Tag: M.W:100-200

Related Products of 56129-55-6, Adding some certain compound to certain chemical reactions, such as: 56129-55-6, name is 1-(Pyridin-3-yl)ethanamine,molecular formula is C7H10N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56129-55-6.

Example 46 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(methyl-pyridin-3-ylmethyl-amino)-thiazol-4-one 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(methyl-pyridin-3-ylmethyl-amino)-thiazol-4-one was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one and Methyl-pyridin-3-ylmethyl-amine following General Procedure B. 1H NMR (400 MHz, DMSO) delta 8.62 (dd, 1H), 8.57 (dd, 0.4H), 8.55 (dd, 0.6H), 8.34 (d, 0.6H), 8.31 (d, 0.4H), 8.16-8.14 (m, 1H), 7.89-7.8 (m, 1H), 7.83 (s, 1H), 7.79-7.75 (m, 2H), 7.72-7.68 (m, 1H), 7.67-7.63 (m, 1H), 7.46-7.41 (m, 1H), 6.78-6.75 (m, 1H), 5.86 (s, 2H), 5.01 (s, 0.6H), 4.90 (s, 0.4H), 3.29 and 3.28 (2s, 3H, rotamers). LC/MS (m/z) [M+1]+ 542.1 (calculated for C26H19ClF3N5OS, 541.1).

According to the analysis of related databases, 56129-55-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIGNAN, Gilles; Gaul, Micheal; Xu, Guozhang; Zhao, Bao-Ping; US2011/200586; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 769-28-8 ,Some common heterocyclic compound, 769-28-8, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[00176] Step 2: tert-butyl ((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)methyl)carbamate: To a solution of 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3- carbonitrile (40 g, 0.27 mol) in THF/CH30H (1:1, 2 L) were added Ni (40 g), Boc20 (110 g,0.5 mol) and Et3N (50 g, 0.5 mol). Then the mixture was stirred in H2 atmosphere at roomtemperature for 48 h. The reaction solution was filtrated and concentrated to give crude product. The crude was added H20 (200 mL) and extracted by DCM (600 mL*3). The organic layer was concentrated to give tert-butyl ((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)methyl)carbamate (40 g, 56 %) for next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,769-28-8, its application will become more common.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; AUDIA, James, Edmund; DAKIN, Les, A.; DUPLESSIS, Martin; GEHLING, Victor, S.; HARMANGE, Jean-Christophe; NASVESCHUK, Christopher, G.; VASWANI, Rishi, G.; WO2015/23915; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 74115-12-1 ,Some common heterocyclic compound, 74115-12-1, molecular formula is C5H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

33b. 3-Chloro-2-(4-nitrophenylazo)-5-hydroxypyridine To a solution of 5-chloro-3-pyridinol (20.0 g, 0.154 mol, Aldrich) and KOH (13.0 g, 0.232 mol) in 300 mL of water at 0 C. was added p-nitrobenzenediazonium tetrafluoroborate (36.6 g, 0.154 mol, Aldrich). After 1 hour, 50 mL of glacial acetic acid was added, and the bright red precipitate was filtered and air-dried. Chromatography (silica gel; CH2 Cl2 /MeOH, 95:5-90:10) afforded the title compound as a bright red solid (28.8 g, 67%): 1 H NMR (DMSO-d6, 300 MHz) delta 7.14 (d, J=2.4 Hz, 1H), 7.89 (d, J=2.4 Hz, 1H), 8.00 (m, 2H), 8.39 (m, 2H); MS (CI/NH3) m/z: 279, 281 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74115-12-1, its application will become more common.

Reference:
Patent; Abbott Laboratories; US6133253; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 40673-25-4 , The common heterocyclic compound, 40673-25-4, name is 4-Chloro-2-hydroxypyridine, molecular formula is C5H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-Chloro-2-hydroxy-pyridine (247 mg, 1.91 mmol), Ag2CO3 (1.58 g, 5.74 mmol) and MeI(0.13 ml, 2.11 mmol) were heated in a sealed tube at 50 0C for 16 hours and then filtered through celite and concentrated at reduced pressure. The residue was purified by FCC (Pentane/Diethyl ether with gradient, 99:1 to 95:5) to provide the title compound as colourless oil (160 mg, 58%).LCMS data: Calculated MH+ (144); Found 100% (MH+) m/z 144, Rt = 1.71 min.NMR data: 1H NMR (500 MHz, CDCl3) delta ppm 8.07 (1 H, d, J=5.5 Hz), 6.89 (1 H, dd, J=5.5,1.5 Hz), 6.77 (1 H, d, J=1.7 Hz), 3.94 (3 H, s).

The synthetic route of 40673-25-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/135842; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 393-53-3 ,Some common heterocyclic compound, 393-53-3, molecular formula is C6H4FNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1 : Synthesis of 3-[(4-iodo-2-fluoro)amino]isonicotinic acid.; 3-Fluoro-isonicotinic acid (1g, 7.09mmol) and 4-iodo-2-fluoroaniline (1.68g, 7.09mmol) was added to 10mI of dry THF and the mixture was cooled to -78C. LiHMDS (1 M in THF, 24.8ml) was added and the mixture was al lowed to warm to room temperature over night. Solid ammonium hydrochloride (2g) was added and after 1h the mixture was filtered and the volatiles were removed in vacuo. The crude material was purified by flash-chromatography using C2-modified silica a nd a gradient of 0-12% methanol in DCM as eluent to give 932mg (2.32mmol; 33% yield) of pure desired carboxylic acid product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 393-53-3, 3-Fluoroisonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2006/45514; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 183208-35-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183208-35-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of commercially available 5-bromo-1H-pyrrolo[2,3-b]pyridine (5.60 g, 28.4 mmol) in CH2Cl2 (25 mL) was added N-iodosuccinimide (7.67 g, 34.1 mmol). The reaction mixture was stirred at ambient temperature for 2 h. The precipitate was filtered and washed with cold CH2Cl2 (2*5 mL) to provide the title compound as a light tan solid (7.17 g, 78% yield) which was used as is in the next step without further purification: MS (ES) m/z 323 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 183208-35-7, 5-Bromo-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; Jacobsen, Eric Jon; Blinn, James Robert; Springer, John Robert; Hockerman, Susan L.; Anderson, David Randolph; (120 pag.)US2018/208594; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33631-09-3, name is 3-Amino-4-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 33631-09-3

To a solution of 4-methoxypyridin-3-amine (purchased from Ark Pharm Inc.), (3 g) in concentrated HCl (22.17 mL) was added bromine (1.49 mL) dropwise over a 30 s period and the mixture stirred at rt for 1 h and then at 55 C. over the weekend. The reaction mixture was allowed to cool to rt and then poured into ice (250 g). Concentrated NH4OH was added until the pH of the solution was basic (pH ?9). The resulting solution was then partitioned between H2O and EtOAc and the two layers separated. The aqueous layer was extracted with EtOAc (2*) and the combined organic layers washed with water and brine, dried (MgSO4), filtered and evaporated under vacuum to give a solid which was dissolved in DCM and purified by column chromatography (normal phase, 100 g, Biotage SNAP cartridge KP-Sil, 50 mL/min, gradient 0-20% EtOAc in n-hexane) to give the desired product (2.74 g). LCMS: m/z 203.37 [M+H]+. 1H NMR (400 MHz, CDCl3) ppm 3.93 (s, 3H) 3.95-4.60 (br. s., 2H) 6.69 (d, J=5.4 Hz, 1H) 7.76 (d, J=5.3 Hz, 1H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33631-09-3, 3-Amino-4-methoxypyridine.

Reference:
Patent; Payne, Andrew; Castro Pineiro, Jose Luis; Birch, Louise Michelle; Khan, Afzal; Braunton, Alan James; Kitulagoda, James Edward; Soejima, Motohiro; US2015/94328; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 929617-35-6, 5-Bromo-1H-pyrazolo[3,4-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Bromo-1H-pyrazolo[3,4-c]pyridine, blongs to pyridine-derivatives compound. Safety of 5-Bromo-1H-pyrazolo[3,4-c]pyridine

General procedure: To a stirred solution of 5-bromo-1H-pyrrolo[2,3-c]pyridine (500 mg, 2.53 mmol) in DMF (5 mL), K2C03(875 mg, 6.345 mmol) was added. After 10min, ferf-butyl 3-bromopropylcarbamate (724 mg, 3.045 mmol) was added and the reaction mixture was heated at 60C for 26h. The reaction mixture was cooled to RT, poured into ice water and extracted with EtOAc (2 x100 mL). The organic layer was washed with brine solution (2 x 20 mL), dried over anhydrous Na2SO4, filtered and the filtrate was concentrated to dryness. The crude compound was triturated with n-pentane to afford the title compound (200 mg, 27%) as a yellow solid. LC-MS (method 1): Rt = 2.15 min; m/z = 354.18 (M+H+).

The synthetic route of 929617-35-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 886372-63-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 886372-63-0, name is 3-Amino-5-fluoro-6-methoxypyridine, molecular formula is C6H7FN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

NaHMDS (1.0M in THF; 1.279 mL, 1.279 mmol) was added to a solution of (¡À)-4-(5-(1-(tert-butyldimethylsilyloxy)propan-2-yl)-2-fluoropyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine (9f; 201.2 mg, 0.533 mmol) and 5-fluoro-6-methoxypyridin-3-amine (27; 91 mg, 0.640 mmol) in THF (5.0 mL) at 0 C, and the resulting solution was stirred at 0 C for 1.5 h. AdditionalNaHMDS (1.0M in THF; 0.300 mL, 0.300 mmol)was then added, and the resulting mixture was stirred at 0 C for 30 min. Excess NaHMDS was carefully quenched with saturated aqueous NH4Cl (5 mL), and the resulting mixture was partitioned between DCM (50 mL) and half-saturated aqueous NH4Cl (30 mL). The aqueous layer was extracted with DCM (30 mL), and the combined organic extracts were dried over sodium sulfate, filtered, and concentrated in vacuo. Chromatographic purification of the residue (silica gel, 0-70% EtOAc/hexanes) furnished (¡À)-4-(5-(1-(tert-butyldimethylsilyloxy)propan-2-yl)-2-(5-fluoro-6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine (241.0 mg, 0.482 mmol, 91% yield) as a yellow-orange solid.

According to the analysis of related databases, 886372-63-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lanman, Brian A.; Reed, Anthony B.; Cee, Victor J.; Hong, Fang-Tsao; Pettus, Liping H.; Wurz, Ryan P.; Andrews, Kristin L.; Jiang, Jian; McCarter, John D.; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Wang, Ling; Whittington, Douglas A.; Wu, Tian; Zalameda, Leeanne; Zhang, Nancy; Tasker, Andrew S.; Hughes, Paul E.; Norman, Mark H.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5630 – 5634;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103-74-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.103-74-2, name is 2-(2-Hydroxyethyl)pyridine, molecular formula is C7H9NO, molecular weight is 123.1525, as common compound, the synthetic route is as follows.

6-Hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (300mg, 1.019mmol) obtained in Preparation Example 2 was dissolved in THFlbenzene (30mL/10mL). 2-Pyridine ethanol (308mg, 2.039mmol) and triphenyl phosphine (534mg, 2.039mmol) were added thereto, and cooled to 0C. Subsequently, diisopropyl azodicarboxilate (412mg, 2.039mmol) was slowly dropped thereto and stirred for lhr at RT. The resulting mixture was washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgS04 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 388g of 6-[2-(pyridine-2-yl)-ethoxy]-l-oxo-3-phenyl-lH-indene-2-carboxylic acid ethyl ester (yield: 89%) as a red solid. Then, 1-oxo-3-phenyl-6-(2-pyridine-2-yl-ethoxy)-lH-indene-2-carboxylic acid ethyl ester (60mg, 0.15mmol) thus obtained was dissolved in THF and phenylmagnesium chloride (0.15mL, 0.3mmol) was added thereto. The mixture was stirred for 5 minutes at RT, washed with sodium chloride solution and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgS04 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 44mg of the titled compound (yield: 61%)

Statistics shows that 103-74-2 is playing an increasingly important role. we look forward to future research findings about 2-(2-Hydroxyethyl)pyridine.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; JEIL PHARM. CO., LTD.; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; CJ CORP.; WO2005/100297; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem