Tag: M.W:100-200

Application of 89-00-9 , The common heterocyclic compound, 89-00-9, name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

take 1mol2,3-pyridinedicarboxylic acid, 1.15mol urea ground into a fine powder mixture,Add 1000ml three-necked flask, purged with nitrogen and heated to 189 ,After melting, stirring for 20 min, cooling to room temperature, to give2,3-pyridine diimide;

The synthetic route of 89-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Wokai Biological Co., Ltd.; Lu Huiyi; Guo Jianguo; Wang Tao; Zhou Yin; (5 pag.)CN106083846; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1034667-22-5, 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

Example 6A 5-Fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine 10 g (65.75 mmol) of 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine were initially charged in THF (329 ml), and the mixture was cooled to 0 C. 16.65 ml (131.46 mmol) of boron trifluoride/diethyl ether complex were then added slowly. The reaction mixture was cooled further to -10 C. A solution of 10.01 g (85.45 mmol) of isopentyl nitrite in THF (24.39 ml) was then added slowly, and the mixture was stirred for a further 30 min. The mixture was diluted with cold diethyl ether (329 ml) and the resulting solid was filtered off. The diazonium salt thus prepared was added a little at a time to a solution at 0 C. of 12.81 g (85.45 mmol) of sodium iodide in acetone (329 ml), and the mixture was stirred at RT for 30 min. The reaction mixture was poured onto ice-water (1.8 l) and extracted twice with ethyl acetate (487 ml each time). The collected organic phases were washed with saturated aqueous sodium chloride solution (244 ml), dried, filtered and concentrated. This gave 12.1 g (86% purity, 60% of theory) of the title compound as a solid. LC-MS (Method 2): Rt=1.68 min MS (ESIpos): m/z=264 (M+H)+

The synthetic route of 1034667-22-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Itasch, Johannes-Peter; Redlich, Gorden; Griebenow, Nils; Wunder, Frank; Li, Volkhart Min-Jian; Lang, Dieter; US2014/100229; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 7295-76-3, 3-Methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 7295-76-3, blongs to pyridine-derivatives compound. Computed Properties of C6H7NO

General procedure: First, 10 mmol of the respective pyridine were dissolved in 50 mL of dried THF. After additionof 0.5 mmol of copper(I) iodide and 3 mL of dimethyl sulphide, the mixture was stirred at room temperature until a clear solution resulted. Then, it was cooled down to -20 C. After 15 min, 10 mmolof acetyl chloride were added dropwise and stirring continued for 15 min. Then, 10 mmol of phenylmagnesium chloride were added and stirring followed for additional 15 min. Then, the mixturewarmed up to room temperature. Then, 50 mL of an ammonium chloride solution (20%) were addedand extraction with diethyl ether followed with portions of 50, 25 and again 25 mL. The unified organiclayer was extracted with each 50 mL of a solution of ammonium chloride in ammonia for two times,with 50 mL water, hydrochloric acid (10%) for two times, water and finally a saturated solution ofsodium chloride in water. The organic layer was then dried over sodium sulphate, filtered and finallyremoved under reduced pressure to give an oily substance that partially crystallized from methanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7295-76-3, its application will become more common.

Reference:
Article; Holzer, Max; Schade, Nico; Opitz, Ansgar; Hilbrich, Isabel; Stieler, Jens; Vogel, Tim; Neukel, Valentina; Oberstadt, Moritz; Totzke, Frank; Schchtele, Christoph; Sippl, Wolfgang; Hilgeroth, Andreas; Molecules; vol. 23; 9; (2018);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 885269-66-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.885269-66-9, name is 6-Methyl-1H-pyrazolo[3,4-b]pyridine, molecular formula is C7H7N3, molecular weight is 133.15, as common compound, the synthetic route is as follows.

To a brown solution of 6-methyl-1H-pyrazolo[3,4-bjpyridine (1.3 g, 9.4 mmol) and iodine (4.8 g, 19 mmol) in DMF (30 mL) at 0 C was KOH (2.lg, 38 mmol). The reaction was allowed to warm to ambient temperature and stir for an hour. The resultant mixture was poured into ice/water (200 mL) and extracted with EtOAc (3 x 200 mL). The combined organic layers were dried over Na2504, filtered and concentrated in vacuo. Purification using silica gel chromatography (30-50% EtOAc/hexanes gradient) afforded 3-iodo-6-methyl- 1H- pyrazolo[3,4-bjpyridine as a light yellow solid (1.8 g, 74% yield).

The chemical industry reduces the impact on the environment during synthesis 885269-66-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; RENNIE, Glen, Robert; BARDEN, Timothy, Claude; LEE, Thomas, Wai-Ho; IYENGAR, Rajesh, R.; NAKAI, Takashi; MERMERIAN, Ara; JIA, James; IYER, Karthik; IM, G-Yoon, Jamie; RENHOWE, Paul, Allan; JUNG, Joon; GERMANO, Peter; TANG, Kim; (240 pag.)WO2018/89330; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 5470-18-8, Adding some certain compound to certain chemical reactions, such as: 5470-18-8, name is 2-Chloro-3-nitropyridine,molecular formula is C5H3ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5470-18-8.

15. Preparation of 2-Hydrazino-3-nitropyridine 2-Chloro-3-nitropyridine (100 g, 0.63 mol), hydrazine monohydrate (70.4 mL, 72.6 g, 1.45 mol) and methanol (1.3 L) were mixed and heated to reflux with stirring. After 30 min the reaction mixture was cooled and filtered collecting the insoluble materials. The filtrate was concentrated by evaporation under reduced pressure and the residue obtained as well as the insoluble materials from the filtration were diluted with water. The insoluble solids present were collected by filtration, washed with water, and dried to obtain 95.2 g (98 percent of theory) of the title compound as a bright yellow powder melting at 168-169 C. Elemental Analysis C5 H6 N4 O2 Calc.: % C, 39.0; % H, 3.90; % N, 36.4; % S, 8.27 Found: % C, 39.1; % H, 4.17; % N, 36.1; % S, 8.18

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5470-18-8, 2-Chloro-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dow AgroSciences LLC; US5763359; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 17282-00-7, 3-Bromo-5-methylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 17282-00-7, blongs to pyridine-derivatives compound. Product Details of 17282-00-7

General procedure: Under N2 atmosphere, to a solution of palladium acetate (120 mg, 0.53 mmol, 5 mol %) and XANTPHOS (309 mg, 0.53 mmol, 5 mol %) in anisole (30 mL) was added 3-bromo-5-methyl-pyridin-2-ylamine (5) (2.0 g, 10.7 mmol, 1.0 equiv), aryl iodides (6) (10.7 mmol) and cesium carbonate (4.9 g, 15.0 mmol, 1.4 equiv), and the mixture was stirred at 130 C for 1-13 h. After cooling to room temperature, water (40 mL) was added to the mixture. The mixture was concentrated in vacuo and ethyl acetate (100 mL) was added to the residue. The organic layer was washed with water (20 mL) and concentrated in vacuo to give the crude product, which was purified by flash chromatography to give 7.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17282-00-7, its application will become more common.

Reference:
Article; Mineno, Masahiro; Sera, Misayo; Ueda, Tsuyoshi; Mizuno, Masahiro; Yamano, Mitsuhisa; Mizufune, Hideya; Zanka, Atsuhiko; Tetrahedron; vol. 70; 35; (2014); p. 5550 – 5557;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 19798-77-7, 4-Amino-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19798-77-7, blongs to pyridine-derivatives compound. Recommanded Product: 19798-77-7

EXAMPLE 60 7-[(3-chloropyridin-4-yl)amino]-5-{[2-metlioxy-4-(piperazin-l -yl)phenyl]amino}pyrid d]pyridazin-4(3H)-one EXAMPLE 60A tert-butyl 4-(4-(7-(3 hloropyridin-4-ylamino)-4-oxo-3,4-dihydropyrido|3,4-i ]pyridazin-5- ylamino)-3-methoxyphenyl)piperazine- l -carboxylate A mixture of EXAMPLE 24A (160 mg, 0.33 mmol), 3-chloropyridin-4-amine (65 mg, 0.45 mmol), tris(dibenzylideneacetone)dipalladium (30 mg, 0.03 mmol),dimethylbisdiphenyl phosphinoxanthene (20 mg, 0.03 mmol), potassium r/-butoxide (1 12 mg, 1 mmol) and /erf-butanol (2 mL) was bubbled with nitrogen and heated at 100C for 18 hours. The mixture was concentrated and the residue was dissolved in dichloromethane, washed with saturated aqueous sodium bicarbonate and brine, dried over sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with 98/2 dichloromethane/methanol to give the title compound. MS : 579 (M + H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-77-7, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13535-01-8 ,Some common heterocyclic compound, 13535-01-8, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 3-amino-5-bromo pyridine (XX) (1.0 g, 5.78 mmol) in dry pyridine (10 mL) was added pivaloyl chloride (XXI) (769 mg, 6.38 mmol). The reaction mixture was stirred at room temperature for 3 h. The reaction was poured into an ice water/saturated aqueous NaHCO3 mixture and stirred for 30 min. The precipitate was filtered, washed with cold water and dried at room temperature to yield N-(5-bromopyridin-3-yl)pivalamide (XXII) as an off- white solid (1.082 g, 4.22 mmol, 73.1% yield). 1H NMR (DMSO-d6, 500 MHz) delta ppm 1.23 (s, 9H), 8.37 (d, J=2Hz, 1H), 8.39 (t, J=2Hz, 1H), 8.80 (d, J=2Hz, 1H), 9.58 (brs, 1H); ESIMS found C10H13BrN2O m/z 258.9 (Br81M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13535-01-8, 5-Bromopyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAMUMED, LLC; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (322 pag.)WO2016/40193; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 929617-35-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929617-35-6, name is 5-Bromo-1H-pyrazolo[3,4-c]pyridine, molecular formula is C6H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirred solution of 5-bromo-1H-pyrrolo[2,3-c]pyridine (500 mg, 2.53 mmol) in DMF (5 mL), K2C03(875 mg, 6.345 mmol) was added. After 10min, ferf-butyl 3-bromopropylcarbamate (724 mg, 3.045 mmol) was added and the reaction mixture was heated at 60C for 26h. The reaction mixture was cooled to RT, poured into ice water and extracted with EtOAc (2 x100 mL). The organic layer was washed with brine solution (2 x 20 mL), dried over anhydrous Na2SO4, filtered and the filtrate was concentrated to dryness. The crude compound was triturated with n-pentane to afford the title compound (200 mg, 27%) as a yellow solid. LC-MS (method 1): Rt = 2.15 min; m/z = 354.18 (M+H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 929617-35-6, 5-Bromo-1H-pyrazolo[3,4-c]pyridine.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 74115-13-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74115-13-2, name is 5-Bromo-3-pyridinol, molecular formula is C5H4BrNO, molecular weight is 174, as common compound, the synthetic route is as follows.

An aqueous sodium hypochlorite solution (5% chlorine, 43 mL) was added to a solution of 5-bromopyridin-3-ol (5.0 g) and sodium hydroxide (1.3 g) in water (50 mL) at room temperature, and the mixture was stirred overnight. After addition of an additional aqueous sodium hypochlorite solution (5% chlorine, 10 mL), the mixture was stirred at room temperature for 3 hr. The reaction mixture was neutralized with acetic acid, and the resulting precipitate was collected by filteration to give the title compound (4.54 g) as a light brown solid, which included 5-bromo-2,4-dichloropyridin-3-ol as a byproduct. The solid was subjected to the next reaction without further purification. 1H NMR (400 MHz, CHLOROFORM-d) delta 7.49 (1H, s), 8.06 (1H, s).

The chemical industry reduces the impact on the environment during synthesis 74115-13-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Takeda Pharmaceutical Company Limited; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; KINA, Asato; EP2848622; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem