Tag: M.W:100-200

Related Products of 1008-91-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1008-91-9, name is 1-(Pyridin-4-yl)piperazine, molecular formula is C9H13N3, molecular weight is 163.22, as common compound, the synthetic route is as follows.

General procedure: To the stirred solution of 1-phenyl-9H-pyrido [3,4-b]indole-3-carboxylic acid 5 (0.29 g, 0.001 mol) in dry THF, HOBt (0.16 g,0.012 mol) and EDC. HCl (0.23 g, 0.012 mol) were added andcontinued stirring for 30 min. To the reaction mixture, substitutedphenyl piperazine (6a-p) (0.001 mol) was added under ice coldtemperature and the reaction mixture was further stirred at roomtemperature for 6 h. After completion of reaction as monitored byTLC, solvent was evaporated under vacuum. Reaction mixture wasextracted with ethyl acetate (2 20 mL), collected organic layerwas dried over anhydrous Na2SO4, concentrated under vacuum andpassed through small bed of silica gel (60e120) using mobile phase(ethyl acetate: hexane; 3:7) to obtain analytically pure final product7.

Statistics shows that 1008-91-9 is playing an increasingly important role. we look forward to future research findings about 1-(Pyridin-4-yl)piperazine.

Reference:
Article; Ashok, Penta; Chander, Subhash; Smith, Terry K.; Sankaranarayanan, Murugesan; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 559 – 566;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 393-53-3, name is 3-Fluoroisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-Fluoroisonicotinic acid

3-Fluoroisonicotinic acid (3.00 g, 21.3 mmol) was dissolved in dioxane (6 mL), and then 30% methylamine aqueous solution (22.0 g, 213 mmol) was added. The reaction solution was heated to 140 C. and then stirred for 14 hours. Concentrated hydrochloric acid (12N, 3 mL) was added to adjust the pH value to pH=3, followed by filtration. The filter cake was dried to give 3-(methylamino)isonicotinic acid (3.00 g, yellow solid) with a yield of 93%. 1H NMR: (400 MHz, DMSO-d6) delta8.46 (s, 1H), 7.89 (s, 1H), 7.69 (d, J=4.8 Hz, 1H), 7.50 (d, J=4.8 Hz, 1H), 2.80 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 393-53-3, 3-Fluoroisonicotinic acid.

Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Linyun; CHEN, Xiaoxin; ZHANG, Peng; LIU, Xing; ZHANG, Li; LIU, Zhuowei; CHEN, Shuhui; LONG, Chaofeng; (75 pag.)US2018/148451; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 13472-85-0, Adding some certain compound to certain chemical reactions, such as: 13472-85-0, name is 5-Bromo-2-methoxypyridine,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13472-85-0.

1.57 g K2CO3, 6.25 ml DMF was added sequentially to a flask equipped with a thermometer, a constant pressure dropping funnel,Stirring in a 100 ml three-necked flask, stirring, 1.41 ml of 5-bromo-2-methoxypyridine slowly,After completion of the dropwise addition, 2.07 g of bisulfonamide was slowly added and the mixture was stirred for 2 hours.Add 1.7 g of 2-chloropyridine stirring reaction 3 hours, diluted with water, stirring 20 min, liquid;The aqueous phase was extracted with ethyl acetate, the organic phases were combined, washed twice with saturated brine,Concentrated under reduced pressure to give a piranone intermediate yellow oil with a purity of 83% and a yield of 85%.

According to the analysis of related databases, 13472-85-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Venturefarm Biotech Corp.; Chen, Mengnan; Zhao, Guolei; (4 pag.)CN105906557; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 98400-69-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 98400-69-2 as follows.

REFERENTIAL EXAMPLE 2 tert-Butyl 3-sulfanylpyridin-4-ylcarbamate: The compound (61.6 g) obtained in Referential Example 1 was dissolved in tetrahydrofuran (2,000 ml), and the solution was stirred at -78¡ã C. for 10 minutes. A hexane solution (1.59 mol/l, 500 ml) of n-butyllithium was added dropwise to the solution, and the mixture was stirred for 10 minutes and then for 2 hours with ice cooling. After the reaction mixture was cooled to -78¡ã C., sulfur powder (12.2 g) was added, and the resultant mixture was warmed to room temperature and stirred for 1 hour. Water (1,000 ml) was added to the reaction mixture to separate a water layer. After 3N hydrochloric acid was added to the water layer to adjust the pH of the water layer to 3 to 4, methylene chloride was added to separate an organic layer. The organic layer was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel (methylene chloride_methanol=50:1) to obtain the title compound (33.2 g). 1H-NMR (DMSO-d6) delta: 1.52(9H,s), 7.89(1H,d,J=6.4 Hz), 7.99(1H,d,J=6.4 Hz), 8.20(1H,s), 9.91(1H,br.s). MS (FAB) m/z: 227(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98400-69-2, its application will become more common.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; US2005/20645; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 18617-50-0 , The common heterocyclic compound, 18617-50-0, name is Ethyl 6-hydroxynicotinate, molecular formula is C8H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Stage 1 : A mixture of {4-[(4-{[(tert-butoxy)carbonyl]amino}piperidin-1-yl)methyl]phenyl}boronic acid (800mg; 2.39 mmol; prepared as described for the synthesis of intermediate X.7 without BOC deprotection step), ethyl 6-hydroxypyridine-3-carboxylate (420 mg; 2.51 mmol), copper(II) acetate (250 mg; 1.38 mmol) and pyridine (210 muIota; 2.60 mmol) in DCM (10 ml) is stirred overnight. The mixture is filtered and extracted with water. The organic layer is dried with sodium sulphate, filtered and evaporated. The residue is purified by silica gel column chromatography (gradient DCM / methanol 98:2 94:4) to yield ethyl 1-{4-[(4-{[(tert-butoxy)carbonyl]amino}piperidin-1-yl)methyl]phenyl}-6-oxo-1,6-dihydropyridine-3-carboxylate. Yield: 580 mg (53percent of theory). C25H33N3O5. ESI Mass spectrum: m/z = 456 [M+H]+.

The synthetic route of 18617-50-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; BLUM, Andreas; HAMPRECHT, Dieter; KLEY, Joerg; WO2013/92674; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 71255-09-9 ,Some common heterocyclic compound, 71255-09-9, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Part F: 2-(4-(2-(2-methoxypyridin-3-yl)-7-methyl-3H-benzo[d]-imidazol-5-yl)piperidin-1-yl)-N-methylethanamine (Example 2); A mixture of tert-butyl 2-(4-(3,4-diamino-5-methylphenyl)piperidin-1-yl)ethyl(methyl)carbamate (0.11 mmol) and 2-methoxynicotinaldehyde (15 mg, 0.11 mmol) in methanol (5 mL) was heated at 60 C. for 4h. solvent was evaporated and the crude intermediate was then treated with TFA in 1,2-dichloroethane (25%, 1 mL) at rt for 2 h. solvent was evaporated and the residue was purified by prep-HPLC to give 2-(4-(2-(2-methoxypyridin-3-yl)-3H-benzo[d]imidazol-5-yl)piperidin-1-yl)-N-methylethanamine as a brown oil (11 mg, 27% yield). MS (ESI) m/z 380.22 (M+H) 1H NMR (CD3OD) delta 8.54 (dd, 1H, J=5.0, 1.7 Hz), 8.48 (dd, 1H, J=7.7, 1.7 Hz), 7.84 (d, 1H, J=8.1 Hz), 7.81 (s, 1H), 7.61 (dd, 1H, J=7.6, 1.1 Hz), 7.33 (dd, 1H, J=7.7, 4.4 Hz), 4.25 (s, 3H), 3.80 (d, 2H, J=12.1 Hz), 3.58 (s, 3H), 3.31 -3.15 (m, 3H), 2.82 (s, 3H), 2.32-2.17 (m, 7H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 71255-09-9, 2-Methoxynicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Purandare, Ashok Vinayak; Wan, Honghe; Huynh, Tram N.; US2006/235037; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6959-48-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6959-48-4 as follows.

Step C: Preparation of Diethyl 2-(1-(pyridin-3-yl)propan-2-yl)malonate. To a suspension of diethyl methyl malonate (1.80 g, 10.2 mmol) in DMF (25 ml) at 0 C. was added sodium hydride (1.25 g, 31.0 mmol, 60%), followed by 3-(chloromethyl)pyridine hydrochloride (2.00 g, 12.2 mmol) and stirred for 8 h at room temperature. The reaction mixture was quenched with acetic acid and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford 2.50 g (91.2%) of diethyl 2-(1-(pyridin-3-yl)propan-2-yl)malonate as pale brown oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6959-48-4, its application will become more common.

Reference:
Patent; Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich; US2011/224225; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H5NO2

General procedure: A diamine compound (0.05 mol) was mixed with a dicarboxylicacid or an acid anhydride (0.025 mol) and the mixture was poured into 50 ml of preheated (100C) polyphosphoric acid. The mixture was stirred and heated at 175C for 3-5 h. The reaction mixture was then poured in ice cold water and allowed to stand overnight.The precipitate was removed by filtration and washed several times with diluted sodium hydrogen carbonate solution and finally with water. The reaction product was then air dried and weighed.The products were characterized with NMR and mass spectroscopy (Table 4) and representative examples were characterized with elemental analysis (Table 3).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 98-98-6, Picolinic acid.

Reference:
Article; Elagab, Hamdi Ali; Alt, Helmut G.; Inorganica Chimica Acta; vol. 431; (2015); p. 266 – 275;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H5BrClN

A mixture of 4-fluorobenzeneboronic acid (38.7 g, 276 mmol), 4-bromopyridine hydrochloride (48.9 g, 250 mmol), [1,4-butanediylbis(diphenylphosphine-kappaP)] dichloropalladium (Organometallics 1998, 17, 661; 1.52 g, 2.5 mmol), 1,2-dimethoxyethane (500 mL) and sodium carbonate solution (2M, 440 mL) was degassed with bubbling nitrogen and stirred at 80 C. for 24 hours. The mixture was cooled and extracted with ethyl acetate. The combined organic fractions were dried (MgSO4) and the solvent was evaporated under reduced pressure to give crude title compound as a brown solid (50.87 g) which was used without further purification. 1H NMR (360 MHz, CDCl3) delta 8.65 (2H, m), 7.61 (2H, m), 7.49 (2H, dd, J 1.6, 4.6 Hz), and 7.09 (2H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19524-06-2, 4-Bromopyridine hydrochloride.

Reference:
Patent; Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John; US2003/236250; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 58481-11-1, Methyl 2-chloroisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 58481-11-1, blongs to pyridine-derivatives compound. Recommanded Product: Methyl 2-chloroisonicotinate

To a stirred solution of methyl 2chloro isonicotinate (2 g, 0.012 mol) in toluene (20 mL) was added hexamethylditin (4.5 g, 0.014 mol), the mixture was degassed with argon for 10 minutes, then Pd(PPh3)4 (1.35 g, 0001 mol) was added, the mixture was degassed again for 5 minutes and the resulting reaction mixture was heated at 110¡ãC for 16h. The progress of the reaction was monitored by LCMS. The reaction mixture was cooled to RT, filtered through the Celite pad, washed with EtOAc and the filtrate was concentrated to get acrude compound. The crude compound was purified by column chromatography using neutral alumina and eluted with 5percentEtOAc/pet ether to afford the title compound (1.5 g, 42percent) as a colorless liquid.LCMS (method 1): R = 1.20 mm; m/z = 301 .99(M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58481-11-1, its application will become more common.

Reference:
Patent; ORYZON GENOMICS, S.A.; ORTEGA MUNOZ, Alberto; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; (176 pag.)WO2017/207813; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem