 mmol) of titanium(III)chloride 20% in water and 24 ml (96 mmol) of a 4M solution of NH4Cl in water are added. The mixture is warmed to RT and stirred over night diluted with EtOAc and water. The organic layer is separated and the aqueous layer is extracted with EtOAc. The combined organic layers are washed with brine, dried and evaporated. The residue is purified by FC (DCM/MeOH 95:5). Yield: 0.3 g (72%), ESI-MS: m/z=220 (M+H)+, Rt(HPLC): 0.41 min (HPLC-G)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1480-87-1, 2-Fluoro-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BLUM, Andreas; GOTTSCHLING, Dirk; HECKEL, Armin; HEHN, Joerg P.; SCHMID, Bernhard; WIEDENMAYER, Dieter; US2015/5278; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 174669-74-0, name is 2-Fluoropyridin-3-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Fluoropyridin-3-ol

Step-1: Preparation of 6-bromo-2-fluoropyridin-3-ol [0175] To a solution of 2-fluoropyridin-3-ol (1 g, 8.842 mmol) and sodium acetate (0.72 g, 8.842 mmol) in acetic acid (10 mL) was added bromine (0.23 mL, 8.842 mmol) at 0 C and the reaction mixture was stirred at room temperature for 4 h. The solution was poured into ice, pH was adjusted to 6 using 2N sodium hydroxide solution and extracted with ethyl acetate (50 mL x 2). The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to afford the crude product, which was purified by silica gel column chromatography (10% ethyl acetate/hexane) to obtain the title compound 6-bromo-2- fluoropyridin-3-ol (0.5 g, 30% yield) as a colorless liquid. Calculated (M+H): 193; Found (M+l): 193.9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 174669-74-0, 2-Fluoropyridin-3-ol.

Reference:
Patent; MNEMOSYNE PHARMACEUTICALS, INC.; ANDERSON, David R.; VOLKMANN, Robert A.; MENNITI, Frank S.; WO2015/48507; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1101120-37-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1101120-37-9, name is Pyrazolo[1,5-a]pyridin-5-amine. A new synthetic method of this compound is introduced below.

A solution of the appropriate carboxylic acid (1 eq.) and the appropriate amine (1.1-1.5 eq.) in pyridine (about 0.1M) was heated to 60 C., and T3P (50% in ethyl acetate, 15 eq.) was added dropwise. Alternatively, T3P was added at RT and the mixture was then stirred at RT or heatedto 60 to 90 C. Afier 1-20 h, the reaction mixture was cooled to RT, and water and ethyl acetate were added. The aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with aqueous buffer solution (pH=5), with saturated aqueous sodium bicarbonate solution and with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated under reduced pressure. The crude product was then optionally purified either by normal phase chromatography (mobile phase: cyclohexane/ethyl acetate mixtures or dichloromethane/methanol mixtures) or by preparative RP-HPLC (water/acetonitrile gradient or water/methanol gradient).; 193 mg (583 jtmol.) of 2-{5-[(benzyloxy)carbo- nyl]-4-hydroxy-2-oxopyridin- 1 (2H)-yl}butanoic acid (race- mate) and 116 mg (874 jtmol. 1.5 eq.) of pyrazol[i,5-a] pyridine-5-amine were reacted according to General Method SD. Yield: 233 mg (purity 94%, 84% of theory)j0872] LC/MS [Method 1]: R=0.9S mm; MS (ESIpos):mlz=447 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1101120-37-9, Pyrazolo[1,5-a]pyridin-5-amine, and friends who are interested can also refer to it.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; ROeHRIG, Susanne; HILLISCH, Alexander; STRASSBURGER, Julia; HEITMEIER, Stefan; SCHMIDT, Martina Victoria; SCHLEMMER, Karl-Heinz; TERSTEEGEN, Adrian; BUCHMUeLLER, Anja; GERDES, Christoph; SCHAeFER, Martina; TELLER, Henrik; JIMENEZ NUNEZ, Eloisa; SCHIROK, Hartmut; KLAR, Juergen; (66 pag.)US2016/272637; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6628-77-9, Adding some certain compound to certain chemical reactions, such as: 6628-77-9, name is 5-Amino-2-methoxypyridine,molecular formula is C6H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6628-77-9.

a 3-Amino-2-bromo-6-methoxypyridine Sodium acetate (1.6 g) was added to a solution of 5-amino-2-methoxypyridine (2.5 g) in acetic acid (15 ml). To the resulting solution bromine (3.0 g) was added dropwise, and the mixture was stirred for 20 min., and then added to a solution of sodium hydroxide (10 g) in water (100 ml). The product was extracted with ethyl acetate (50 ml), dried (anhydrous magnesium sulfate), and concentrated in vacuo. The product was purified over a silica gel column (ethyl acetate/hexane, 1:4) to give 2.7 g of the title compound, suitable for use in the next reaction.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6628-77-9, 5-Amino-2-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US5366972; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 38875-53-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 38875-53-5 as follows.

To a solution of 2,3-diamino-5-bromopyridine (5 g, 27 mmol) in THF (87 mL) was added CDI (3.02 g, 18.6 mmol), and the reaction mixture was stirred at 80 C for 16 h. Then, water was added, and the mixture was filtered. The solids were collected by filtration, washed with water and Et2O, and dried under vacuum to afford the title compound (5.3 g, 25 mmol, 93%), which was used in the next step without further purification. MS (ESI): mass calcd. for C6H4BrN3O, 212.95; m/z found, 214 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38875-53-5, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHROVIAN, Christa C.; LETAVIC, Michael A.; RECH, Jason C.; RUDOLPH, Dale A.; JOHNSON, Akinola Soyode; STENNE, Brice M.; WALL, Jessica L.; (533 pag.)WO2018/67786; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6972-69-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6972-69-6, name is N,N-Dimethylnicotinamide. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of docetaxel [501](0.075 g, 0.093 mmol, 1.0 eq) in ACN (5 ml) was added Nal (0.055 g, 0.372 mmol, 4.0 eq) and Nu,Nu-dimethyl nicotinamide (0.023 g, 0.186 mmol, 2.0 eq) at RT. The reaction mixture was 60C over night. Solvent was removed under vacuum, solid residue taken in DCM, inorganic impurities filtered off, DCM removed under vacuum and the product triturated with ether, filtered and vacuum dried to get the product [502].

According to the analysis of related databases, 6972-69-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; WO2012/137225; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89937-77-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89937-77-9, name is Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Step 1 4-Hydroxymethyl-1H-pyridin-2-one 2-Oxo-1,2-dihydropyridine-4-carboxylic acid methyl ester (1.8 g, 12.2 mmol), prepared as described in J. Org. Chem., 26, 428 (1961), was suspended in THF (100 ml). A small amount of DMF was added to help increase solubility. LiBH4 (61 mmol) was added and the reaction was stirred for 18 hours at room temperature. MeOH and H2O are added to quench the reaction. The reaction is then concentrated to yield a yellow oil. Flash chromatography (5% MeOH/CHCl3 to 20% MeOH/CHCl3) yielded 4-hydroxymethyl-1H-pyridin-2-one as a white solid. 1H NMR (400 MHz, CD3OD) delta 7.38-7.36 (1H,d); 6.56 (s, 1H); 6.37-6.36 (d, 1H); 4.50 s, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89937-77-9, Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate.

Reference:
Patent; Defeo-Jones, Deborah; Jones, Raymond E.; Oliff, Allen I.; US2003/220241; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 63636-89-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63636-89-5, name is Pyridine-2-sulfonamide, molecular formula is C5H6N2O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 6 N-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)aminothioxomethyl]-2-pyridinesulfonamide A mixture of 1.58 g of 2-pyridinesulfonamide, 2.04 g of 4,6-dimethoxy-2-isothiocyanato-1,3,5-triazine and 1.5 g of anhydrous potassium carbonate is stirred in 75 ml of acetone for 60 hours at ambient temperature. The reaction mixture is then poured into 500 ml of cold water, acidified with hydrochloric acid and the precipitated product removed by filtration.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63636-89-5, Pyridine-2-sulfonamide.

Reference:
Patent; E. I. Du Pont de Nemours and Company; US4435206; (1984); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 7418-66-8, Adding some certain compound to certain chemical reactions, such as: 7418-66-8, name is 4-Aminonicotinamide,molecular formula is C6H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7418-66-8.

To a stirred solution of 4-aminopyridine-3-carboxamide (500 mg, 3.65 mmol), 4-tert-butoxy-4-oxo-butanoic acid (762 mg, 4.38 mmol), TEA (1 mL, 7.29 mmol) in DMF (10 mL), 50%T3P solution in EtOAc (3.5 mL, 5.5 mmol) was added at RT and stirred for 12 h (TLCindicated complete consumption of starting material). The reaction mixture was quenchedwith water (50 mL) and extracted with DCM (2 x 35 mL). The combined organic extractswere washed with brine (30 mL), dried over Na2S04, concentrated under reduced pressure togive the crude product which was purified by column chromatography (100-200 silica gel, 20g, 10% MeOH-10% NH40H-DCM) to afford tert-butyl4-[(3-carbamoyl-4-pyridyl)amino]-4-oxo-butanoate (500 mg, 47%) as a yellow solid.1H NMR [400 MHz, CDCh]: J 11.74 (s, 1H), 9.07 (s, 1H), 8.69 (d, J = 5.2 Hz, 1H), 8.52 (d,J = 5.2 Hz, 1H), 7.11 (brs, 1H), 5.83 (brs, 1H), 2.75-2.70 (m, 2H), 2.68-2.63 (m, 2H), 1.44 (s,9H). LCMS (ESI+): m/z: 316.59 [M+Nat.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7418-66-8, 4-Aminonicotinamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 127838-58-8, 4-(Hydroxymethyl)pyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-(Hydroxymethyl)pyridin-2(1H)-one, blongs to pyridine-derivatives compound. name: 4-(Hydroxymethyl)pyridin-2(1H)-one

To a suspension of 4-(hydroxymethyl)-2(1 /-/)-pyridinone (0.98 g, 7.9 mmol) and DMF (10 ml_) was added imidazole (0.64 g, 9.45 mmol) and ferf-butyldimethylsilyl chloride (1.25 g, 8.26 mmol), and the mixture was stirred at ambient temperature under a nitrogen atmosphere for 18 h. The mixture was poured into water (30 ml_), and stirred for 30 min. The solid was filtered, rinsed with water, and air-dried to provide 4-({[(1 ,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2(1 /-/)-pyridinone as an off-white solid (1.64 g, 88%): 1H NMR (400 MHz, DMSOd6) delta ppm 1 1.34 (br s, 1 H), 7.26 (d, J = 6.6 Hz, 1 H), 6.21 (s, 1 H), 6.01 (dd, J = 6.6, 1.5 Hz, 1 H), 4.5 (s, 2H), 0.88 (s, 9H), 0.05 (s, 6H); EI-LCMS m/z 241 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,127838-58-8, 4-(Hydroxymethyl)pyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/76387; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem