Tag: M.W:100-200

Related Products of 16063-70-0, Adding some certain compound to certain chemical reactions, such as: 16063-70-0, name is 2,3,5-Trichloropyridine,molecular formula is C5H2Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16063-70-0.

To 30.74 g of potassium tert-butoxide in 100 ml of dimethylsulfoxide, 16.72 g of nitromethane was added dropwise with stirring under cooling with ice, and after the addition, the mixture was stirred at room temperature for another 1 hour. Then, the reaction mixture was cooled with ice again, and to the reaction mixture, 25.00 g of 2,3,5-trichloropyridine in 100 ml of dimethylsulfoxide was added dropwise with stirring, and after the addition, the mixture was stirred at 70 C. for another 6 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, poured into 200 ml of 10% aqueous hydrochloric acid with stirring under cooling with ice and extracted with ethyl acetate (200 ml¡Á1). The resulting organic layer was washed with water (100 ml¡Á1) and dried over saturated aqueous sodium chloride and then anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 5:95 to 10:90) as the eluent to obtain 10.10 g of the desired product as a pale yellow oil

According to the analysis of related databases, 16063-70-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES LIMITED; Iwasa, Motoyoshi; Tomizawa, Mitsutaka; Tsuji, Keisuke; Nakamura, Toshiyuki; Mita, Takeshi; Kuwahara, Hidehito; asahi, Miho; Imanaka, Hotaka; (342 pag.)JP2016/11286; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 106877-33-2, Adding some certain compound to certain chemical reactions, such as: 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine,molecular formula is C6H5F3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106877-33-2.

[0372] A stirred solution of 7-bromo-6-methylquinoline Int-1 (Example 86) (150 mg, 0.675 mmol), 6-(trifluoromethyl)pyridin-3-amine (131 mg, 0.810 mmol) and Na2CC>3 (142 mg, 1.351 mmol) in acetonitrile (5 mL) was degassed with Argon in a microwave vessel for 15 min. Then Mo(CO)6 (178 mg, 0.675 mmol), 3RhoEtaBetaEpsilon4 (19.6 mg, 0.0675 mmol) and Pd(OAc)2 (15.1 mg, 0.0675 mmol) were added, and degassing was continued for additional 10 min. Then the reaction mixture was irradiated in microwave at 90 C for 3 hrs. After completion (checked by TLC), the reaction mixture was diluted with water (20 mL) and extracted with Ethyl Acetate (2×50 mL). Combined organic layer was washed with water (2×20 mL), brine (20 mL) and dried over anhydrous sodium sulfate. The organic layer was evaporated under reduced pressure to afford crude product. The crude compound was purified by Grace (reverse phase) column chromatography using 0.05 % HCOOH in CCN as eluent to afford 50 mg (21% yield) of the desired compound 160 as an off- white solid. MS (ESI) m/z: 332.21 [M+H]+. 1H NMR (DMSO-i/6, 400 MHz): delta 11.18 (s, 1H), 9.07 (d, J = 2.0 Hz, 1H), 8.94 (dd, J = 4.4, 2.0 Hz, 1H), 8.50 (dd, J = 8.0, 1.6 Hz, 1H), 8.35 (dd, J Hz, 1H), 8.24 (s, 1H), 7 ‘.95-7 ‘.92 (m, 2H), 7.60 (dd, J= 8.4, 4.0 Hz, 1H), 2.61 (s, 3H).

According to the analysis of related databases, 106877-33-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTAVALON, INC.; DNEPROVSKAIA, Elena, V.; HOLZWARTH, Michael, S.; RYCHNOVSKY, Scott, D.; (184 pag.)WO2018/85348; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.164666-68-6, name is 6-Chloro-2-methylpyridin-3-amine, molecular formula is C6H7ClN2, molecular weight is 142.59, as common compound, the synthetic route is as follows.Application In Synthesis of 6-Chloro-2-methylpyridin-3-amine

To an ice cold solution of 6-chloro-2-methylpyridin-3-amine (12 g, 84 mmol) and AcOH (5.1 g, 84 mmol) in MeOH (198 g, 250 mL) was dropwise added bromine (13.5 g, 84 mmol). The resulting solution was stirred at ice bath temperature overnight after which it was concentrated under vacuo. The obtained residue was dissolved in EtOAc and sequentially washed with saturated aqueous NaHCO3 solution, 10% Na2S2O3 aqueous solution, brine and dried (Na2SO4). The solvent was removed under vacuo and the obtained crude material was purified by flash chromatography to afford 4-bromo-6-chloro-2-methylpyridin-3-amine (12.6 g). 1H NMR (500 MHz, Chloroform-d) delta 7.30 (s, 1H), 4.04 (brs, 2H), 2.46 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,164666-68-6, 6-Chloro-2-methylpyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; H. Lundbeck A/S; Juhl, Karsten; Jessing, Mikkel; Langgard, Morten; Vital, Paulo Jorge Vieira; Kehler, Jan; Rasmussen, Lars Kyhn; Clementson, Carl Martin Sebastian; Marigo, Mauro; US2019/185489; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 77168-63-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.77168-63-9, name is 4-(Pyridin-4-yl)thiazole-2-thiol, molecular formula is C8H6N2S2, molecular weight is 194.28, as common compound, the synthetic route is as follows.

Reference Example 6 4-(4-pyridyl)-1,3-thiazole-2-thiol sodium salt 4-(4-Pyridyl)-1,3-thiazole-2-thiol (194 g, 1.0 mol) was suspended in methanol (1 L) and a powder of sodium methylate (71.5 g, 1.2 mol) was added at 25OEC. The mixture was stirred for 30 min and the reaction mixture was concentrated under reduced pressure to 50-60 mL. The mixture was preserved overnight in a refrigerator. The precipitated crystals were collected by filtration and dried in vacuo in the presence of phosphorus pentoxide at 40OEC to give the title compound (160 g, 0.74 mol). yield: 74percent.

Statistics shows that 77168-63-9 is playing an increasingly important role. we look forward to future research findings about 4-(Pyridin-4-yl)thiazole-2-thiol.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1310502; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15513-52-7, name is 2,6-Dimethyl-3-nitropyridine, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C7H8N2O2

A solution of 2,6-dimethyl-3-nitropyridine (50 g, 329 mmol) and SeO2 (5.02 g, 27.9 mmol) in dioxane (500 mL) was heated at reflux for 16 hours. The solution was filtered, the solvent removed and the residue purified by column chromatography directly (20% EtOAc/hexanes). The material was recrystalized from ethyl acetate to give 41 g of 6-methyl-5-nitropicolinaldehyde (41 g, 75%), a pale yellow solid; 1HNMR (CDCl3, 400 MHz) delta 2.94(s, 3H), 7.98 (d, J=8.34, 1H), 8.41 (d, J=8.34, 1H), 10.09 (s, 1H). Exact mass calculated for C7H6N2O3: 166.04, found: 167.12 MS m/z (MH+).

With the rapid development of chemical substances, we look forward to future research findings about 15513-52-7.

Reference:
Patent; Jones, Robert M.; Lehmann, Juerg; Wong, Amy Siu-Ting; Hurst, David; Shin, Young-Jun; US2006/155128; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19437-26-4, name is Di(pyridin-2-yl)methanone, molecular formula is C11H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

A mixture of p-toulenesulphonyl hydrazine (200 mg,1.29 mmol) and dipyridyl ketone (238 mg, 1.29 mmol) alongwith two drops of glacial acetic acid was refluxed inmethanol for 6 h (Scheme 1). The solvent was removed usingrotavapor and the product, yellow oily mixture was passedthrough silica gel column using hexane and methanol (1:1)as solvents. The compound was obtained as yellow solid.M.p.: 160C. Yield: (75%). FTIR (KBr pellet, cm-1): 3079nu(C-H), 1631 nu(C=N), 1601 nu(C=C). 1H NMR (DMSO-d6, 400MHz, delta, ppm): 9.24 (d, 1H, JHH = 7.2 Hz), 8.75 (d, 1H,JHH = 4.4 Hz), 8.53 (d, 1H, JHH = 8.8 Hz), 8.37 (d, 1H,JHH = 7.6 Hz), 8.20-8.13 (m, 2H), 7.67 (t, 1H, JHH = 7.6Hz), 7.36 (t, 1H, JHH = 7.6 Hz). UV/Vis (MeOH) lambdamax, nm(epsilon, M-1 cm-1) = 222 (2.12 ¡Á 105), 264 (1.0 ¡Á 105), 306(1.21 ¡Á 105). HRMS (ESI) m/z: calcd.: 196.0749, found: 197.0851 [M+H]+. Anal. Calcd. (%) for C11H8N4C, 67.34;H, 4.11; N, 28.55. Found (%): C, 67.64; H, 3.91; N, 28.75.

With the rapid development of chemical substances, we look forward to future research findings about 19437-26-4.

Reference:
Article; Palepu, Narasinga Rao; Kollipara, Mohan Rao; Journal of Chemical Sciences; vol. 129; 2; (2017); p. 177 – 184;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1184172-46-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1184172-46-0, name is 2-Chloro-3-fluoro-4-hydroxypyridine, molecular formula is C5H3ClFNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Chloro-3-fluoro-4-hydroxypyridine (10 mmol), methyl iodide (20 mmol) and potassium carbonate (20 mmol) in acetone (100 ml) was refluxed overnight. The inorganic salt was filtered and the solvent was evaporated. The residue was purified on column (eluent: ethyl acetate: hexane = 1 :5) to afford a colorless liquid (52%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1184172-46-0, 2-Chloro-3-fluoro-4-hydroxypyridine.

Reference:
Patent; BTG INTERNATIONAL LIMITED; WO2009/103950; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 98549-88-3 ,Some common heterocyclic compound, 98549-88-3, molecular formula is C7H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of formula 8 (R=methyl and X=F, 100 g), formula 7 (152 g), potassium phosphate (190 g),and diglyme were stirred at 1 1 OmicronC for 20-22 hours. Afte r cooling, the reaction mixture was filtered through a Celite bed and the filtrate was washed with diglyme (150 mL). Activated carbon (10 g) was charged and the mixture was stirred for 1 hour. The reaction mass was filtered through a Celite bed and the filtrate was washed with diglyme. Water (3000 mL)was added to the mother liquor and the mixture was stirred at 0- 5C for 2 hours. The mixture was then filtered and the obtained solid was washed with water (450 mL) then dried at 60C under vacuum. Toluene was added and the mixture was stirred at 80C. After cooling to 0-5C, the reaction mixture stirred for 2 hours, filtered, and the obtained solid was washed with chilled toluene. The solid was suck dried then dried under vacuum (50mm Hg) at 50 (80g, Yield: 0.8 w/w).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98549-88-3, its application will become more common.

Reference:
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73998-95-5, name is (4,6-Dichloropyridin-3-yl)methanol, molecular formula is C6H5Cl2NO, molecular weight is 178.02, as common compound, the synthetic route is as follows.Computed Properties of C6H5Cl2NO

^-Dichloro-S-trichloromethyl-pyridine:; To a solution of (4,6-dichIoropyridin-3-yl)methanol (7 g, 39 mmol) in CCl4 (200 mL), was added sulfuryl dichloride (120 mL) dropwise with stirring. The resulting solution was heated at reflux overnight. The mixture was concentrated and the pH was adjusted to pH 8 by the addition OfNaHCO3 (2N). The resulting solution was extracted with EtOAc (2 x 100 mL) and the organic layers were combined and dried over Na2SO4. The residue was purified bysilica gel column chromatography to afford 1.2 g (12%) of 2,4-dichloro-5-(trichloromethyl)pyridine.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73998-95-5, (4,6-Dichloropyridin-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; KALYSPSYS, INC.; NOBLE, Stewart A.; OSHIRO, Guy; MALECHA, James W.; ZHAO, Cunxiang; ROBINSON, Carmen K. M.; DURON, Sergio G.; SERTIC, Michael; LINDSTROM, Andrew; SHIAU, Andrew; BAYNE, Christopher; KAHRAMAN, Mehmet; LOU, Boliang; GOVEK, Steven; WO2006/55187; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 694-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 694-85-9, name is 1-Methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.

i) [(l,6-dihydro-l-methyl-6-oxo-3-pyridinyl)sulfonyl]-, 1,1-dimethylethyl ester carbamic acid; hlorosulfonyl isocyanate (6mL) was added dropwise to a solution of 2-methyl-2-propanol(6.5mL) in DCM (75mL) at 0¡ãC. After 5min, l-methyl-2(lNo.)-pyridinone (9mL) was addeddropwise followed by A^Af-du’sopropylethylamine (14.5mL) also added dropwise. Thereaction mixture was then allowed to warm to room temperature over 18h. E^O (lOOmL) wasadded to the reaction mixture and the organic layer was separated. The aqueous was thenfurther extracted with DCM (2xlOOmL). The combined organic layers were dried (MgSO4),filtered and evaporated to give the subtitle compound as a pale yellow oil. Yield: 7gJH NMR: 5 (CDC13) 1.45 (s, 9H), 3.62 (s, 3H), 6.60-6.64 (m, 1H), 7.69-7.74 (m, 1H), 8.21-8.24 (m, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,694-85-9, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/24823; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem