Tag: M.W:100-200

Synthetic Route of 105250-17-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 105250-17-7 as follows.

To a solution of 4-nitronaphthalen-1-ol (2) (5.17 g, 27.3 mmol), PPh3 (10.75 g, 41.0 mmol) and 2-aminopyridine-4-methanol (1) (5.09 g, 41.0 mmol) in THF (50 mL) was added dropwise DIAD (8.07 mL, 41.0 mmol) at -15¡ã C.The mixture was stirred overnight at RT and the volatiles were removed in vacuo.The crude product was triturated from EtOAc (150 mL) and was collected by filtration and washed with EtOAc (100 mL).A second trituration from MeOH (100 mL) gave 2-amino-4-((4-nitronaphthalen-1-yloxy)methyl)pyridine (3) (4.54 g, 56percent) as a yellow solid: m/z 296 (M+H)+ (ES+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,105250-17-7, its application will become more common.

Reference:
Patent; Charron, Catherine Elisabeth; Fenton, Robert; Crowe, Scott; Ito, Kazuhiro; Strong, Peter; Rapeport, William Garth; Ray, Keith; US2012/244120; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 21717-96-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 21717-96-4, name is 2-Amino-5-fluoropyridine, molecular formula is C5H5FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

NBS (10 g, 56.2 mmol) was added slowly to a solution of 5-fluoro-pyridin-2- ylamine (55) (12.4 g, 56.2 mmol) in MeCN (200 mL). The reaction mixture was stirred at RT overnight. After completion, the solution was filtered and the filtrate was concentrated to obtain a residue, which was purified by silica gel chromatography (10%> to 20%> EtOAc in petroleum ether) to give 3-bromo-5-fluoro-pyridin-2-ylamine (56) (5.2 g, 27.2 mmol, 31%> yield) as a yellow solid.ESI-MS (M+l): 191 calc. for C5H4BrFN2 190.

According to the analysis of related databases, 21717-96-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge; WO2011/143365; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141-86-6, name is 2,6-Diaminopyridine, the common compound, a new synthetic route is introduced below. name: 2,6-Diaminopyridine

N,N’-(pyridine-2,6-diyl)bis(2,2-dimethylpropanamide) (S17). Trimethylacetyl chloride (4.40mL, 36 mmol) was added to a stirred solution of 2,6 diaminopyridine (1.64 g, 15 mmol) andtriethylamine (6.30 mL, 45 mmol) in dichloromethane at 0 C. The solution was allowed to stir atroom temperature for 21 hours. The reaction mixture was washed with water and back extractedwith dichloromethane. The product was purified by column chromatography eluting with 20%ethyl acetate/hexanes to yield S17 (3.67, 13.2 mmol, 88%) as a light yellow solid.Rf: 0.28 (20% ethyl acetate/hexanes).1H NMR (600 MHz, CDCl3): delta =7.92 (d, J = 8.1 Hz, 2H), 7.73 (s, 2H), 7.69 (t, J = 8.1 Hz, 1H),1.32 (s, 18H)13C NMR (150 MHz, CDCl3): delta = 176.9, 149.8, 140.9, 109.5, 39.9, 27.6

The synthetic route of 141-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 118289-17-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 118289-17-1, name is 2-Bromopyridine-4-carboxaldehyde, molecular formula is C6H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 102 (method 2) (Synthetic Intermediate)(2-Bromo-pyridin-4-yl)-[5-(4-dimethylamino-piperidin-1-yl)-1-(2-trimethylsilanyl- ethoxymethyl)-1 H-benzoimidazol-2-yl]-methanone (as a mixture with the 6- regioisomer). Starting with Example 25, Step 1 was performed by following procedures describe for Example 42. Step 2 and Step 3 were performed by following procedures describe for Example 48.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 118289-17-1, 2-Bromopyridine-4-carboxaldehyde.

Reference:
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7579-20-6, name is 3-Aminoisonicotinic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

Preparation 19 2-Methyl-3-oxa-1,7-diaza-naphthalen-4-one A mixture of 3-aminopyridine-4-carboxylic acid (3.38 g, 24.5 mmol), acetic anhydride (15 mL), and sulfuric acid (3 drops) was refluxed 4 hours. The reaction was cooled and carefully quenched with solid sodium bicarbonate. The mixture was filtered through Celite.(R). (trademark). The filtrate was extracted with ethyl acetate. This organic phase was washed with brine, dried over magnesium sulfate and concentrated to give 2-methyl-3-oxa-1,7-diaza-naphthalen-4-one (1.95 g, 49percent) as a brown crystalline material. 1H NMR delta9.00 (s, 1 H), 8.78 (d, J=5 Hz, 1 H), 7.96 (d, J=5 Hz, 1 H), 2.52 (s, 3 H). The product was suitable for use without further purification.

The synthetic route of 7579-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc; US6323208; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1597-32-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1597-32-6, name is 2-Amino-6-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

NBS (50. Og, 280.99mmol) was added slowly to 6-fluoropyridin-2-amine (30 g, 267.61 mmol) in MeCN (300 mL) cooled to 10-20C over a period of 30 minutes. The resulting solution was stirred at ambient temperature for 60 minutes then the solvent removed under reduced pressure. The residue was diluted with water, the precipitate collected by filtration, washed with water (200 mL) and dried under vacuum to afford the desired material (50.0 g, 98%) as a white solid, which was used without further purification. NMR Spectrum: JH NMR (300MHz, DMSO-d6) delta 6.29 (1H, d), 6.57 (2H, bs), 7.65 (1H, t). Mass Spectrum: m z (ES+)[M+H]+ = 191.

According to the analysis of related databases, 1597-32-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; PIKE, Kurt, Gordon; BARLAAM, Bernard, Christophe; HUNT, Thomas, Anthony; EATHERTON, Andrew, John; (103 pag.)WO2017/46216; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 63071-09-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 63071-09-0, name is 2-Hydroxymethyl-3-methylpyridine. A new synthetic method of this compound is introduced below.

2-Amino-4-(3-methyl-pyridin-2-ylmethoxy)-6-pyrazol-1-yl-pyrimidine-5-carbonitrile From 2-amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile, 3-methyl-2-pyridinemethanol and DBU in DME. ES-MS m /e (%): 308 (M+H+, 100).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63071-09-0, 2-Hydroxymethyl-3-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; Borroni, Edilio Maurizio; Huber-Trottmann, Gerda; Kilpatrick, Gavin John; Norcross, Roger David; US2001/27196; (2001); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2002-04-2, name is 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 2002-04-2

General procedure: 2-Amino-5-(4-pyridinyl)-1,3,4-thiadiazole (0.057 g, 0.32 mmol) was mixed with 3,4-dichlorophenyl isocyanate (0.050 g, 0.027 mmol), dissolved in DMF (1 mL), and heated at 90C for 30 min. The mixture was allowed to cool before quenching with DI water (1 mL) to yield a precipitate.

The synthetic route of 2002-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rosenthal, Andrew S.; Dexheimer, Thomas S.; Gileadi, Opher; Nguyen, Giang H.; Chu, Wai Kit; Hickson, Ian D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 20; (2013); p. 5660 – 5666;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 66093-07-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 66093-07-0, name is 5,6-Dimethylpyridin-3-amine. A new synthetic method of this compound is introduced below.

Under inert atmosphere, 5,6-dimethyl-3-amino-pyridine (512 mg, 4.2 mmol) was dissolved in di- chloromethane (15 ml.) and treated with NEt3 (424 mg, 4.2 mmol). The mixture was cooled to 0 C, treated with a solution of 2-benzyl-2,4-dimethyl-pentanoyl chloride (553 mg, 2.3 mmol) in di- chloromethane (3 ml_), stirred at 0 C for 20 min and subsequently at 25 C over night. Water was added and phases were separated. The aq. phase was extracted with dichloromethane and the combined organic phases were washed with aq. sat. NH4CI solution, aq. sat. NaHCC>3 solution, and brine, dried over MgS04, and evaporated. Column chromatography (S1O2; cyclo- hexane/ethyl acetate 2:1) yielded Target Molecule Ex-80 (550 mg, 73%) as colorless powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,66093-07-0, 5,6-Dimethylpyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; SEET, Michael; WOLF, Antje; MUELLER, Bernd; RIEDIGER, Nadine; FEHR, Marcus; MENTZEL, Tobias; GROTE, Thomas; RUDOLF, Georg Christoph; LOHMANN, Jan Klaas; WINTER, Christian; GRAMMENOS, Wassilios; WIEBE, Christine; TERTERYAN-SEISER, Violeta; ESCRIBANO CUESTA, Ana; (200 pag.)WO2019/154663; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 644-98-4 , The common heterocyclic compound, 644-98-4, name is 2-Isopropylpyridine, molecular formula is C8H11N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 23: Cvclopropanesulfonic acid {17-[2-(6-isopropyl-2-pyridyl)-7-methoxy-8- methyl-quinolin-4-yloxy] – 13 -methyl-2, 14-dioxo-3 , 13 -diaza-tricyclo[ 13.3.0.O4’6] – octadec-7-ene-4-carbonyl} -amide (114). EPO 114A: Synthesis of 2-isopropylpyridine-iV-oxide (104).A mixture of isopropylpyridine (2.1 g, 17.75 mmol) and r¡ã-CPBA (5.0 g, 1.3 eq.) in CH2CI2 was stirred overnight at room temperature. Then, the reaction mixture was diluted with CH2CI2 (twice the volume) and successively washed with aqueous sodium bicarbonate (twice) and brine, dried (Na2SO4) and evaporated to give 2.0 g (85%) of the title compound 104.

The synthetic route of 644-98-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB; WO2007/14926; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem