Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33674-96-3, name is (6-Bromopyridin-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To a solution of (6-bromo-pyridin-2-yl)-methanol (1.5 g, 8.0 mmol) in chloroform (10 mL) was added dropwise sulfuryl choride (1.29 mL, 16 mmol) and the reaction stirred overnight. The reaction was concentrated under reduced pressure to provide a yellow semi-solid. The material was triturated with diethyl ether/hexanes and the solid collected to provide 2-bromo-6-chloromethyl-pyridine (900 mg, 4.37 mmol) as a sticky white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33674-96-3, (6-Bromopyridin-2-yl)methanol.

Reference:
Patent; WYETH; WO2008/73934; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 886372-63-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 886372-63-0 as follows.

To a solution of 5-fluoro-6-methoxypyridin-3-amine (0.100 g, 0.704 mmol) in acetone (1 mL) was added dropwise benzoyl isothiocyanate (0. 104 mL, 0.774 mmol). The reaction mixture was all owed to stir at room temperature for 3 h. The reaction mixture was diluted with water and EtOAc. The layers were separated and the organic layer was washed with brine, dried with sodium sulfate, and concentrated under reduced pressure to yield Intermediate 1-21 A (0.215 g, 0.704 mmol, 100 % yield): 1H NMR (400MHz, CDCl3) delta 12,48 (brs, 1H), 9.12 (br s, 1 H), 8,06 (d, 2.0 Hz, 1H ). 8.01 (dd, J=10.8, 2,2 Hz, 1H), 7.91 (d, J=1.1Hz, 1 H), 7.89 (d, J = 1 .5 Hz, 1H), 7.71-7.65 (m, 1H), 7.60-7.54 (m, 2H), 4,06 (s, 3H), LC-MS: method H, RT = 1.18 rnin. MS (ESI) m/z: 306.1 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,886372-63-0, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; FU, Qinghong; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (184 pag.)WO2018/13770; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 944937-53-5, name is 6-Bromo-1H-pyrrolo[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 6-Bromo-1H-pyrrolo[3,2-b]pyridine

To a soution of 6-bromo-1 H-pyrroo[3,2-b]pyridine (300 mg, 1.5 mmo) inDMF (2 mL), at 0 C, was added NaH (183 mg, 4.6 mmoL 60% dispersion in oi?). The reaction mixture was warmed to room temperature and stirred for 10 minutes and then cooed to 0 C and 3-(choromethy 5-methyisoxazoe (240 mg, 1.8 mmo) was added. The mixture was stirred at 0 C for 10 minutes then warmed to room temperature and stirred for 4 hours. Water was addedand the reaction mixture was extracted with EtOAc. The combined organicayers were dried (MgSO4), fi[tered and evaporated. Purification (FCC, Si02,0-100% EtOAc in hexanes) gave the tiUe compound (407 mg, 92%). 1H NMR(400 MHz, DMSO-d6) oe 8.41 (d, J = 2.0 Hz, I H), 8.26 (dd, J = 2.0, 0.9 Hz, I H),7.78 (d, J = 3.4 Hz, I H), 6.64 (dd, J = 3.3, 1.0 Hz, I H), 6.07 (d, J = 1.0 Hz,1 H), 5.52 (s, 2H), 2.33 (d, J = 0.9 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 944937-53-5.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHROVIAN, Christa C.; LETAVIC, Michael A.; RECH, Jason C.; SOYODE-JOHNSON, Akinola; WALL, Jessica L.; (533 pag.)WO2017/7938; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 107504-08-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 107504-08-5, name is 5-Fluoro-2-picolinic acid, molecular formula is C6H4FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In the 0 C will be under 5-fluoropyridine-2-carboxylic acid (212 mg, 1.5 mmol) and methylene chloride (10 ml) is added to the 100 ml flask in a single port, adding N, N – diisopropyl ethylamine (0.37 ml, 2.2 mmol) and HATU (600 mg, 1.5 mmol), under the protection of nitrogen to continue the reaction 0.5 hours; then adding (R)-tert-butyl (5-(5-amino-2-fluorophenyl)-2-cyclopropyl-5-methyl-1,1-dioxo-1,2,4-thiadiazine 3-methylene)carbamate (310 mg, 0 . 75 mmol), transferred to the 25 C reaction under 2 hours; stopping the reaction, by adding water (20 ml), then dichloromethane is used for extraction (30 ml ¡Á 2), the collection of organic phase, adding anhydrous sodium sulfate (2 g) drying, filtering, the filtrate is pressure reduced turns on lathe does, column chromatography separation and purification (petroleum ether/ethyl acetate (v/v)=4/1) to obtain the title compound as a white solid (0.34 g, 84.5%).

According to the analysis of related databases, 107504-08-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Zhong Wenhe; Xu Tengfei; Xue Yaping; (40 pag.)CN109180670; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 17368-12-6, 2-Chloro-4-hydroxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Tert-butyl 4-((2-chloropyridin-4-yl)oxy)piperidine-1-carboxylate (X22) To a solution of DEAD (97.4 mg, 0.56 mmol, 1.5 eq.) and PPh3 (146.6 mg, 0.56 mmol, 1.5 eq.) in THE (4 mL) at room temperature was added 1-Boc-4-hydroxypiperidine (75 mg, 0.37 mmol, 1.0 eq.). After 10 min, 2-chloro-4-hydroxypyridine (72.4 mg, 0.56 mmol, 1.5 eq.) was added and the reaction was heated to 50 C. The reaction was monitored via LCMS and after 12 h, the reaction was filtered through a syringe filter. The solvent was removed under vacuum. The crude residue was dissolved in DMSO (3 mL) and purified by Gilson HPLC (30*100 mm, 40-100% MeCN/H2O w/ 0.1% TFA). The desired fractions were concentrated to afford tert-butyl 4-((2-chloropyridin-4-yl)oxy)piperidine-1-carboxylate. ES-MS [M+1]+: 313.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,17368-12-6, 2-Chloro-4-hydroxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; Vanderbilt University; Lindsley, Craig W.; Conn, P. Jeffrey; Engers, Darren W.; Bollinger, Sean; Tarr, James C.; Spearing, Paul; Engers, Julie L.; Long, Madeline; Bridges, Thomas M.; (151 pag.)US2017/369505; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 884495-03-8, name is 3-Amino-2-bromo-5-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Amino-2-bromo-5-fluoropyridine

Synthesis of Methyl 3-amino-5-fluoropicolinate[00148] To a steel bomb reactor, 2-bromo-5-fluoropyridin-3 -amine (1.0 equiv.), triethylamine (1.6 equiv.), Pd(BINAP)Cl2 (0.0015 equiv.) and anhydrous methanol (0.4 M solution) were added. After degassed by nitrogen stream for 15 min, the steel bomb reactor was closed and filled with CO gas up to 60 psi. The reactor was then heated to 100 C. After 3 h, more Pd catalyst (0.0015 equiv.) was added and the reaction mixture was re-heated to the same temperature for 3 h. After cooling down to room temperature, a brown precipitate was filtered off and the filtrate was extracted with EtOAc, which was washed with water and brine, dried over anhydrous sodium sulfate, and filtered. After removing volatile materials, the crude yellow product was obtained and used for the next step without further purification (40%). LCMS (m/z): 271.2 (MH+); LC R, = 3.56 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 884495-03-8, 3-Amino-2-bromo-5-fluoropyridine.

Reference:
Patent; NOVARTIS AG; BURGER, Matthew; DING, Yu; HAN, Wooseok; LINDVALL, Mika; NISHIGUCHI, Gisele A.; RICO, Alice; SMITH, Aaron; TANNER, Huw; WAN, Lifeng; WO2012/4217; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65938-77-4, 5-Methyl-2-pyridinesulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 65938-77-4, blongs to pyridine-derivatives compound. Product Details of 65938-77-4

To a mixture of 5-methylpyridine-2-sulfonamide (109 mg, 0.63 mmol) in 1 M aqueous NaOH (0.63 mL, 0.63 mmol) was added tert-butyl hypochlorite (86 uL, 0.76 mmol) and the reaction stirred at room temperature for 1 .5h in the dark. The reaction was evaporated and the desired product washed with diethyl ether and dried under reducedpressure to yield the crude product. Used in the next step without further purification. It was assumed that the reaction gave quantitative yield. LCMS m/z 207 [M+H] – Na.

The synthetic route of 65938-77-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLACTONE PHARMA DEVELOPMENT AB; JOHANSSON, Martin; STERNER, Olov; (84 pag.)WO2018/104295; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6602-32-0, name is 2-Bromo-3-hydroxypyridine, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6602-32-0

EXAMPLES; Example 1; 2-Bromo-3-hydroxy-6-iodopyridine; To a mixture of 14g of 2-bromo-3-hydroxypyridine (80.5 mmol), and 22.3g of K2CO3 (161 mmol) in 180 mL of water at room temperature was added 21. 0g of 12 (82. 7 mmol) in one portion. The mixture was stirred at room temperature for 2h then carefully neutralized with 3N HC1 (aq) to pH = 6. The solid was collected by vacuum filtration and washed with water (100 mL), 2M aqueous sodium bisulfite (50 mL), and water (100 mL). The solid was dried in vacuo to give 16. lg of 2-bromo-3-hydroxy-6-iodopyridine as a tan solid. IH NMR (300 MHz, MeOD) 5 7.57 (d, J=8.3Hz, 1H), 6.95 (d, J=8.3Hz, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 6602-32-0.

Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2005/61458; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1060811-62-2, Adding some certain compound to certain chemical reactions, such as: 1060811-62-2, name is 4,6-Dichloronicotinaldehyde,molecular formula is C6H3Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1060811-62-2.

Step B: 2-(4,6-difluoropyridin-3 -yl)-6-(trifluoromethyl)- 1 -H-benzimidazoleA solution of 4-(trifluoromethy)benzene-l ,2-diamine (250 mg, 1.419 mmol) in DMF (5.0 ml) and water (0.5 ml) was treated with the Intermediate from Step A (250 mg, 1.419 mmol) slowly and the mixture stirred at room temperature for 5 min. Potassium peroxymonosulfate (873 mg, 1.419 mmol) was then added and the mixture stirred for another 50 min. The mixture was poured slowly in 75 ml of water containing 6 ml (2 M K2CO3) and the mixture stirred at room temperature for 5 min. The mixture was diluted with EtOAc and the layers separated. The organic layer was dried (MgS04) and concentrated under vacuum. The resulting residue was then purification on the ISCO CombiFlash Companion (with a 24 g column) eluting with 20 to 40 percent ethylacetate / hexane gradient The desired fractions were concentrated to afford the title compound. LC-MS (ES> m/z) C13H6CI2F3N3: 332; Found: 332, 334, 336 [M, M+2.M+4].’HNMR (500 MHz, COCh, ppm) delta 7.58 (1H, s), 7.66 (1H, d, 8.5 Hz), 7.84 (1 H, d, 8.4 Hz), 8.08 (1H, s), 9.37 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1060811-62-2, 4,6-Dichloronicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; BALKOVEC, James, M.; KRIKORIAN, Arto, D.; GUIADEEN, Deodial; YANG, Ginger; JIAN, Tianying; WU, Zhicai; YU, Yang; NARGUND, Ravi, P.; VACHAL, Petr; DEVITA, Robert, J.; HE, Shuwen; LAI, Zhong; BLEVIS-BAL, Radhika, M.; CERNAK, Timothy, A.; SPERBECK, Donald, M.; HONG, Qingmei; WO2012/96813; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 71255-09-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71255-09-9, name is 2-Methoxynicotinaldehyde, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.

General procedure: The ketone or aldehyde (0.72mmol) was added to a stirred solution of amine (0.63mmol, HCl salt) and acetic acid (0.68mmol) in 10mL DCE with ice cooling. After stirring for 10minat rt, sodium triacetoxyborohyride (1.26mmol) was added to the reaction mixture. After stirring at for 6h, the reaction mixture was diluted with dichloromethane (50mL), washed with saturated sodium bicarbonate solution, brine, dried over MgSO4, filtered, and concentrated under vacuum. The residue was purified by silica gel column chromatography to give the N-alkylated product.

The chemical industry reduces the impact on the environment during synthesis 71255-09-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ji, Yue-Yang; Lin, Sen-Dong; Wang, Yu-Jie; Su, Ming-Bo; Zhang, Wei; Gunosewoyo, Hendra; Yang, Fan; Li, Jia; Tang, Jie; Zhou, Yu-Bo; Yu, Li-Fang; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 101 – 112;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem