Tag: M.W:100-200

Related Products of 89-00-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89-00-9, name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the solution of pyridine-2,3-dicarboxylic acid (50 g, 300 mmol) in MeOH (300 mL) was added SOCl2 (44 mL, 600 mmol), and the mixture was refluxed overnight. Volatiles were removed under vacuum, sat. Na2CO3 was added, and the mixture was extracted with EtOAc. The organic phase was washed with brine, dried (Na2SO4) and evaporated under vacuum to give dimethyl pyridine-2,3-dicarboxylate as a colorless oil. Yield 32 g, 54percent.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89-00-9, Pyridine-2,3-dicarboxylic acid.

Reference:
Patent; MICURX PHARMACEUTICALS, INC.; WO2008/108988; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 607373-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2-chloro-4-methoxy-5-nitropyridine (0.6 g, 3.19 mmol), thiophene-2-boronic acid (0.45 g, 3.5 mmol), [l,l ‘-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.26 g, 0.32 mmol) and cesium carbonate (1.55 g, 4.8 mmol) in DMF (12 mL) were stirred and heated in a sealed tube at 90C for 18h. The reaction mixture was cooled to room temperature, filtered through Celite and washed through with DCM. The filtrate was washed with water, dried (hydrophobic frit) and concentrated in vacuo. The residue was purified by column chromatography using silica gel and eluting with EtOAc in hexane (0-30%) to give the desired compound.

According to the analysis of related databases, 607373-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoit Antoine; GENEY, Raphael Jean Joel; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart; WO2013/117645; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 884494-37-5 ,Some common heterocyclic compound, 884494-37-5, molecular formula is C6H5BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[00415] Intermediate 44A. Methyl l-(3-fluoro-4-methylpyridin-2-yl)-lH-imidazole-4- carboxylate: A suspension of methyl lH-imidazole-4-carboxylate (83 mg, 0.658 mmol), 2-bromo-3-fluoro-4-methylpyridine (200 mg, 1.053 mmol), copper (I) iodide (125 mg, 0.658 mmol) and potassium carbonate (546 mg, 3.95 mmol) in DMSO (2 mL) was heated at 120 for 90 min under microwave conditions. The reaction mixture was quenched with H20, and the solid was suspended in EtOAc and MeOH. The combined organic layer was concentrated in vacuo, yielding oily residue, which was purified by reverse phase HPLC to give the desired product (5 mg, 3%). MS(ESI) m/z: 236.1 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 884494-37-5, 2-Bromo-3-fluoro-4-picoline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.; WO2013/22818; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 88139-91-7, Adding some certain compound to certain chemical reactions, such as: 88139-91-7, name is 5-Bromo-2-hydroxymethylpyridine,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88139-91-7.

NaH (0.525 g, 13.1 mmol, 60% in mineral oil) was added to a solution of alcohol 41 (1.872, 10.1 mmol) and 5-bromo-2-(chloromethyl)pyridine (58) (prepared by chlorination of (5-bromo-2-pyridinyl)methanol, as reported by van den Heuvel et al., 2004) (2.5 g, 12.1 mmol) in anhydrous DMF (40 rnL) at 5 0C. The resulting mixture was stirred at room temperature for 2 h and then quenched with water (300 mL). The precipitate was filtered off, washed with water and dried to give (6S)-6-[(5-bromo-2-pyridinyl)methoxy]-2-nitro-6,7- dihydro-5H-imidazo[2,l-6][l,3]oxazine (59) (3.087 g, 86%) as a light brown solid: mp 171-173 0C; 1H NMR [(CD3)2SO] delta 8.65 (dd, J= 2.3, 0.4 Hz, 1 H), 8.04 (dd, J = 8.4, 2.4 Hz, 1 H), 8.02 (s, 1 H), 7.35 (dd, J = 8.4, 0.4 Hz, 1 H), 4.72-4.66 (m, 3 H), 4.49 (br d, J= 12.0 Hz, 1 H), 4.35- 4.21 (m, 3 H). Anal. (Ci2HnBrN4O4) C, H, N. HPLC purity: 99.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 88139-91-7, 5-Bromo-2-hydroxymethylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT; DENNY, William, Alexander; THOMPSON, Andrew, M.; BLASER, Adrian; MA, Zhenkun; PALMER, Brian, Desmond; SUTHERLAND, Hamish, Scott; KMENTOVA, Iveta; WO2011/14774; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 101990-70-9, Adding some certain compound to certain chemical reactions, such as: 101990-70-9, name is 5-(Chloromethyl)-2-methoxypyridine,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101990-70-9.

tert-Butyl (5S)-2-[(6-methoxypyridin-3-yl)methyl]-3-oxo-2,3,5,6,7,8-hexahydro[1,2,4]triazolo[4,3-a]pyridine-5-carboxylate tert-Butyl (5S)-3-oxo-2,3,5,6,7,8-hexahydro[1,2,4]triazolo[4,3-a]pyridine-5-carboxylate (1.33 g, 5.55 mmol) was initially charged in acetonitrile (30 ml). Caesium carbonate (4.52 g, 13.9 mmol), 5-(chloromethyl)-2-methoxypyridine (963 mg, 6.11 mmol) and sodium iodide (5.00 mg, 0.03 mmol) were subsequently added. After stirring for 4 days, the reaction mixture was admixed at room temperature with water and ethyl acetate. The organic phase was removed and the aqueous phase was extracted three times with ethyl acetate. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and filtered, and the filtrate was concentrated. The residue was purified via column chromatography (silica gel, eluent: cyclohexane/ethyl acetate gradient). The product-containing fractions were concentrated under reduced pressure, and 751 mg (37% of theory) of the title compound were obtained. LC-MS (Method 3): Rt=1.56 min; MS (ESIpos): m/z=361 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.385 (16.00), 2.048 (0.54), 2.058 (0.48), 2.525 (0.41), 3.825 (6.81), 4.424 (0.60), 4.791 (2.68), 6.785 (0.78), 6.807 (0.84), 7.574 (0.51), 7.580 (0.52), 7.595 (0.49), 7.602 (0.50), 8.074 (0.67), 8.080 (0.65).

According to the analysis of related databases, 101990-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; BIBER, Nicole; BROCKSCHNIEDER, Damian; GERICKE, Kersten Matthias; KOeLLING, Florian; LUSTIG, Klemens; MEDING, Joerg; MEIER, Heinrich; NEUBAUER, Thomas; SCHAeFER, Martina; TIMMERMANN, Andreas; ZUBOV, Dmitry; TERJUNG, Carsten; LINDNER, Niels; BADOCK, Volker; MOOSMAYER, Dieter; MIYATAKE ONDOZABAL, Hideki; MOORE, Steven; SCHULZ, Alexander; (458 pag.)US2019/160048; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 67515-76-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 67515-76-8 as follows.

The substrate 2,4-dichloro-6-hydroxybenzaldehyde (84 mg, 0.44 mmol)Dissolved in 10mL of 1,2-dichloroethane,To the solution was added 5-amino-2-methoxycarbonylpyridine (67 mg, 0.44 mmol)And titanium tetraisopropoxide (250 mg, 0.88 mmol). The reaction solution was stirred under reflux for 4 hours.Cool to room temperature and add 1 drop of acetic acid and sodium cyanoborohydride (83 mg, 1.32 mmol).Continue to reflux and stir overnight. Quenched with water, extracted with dichloromethane, combined, dried,The crude compound 29A (200 mg) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,67515-76-8, its application will become more common.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 54189-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54189-82-1, name is 6-Chloro-N-methylnicotinamide. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of (R)-2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-ol (Example 47) in N,N-dimethylformamide (0.06 M) under a dry nitrogen atmosphere is placed in a microwave vial and stirred. Sodium hydride or a 1 M solution of sodium bis(trimethylsilyl)amide in tetrahydrofuran (1.2 equivalents) is added to the reaction mixture and stirring is continued for 45 minutes. 6-Chloro-N-methyl-3-pyridinecarboxamide (CAS No.54189-82-1, 1.2 equivalents) is added to the reaction mixture and stirring is continued for 2-3 hours at 100 C. under microwave irradiation with the cooling air remaining on for the duration of the heating cycle. The reaction mixture is cooled to ambient temperature, dried (MgSO4), and filtered. The filtrate is concentrated under reduced pressure and the residue is purified by column chromatography on silica gel, eluting with 98:2 dichloromethane/2 M NH3 in methanol. Fractions containing product are combined and concentrated under reduced pressure to give (R)-N-methyl-6-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-yloxy)nicotinamide.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54189-82-1, 6-Chloro-N-methylnicotinamide.

Reference:
Patent; Abbott Laboratories; US2009/163464; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 115170-40-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To the autoclave was added 100 kg of dihydro-5-bromo-7-azaindole, 100 kg of manganese dioxide and 950 kg of glacial acetic acid,Control the temperature of 80-90 degrees Celsius, reaction 2h, then the reaction solution cooled to 20 degrees Celsius, filtered, washed with water, centrifuged for 0.5 hours, dried product 5 – bromo-7-azaindole 82kg.

According to the analysis of related databases, 115170-40-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NANTONG ABA CHEMICALS CO., LTD.; WU, ZHENGGUANG; NIU, YUEHUI; LYU, JIAN; (5 pag.)CN106188050; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 74115-12-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74115-12-1, name is 5-Chloro-3-hydroxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

5-chloropyridin-3-ol(2.00 g, 15.4 mmol) was dissolved in concentrated H2SO4(15 mL) at 5 C. Concentrated nitric acid (1.0 mL) was then added. The reactionwas allowed to warm to room temperature over 3 hrs. The reaction solution waspoured onto ice water (25 mL). The resultant precipitate was filtered, washedwith water and dried overnight at 40 C in vacuo to afford was obtained as ayellow powder, (1.80g, 67%); H NMR (400 MHz, CDCI3) delta7.68 (d, 1H), 8.15 (d, 1H), 10.29 (s, 1H).

According to the analysis of related databases, 74115-12-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 94805-51-3, name is 2-Oxo-1,2-dihydropyridine-4-carbonitrile, molecular formula is C6H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H4N2O

Int-3 1-(6-Methoxy-3′-nitro-biphenyl-3-ylmethyl)-2-oxo-1,2-dihydro-pyridine-4-carbonitrile Into a 100 mL RBF with stir bar was added Int-2 (2.76 g, 8.55 mmol), 2-Hydroxy-isonicotinonitrile (934 mg, 7.78 mmol), K2CO3 (2.36 g, 17.11 mmol), and DME (30 mL). The suspension was stirred for 18 hours at 80 C. and then RT for 2 days. The reaction was filtered, the filtrate was concentrated and the resulting solid was triturated with ether to give 2.12 g (75%) of Int-3 as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta=8.29 (s, 1H), 8.20 (dd, J=1.3, 8.3 Hz, 1H), 8.12 (d, J=7.1 Hz, 1H), 7.93 (d, J=7.8 Hz, 1H), 7.73 (t, J=8.0 Hz, 1H), 7.49 (d, J=2.0 Hz, 1H), 7.43 (dd, J=1.9, 8.5 Hz, 1H), 7.16 (d, J=8.6 Hz, 1H), 7.04 (d, J=1.3 Hz, 1H), 6.56 (dd, J=1.7, 7.0 Hz, 1H), 5.12 (s, 2H), 3.79 (s, 3H). LC/MS=96.1%, 361.0 (APCI-).

With the rapid development of chemical substances, we look forward to future research findings about 94805-51-3.

Reference:
Patent; DECODE GENETICS EHF; US2009/136473; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem