Tag: M.W:100-200

Reference of 850663-54-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 850663-54-6, name is 4-Chloro-5-nitropyridin-2(1H)-one, molecular formula is C5H3ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3.2, 4-Dichloro-5-nitropyridine The product from Step 2 (40.0 g, 229 mmol) was suspended in toluene (300 mL) and POC13 (65 mL, 697 mmol) was added over 10 min, then the mixture was heated to relux for 6 h then cooled to 60 C and allowed to stir overnight at that temperature. The heterogeneous mixture was cooled and concentrated, the residue was carefully made basic with aq. K2CO3 solution and extracted with EtOAc. The organic layers were combined, washed with H20 and brine, dried (Na2S04), filtered and the filtrate was concentrated to give an oil. The crude oil was passed through a plug of silica gel (50% EtOAc in hexanes) to give the title compound (32.5 g, 74 %) as an orange oil which solidified on standing. MS (ES+) m/e 194 [M+H] +.

According to the analysis of related databases, 850663-54-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/37197; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 22245-83-6 , The common heterocyclic compound, 22245-83-6, name is 3-(Trifluoromethyl)pyridin-2-ol, molecular formula is C6H4F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 3- (trifluoromethyl) pyridin-2-ol (2 g 12.26 mmol) was added nitric acid (1.644 mL 36.8 mmol) and H2SO4(12.03 g 123 mmol) at 0 . Then the mixture was stirred at 25 for 16 h. The mixture was then warmed to 60 for 5 h cooled and added to 150 g of ice. The mixture was extracted with EA (2 x 100 mL) and washed with H2O (100 mL) to give the organic layer. The combined organic extract was washed with brine dried over Na2SO4 concentrated to yield a brown solid of 5-nitro-3- (trifluoromethyl) pyridin-2-ol (2.2 g 8.99 mmol 73.3yield) 1HNMR(400 MHz CD3OD) delta 8.91 (d J 2.43 Hz 1H) 9.42 (d J 2.43 Hz 1H) ES-LCMS m/z 209.0 (M+H)

The synthetic route of 22245-83-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 96424-68-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 96424-68-9, name is 2-Bromo-3-chloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a flame-dried flask were added Pd(PPh3)4 (10 mol %), Xantphos (10 mol %), Cs2CO3 (3 eq) and 2-bromo-3-chloropyridine (1.2 eq). Then, 1OB (1 eq) and DMF (0.15 M) were added to the reaction mixture under an N2 atmosphere. The reaction mixture was stirred for 10 min at room temperature, and then heated at 140 C. in a pre-heated oil bath for 24 h. After that, the reaction mixture was cooled to room temperature, diluted with CH2Cl2, filtered through a short pad of Celite, and washed with CH2Cl2. The combined organic extracts were concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel to provide the product DFE-1OB-3 in 36% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 96424-68-9, 2-Bromo-3-chloropyridine.

Reference:
Patent; Arizona Board of Regents on behalf of Arizona State University; Li, Jian; Zhu, Zhi-Qiang; (232 pag.)US2018/337345; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71902-33-5, name is 3,5-Difluoropyridine, molecular formula is C5H3F2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 71902-33-5

3,5-Difluoropyridine (5.0 g, 43.45 mmol) in THF was cooled to -720C (external -8O0C). LDA (23.9 mL, 1.1 eq.) was added drop-wise so that the internal temp did not increase more than 30C during addition. The reaction mixture turned into a deep brownish, thick phase and was stirred for 30 minutes at this temperature. TMS-Cl (43.4 mL, 43.45 mmol) was added drop-wise in a relatively fast fashion. The reaction became a clear and light yellow solution. LDA (23.9 mL, 1.1 eq.) was added drop-wise in a quicker version, and the reaction mixture was allowed to stir for 2h. Methyl 2-methoxyacetate (5.59 mL, 56.48 mmol) was added quickly through a syringe. The reaction mixture was quenched at -780C by adding 20 ml of saturated NH4Cl solution. Evaporation of the organic extracts under reduced pressure gave a colored residue. Purification utilizing ISCO (0-25percent EtOAc/hexanes), gave the title compound (3 g). LCMS: 188 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 71902-33-5.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; ALMEIDA, Lynsie; CHUAQUI, Claudio, Edmundo; GUAN, Amy; IOANNIDIS, Stephanos; LAMB, Michelle; PENG, Bo; SU, Qibin; WO2010/20810; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55-22-1, Isonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55-22-1, blongs to pyridine-derivatives compound. Safety of Isonicotinic acid

General procedure: A mixture of o-aminobenzenethiol (1 mmol), carboxylic acid (1 mmol), N,N-diisopropylethylamine (1.5 mmol) and propylphosphonic anhydride (1 mmol, 50% w/w in AcOEt) was irradiated for 10 min under microwave at 100 C in a sealed tube. It was diluted with H2O, followed by alkalinization with saturated aqueous NaHCO3 solution. The precipitate was collected by filtration and washed thoroughly with H2O to afford the respective benzothiazole. If necessary, simple recrystallization was carried out in EtOH/H2O.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55-22-1, its application will become more common.

Reference:
Article; Wen, Xiaoan; Bakali, Jamal El; Deprez-Poulain, Rebecca; Deprez, Benoit; Tetrahedron Letters; vol. 53; 19; (2012); p. 2440 – 2443;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 10201-73-7, 2-Amino-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4-methoxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4-methoxypyridine

(41c). A mixture of 2-amino-4-methoxypyridine (2.4 g, 19 mol)and N-bromosuccinimide (3.1 g, 17 mmol) was dissolved in aceticacid (6 mL) and stirred at room temperature for 1 h. The reactionmixture was concentrated under vacuum, basified with saturatedaqueous K2CO3 and extracted with EtOAc. The combined organicswere dried, concentrated under vacuum, and purified by silicagel column chromatography, eluting with 50:1 CH2Cl2:MeOH, togive 41c (1.85 g, 47%). LCMS 203 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10201-73-7, 2-Amino-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Article; Cloudsdale, Ian S.; Dickson, John K.; Barta, Thomas E.; Grella, Brian S.; Smith, Emilie D.; Kulp, John L.; Guarnieri, Frank; Kulp, John L.; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 3947 – 3963;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-55-1, name is 3-Bromopyridine, the common compound, a new synthetic route is introduced below. Computed Properties of C5H4BrN

General procedure: In a well-ventilated fume hood, a 15 mL round-bottomed flaskequipped with a Teflon-coated magnetic stirrer bar was chargedwith NiBr2¡¤3H2O (40.9 mg, 0.150 mmol, 0.05 equiv), bathophenanthroline(4; 49.9 mg, 0.150 mmol, 0.05 equiv), DMF (2.0 mL), andalkyl bromide 2 (3.3 mmol, 1.1 equiv). The vessel was stopperedwith a rubber septum and heated to 40 C in a fume hood until agreen homogeneous solution formed (~20 min). The vessel wasthen removed from the heat and 2-halopyridine 1 (3.00 mmol, 1.00equiv) and manganese(0) (-325 mesh; 330 mg, 6.00 mmol, 2.00equiv) were added. The vessel was resealed with the septum, purgedwith argon, and heated again to 40 C while the progress of the reactionwas monitored by GC analysis of aliquots of the crude reactionmixture. In general, the mixtures turned dark brown or blackwhen the reaction was complete. Upon completion of the reaction,the mixture was cooled to r.t., diluted with Et2O (10 mL), and filteredthrough a short pad of Celite 545 (approx. 1 ¡Á 1 ¡Á 1 inch) wettedwith Et2O (~10 mL) to remove metal salts. The Celite pad waswashed with additional Et2O (2 ¡Á 10 mL), and the filtrate was transferredto a separatory funnel and washed with 1 M aq NH4Cl (10mL). The layers were separated and the aqueous layer was washedwith additional Et2O (3 ¡Á 10 mL). The organic extracts were combined,washed with brine (10 mL), dried (MgSO4), filtered, and concentratedunder reduced pressure. The crude products were purifiedby flash column chromatography on silica gel.

The synthetic route of 626-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Everson, Daniel A.; Buonomo, Joseph A.; Weix, Daniel J.; Synlett; vol. 25; 2; (2014); p. 233 – 238;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6302-02-9, name is 1-(Pyridin-2-yl)propan-2-one. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H9NO

EXAMPLE 15 2-Methylamino-4-methyl-5-(2-pyridyl)thiazole (1.8 g) was obtained according to substantially the same manner as that of Example 11 from 1-(2-pyridyl)acetone (2.03 g) and N-methylthiourea (2.7 g). mp 279-282 C. IR (Nujol): 3170, 1620, 1580, 1550, 1295, 1280 cm-1 NMR (D2 O+DCl, delta): 2.46 (3H, s), 3.20 (3H, s), 8.0-9.0 (4H, m) Mass. 205 (M+)

With the rapid development of chemical substances, we look forward to future research findings about 6302-02-9.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4649146; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1192813-41-4, 2-(Difluoromethoxy)-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1192813-41-4, blongs to pyridine-derivatives compound. Recommanded Product: 1192813-41-4

Step B: 6-(difluoromethoxy)pyridin-3-amine To 2-(difluoromethoxy)-5-nitropyridine (4.7 g, 24.7 mmol) in degassed methanol (100 mL) was added 10% palladium on carbon (500 mg, 0.47 mmol) and the reaction was hydrogenated at atmospheric pressure for 1 hour. To this was added acetic acid (2.83 mL, 49.4 mmol) and the reaction was filtered through Celite and concentrated in vacuo to afford 6-(difluoromethoxy)pyridin-3-amine (6.33 g, 25.9 mmol, 105 % yield) as an olive green liquid. XH NMR (400 MHz, MeOD-d4) delta ppm 7.60 (d, J=2.76 Hz, 1 H), 7.37 (s, 0.5 H), 7.15 (dd, J=8.66, 2.89 Hz, 1 H), 7.00 (s, 0.5 H), 6.71 (d, J=8.78 Hz, 1 H).

The synthetic route of 1192813-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.; WO2011/53292; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1824-81-3, name is 2-Amino-6-picoline. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8N2

21.6 g of 2-amino-6-methylpyridine and 24 g of triethylamine were added to 200 ml of chloroform, and 26 g of pivaloyl chloride was added dropwise at 0C to the mixture. The obtained mixture was stirred at a room temperature for 1 day. Thereafter, a sodium bicarbonate aqueous solution was added to the reaction mixture, and it was then extracted with chloroform twice. The organic layer was dried over magnesium sulfate, and it was then concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography, so as to obtain 36.8 g of N-(6-methylpyridin-2-yl)-2,2-dimethylpropionic acid amide.N-(6-methylpyridin-2-yl)-2,2-dimethylpropionic acid amide [Show Image] 1H-NMR (CDCl3) delta: 1.33 (9H, s), 2.45 (3H, s), 6.88 (1H, d, J = 7.7 Hz), 7.58 (1H, dd, J = 8.1, 7.7 Hz), 7.94 (1H, br s), 8.05 (1H, d, J = 8.1 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1824-81-3, 2-Amino-6-picoline.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2248423; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem