Tag: M.W:100-200

Related Products of 66909-29-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66909-29-3, name is 6-Chloro-5-methylnicotinic acid, molecular formula is C7H6ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(61a) 5-(Azetidin-1-ylcarbonyl)-2-chloro-3-methylpyridine Commercially available 6-chloro-5-methylnicotinic acid (200 mg, 1.29 mmol) was dissolved in dichloromethane (7.0 mL), and azetidine hydrochloride (160 mg, 1.71 mmol), HATU (1000 mg, 2.63 mmol) and N,N-diisopropylethylamine (0.69 mL, 3.96 mmol) were added, followed by stirring at room temperature overnight under nitrogen atmosphere. 0.5N hydrochloric acid (30 mL) was added, and extraction was carried out with dichloromethane (30 mL). The organic layer was washed with saturated brine, and subsequently dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified using silica gel column chromatography (elution solvent: ethyl acetate/hexane=60%-75%) to afford the desired compound (160 mg, yield 64%) as a colorless liquid. 1H-NMR (CDCl3, 400 MHz): delta 2.32 (3H, s), 2.36-2.42 (2H, m), 4.24 (2H, t, J=7.6 Hz), 4.35 (2H, t, J=7.6 Hz), 7.95 (1H, dd, J=9.3, 1.0 Hz), 8.26 (1H, d, J=1.0 Hz).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 66909-29-3, 6-Chloro-5-methylnicotinic acid.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP2239253; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 16063-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16063-70-0, name is 2,3,5-Trichloropyridine. A new synthetic method of this compound is introduced below.

At room temperature, 2,3,5-trichloropyridine (20 g, 109 mmol) and 2-methoxyphenylboronic acid (21.5 g, 141.7 mmol) are added to a 2-neck flask.Pd (PPh 3) 4 (5.04 g, 5.67 mmol) and potassium fluoride (15.8 g, 272.5 mmol) are added.After addition of 300 ml of toluene, the mixture was stirred at 100 C for 5 hours. After completion of the reaction, the solution is filtered through silica.Column chromatography after solvent removal (MC: Hexane = 1: 1)After purification, an oil type transparent compound S-1 (32.6 g, yield 90%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16063-70-0, its application will become more common.

Reference:
Patent; Doosan Co., Ltd; Shin Hwan-gyu; Park Jeong-geun; (76 pag.)KR2019/76376; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 872-85-5, name is 4-Pyridinecarboxaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 872-85-5

EXAMPLE 101 A mixture consisting of 25 g of isonicotine aldehyde, 82 g of ethyl (triphenylphosphoranilidene)acetate and 300 ml of toluene is stirred at 100 C. for 3 hours. After cooling, the deposited crystals are removed by filtration, and the filtrate is concentrated under reduced pressure. A mixture of ethyl acetate and petorleum ether (1:1, 400 ml) is added to the residue, and the mixture is extracted with 500 ml of 5% hydrochloric acid. The aqueous solution portion is extracted with 50 ml of ethyl acetate, followed by neutralization with potassium carbonate and cooling. The deposited crystals are collected by filtration and dried to give 34 g of 3-(4-pyridyl)acrylate as colorless prisms. m.p. 64-66 C.

With the rapid development of chemical substances, we look forward to future research findings about 872-85-5.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4638000; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6969-71-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6969-71-7, name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one. This compound has unique chemical properties. The synthetic route is as follows.

2-(3-Bromopropyl-1,1,3,3-d4)-[1,2,4}triazolo[4,3-a]pyridin-3(2H)-one: A mixture of [1,2,4]triazolo[4,3-a]pyridin-3-(2H)-one (0.300 g, 2.22 mmol), 1,3-dibromopropane-1,1,3,3-d4 (0.453 g, 2.20 mmol), potassium carbonate (1.220 g, 8.88 mmol) and acetonitrile (10 mL) was heated at about 60 C. for about 18 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo, and the resulting crude residue was purified by column chromatography on neutral alumina (15% ethyl acetate in petroleum ether) to yield the title product as an off-white solid (0.180 g, 31%). 1H NMR (400 MHz, CDCl3) delta 2.39 (s, 2H), 6.47-6.53 (m, 1H), 7.07-7.12 (m, 2H), 7.77 (d, J=7.2 Hz, 1H); IR (KBr) nu 3094, 3045, 1710, 1637, 1531, 1437, 1348 cm-1; MS 260, 262 [(M+1), (M+3)].

According to the analysis of related databases, 6969-71-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2009/209550; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 100-54-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-54-9, name is Nicotinonitrile, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Sodium bicarbonate (5.88 g, 70 mmol) was added in portionsto a solution of 4.79 g hydroxylamine hydrochloride(70 mmol) in 20 cm3 of water. A solution of aryl nitriles(35 mmol) in 50 cm3 of ethanol was then added, and themixture stirred under reflux for 6 h. The precipitate formedwas filtered off and purified by crystallization from ethanol.Melting points of compounds 1b-1f were in agreementwith the literature values [23, 25-28].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-54-9, Nicotinonitrile.

Reference:
Article; Dinesha; Viveka, Shivapura; Khandige, Prasanna S.; Nagaraja, Gundibasappa K.; Monatshefte fur Chemie; vol. 147; 2; (2016); p. 435 – 443;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183208-35-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C7H5BrN2

Step-i: 5-Bromo-3-iodo-1H-pyrrolo[2.3-b ]pyridinePCT/IB2013/0553885-Bromo-1H-pyrrolo[2,3-b]pyridine (5 g, 25 mmol) was dissolved in anhydrous acetone (7510 ml) and added N-iodo succinimide (6.18 g, 27.5 mmol) under nitrogen atmosphere and stirredat RT for 2 h. The reaction was monitored by TLC (10% Ethyl acetate in hexane). Thereaction mixture was cooled to RT and filtered, washed with cold acetone (50 ml) and driedunder vacuum to afford 7.05 g (87% yield) of 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine.MS: m/z = 324.6 (M+1); HPLC: 91.11% in method B.

With the rapid development of chemical substances, we look forward to future research findings about 183208-35-7.

Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; UM PHARMAUJI SDN. BHD; GUMMADI, Venkateshwar, Rao; HOSAHALLI, Subramanya; NANDURI, Srinivas; AGGUNDA RENUKAPPA, Girish; WO2014/6554; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H5F3N2, blongs to pyridine-derivatives compound. Formula: C6H5F3N2

Thionyl chloride (31 mL, 0.43 mol) was slowly added to 175 mL, of water at 0 C. During the addition the temperature was maintained between 0-5 C. After addition the solution was warmed to 15 C. and 0.47 g (4.8 mmol) of CuCl was added. The solution was diluted with 100 mL of water and cooled back to 0 C. A solution of 7.21 g (0.10 mol) of NaNO2 in 100 mL, of water was slowly added to a solution of 15.39 g (0.10 mol) of 5-amino-2-(trifluoromethyl)pyridine (95) in 125 mL of conc. HCl at 0 C. During addition the temperature was maintained between 0-5 C. This mixture was then slowly added to the above prepared solution so as to maintain a temperature between 0-5 C. A voluminous precipitate formed. The mixture was stirred for an additional 30 min after addition and the solid was then collected by filtration. The solid was washed with water and dissolved in CHCl3. The solution was dried over MgSO4, filtered and the solvent was removed to afford 18.03 g (77%) of sulfonyl chloride (83) as a tan solid. 1H NMR (CDCl3) delta 9.34 (d, J=2.2 Hz, 1 H), 8.53 (dd, J=8.4, 2.2 Hz, 1H), 7.98 (d, J=8.4 Hz, 1H).

The synthetic route of 106877-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Konradi, Andrei W.; Probst, Gary; Aubele, Danielle L.; Garofalo, Albert W.; Hom, Roy; Neitzel, Martin L.; Semko, Christopher M.; Truong, Anh P.; US2008/21056; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 14254-57-0 ,Some common heterocyclic compound, 14254-57-0, molecular formula is C6H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of (1R,2S,3R,5R)-3-amino-5-(hydroxymethyl)cyclopentane-1,2-diyl dibenzoate hydrochloride (150. mg, 0.380 mmol) in DCM (10.0 mL) at 0 C. was treated with EtN (0.170 mL, 1.22 mmol) and stirred for 20 min. Isonicotinoyl chloride (88.0 mg, 0.490 mmol) was then added and the mixture was stirred for 2 h. The reaction was treated with saturated aqueous solution of ammonium chloride (50 mL) and extracted with DCM (2¡Á50 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo. The resulting residue was purified via silica gel chromatography eluting with a gradient of 0 to 10% MeOH in DCM to afford the title compound (100. mg, 60%). LC/MS: Rt=1.49 min, ES+ 461 (FA standard).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14254-57-0, its application will become more common.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2008/51404; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 7379-35-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7379-35-3, name is 4-Chloropyridine hydrochloride. A new synthetic method of this compound is introduced below.

To a solution of 4-aminothiophenol (20.2 g, 156.5 mmol) in anhydrous DMF (200 mL) was added 4-chloropyridine hydrochloride (24.4 g, 161.0 mmol) followed by potassium carbonate (44 g, 318.4 mmol). The reaction mixture was heated at 80¡ã C. overnight, then diluted with ethyl acetate (400 mL) and water (400 mL). The aqueous layer was back-extracted with ethyl acetate (2.x.200 mL). The combined organic layers were washed with a saturated aqueous NaCl solution (200 mL), dried over anhy MgSO4, and concentrated under reduced pressure. The residue was filtered through a pad of silica with ethyl acetate and the resulting material was triturated with an ethyl ether/hexane solution to afford the desired product (24.7 g, 78percent). TLC (50percent ethyl acetate/50percent hexane) Rf 0.25; 1H-NMR (DMSO-d6) delta 5.67 (bs, 2H), 6.65 (d, J=8.4 Hz, 2H), 6.88 (d, J=6.2 Hz, 2H), 7.19 (d, J=8.4 Hz, 2H), 8.27 (d, J=6.2 Hz, 2H), MS[M+H]+=203.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7379-35-3, 4-Chloropyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; BAYER CORPORATION; US2004/2507; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 62733-99-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62733-99-7, name is Methyl 3-hydroxypicolinate. A new synthetic method of this compound is introduced below.

To a solution of 3-hydroxy-pyridine-2-carboxylic acid methyl ester (200 mg, 1.3 mmol) in N,N-dimethylformamide (2.0 ml) was added at 22 C sodium hydride (55% in oil, 64 mg) and stirring was continued until gas evolution ceased. The suspension was cooled to 0 C and treated with trifluoro ethyl trifluormethanesulfonate (728 mg) and stirring was continued at 22 C for 2 hours. The mixture was partitioned between saturated sodium hydrogen-carbonate solution and ethyl acetate, and the organic layer was dried and evaporated. The residue was purified by chromatography on silica using n-heptane and ethyl acetate (3: 1) as the eluent to give 3-(2,2,2- trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester as a pale green oil. MS (ESI): m/z = 236.2 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62733-99-7, Methyl 3-hydroxypicolinate, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BANNER, David; HILPERT, Hans; MAUSER, Harald; MAYWEG, Alexander V.; ROGERS-EVANS, Mark; WO2011/70029; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem