Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5975-12-2, name is 2,4-Dichloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H2Cl2N2O2

Step 1 2-chloro-3-nitro-4-[2-(2-thiophenyl)ethyl]aminopyridine A mixture of 2,4-dichloro-3-nitropyridine (1.5 g), 2-aminoethylthiophene (1 g) and triethylamine (5 ml) is heated to reflux in EtOH (60 ml). The reaction mixture is cooled, the solvent evaporated and the residue chromatographed on silica gel (10% hexane/CH2 Cl2) to yield the desired addition product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5975-12-2, 2,4-Dichloro-3-nitropyridine.

Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5364862; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 953780-42-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 953780-42-2, name is 5-Fluoro-6-methoxynicotinic acid. A new synthetic method of this compound is introduced below.

Triethylamine (267 mul), tert-butanol (230 mul), and DPPA(413 mul) were added to a toluene (5 ml) solution containing 5-fluoro-6-methoxynicotinic acid (275 mg), followed by reflux for 3 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate. Subsequently, the solvent was distilled away under reduced pressure, the obtained residue was purified by silica gel chromatography (n-hexane : ethyl acetate = 10:1 to 3:1), and colorless oily matter of tert-butyl(5-fluoro-6-methoxypyridin-3-yl)carbamate (279 mg) was thus obtained. MS (ESI m/z): 243 (M+H) RT (min): 1.46

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,953780-42-2, its application will become more common.

Reference:
Patent; FUJIFILM Corporation; FUJIWARA, Hideyasu; SATO, Kimihiko; MIZUMOTO, Shinsuke; SATO, Yuichiro; KURIHARA, Hideki; KUBO, Yohei; NAKATA, Hiyoku; BABA, Yasutaka; TAMURA, Takashi; KUNIYOSHI, Hidenobu; HAGIWARA, Shinji; YAMAMOTO, Mari; (630 pag.)EP2589592; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1072-97-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-97-5, name is 5-Bromopyridin-2-amine. A new synthetic method of this compound is introduced below.

Step 1 – Synthesis of 6-bromoimidazo[l,2-] yridine [0251] To a solution of 5-bromopyridin-2-amine (2 g, 11.6 mmol) in ethanol (20 mL) was added 2-chloroacetaldehyde (2.00 g, 25.5 mmol) at room temperature and heated to reflux overnight. The reaction was cooled and concentrated and the resulting solid diluted with saturated sodium bicarbonate and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated to afford 6- bromoimidazo[l,2-a]pyridine as a brown solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-97-5, 5-Bromopyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas D.; VAN HUIS, Chad A.; MACLEAN, John K.; ANDRESEN, Brian M.; BARR, Kenneth J.; BIENSTOCK, Corey E.; ANTHONY, Neville J.; DANIELS, Matthew; LIU, Yuan; WHITE, Catherine M.; LAPOINTE, Blair T.; SCIAMMETTA, Nunzio; SIMOV, Vladimir; TROTTER, Wesley, B.; LIU, Kun; WO2015/95788; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 68470-59-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, molecular weight is 186.0491, as common compound, the synthetic route is as follows.

Step B: Preparation of 3 -iodo- 1 -((6-methylpyridin-2-yl)methyl)-4-nitro- 1 H- indazole: To a solution of 3-iodo-4-nitro-lH-indazole (172 mg, 0.596 mmol) in dry DMF (3 mL) under an atmosphere of dry nitrogen was added 2-(bromomethyl)-6-methylpyridine (122 mg, 0.656 mmol) and potassium carbonate (165 mg, 1.19 mmol) with stirring. The mixture was stirred at ambient temperature for 3 days. The reaction mixture was diluted with water (20 mL) and extracted into ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting material was purified using preparative chromatography on silica, eluting with hexane/ethyl acetate (3: 1) to give 3-iodo-l-((6-methylpyridin-2- yl)methyl)-4-nitro-lH-indazole (213 mg).

Statistics shows that 68470-59-7 is playing an increasingly important role. we look forward to future research findings about 2-(Bromomethyl)-6-methylpyridine.

Reference:
Patent; ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian; WO2012/82689; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13534-98-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13534-98-0, name is 4-Amino-3-bromopyridine. A new synthetic method of this compound is introduced below.

To a lOOmL reaction flask was added 3-bromo-4-amino-pyridine (1.73 g, lOmmol), p-fluorobenzeneboronic acid (1.68 g, 12 mmol), anhydrous sodium carbonate (1.59 g, 15 mmol), dioxane (20 mL), and water (10 mL) were replaced with nitrogen, The reaction was carried out for about 3 hours. After completion of the reaction, water (20 mL) was added, extracted three times with ethyl acetate (3 X 20 mL), and the mixture was stirred at room temperature The layers were combined, dried over anhydrous sodium sulfate, filtered and steamed off Column 31 (1.738) yield 92% yield. ]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13534-98-0, 4-Amino-3-bromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; Chengdu Haichuang Pharmaceutical Co., Ltd.; Fan Lei; Du Wu; Li Xinghai; Chen Yuanwei; Xu Kexin; Chen Ke; Zhang Shaohua; Luo Tongchuan; (40 pag.)CN106831556; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 59663-96-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59663-96-6, name is Ethyl 4-(hydroxymethyl)picolinate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 13.9 g of ethyl 4-(hydroxymethyl)-pyridine-2-carboxylate, 5 g platinum oxide in 250 ml acetic acid is hydrogenated at 50 lbs/in2. Filtration, concentration in vacuo, and neutralization with potassium carbonate in methylene chloride yields an oil that is purified by flash chromatography using methylene chloride/methanol saturated with ammonia (20:1) to yield ethyl 4-(hydroxymethyl)-piperidine-2-carboxylate.

According to the analysis of related databases, 59663-96-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ciba-Geigy Corporation; US4906621; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.171919-36-1, name is 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde, molecular formula is C9H8N2O, molecular weight is 160.17, as common compound, the synthetic route is as follows.COA of Formula: C9H8N2O

c) 1-Methyl-3-(methylaminomethyl)-1H-pyrrolo[2,3-b]pyridine According to the procedure of Preparation 40 (c), except substituting 1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.4 g, 2.5 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.2 g, 45%) was prepared as a yellow oil: MS (ES) m/e 176 (M + H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,171919-36-1, 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Affinium Pharmaceuticals, Inc.; EP1226138; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 846021-26-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 846021-26-9, name is 2-Amino-6-methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-6-methyl nicotinic acid (3.04 g) was suspended in N,N-dimethylformamide (60 mL), and potassium carbonate (5.53 g) was added to the suspension, followed by stirring at 40 C. for 30 minutes. Solution (I) was dropwise added to the resulting suspension, followed by stirring with heating at 80 C. for 2 hours. The reaction solution was cooled to room temperature, and the N,N-dimethylformamide (45 mL, 64%) was removed by distillation under reduced pressure. Iced water (100 mL) was added to the residue, followed by stirring at room temperature for minutes. Precipitated crystals were collected by filtration and were dried to give 6.42 g (yield: 92%) of the target product (Compound 4 shown in Table 1). According to purity analysis by liquid chromatography, the purity of thus obtained target product was high, 99.1%. A melting point thereof was 94 C. to 96 C.10058] ?H-NMR (CDC13) oeppm: 2.33 (3H, s), 2.40 (3H, s), 5.27 (2H, s), 6.08-6.82 (2H, br), 6.44 (1H, d), 6.90-7.00 (5H, m), 7.14 (2H, d), 7.37 (2H, d), 8.02 (1H, d)

According to the analysis of related databases, 846021-26-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGRO-KANESHO CO., LTD.; AIZAWA, Ryo; OKADA, Itaru; (8 pag.)US2016/318868; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52313-50-5, Picolinimidamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 52313-50-5, blongs to pyridine-derivatives compound. Safety of Picolinimidamide

Example 90 5-(2-Fluoro-4-methoxy-benzyl)-2-pyridin-2-yl-pyrimidine-4,6-diamine In a similar fashion using route 17 general procedure 55, pyridine-2-carboxamidine (100 mg, 0.83 mmol), 2-(2-fluoro-4-methoxy-benzyl)-malononitrile (186 mg, 0.91 mmol) and NaOMe (89 mg, 1.65 mmol) gave the title compound (14 mg, 5%) after purification by trituration from MeCN/Et2O.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52313-50-5, its application will become more common.

Reference:
Patent; VIFOR (INTERNATIONAL) AG; US2012/202806; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 5-(Trifluoromethyl)pyridin-2-amine

To a solution of phenyl carbonochloridate (1.72 g, 1 1.0 mmol) in dichloromethane (20.0 ml_) was added 5-(trifluoromethyl)pyridin-2-amine (1.62 g, 10.0 mmol) at room temperature under N2. Pyridine (0.870 g, 1 1.0 mmol) was then added to the reaction at 0 C and the resulting mixture stirred for 0.5 h. The reaction mixture was poured into water and extracted with ethyl acetate followed by drying with sodium sulfate. After concentration, the residue was purified with the column chromatography (eluent: dichloromethane: petroleum ether (1 :2)) to afford 1.2 g of the title compound. NMR (400 MHz, DMSO) d 1 1 .24 (s, 1 H), 8.70 (d, J = 0.9 Hz, 1 H), 8.18 (dd, J = 8.9, 2.3 Hz, 1 H), 7.99 (d, J = 8.8 Hz, 1 H), 7.43 (dd, J = 1 1.0, 4.8 Hz, 2H), 7.31 – 7.18 (m, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 74784-70-6.

Reference:
Patent; SYNGENTA CROP PROTECTION AG; SYNGENTA CHINA INVESTMENT COMPANY LIMITED; SCHAETZER, Juergen, Harry; BIGOT, Aurelien; JUNG, Pierre, Joseph, Marcel; STOLLER, Andre; GAGNEPAIN, Julien, Daniel, Henri; HALL, Roger, Graham; RENDINE, Stefano; LU, Long; YANG, Jianzhong; CHEN, Ruifang; (113 pag.)WO2020/30754; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem