Tag: M.W:100-200

Application of 1121-60-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, molecular weight is 107.11, as common compound, the synthetic route is as follows.

General procedure: Equimolar mixture of pyridine carboxaldehyde deriva-tives (1 mmol) and sodium metabisulphite (1 mmol) in DMF (10 mL) was stirred for 10 to 15 min, followed by the addi-tion of o-phenylene diamine/2-aminothiophenol (1 mmol) into it and refluxed for 3 h. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was poured into crushed ice, precipitates were formed which were collected by filtration to afford compounds 1-27 in good yields. Recrystallization from methanol yielded pure crystals.

The chemical industry reduces the impact on the environment during synthesis 1121-60-4, I believe this compound will play a more active role in future production and life.

Reference:
Article; Khan, Momin; Ahmad, Riaz; Rehman, Gauhar; Gul, Naeem; Shah, Sana; Salar, Uzma; Perveen, Shahnaz; Khan, Khalid Mohammed; Letters in drug design and discovery; vol. 16; 9; (2019); p. 984 – 993;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1101120-05-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1101120-05-1 as follows.

General procedure: These were made using NaHCO3 or 2,6-lutidine as detailed below, unless otherwise stated. Methylhydrazine sulfate (1.2 equiv) and NaHCO3 (5 equiv) were added to a solution of 3-formylpyrazolo[1,5-a]pyridine-5-carbonitrile (2) (1 equiv) in MeOH (5 mL). After all of the aldehyde was consumed, sulfonyl chloride or acyl chloride (1.3 equiv) was added and the reaction mixture stirred for a further 30 min. The solvent was removed in vacuo and the residue taken up in CH2Cl2 and water. The layers were separated and the aqueous phase extracted with CH2Cl2, then the combined organic layers were dried (Na2SO4) and the solvent removed in vacuo. Chromatography or trituration then afforded the hydrazides. Alternatively, methylhydrazine sulfate (1.2 equiv) and 2,6-lutidine (5 equiv) were added to a solution of 2 (1 equiv) in MeOH (5 mL). After all of the aldehyde was consumed, sulfonyl chloride or acyl chloride (1.3 equiv) was added and the reaction mixture stirred for a further 30 min. The hydrazide was then filtered off, washed with MeOH and dried.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1101120-05-1, its application will become more common.

Reference:
Article; Kendall, Jackie D.; Giddens, Anna C.; Tsang, Kit Yee; Frederick, Raphael; Marshall, Elaine S.; Singh, Ripudaman; Lill, Claire L.; Lee, Woo-Jeong; Kolekar, Sharada; Chao, Mindy; Malik, Alisha; Yu, Shuqiao; Chaussade, Claire; Buchanan, Christina; Rewcastle, Gordon W.; Baguley, Bruce C.; Flanagan, Jack U.; Jamieson, Stephen M.F.; Denny, William A.; Shepherd, Peter R.; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 58 – 68;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 81719-53-1, 3,5-Dichloropyridine-2-carboxylic Acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3,5-Dichloropyridine-2-carboxylic Acid, blongs to pyridine-derivatives compound. name: 3,5-Dichloropyridine-2-carboxylic Acid

Production Example 32 (1) [0773] 5.53 ml of thionyl chloride was added to a mixture of 4.7 g of 3,5-dichloropicolinic acid, 49 ml of toluene and 0.1 ml of DMF, and the mixture was stirred at 80C for 2 hours. The cooled reaction mixture was concentrated under reduced pressure, and 49 ml of toluene, 4.84 g of N-methyl-4-trifluoromethylsulfanylaniline and 8.05 ml of diisopropylethylamine were added, and the mixture was stirred at 80C for 2 hours. The cooled reaction mixture was poured to a saturated aqueous sodium bicarbonate solution, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting residue was applied to a silica gel column chromatography to obtain 8.92 g of 3,5-dichloro-N-methyl-N-(4-trifluoromethylsulfanylphenyl)pi colinamide. RRN 1573,5-Dichloro-N-methyl-N-(4-trifluoromethylsulfanylphenyl)pi colinamide [0774] 1H-NMR(CDCl3)delta: 8.28(1H, d), 7.58(1H, d), 7.50(2H, d), 7.19(2H, d), 3.54(3H, s).

The synthetic route of 81719-53-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Chemical Company, Limited; MAEHATA, Ryota; MIZUNO, Hajime; SHIMIZU, Chie; NOKURA, Yoshihiko; EP2881386; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 65169-43-9, name is Methyl 2-chloro-5-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 65169-43-9

j0352] To a sealed tube containing methyl 2-chloro-5-me- thylnicotinate (CAS 65 169-43-9) (745 g, 4.01 mmol), Cul (38 mg, 0.2 mmol), LiC1 (169 g, 4.01 mmol), and Pd(PPh3)4 (231 g, 0.2 mmol) in toluene (15 mE) was added 2-(tributyl- stannyl)pyrimidine (1.5 mE, 4.4 mmol), and the reaction mixture was heated at 120 C. overnight. The reaction mixture was diluted with water and extracted with DCM. The combined organic layers were dried over Mg504, filtered and evaporated. Purification via silica gel chromatography (0-50% EtOAc in hexanes) gave the title compound (494 g, 52%). MS (ESI) mass calcd. for C,2H,,N302, 229.1; mlz found 229.99.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 65169-43-9, Methyl 2-chloro-5-methylnicotinate.

Reference:
Patent; Janssen Pharmaceutica NV; COATE, Heather R.; DVORAK, Curt A.; FITZGERALD, Anne E.; LEBOLD, Terry P.; PREVILLE, Cathy; SHIREMAN, Brock T.; (473 pag.)US2016/46640; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6221-01-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6221-01-8, name is Pyridine-2,5-dicarbaldehyde. A new synthetic method of this compound is introduced below.

General procedure: To a stirred solution of 2,5-pyridinedicarboxaldehyde(0.37 mmol) in 5 mL EtOH was added the indole (1.85 mmol) andI2 (0.15 mmol). The resulting mixture was stirred at reflux for 6 hcooled and treated with aqueous Na2S2O3. The combined organiclayers obtained by extraction with EA (3 30 mL) were washedwith H2O (2 10 mL) and brine (2 10 mL), dried over MgSO4 and concentrated under reduced pressure to give a residue, which wassubjected to flash column chromatography, followed by normalphaseHPLC to afford the pure product. 4.3.2 3,3′,3″,3?-(Pyridine-2,5-diylbis(methanetriyl))tetrakis(1H-indole) (3a) Yield 50% (white powder), mp 164-165 C, 1H NMR (400 MHz, DMSO-d6): delta 10.85 (s, 2H, NH), 10.81 (s, 2H, NH), 8.51 (s, 1H, ArH), 7.59 (d, J = 8.4 Hz, 1H, ArH), 7.35-7.25 (m, 9H, ArH), 7.05-7.00 (m, 4H, ArH), 6.90 (s, 2H, ArH), 6.87-6.83 (m, 6H, ArH), 5.89 (s, 1H, CH), 5.86 (s, 1H, CH). 13C NMR (100 MHz, DMSO-d6): delta 162.48, 149.53, 138.42, 137.51, 137.36, 136.97, 127.65, 127.36, 124.49, 124.42, 122.88, 121.90, 121.74, 119.92, 119.20, 119.12, 118.32, 118.05, 112.45, 112.35, 43.21, 37.74. HRMS calcd for C39H30N5 (M + H)+, 568.2501; found, 568.2500.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6221-01-8, its application will become more common.

Reference:
Article; Fu, Chih-Wei; Hsieh, Yun-Jung; Chang, Tzu Ting; Chen, Chia-Ling; Yang, Cheng-Yu; Liao, Anne; Hsiao, Pei-Wen; Li, Wen-Shan; European Journal of Medicinal Chemistry; vol. 104; (2015); p. 165 – 176;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 56129-55-6, Adding some certain compound to certain chemical reactions, such as: 56129-55-6, name is 1-(Pyridin-3-yl)ethanamine,molecular formula is C7H10N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56129-55-6.

A sealed tube is charged with 7-chloro-5-(1 -methyl- 7 – -indol-6-yl)-quinoxaline (60.00 mg; 0.20 mmol; 1.0 eqr.) (Intermediate 4), 1-pyridin-3-yl-ethylamine (0.05 ml0.41 mmol; 2.0 eqf.), NaOtBu (58.77 mg; 0.61 mmol; 3.00 eqf.) and toluene (2.0 ml_). RM is purged with argon and then BINAP (25.39 mg; 0.04 mmol; 0.20 eqf.) and Pd2(dba)3 (18.67 mg; 0.02 mmol; 0.10 eq.) are added. RM is sealed and heated at 1 10C for 16 h. After this time, the mixture is filtered through a Celite pad and the filtrate is diluted with EtOAc and extracted with water. Combined organic phases are washed with brine, dried over Na2S04. Solvent is evaporated and the residue is purified by FCC (hexane/EtOAc; gradient). [8-(1 -Methyl- 7H-indol-6-yl)-quinoxalin-6-yl]-(1 – pyridin-3-yl-ethyl)-amine is obtained as a yellow powder (60.00 mg; yield 79%; 97% by HPLC).

According to the analysis of related databases, 56129-55-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 19355-04-5, Adding some certain compound to certain chemical reactions, such as: 19355-04-5, name is 3-Methoxy-4-nitropyridine 1-oxide,molecular formula is C6H6N2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19355-04-5.

EXAMPLE a) Preparation of 2-cyano-3-methoxy-4-nitropyridine A mixture of 12.5 g (12.5 moles) of the N-oxide of 3-methoxy-4-nitropyridine, 7.72 mL (1.1 eq.) of methyl sulphate and 70 mL of 1,2-dichloroethane is heated at 70 C. for 2.5 hours. It is allowed to cool and 70 mL of water are added. It is cooled in a salt and ice bath and, in portions, 7.55 g (2.1 moles) of sodium cyanide are added, controlling the temperature so as not to exceed 10 C. After 4 hours stirring, the reaction mixture is extracted with ethyl ether, the organic phase is washed with water, concentrated and the residue chromatographed (ethyl acetate/dichloromethane). There is obtained 7.06 g of a yellow oil (yield 53%).

According to the analysis of related databases, 19355-04-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nieto-Roman, Francisco; Vors, Jean-Pierre; Villier, Alain; Lachaise, Helene; Mousques, Adeline; Hartmann, Benoit; Hutin, Pierre; Molina, Jose Lorenzo; Muller, Benoit; US2003/191113; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 126954-66-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 126954-66-3, name is 2,5-Dichloronicotinonitrile. A new synthetic method of this compound is introduced below.

To a solution of 2,5-dichloronicotinonitrile (160 mg, 0.92 mmol) in n-butanol (15.0 mL) was added hydrazine hydrate (0.4 mL, 15 mmol). The mixture was stirred at 120 C for 7 h. The reaction mixture was concentrated in vacuo to remove the solvent, and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 4/1) to give the title compound as a white solid (86 mg, 55 %).MS (ESI, pos. ion) m/z: 169.0 [M+H]?H NIVIR (400 MHz, CDC13) (ppm): 8.33 (s, 1H), 8.29 (s, 1H), 5.69 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,126954-66-3, 2,5-Dichloronicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (215 pag.)WO2018/127096; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 17228-69-2 ,Some common heterocyclic compound, 17228-69-2, molecular formula is C6H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Under an N2 atmosphere, KOtBu (1.3 mmol), complex 1 (1 mol %), dioxane (2 ml), amines (1.3 mmol) and aryl chlorides (1.0 mmol) were successively added into a Schlenk tube. The mixture was stirred vigorously at 90 C for 4 h. Then the solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: PE/EA = 15:1) to give the pure products. The reported yields are the average of two runs.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17228-69-2, 2-Chloro-4-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nirmala, Muthukumaran; Saranya, Gandhi; Viswanathamurthi, Periasamy; Bertani, Roberta; Sgarbossa, Paolo; Malecki, Jan Grzegorz; Journal of Organometallic Chemistry; vol. 831; (2017); p. 1 – 10;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 116632-24-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116632-24-7, name is 2-Amino-4,6-dichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2,4-Dichloro-6-hydroxypyridine; Sodium nitrite (64 mg, 0.93 mmol) dissolved in water (0.6 mL), was added dropwise to a stirred solution of 2-amino-4,6-dichloropyridine (prepared according to the method described in Recl. Trav. Chim. Pays-Bas, 1950, 69, 673) (126 mg, 0.77 mmol) in 5% sulphuric acid (aq) (5 mL) at 0 C., over 5 min. The mixture was stirred at 0 C. for 1 h and then diluted with water (20 mL) and extracted with DCM (3×20 mL). The combined extracts were washed with brine (20 mL), dried over MgSO4 and concentrated in vacuo to afford the 2,4-dichloro-6-hydroxypyridine (116 mg, 0.71 mmol, 92%) M.S. (ESI) (m/z) 164,166 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 116632-24-7, 2-Amino-4,6-dichloropyridine.

Reference:
Patent; N.V. Organon; US2007/185156; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem