Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 84249-14-9, 2-Amino-4-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H5BrN2, blongs to pyridine-derivatives compound. COA of Formula: C5H5BrN2

Dissolve 2-amino-4-bromopyridine (1.0 g, 5.8 mmol), di-tert-butyl dicarbonate (Boc2O, 1.4 g, 6.4 mmol) in t-BuOH (15 mL), heat the mixture at 50 C. overnight. Cool to room temperature, pour to water (50 mL), extract with EtOAc (15 mL*3). Combine the organic layers, dry over anhydrous Na2SO4; concentrate under reduced pressure to afford the crude product (1.24 g) which is used without further purification. MS: (M+1): 219.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,84249-14-9, 2-Amino-4-bromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; Zhang, Deyi; Zhang, Ruihao; Zhong, Boyu; Shih, Chuan; US2015/197511; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1121-76-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1121-76-2, name is 4-Chloropyridine 1-oxide. A new synthetic method of this compound is introduced below.

4-Chloropyridine-N-oxide (3.0 g, 23 mmol), 4-trifluoromethylphenylboronic acid (6.57 g, 34.6 mmol), K2CO3 (4.8 g, 35 mmol) and PdCl2 (dppf) (470 mg, 0.57 mmol) were stirred in DMSO (40 mL) under vacuum for 30 min. The flask was flushed with nitrogen, and the mixture was heated to 80 C. for 10 min. Upon cooling, the mixture was diluted with methylene chloride and washed with 5% lithium chloride solution (5¡Á), dried, concentrated, and the residue was purified by flash column chromatography (40 g ISCO column eluting with methylene chloride and a methanol/ammonia mixture (10:1); gradient 100% methylene chloride to 80% methylene chloride over 30 min at 40 mL/min) to provide the title compound (1.90 g, 34%) as a tan solid: ESI MS m/z 240 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1121-76-2, 4-Chloropyridine 1-oxide, and friends who are interested can also refer to it.

Reference:
Patent; ALBANY MOLECULAR RESEARCH, INC.; US2011/3738; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6959-48-4, name is 3-(Chloromethyl)pyridine hydrochloride, molecular formula is C6H7Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 3-(Chloromethyl)pyridine hydrochloride

General procedure C: A suspension of 2-morpholino-naphth[2,1-e]-1,3-oxazine 10b, 13b, and 13c (1 mmol), cesium carbonate (8.5 mmol) and 2-(bromomethyl)-pyridine hydrobromide, 3-(chloromethyl)-pyridine hydrochloride (2 mmol) in acetonitrile, according to the previously reported procedure.10 The solid was collected and recrystallised from a suitable solvent.

With the rapid development of chemical substances, we look forward to future research findings about 6959-48-4.

Reference:
Article; Ihmaid, Saleh; Al-Rawi, Jasim; Bradley, Christopher; Angove, Michael J.; Robertson, Murray N.; Clark, Rachel L.; Bioorganic and Medicinal Chemistry; vol. 19; 13; (2011); p. 3983 – 3994;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 791644-48-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 791644-48-9, name is 2-Chloro-5-fluoronicotinonitrile, molecular formula is C6H2ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3. 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine 2-Chloro-5-fluoro-3-pyridinecarbonitrile (15.3 g, 98 mmol) was dissolved in 1-butanol (300 mL), and then hydrazine monohydrate (16.82 mL, 293 mmol) was added, followed by hydrochloric acid (4N in dioxane) (0.244 mL, 0.977 mmol). The reaction mixture was maintained at 70 C for 4 hours, and the resulting yellow crystalline solid was collected by filtration (12.5 g, 84 % yield). MS (m/z) 153 (M+H+). 1H NMR (400 MHz, DMSO-d6) delta ppm 5.56 (s, 2 H), 7.97 (dd, 1 H), 8.39(m, 1 H), 12.07 (s, 1 H).

According to the analysis of related databases, 791644-48-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GlaxoSmithKline Intellectual Property Development Limited; BURY, Michael, Jonathan; CASILLAS, Linda, N.; CHARNLEY, Adam, Kenneth; HAILE, Pamela, A.; MARQUIS, Robert, W., Jr.; MEHLMANN, John, F.; ROMANO, Joseph, J.; SINGHAUS, Robert, R.; WANG, Gren, Z.; (83 pag.)EP2680844; (2016); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24100-18-3, name is 2-Bromo-3-methoxypyridine, the common compound, a new synthetic route is introduced below. SDS of cas: 24100-18-3

262 mL of conc. sulfuric acid was cooled down to -2C, and 262 mL of 90 % nitric acid was carefully added thereto. Subsequently, 65.3 g (corresponding to 0.347 mmol) of 2-bromo-3-methoxypyridine was carefully added thereto. After the reaction mixture was stirred in an ice bath for 10 minutes, the mixture was stirred at room temperature for 30 minutes, and then was heated to 55C and further stirred for 1.5 hours. After the reaction solution was cooled to room temperature, the reaction solution was poured little by little into crushed ice to generate precipitates. The precipitates were filtered and washed with water, and then dried over phosphorous pentoxide under reduced pressure, to obtain 55.7 g (corresponding to 0.239 mol) of 2-bromo-3-methoxy-6-nitropyridine (Fig. 3, Step 2).

The synthetic route of 24100-18-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nihon Medi-Physics Co., Ltd.; EP2213671; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1480-64-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1480-64-4, name is 3-Chloro-2-fluoropyridine, molecular formula is C5H3ClFN, molecular weight is 131.54, as common compound, the synthetic route is as follows.

Example 97 (4S,6S)-4-(5-((3-chloropyridin-2-yl)oxy)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine The title compound was synthesized using steps and procedures analogous to those described in Method M (Example 92) above, but using 3-chloro-2-fluoropyridine (Matrix) in step 5. MS m/z=422 [M]+. Calculated for C17H13ClF5N3O2: 421.75. 1H NMR (300 MHz, CHLOROFORM-d) ppm 2.19 (t, J=13.15 Hz, 1H) 2.69 (d, J=13.74 Hz, 1H) 4.18 (d, J=8.92 Hz, 3H) 4.34-4.58 (m, 1H) 4.61-4.86 (m, 1H) 6.98 (dd, J=7.38, 4.90 Hz, 1H) 7.12 (d, J=8.62 Hz, 2H) 7.30 (d, J=7.31 Hz, 2H) 7.76 (d, J=7.60 Hz, 1H) 8.00 (d, J=4.82 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis 1480-64-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MINATTI, Ana Elena; LOW, Jonathan D.; ALLEN, Jennifer R.; CHEN, Jian; CHEN, Ning; CHENG, Yuan; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; TAMAYO, Nuria A.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; US2014/249104; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6959-48-4, name is 3-(Chloromethyl)pyridine hydrochloride, molecular formula is C6H7Cl2N, molecular weight is 164.03, as common compound, the synthetic route is as follows.Application In Synthesis of 3-(Chloromethyl)pyridine hydrochloride

A mixture of ethyl 3-[3-ethoxy-1-(4-hydroxy-3-methoxybenzyl)-1H-pyrazol-4-yl]propionate (505 mg), 3-picolyl chloride hydrochloride (476 mg), potassium carbonate (601 mg) and N,N-dimethylformamide (10 ml) was stirred overnight at room temperature. The reaction mixture was poured into water and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then with saturated brine, dried (MgSO4) and concentrated. The residue was applied to silica gel column chromatography and compound G (531 mg, yield 83%) was obtained as a colorless oil from a fraction eluted with ethyl acetate. NMR(CDCl3)delta:1.21 (3H, t, J=7.0 Hz), 1.37 (3H, t, J=7.0 Hz), 2.47-2.55 (2H, m), 2.61-2.69 (2H, m), 3.84 (3H, s), 4.09 (2H, q, J=7.0 Hz), 4.22 (2H, q, J=7.0 Hz), 4.99 (2H, s), 5.13 (2H, s), 6.68 (1H, dd, J=8.0, 2.2 Hz), 6.77 (1H, d, J=2.2 Hz), 6.84 (1H, d, J=8.0 Hz), 6.95 (1H, s), 7.31 (1H, dd, J=8.0, 4.8 Hz), 7.79 (1H, dt, J=8.0, 1.8 Hz), 8.57 (1H, d, J=4.8 Hz), 8.67 (1H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6959-48-4, 3-(Chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1445254; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56026-36-9, Methyl 6-(hydroxymethyl)nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56026-36-9, blongs to pyridine-derivatives compound. Product Details of 56026-36-9

6-hydroxymethyl nicotinic acid methyl ester (11 ) (10.0 g, 59.8 mmol) was azeotroped with acetonitrile ( 2 x 100 mL) then dissolved in (0261) dichloromethane (alcohol free, 150 mL) and treated with (0262) diisopropylethylamine (12.5 mL, 71 .8 mmol) followed by 2-cyanoethyl-N,N- diisopropylchlorophosphoramidite (13.4g, 56.8 mmol). The reaction mixture was stirred at RT, under argon for 1 .5 hours. TLC (1 : 1 hexane: EtOAc, visualised by PMA/heat) showed reaction completion (SM Rf ~ 0.3, prod Rf ~ 0.5). (0263) The mixture was washed with sat. NaHC03(aq) (100 mL) and the layers were separated. The organic phase was washed with 100 mL sat. then dried over anhydrous sodium sulphate, filtered and concentrated in vacuo to give a brown oil. This was triturated with pentane (2 x 150 mL). (0264) The crude material was purified by flash column chromatography on pre- equilibrated silica gel (1 : 1 EtOAc : pentane + 1 % NEt3) eluting with 1 : 1 EtOAc : pentane, the crude product was loaded in DCM. Product containing fractions were selected by TLC and concentrated in vacuo to give a colourless oil. This was azeotroped with MeCN and dried on the freeze-drier overnight to give 12 (6.55g, 30%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56026-36-9, its application will become more common.

Reference:
Patent; LINK TECHNOLOGIES LIMITED; MCGEOCH, Grant; MCKEEN, Catherine; OSNOWSKI, Andrew; WILSON, Jennifer; WO2015/132577; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65719-09-7, Methyl 2-methylnicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9NO2, blongs to pyridine-derivatives compound. Computed Properties of C8H9NO2

a) 2-methylnicotinic Acid Following the procedure of Example 1(g), except substituting methyl-2-methylnicotinate for N-(4-pyridinylmethoxycarbonyl)-L-leucine methyl ester, the title compound was prepared as a white solid (1.6 g, 100percent). MS (ESI): 138.2 (M+H)+.

The synthetic route of 65719-09-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Halbert, Stacie Marie; Michaud, Evelyne; Thompson, Scott Kevin; Veber, Daniel Frank; US2002/49316; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 54221-96-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54221-96-4, name is 6-Methoxypicolinaldehyde, molecular formula is C7H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: General procedure: 8-Hydrazinocaffeine (3) (112 mg;0.5 mmol) and carbonyl compound (1 mmol; 2 eq.) were mixedin ethanol (20 mL, containing 0.2 mL of acetic acid) and heated at 75 omicronC for 3 days. After cooling down, reaction mixture was evaporatedto dryness and solid residue was suspended in diethyl ether(50 mL), filtered off, washed with additional portion of diethylether (3 25 mL) and dried in vacuo at 50 C to obtain the hydrazone.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54221-96-4, 6-Methoxypicolinaldehyde.

Reference:
Article; Kaplanek, Robert; Jakubek, Milan; Rak, Jakub; Kejik, Zden?k; Havlik, Martin; Dolensky, Bohumil; Frydrych, Ivo; Hajduch, Marian; Kola?, Milan; Bogdanova, Kate?ina; Kralova, Jarmila; D?ubak, Petr; Kral, Vladimir; Bioorganic Chemistry; vol. 60; (2015); p. 19 – 29;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem