Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 15855-06-8, 2-Chloro-6-methoxypyridine-4-carboxylic Acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 15855-06-8, blongs to pyridine-derivatives compound. SDS of cas: 15855-06-8

Example 4.2: (S)-2-chloro-6-methoxy-N-methyl-N-(4-M-methyl-1 H-pyrrole-2- carboxamido)-1-phenylbutan-2-yl)isonicotinamide1-Methyl-1 H-pyrrole-2-carboxylic acid ((S)-3-methylamino-4-phenyl-butyl)-amide hydrochloride (100 mg, 0.31 mmol), 2-chloro-6-methoxyisonicotinic acid (58 mg, 0.31 mmol), HOBt (74 mg, 0.466 mmol), EDC x HCI (72 mg, 0.37 mmol), and triethylamine (0.108 ml, 0.78 mmol) were dissolved in DCM (3 ml) and stirred at rt for 16 h. The mixture was concentrated and the crude product was purified by chromatography (Flashmaster, DCM to DCM:EtOAc 1 :1 over 15 min) to yield 108 mg (76 %) of the title compound as white solid. [1 H-NMR (DMSO, 600 MHz) 7.95-7.90 (m, 1 H), 7.33.7.22, 7.10-7.06 (2m, 5H), 6.87 (d, 1 H), 6.70/6.63 (d, 1H), 6.65/6.33 (s, 1 H), 6.06/5.71 (br.s, 1H), 6.00-5.97 (m, 1 H), 4.88-4.81/3.55-3.49 (m, 1H), 3.84/3.71 (s, 3H), 3.80/3.79 (s, 3H), 3.27-3.18/3.05-2.99 (m, 2H), 2.97/2.62 (s, 3H), 2.95-2.90/2.84-2.76 (m, 2H), 1.91-1.75 (m, 2H); LCMS Rtc = 2.466 min; [M+H]+ = 455.2].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15855-06-8, 2-Chloro-6-methoxypyridine-4-carboxylic Acid, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; WAGNER, Juergen; ROY, Bernard, Lucien; GERSPACHER, Marc; VON MATT, Anette; BEHNKE, Dirk; WO2011/73316; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6969-71-7, [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H5N3O, blongs to pyridine-derivatives compound. Formula: C6H5N3O

At room temperature, [1,2,4] triazolo [4,3-a] pyridine-3 (2H) -one (500mg, 3.70mmol), 1,2-bromomethane (0.73mL, 8.50mmol) and DMF (10.0 mL), then NaH (125 mg) was added, and the reaction mixture was stirred at room temperature for 6 h.The reaction was quenched by adding water (30 mL), and then extracted with EA (30 mL × 2). The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent. Petroleum ether (10 mL) was added to it, stirred for 30 min, filtered, the filtrate was collected, and dried in vacuo to give the title compound as a red solid (490 mg, 2.02 mmol, 54.70%).

The synthetic route of 6969-71-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Huang Jianzhou; Ren Qingyun; Xiong Jinfeng; Liu Yang; Yu Fangcai; Liu Weishun; Wang Yifeng; Zhang Yingjun; (104 pag.)CN110903284; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6959-48-4 ,Some common heterocyclic compound, 6959-48-4, molecular formula is C6H7Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A suspension of calixarene 1 (0.17 g, 0.40 mmol), K2CO3(1.77 g, 12.8 mmol) and 3-(chloromethyl)pyridine hydrochloride (0.52 g, 3.2 mmol) in anhydrous CH3CN (10 ml) was stirred under nitrogen at 508C for 20 h. The reaction mixture was quenched with water and the residue was collected by filtration, dissolved in CH2Cl2 and washed withaNa2CO3 solution. The organic solvent was removed under reduced pressure and the residue was purified by column chromatography (SiO2;CH2Cl2 to CH2Cl2/ CH3OH, 95:5). The pure final product was obtained with a 51% yield (0.13 g).1H NMR (CDCl3,278C, 500 MHz): d 8.77 (s, 2H, H8),8.63 (d, J 5.0 Hz, 2H, H11), 8.06 (d, J 7.7Hz,2H, H9),7.57 (s, 2H, H6), 7.25 (dd, J1 7.7Hz, J2 5.0Hz, 2H, H10), 7.09 (d, J 7.6Hz, 4H, H4), 6.83 (d, J 7.6 Hz, 4H, H2), 6.71 (t, J 7.6 Hz, 4H, H1, H3),5.08 (s, 4H, H7), 4.26 (d, J 13.0 Hz, 4H, H5ax), 3.38 (d, J 13.0 Hz, 4H, H5eq). 13CNMR (CDCl3,278C, 125MHz): d 153.10, 151.51, 149.69, 148.78, 135.44,133.00, 132.25, 129.21, 128.58, 127.79, 125.77, 123.93, 119.25, 75.71, 31.41. ESI-MS: m/z 607 [M H], 629 [M Na]. UV- vis absorption (CH3CN, l268 nm): 1 7275M21 cm 21

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6959-48-4, 3-(Chloromethyl)pyridine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Bonaccorso, Carmela; Nicoletta, Francesca; Zito, Valeria; Arena, Giuseppe; Sciotto, Domenico; Sgarlata, Carmelo; Supramolecular Chemistry; vol. 25; 9-11; (2013); p. 615 – 625;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 13534-99-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13534-99-1, name is 2-Amino-3-bromopyridine, molecular formula is C5H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 2a, 2c or 2h (3 mmol, 0.5 g) in ethylene glycol (5 mL) was added successively the boronic acid (4.5 or 9.0 mmol, 1.5 or 3 equiv), Pd(PPh3)4 (1molpercent), and a solution of K3PO4 (6 mmol, 2 equiv) inwater (2 mL). The reaction mixture was heated at 80°C for 16 h and was then hydrolyzed with a 1 M solution of sodium hydroxide (20 mL). The aqueous phase was extracted with ethylacetate (3 x 30 mL) and the combined organic layers were washed with brine (50 mL), dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel with petroleum ether/EtOAc (60/40) as eluent.

According to the analysis of related databases, 13534-99-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Silpa, Laurence; Niepceron, Alisson; Laurent, Fabrice; Brossier, Fabien; Penichon, Melanie; Enguehard-Gueiffier, Cecile; Abarbri, Mohamed; Silvestre, Anne; Petrignet, Julien; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 114 – 120;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 350-03-8, 1-(Pyridin-3-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1-(Pyridin-3-yl)ethanone, blongs to pyridine-derivatives compound. name: 1-(Pyridin-3-yl)ethanone

A mixture of 30 g of 3-acetylpyridine and 60 g of N, -dimethylformamidedimethylacetal was stirred for 6 hours under reflux with heat. After cooling down to room temperature, the mixture was concentrated under reduced pressure. 3-dimethylamino-l- (pyridin-3-yl ) – propenone (43 g) was obtained. 1 H-N R (CDC13) delta: 9.09-9.07 (1H, m) , 8.68-8.65 (1H, m) , 8.19 (1H, dt), 7.85 (1H, d) , 7.38-7.34 (1H, m) , 5.68 (1H, d) , 3.19 (3H, s), 2.96 (3H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,350-03-8, 1-(Pyridin-3-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; ARIMORI, Sadayuki; SHUTO, Akira; MIZUNO, Hajime; WO2011/49150; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 605-38-9, Adding some certain compound to certain chemical reactions, such as: 605-38-9, name is Dimethyl pyridine-2,3-dicarboxylate,molecular formula is C9H9NO4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 605-38-9.

Preparation of the starting substance: STR28 A solution of 19.5 g (0.1 mole) of 2,3-dimethoxycarbonyl-pyridine and 12 g (0.1 mole) of acetophenone in 300 ml of toluene is added dropwise to a suspension of 2.4 g (0.1 mole) of sodium hydride in 100 ml of toluene, while stirring. The mixture is then boiled under reflux for 3 hours, during which the methyl alcohol formed and about half of the toluene are distilled off. The residue which remains is poured onto a mixture of 15 g of ice and 7.2 g of acetic acid. The organic phase is separated off, the aqueous phase is extracted with chloroform (3 portions of 100 ml each) and the organic phases are combined, dried over sodium sulphate and evaporated in vacuo. The residue is fractionated over silica gel with chloroform as the mobile phase and chromatographed and the corresponding fractions are recrystallized from legroin. 17 g (60percent of theory) of 2-(1,3-dioxo-3-phenyl-prop-1-yl)-3-methoxycarbonyl-pyridine are obtained as white crystals of melting point 87° C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 605-38-9, Dimethyl pyridine-2,3-dicarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; US4752324; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 101990-69-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 101990-69-6 as follows.

EXAMPLE 7F 2 ,6-dichloroisonicotinaldehy de To a solution of EXAMPLE 7E (3.2 g, 18. 1 mmol) in dichloromethane ( 100 mL) was added Dess-Martin periodinane (9.2 g, 21.7 mmol) in portions and the mixture was stirred at room temperature for 30 minutes. The mixture was filtered and the filtrate was concentrated. The residue was purified by flash chromatography eluting with 1/20 ethyl acetate/ petroleum ether to afford the title compound. MS: 176 (M + HT).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101990-69-6, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 779345-37-8, 5-Fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 779345-37-8, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Fluoro-2-nitropyridine

To a stirred solution of 5-fluoro-2-nitropyridine (1.00 g, 7.04 mmol) in ethanol (20 mL) was added hunig’s base (2.5 mL, 14.084 mmol) and 2-(3-fluorophenyl)pyrrolidine (1.74 g, 10.56 mmol) at room temperature. The resulting mixture was stirred at 100C for 16 h in a sealed tube. On completion, Reaction mixture was concentrated under reduced pressure. The residue was diluted with water (30 mL) and extracted with ethyl acetate (2 x 30 mL). Combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford the title compound (1.8 g, 89%) as a pale brown solid. LCMS (ESI): m/z 288 [M + H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,779345-37-8, its application will become more common.

Reference:
Patent; LEO PHARMA A/S; MAANSSON, Kristoffer; HENRIKSSON, Krister; (76 pag.)WO2020/35557; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-97-5, name is 5-Bromopyridin-2-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 1072-97-5

5-Bromo-2-aminopyridine (5.19 g, 30 mmol) was dissolved in 100 ml of dry dichloromethane and then 20 ml of triethylamine.Acetyl chloride (2.54 ml) was slowly added dropwise to the above solution under ice-cooling, and after the dropwise addition was completed, the ice bath was removed, and the mixture was allowed to react at room temperature overnight.After completion of the reaction, it was diluted with dichloromethane, washed with water (30 ml × 3), washed with a saturated NaHCO 3 solution (30 ml × 3), washed with saturated NaCl (30 ml), and dried over anhydrous Na2SO4.Column chromatography gave 5.65 g of a white solid, yield 88%

The synthetic route of 1072-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Pan Xiaoyan; Liang Liyuan; Lu Wen; Wang Sicen; He Langchong; Si Ru; Wang Jin; (15 pag.)CN109761957; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6188-25-6, Adding some certain compound to certain chemical reactions, such as: 6188-25-6, name is 6-Chloroimidazo[1,2-a]pyridine,molecular formula is C7H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6188-25-6.

To 6-chloro-imidazo[1,2-a]pyridine (1 eq, 253 mmol, 39 g) in acetic acid (500 ml) under inert atmosphere, is added dropwise bromine (1 eq, 253 mmol, 13 ml). After 1 hour stirring at room temperature, the reaction mixture is filtered and to give a beige solid (64 g) 3-Bromo-6-chloro-imidazo[1,2-a]pyridine hydrobromide;[M+H]+ 232(234)

According to the analysis of related databases, 6188-25-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; WO2009/50183; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem