Tag: M.W:100-200

Application of 18437-58-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18437-58-6, name is 4-Amino-2-picoline, molecular formula is C6H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Amino-2-methylpyridine (0.522 g, 4.8 mmol) and CuCl2 (0.324 g, 2.1 mmol) were added to a solution of 4 ml of conc. aq. HCl in 20 ml of 1-propanol to give a green solution. Slow evaporation at room temperature over the course of 3 weeks yielded yellow crystals which were isolated by filtration, washed with a small amount to cold 1-propanol, and air-dried to give 0.61 g (58%). IR (KBr) nu 3383m, 3319m, 3244m, 3212m, 3121m, 2984m, 1659s, 1614s, 1522m, 1239 m cm-1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18437-58-6, 4-Amino-2-picoline.

Reference:
Article; Wikaira, Jan L.; Landee, Christopher P.; Ludy, Sarah J.; Turnbull, Mark M.; Polyhedron; vol. 52; (2013); p. 770 – 780;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6602-32-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6602-32-0 as follows.

Example 33; K2CO3 Part A; Compound 936A (5.00 g, 28.7 mmol) and potassium carbonate (7.90 g, 57.5 mmol) were dissolved in water (66 ml_) and iodine (7.51 g, 29.6 mmol) was added. The reaction was allowed to proceed at rt for 3 d. Excess iodine was quenched by addition of solid sodium bisulfite. The pH of the solution was adjusted to -5-6 using glacial acetic acid. A solid formed during the process and was collected by filtration and dried in vacuo. The desired product, Compound 936B, was obtained as a light gray solid (8.25 g, 96% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6602-32-0, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; KOZLOWSKI, Joseph, A.; YU, Wensheng; WONG, Michael, K.C.; KIM, Seong-Heon; TONG, Ling; LAVEY, Brian, J.; SHANKAR, Bandarpalle, B.; YANG, De-Yi; FELTZ, Robert; KOSINSKI, Aneta, Maria; ZHOU, Guowei; RIZVI, Razia, K.; DAI, Chaoyang; FIRE, Luke; GIRIJAVALLABHAN, Vinay, M.; LI, Dansu; POPOVICI-MULLER, Janeta; RICHARD, Judson, E.; ROSNER, Kristin, E.; SIDDIQUI, M., Arshad; YANG, Liping; WO2010/54279; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1452-63-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1452-63-7, name is Picolinohydrazide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of appropriate carboxylic acid hydrazide 1a-1h(0.01 mol) and allylisocyanate (0.01 mol) in 15 ml diethyl ether waskept for 48 h at room temperature. Obtained product was filteredoff and washed with diethyl ether and water. After drying semicarbazidederivatives were crystallized from ethanol.

According to the analysis of related databases, 1452-63-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Drozd, Monika; Ginalska, Grazyna; Karczmarzyk, Zbigniew; Kowalczuk, Dorota; Morawiak, Maja; Pitucha, Monika; Swatko-Ossor, Marta; Urbanczyk-Lipkowska, Zofia; Wysocki, Waldemar; Journal of Molecular Structure; vol. 1219; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 74784-70-6

Phenyl chloroformate (620mg, 3.96 mmol) was added to a solution of 5-(trifluoromethyl)pyridin-2-amine (615 mg, 3.79 mmol) and pyridine (323 mg, 4.08 mmol) in ACN (50 mL) at 0C. After stirring the solution overnight at room temperature, the reaction was quenched with H20. The resulting precipitate was filtered, dried and used without further purification. The product was a white solid (905mg, 3.21 mmol, 84% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 74784-70-6, 5-(Trifluoromethyl)pyridin-2-amine.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HAMMOCK, Bruce; KODANI, Sean; (110 pag.)WO2017/160861; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1594-57-6, name is N-Hydroxyisonicotinimidamide, molecular formula is C6H7N3O, molecular weight is 137.14, as common compound, the synthetic route is as follows.category: pyridine-derivatives

Example 1: 4- (3-Pyridin-4-yl- [1, 2,4] oxadiazol-5-ylmethoxy) piperidine-1-carboxylic acid tert- butyl ester A stirred solution of triethylamine (123mul, 0. 87mmol) and 4-carboxymethoxypiperidine- 1-carboxylic acid tert-butyl ester (Preparation 1,227mg, 0. 87mmo1) in toluene (10ml) was treated with isobutylchloroformate (113mul, 0. 87mmol). After 20min, activated powdered 3A molecular sieves (0.7g) andN-hydroxyisonicotinamidine (lOOmg, 0. 73mmol) were added and the mixture heated under reflux for 18h. On cooling, the mixture was filtered through celite, the solvent removed in vacuo and the residue purified by flash chromatography (IH-EtOAc, 7: 13) to afford the title compound: RT = 3. 29min ; m/z (ES+) 361.3 [M+H] + ; OH (CDC13) 1.40 (9H, s), 1.55-1. 63 (2H, m), 1.80-1. 92 (2H, m), 3.05-3. 15 (2H, m), 3.64-3. 79 (3H, m), 4.80 (2H, s), 7.90 (2H, d), 8.75 (2H, d).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1594-57-6, N-Hydroxyisonicotinimidamide, and friends who are interested can also refer to it.

Reference:
Patent; PROSIDION LIMITED; WO2005/61489; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3430-17-9, name is 2-Bromo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Bromo-3-methylpyridine

General procedure: To a 10-mL reaction vial, heteroaryl halide (1.0 mmol), boronic acid (1.2 mmol), K3PO4 (2.0 mmol), tetra-butylammonium bromide (TBAB) (0.5 mmol), and 4 (0.1 mol %) in water (3.5 mL) were added. The reaction mixture was stirred at 85 C and the reaction progress was monitored by GC-MS analysis. After completion of the reaction, it was diluted with H2O and CH2Cl2. The organic layer was separated from mixture, the dried organic layer over MgSO4, and evaporated under reduced pressure. The crude reaction product was purified using column chromatography on silica-gel to afford the corresponding product with isolated yield up to 98%.

With the rapid development of chemical substances, we look forward to future research findings about 3430-17-9.

Reference:
Article; Taher, Abu; Lee, Dong-Jin; Lee, Ik-Mo; Rahman, Md. Lutfor; Sarker, Md Shaheen; Bulletin of the Korean Chemical Society; vol. 37; 9; (2016); p. 1478 – 1485;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 19621-92-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below.

Compound 1-193[00475] Compound 1-193 was synthesized as a yellow solid (33%) via the condensation of Compound 1-107 (1 equiv) with 6-hydroxypicolinic acid (3.0 equiv), HATU (2.5 equiv) and Hunig’s base (5 equiv) in acetonitrile at 45 C. Purification was carried out using Si02 chromatography employing a 0-40% (7:1 acetonitrile/MeOH)/DCM gradient following a DCM and sodium bicarbonate-based work-up.1H NMR (400 MHz, CD3OD) 8.85 (d, IH), 8.82-8.79 (m, 2H), 8.47 (s, IH), 8.02-7.98 (m, 2H), 7.62 (s, IH), 7.35-7.27 (m, IH), 7.14-7.06 (m, 2H), 7.05-6.95 (m, IH), 6.93 (d, IH), 6.04 (s, 2H) ppm. 1H NMR (400 MHz, CD3OD) 8.81 (d, IH), 8.45 (s, IH), 7.85-7.77 (m, IH), 7.77-7.40 (bs, IH), 7.55 (s, IH), 7.33-7.27 (m, IH), 7.13-7.05 (m, 2H), 6.98-6.93 (m, IH), 6.91 (d, IH), 6.91-6.86 (m, IH), 6.01 (s, 2H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19621-92-2, its application will become more common.

Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; KIM, Charles; NAKAI, Takashi; WAI-HO LEE, Thomas; MOORE, Joel; PERL, Nicholas, Robert; ROHDE, Jason; IYENGAR, Rajesh, R.; MERMERIAN, Ara; WO2012/3405; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89466-16-0 ,Some common heterocyclic compound, 89466-16-0, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of scheme 8-38 compound S1 (1 g, 3.89 mmol) and 6-bromo-3-methylpyridin-2-amine (870 mg, 4.67 mmol) in DCE (10 ml) was added DIPEA (2.56 mL, 15.56 mmol) and EEDQ (1.92 g, 7.78 mmol). The reaction was stirred at 90 C. overnight. The solvent was removed under vacuum. The residue was purified by column chromatography on silica gel (petroleum ether: ethyl acetate=2:1) to afford compound 2 (710 mg, 43.0% yield) as a white solid. LC/MS (ESI) m/z: 426 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89466-16-0, 6-Bromo-3-methylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6313-54-8 ,Some common heterocyclic compound, 6313-54-8, molecular formula is C6H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 1; SYNTHESIS OF 2-[4-(5-FLUORO-2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]ISONICOTINIC ACID METHYL ESTER; A. A mixture of 2-chloroisonicotinic acid (1.000 g, 6.340 mmol) and 5 drops of concentrated sulfuric acid in anhydrous methanol (50 mL) was refluxed for 3 hours. The reaction mixture was concentrated in vacuo, diluted with 20 mL of water and extracted with ethyl acetate. The organic phase was washed with water and brine, dried and concentrated. The compound obtained was used for next step reaction without further purification. Yield 0.816 g, 75%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6313-54-8, 2-Chloroisonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; XENON PHARMACEUTICALS INC.; US2008/167321; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132865-44-2, name is 5-Chloro-6-methoxynicotinaldehyde, the common compound, a new synthetic route is introduced below. Computed Properties of C7H6ClNO2

A mixture of 5-chloro-6-methoxynicotinaldehyde (59.56 mg, 0.347 1 mmol), 4-(2-(3,6- diazabicyclo[3. 1.1 ]heptan-3 -yl)pyrimidin-5 -yl)-6-(2-morpholinoethoxy)pyrazolo[ 1,5 -a]pyridine3-carbonitrile (Intermediate P117; 31 mg, 0.069 mmol) and NaBH(AcO)3 (147.1 mg, 0.6943 mmol) in DCM (694.3 tL) was stirred overnight at ambient temperature. The reaction mixture was purified directly by silica chromatography (using 0-10% MeOH in EtOAc with 0.1% NH4OH as the gradient eluent) to cleanly afford the title compound (15.19 mg, 35% yield). MS (apci) m/z = 602.3 (M+H).

The synthetic route of 132865-44-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; TANG, Tony P.; REN, Li; (668 pag.)WO2018/71447; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem