Tag: M.W:100-200

Related Products of 57266-69-0 ,Some common heterocyclic compound, 57266-69-0, molecular formula is C6H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Chloro-2-picolinic acid (47.3 mg, 0.3 mmol), styrene (33 muL, 0.3 mmol), tert-butyl hypochlorite (68 muL, 0.6 mmol) was weighed into a 25 mL Schlenk reaction flask.Then THF (1 mL) was added and placed in a 25 C oil bath for 6 h. After the reaction,The solvent was removed under reduced pressure, using petroleum ether / ethyl acetate as eluent,The yield of the product was 63%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,57266-69-0, its application will become more common.

Reference:
Patent; Dalian University of Technology; Feng Xiujuan; Zhang Xitao; Bao Ming; Yu Xiaoqiang; Zhang Sheng; (24 pag.)CN110105270; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 769-28-8, 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 769-28-8, blongs to pyridine-derivatives compound. Application In Synthesis of 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

To the suspension of 3-cyano-4,6,-dimethyl-2-pyridone (3 g, 0.02 mol) and powdered NaOH (0.80 g, 0.02 mol) in dry DMF (10 ml) stirred at r.t. for 15 min was added 1,3-dibromopropane (2.02 g, 0.01 mol) slowly with constant stirring [41]. The reaction mixture was stirred at room temperature for 12 h. Completion of reaction was confirmed via TLC. There were 3 spots visualized on TLC indicating the formation of region isomers. DMF was removed under reduced pressure using rotavapour and the product was treated with 1:1 CHCl3:H2O system (300 ml). The organic layer was collected and the aqueous layer was washed three times with 300 ml of CHCl3 (100 ml each). The organic layers were combined and washed with water (100 ml) and dried over anhydrous Na2SO4. Column chromatography was done for separation of regioisomers. The first fraction collected at 20% ethyl acetate:hexane was characterized as title compound. This was crystallized with 5% ethyl acetate:hexane and ethyl acetate solution, respectively.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,769-28-8, its application will become more common.

Reference:
Article; Tewari, Ashish Kumar; Singh, Ved Prakash; Dubey, Rashmi; Puerta, Carmen; Valerga, Pedro; Verma, Rajnikant; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 79; 5; (2011); p. 1267 – 1275;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19230-57-0, name is 2-Bromo-3-methylpyridine 1-oxide, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H6BrNO

To a stirred solution of 2-bromo-3-methyl pyridine-1-oxide (25g) and pyridine (42g) in acetonitrile (250mL) at about 70C, was added a solution of trifluoromethanesulfonic anhydride (55g) in acetonitrile (5OmL). The reaction mixture was stirred for about lh atabout the same temperature. The mixture was cooled to about 10C to about 15C and ethanolamine (80.52g) was added to it. The reaction mixture was stirred for about 3h at about room temperature and water and ethyl acetate were added to it. The two layers were separated and the organic layer was washed with saturated brine solution, dried and concentrated under reduced pressure at about 40C. The residue was purified by columnchromatography (15-20% ethyl acetate in hexane). Yield: 4g (16%)?H NIVIR (300IVIHz, CDC13): oe 7.26-7.24 (d,J8.lOHz,1H), 6.42-6.39 (d,J8.4Hz,1H), 4.28 (brs,2H), 2.22 (s,3H)?3CNMR(400MHz, CDC13): 156.52, 141.56, 140.50, 122.99, 107.26, 20.58 IR: 3364, 3199, 2913, 1635, 1601, 1373, 1058, 819 cm4-Amino-2-bromo-3-methyl pyridine (3g) was obtained which was eluted at 25-30% ethyl acetate in hexane.?H NIVIR (300IVIHz, CDC13): oe 7.82-7.80 (d,J5.4Hz,1H), 6.48-6.46 (d,J 5.4Hz,1H), 4.35 (brs,2H), 2.21 (s,3H)?3CNMR(400MHz, CDC13): 152.70, 146.94, 145.05, 116.88, 109.25, 15.73

With the rapid development of chemical substances, we look forward to future research findings about 19230-57-0.

Reference:
Patent; GLENMARK PHARMACEUTICALS LIMITED; BHIRUD, Shekhar Bhaskar; KADAM, Suresh Mahadev; KANSAGRA, Bipin Parsottam; BHADANE, Shailendra Nilkanth; KALE, Shrikrishna Kantilal; PATIL, Ulhas Digambar; (57 pag.)WO2017/56031; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 174610-12-9, name is 1H-Pyrrolo[2,3-c]pyridin-5-amine, the common compound, a new synthetic route is introduced below. Product Details of 174610-12-9

General procedure: To a solution of the corresponding amine (4 or 5, 1.2 equiv), dihalo-substituted benzoic acid (2c, 2d, 2e or 2f, 1.0 equiv), and 1-hydroxybenzotriazole hydrate (HOBt, 1.2 equiv) in DMF (8.0-10.0mL/mmol; extra dry over molecular sieves, 99.8%, Acros) were added EDC-HCl (1.2 eqiv) and DIPEA (2.5 equiv). The mixture was stirred at room temperature until completed conversion (TLC control: CH2Cl2/MeOH 9/1 v/v). Then, the solvent was removed in vacuo and the residue washed with water (20mL/mmol) and dried at 70C. The crude product was purified by column chromatography on silica gel (eluent: CH2Cl2/MeOH 9/1 v/v) following by reversed phase HPLC (for purification methods, see Supporting Information, TableS2) and/or recrystallization as described below.

The synthetic route of 174610-12-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tzvetkov, Nikolay T.; Stammler, Hans-Georg; Hristova, Silvia; Atanasov, Atanas G.; Antonov, Liudmil; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 793 – 809;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 138116-34-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 138116-34-4 as follows.

Step 5: To a stirred solution of (4-aminopyridin-3-yl)methanol (200 mg, 1.61 mmol) in dimethylformamide were added imidazole (219 mg, 3.22 mmol, 2 eq) and tert-butyldimethylchlorosilane (267 mg, 1.77 mmol, 1.1 eq). The reaction mixture was stirred at room temperature for 5 h. The mixture was dissolved in ethylacetate and washed with water several times. The organic layer was dried over MgSO4 and filtered. The filtrate was removed in vacuo. The crude was purified by column chromatography get 3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-amine (325 mg, 85%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,138116-34-4, its application will become more common.

Reference:
Patent; Gruenenthal GmbH; FRANK, Robert; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo; US2013/29961; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 101066-61-9, 2-Chloroisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A slurry of 2-chloro-4-formylpyridine (1.49 Kg, 10.5 mole, 1.05 equiv), 2-aminothiazole (1.27 Kg, 10.0 mole, 1.0 equiv), K3PO4 (2.34 Kg, 11.0 mole, 1.1 equiv) in toluene (20 L) is degassed by two vacuum/nitrogen cycles. Pd2(dba)3 (114.5 g, 0.125 mmol, 2.5mol % Pd) and Xantphos (159 g, 0.275 mole, 2.75mol %) are then added and the mixture is degassed by one vacuum/nitrogen cycle followed by bubbling nitrogen through the slurry for 10 minutes. The mixture is heated to 60 C. and degassed water (90 mL, 5.0 mole, 0.5 equiv) was added over 5 minutes. The mixture is then heated to 90 C. and aged for 8 h. [0227] It is cooled to rt and filtered. The filter cake is washed with toluene (20 L) until very little DBA is observed in the wash. DMAc (24 L) is added to the filter cake to dissolve the product. The insoluble is filtered off and washed with more DMAc (6 L). The filtrate is acidified with concentrate HCl (110 mL) to pH 2.7. Water (3 L) is added and the mixture is concentrated at 40-50 C. under vacuum to remove most of the residual toluene by azeotropic distillation. More water (3 X 1L) is added as the distillation progress. [0228] The mixture is seeded and then water (13 L) is added at a rate of about 1.3 L/h. The product is filtered and washed with 5/4 DMAc/water (4.0 L X 2), water (4.0 L), acetone (4 L X 2), and then oven dried at 40 C. under vacuum (100 mmHg) with nitrogen sweep to give the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101066-61-9, 2-Chloroisonicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Zhao, Matthew M.; Bilodeau, Mark T.; US2004/23980; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 7356-60-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7356-60-7, name is Nicotinimidamide hydrochloride, molecular formula is C6H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3: To a solution of nicotinamidine hydrochloride (1 g, 6.35 mmol) in anhydrous DMF (12 mL) is added sodium salt of 2-dimethoxymethyl-3-hydroxy-acrylicacid methyl ester (1.46 g, 7.36 mmol) and the reaction mixture is heated at 1000C under N2 for 3 hours. After this time the reaction is cooled to room temperature and water (48 mL) is added. The precipitate is collected by filtration, washed with water and vacuum dried to afford 2-pyridin-3-yl- pyrimidine-5-carboxylic acid methyl ester (0.7 g, 51%). MS: 216 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7356-60-7, Nicotinimidamide hydrochloride.

Reference:
Patent; SANOFI-AVENTIS; WO2008/121670; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58481-11-1, name is Methyl 2-chloroisonicotinate, molecular formula is C7H6ClNO2, molecular weight is 171.58, as common compound, the synthetic route is as follows.Recommanded Product: Methyl 2-chloroisonicotinate

To a suspension of lithium aluminum hydride (221 mg) in Et2O (10.0 mL) cooled to -40C was added methyl 2-chloroisonicotinate (1.00 g) in Et2O (2 mL) dropwise and the mixture was stirred at -4 0C for 30 min and quenched with water. The aqueous layer was extracted with EtOAc three times. The combined organic layer was washed with aqueous saturated NaCl, dried over MgSO4, filtered, and concentrated under reduced pressure to give (2-chloropyridin-4-yl)methanol (641 mg) as a pale brown solid.1HNMR (300 MHz, CDCl3, delta): 2.81-2.93 (m, IH), 4.72-4.80 (m, 2H), 7.17-7.26 (m, IH), 7.34-7.41 (m, IH), 8.30 (dd, J= 5.1, 0.6 Hz5 IH); ESI MS m/z 144 (M++., 100percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58481-11-1, Methyl 2-chloroisonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; ARENA PHARMACEUTICALS, INC.; WO2006/35967; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 93683-65-9, 6-Chloro-3-nitropicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 93683-65-9, blongs to pyridine-derivatives compound. Product Details of 93683-65-9

To a 1 L flask was added 2 (20.0 g, 108.8 mmol), 400 mL CH2Cl2,TBAB (16 g, 52 mmol) and a solution of rongalite (140.4 g /400 mL H2O) in proper order, the suspension wasstirred acutely at room temperature for 2 hours, after addition of another 75.2 g rongalite, the reaction mixturewas kept stirred for another 1.5 hours. After the reaction, the mixture was neutralized with saturated potassiumcarbonate and stirred for 30 minutes, then the mixture was poured into separator funnel and separated to obtainthe organic phase, the aqueous phase was extracted with CH2Cl2 (300 mL ×2), the organic phase was collectedand dried with MgSO4. After concentrating to saturate state, it was salified with hydrogen chloride saturated indiethyl ether. The white solid appeared was filtered, dissolved in water and precipitated absolutely with additionof aqueous ammonia. The mixture was filtered again to yield 14.6 g white solid (40%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,93683-65-9, its application will become more common.

Reference:
Article; Fan, Yin-Bo; Li, Kun; Huang, Min; Cao, Yu; Li, Ying; Jin, Shu-Yu; Liu, Wen-Bing; Wen, Jia-Chen; Liu, Dan; Zhao, Lin-Xiang; Bioorganic and Medicinal Chemistry Letters; vol. 26; 4; (2016); p. 1224 – 1228;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1822-51-1, 4-(Chloromethyl)pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H7Cl2N, blongs to pyridine-derivatives compound. Computed Properties of C6H7Cl2N

General procedure: Intermediate 9a (or 9b, 0.5 mmol) was dissolved in anhydrous DMF (10 mL) in the presenceof anhydrous K2CO3 (0.14 g, 1 mmol), followed by addition of appropriate substituted benzyl chloride (or 4-picolyl chloride hydrochloride) (0.5 mmol). The reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, and water (20 mL) was added. Extracted with ethyl acetate (2 × 10 mL), and the organic phase was washed with saturated sodium chloride solution (10 mL), and dried over anhydrous Na2SO4, which was purified by flash column chromatography to afford title compounds 10a1~a3 and 10b1~b3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1822-51-1, 4-(Chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Article; Chen, Xuwang; Liu, Xin; Meng, Qing; Wang, Ding; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Balzarini, Jan; Liu, Xinyong; Bioorganic and Medicinal Chemistry Letters; vol. 23; 24; (2013); p. 6593 – 6597;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem