Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5912-18-5, name is 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Safety of 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine

4,6-Dichloro-lH-pyrrolo[2,3-6]pyridine (1.0 g, 5.4 mmol) was combined with (R)-(+)-l -phenyl ethylamine (5.5 mL, 43 mmol) and the mixture was heated in the microwave reactor at 220 C for 4 hours. The mixture was cooled and washed three times with 10% aqueous citric acid, water, saturated NaCl, dried over Na2SC”4 and concentrated in vacuo. The dark residue was slurried in methylene chloride and the undissolved solids were removed by filtration, washed with methylene chloride then the filtrate was chromatographed on Si02 (Biotage SNAP 25g) and eluted with a gradient of ethyl acetate / hexanes. Two isomeric materials eluted from the column. The less polar material was confirmed as the desired product by NMR, (336 mg). LCMS ESI (+) m/z 272.1 (M+H).

The synthetic route of 5912-18-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PELOTON THERAPEUTICS, INC.; WANG, Bin; YANG, Hanbiao; BEDKE, Karl; WEHN, Paul; RIZZI, James P.; (241 pag.)WO2018/183635; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 88912-27-0 , The common heterocyclic compound, 88912-27-0, name is 3-Chloroisonicotinic acid, molecular formula is C6H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Production Example 48 A mixture of 0.3 g of 2-amino-4-trifluoromethoxy phenol, 0.29 g of 3-chloroisonicotinic acid, 1.04 g of (benzotriazole-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (hereinafter, referred to as a BOP reagent), 0.24 g of triethylamine and 5 ml of DMF was stirred at room temperature for two hours. Water was added to the reaction mixture, precipitated solid was collected by filtration. The resultant solid was dissolved in ethyl acetate. Then, the organic layer was washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.43 g of 3-chloro-N-[2-hydroxy-5-(trifluoromethoxy)phenyl]isonicotinamide. [Show Image] 1H-NMR (DMSO-d6) delta: 10.37 (br s, 1H), 10.15 (br s, 1H), 8.75-8.73 (m, 1H), 8.64-8.61 (m, 1H), 8.04-8.01 (m, 1H), 7.63-7.60 (m, 1H), 7.07-7.02 (m, 1H), 6.98-6.94 (m, 1H)

The synthetic route of 88912-27-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2274983; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 573762-62-6, Adding some certain compound to certain chemical reactions, such as: 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile,molecular formula is C7H4F3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 573762-62-6.

Compound 3 (0.50 g, 2.0 mmol) was added to a 25 mL two-necked flask. 3-trifluoromethyl-4 cyanoaniline (0.448 g, 2.40 mmol) and 6.5 mL N,N-dimethylacetamide, thiophosgene (0.28 ml, 3.20 mmol) was added dropwise to the solution, and the mixture was heated to 70 C for 24 h. After cooling to room temperature, 2 mL of methanol, 0.5 mL of concentrated hydrochloric acid and 2 mL of water were added, and the mixture was stirred under reflux for 2 h. After cooling to room temperature, ethyl acetate (10¡Á3 mL) was evaporated.The residue is purified by column chromatography to give compound 5, 0.286 g, pale yellow solid, yield 29.9%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Changsha Zeda Pharmaceutical Technology Co., Ltd.; Chen Yongheng; Xu Guangyu; Zhou Wenqiang; (23 pag.)CN108976171; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate, molecular formula is C8H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1658-42-0

General procedure: In a reaction tube 66.0 mg (0.4 mmol) of ethyl 2-(pyridin-2-yl)acetate (1a), 41.6 mg (0.2 mmol) of 1,3-diphenyl-2-propenone (2b), 12.65 mg (0.05 mmol) of I2 and 58.4 mg (0.4 mmol) of DTBP were added to 1.0 mL of 1,2-dichlorobenzene and stirred the reaction mixture at 120 ¡ãC, after 24 h of the reaction time, the mixture was allowed to attain room temperature, and quenched the I2 with Na2S2O3 solution, after adding 10 mL of brine solution to reaction mixture, the organic portion was extractedwith ethyl acetate (3×10 mL) and combined organic layers dried over anhydrous Na2SO4, crude mixture obtained after removal of ethyl acetate under reduced presure was purified by column chromatography to isolate 3a with 87 percent yield.

With the rapid development of chemical substances, we look forward to future research findings about 1658-42-0.

Reference:
Article; Reddy, N. Naresh Kumar; Donthiri, Ramachandra Reddy; Ravi, Chitrakar; Adimurthy, Subbarayappa; Tetrahedron Letters; vol. 57; 30; (2016); p. 3243 – 3246;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17228-64-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17228-64-7, name is 2-Chloro-6-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

An oven dried threaded 2 dram, 17*60 mm reaction vial equipped with a Teflon-coated magnetic stir bar is charged with [(pi-allyl)Pd(Bippyphos)]OTf (16 mg, 0.02 mmol, 2 mol %), BippyPhos (10 mg, 0.02 mmol, 2 mol %), 2-phenylindole (193 mg, 1.00 mmol), and NaOt-Bu (135 mg, 1.40 mmol). The vial is capped with a polypropylene cap with PTFE-faced silicone septum and is evacuated and backfilled with nitrogen. This evacuation/backfill cycle is repeated two additional times. Anhydrous toluene (4 mL) and 2-chloro-6-methoxypyridine (119 muL, 1.00 mmol) are added sequentially via syringe. The nitrogen needle is removed and the vial is placed on a preheated aluminum block (110 C.) and stirred for 16 hours. The tube is then removed from the heating block and allowed to cool to room temperature. The reaction mixture is diluted with 10 mL of EtOAc, filtered through a pad of Celite, and concentrated in vacuo. The residue is chromatographed on silica gel using a Teledyne ISCO CombiFlashRf with a gradient of 0-5% EtOAc/hexanes as the eluent to give 293 mg (0.98 mmol, 98%) of 1-(6-methoxypyridin-2-yl)-2-phenyl-1H-indole as a colorless oil. 1H NMR (400 MHz, CDCl3, delta): 7.75 (d, J=7.8 Hz, 1H), 7.69 (d, J=7.8 Hz, 1H), 7.55 (t, J=7.8 Hz, 1H), 7.31-7.20 (m, 7H), 6.80 (s, 1H), 6.67-6.62 (m, 2H), 3.76 (s, 3H). 13C NMR (100 MHz, CDCl3, delta): 163.7, 149.6, 140.6, 140.1, 138.4, 133.5, 129.0, 128.9, 128.3, 127.5, 123.0, 121.5, 120.8, 113.6, 111.7, 108.6, 105.6, 53.8.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17228-64-7, 2-Chloro-6-methoxypyridine.

Reference:
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas; Jon Deangelis, Andrew; (66 pag.)US9777030; (2017); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60186-15-4, name is 2,4-Difluoro-5-nitropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2,4-Difluoro-5-nitropyridine

4-(2-Fluoro-5-nitropyridin-4-yl)morpholine. In a 50 mL round-bottom flask vial was dissolved 2,4-difluoro-5-nitropyridine (175.7 mg, 1.098 mmol) in tetrahydrofuran (5 mL) to give a tan solution. After cooling to -40C, morpholine (0.080 mL, 0.918 mmol) was added, followed by Et3N (0.256 mL, 1.83 mmol). The cloudy yellow mixture was stirred at-40 C – 0C for 3 h. The mixture was concentrated togive a yellow solid. The solid was purified by flash column chromatography on silica gel, eluting with 60% ethyl acetate/hexane, to afford the desired product (209 mg, 100%) as a yellow solid: 1H NMR (400 MHz, Chloroform- d) delta 8.60 (s, 1H), 6.42 (s, 1H), 3.96 – 3.81 (m, 4H), 3.33 – 3.18 (m, 4H);19F NMR (376 MHz, Chloroform-d) delta -61.42.

The synthetic route of 60186-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 886365-00-0 ,Some common heterocyclic compound, 886365-00-0, molecular formula is C6H5Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 6 (1.55 mmol), 2 (0.77 mmol), and i-Pr2NEt(1.55 mmol) in toluene (unless otherwise stated) (0.77 ml) was stirred at 120 C in a sealed tube for 16 h. The mixture was allowed to cool to room temperature. Purification method A: the mixture was concentrated and the residue was purified by reverse phase automatedpreparative HPLC. Purification method B: the mixture was concentrated and the residue was purified by flash column chromatography (SiO2). Purification method C: the mixture was diluted(DCM), washed (satd Na2CO3), dried (filtered through a Biotage phase separator), and concentrated. The residue was purified by reverse phase automated preparative HPLC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,886365-00-0, its application will become more common.

Reference:
Article; Mammoliti, Oscar; Quinton, Evelyne M.; Loones, Kristof T.J.; Nguyen, Anh Tho; Wouters, Johan; Van Lommen, Guy; Tetrahedron; vol. 69; 5; (2013); p. 1669 – 1680;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 16135-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16135-36-7, name is Methyl 4-aminonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-chloro-2-(5-chloro-2-fluoro-phenyl)-5-(l-methoxy-l-methyl- ethyl)pyridine (200 mg, 0.636 mmol), methyl 4-aminopyridine-3 -carboxylate (107 mg, 0.703 mmol) and K3P04 (270 mg, 1.271 mmol) in dioxane (1.5 mL) was purged with nitrogen for 10 min, followed by addition of Pd2(dba)3 (58 mg, 0.063 m mol) and Xantphos (74 mg, 0.127 mmol) and again purged for 2 min. The reaction mixture was heated in a microwave at 100 C for 2 h. The progress of reaction was monitored by TLC and LCMS. After completion of reaction, the mixture was diluted with EtOAc (15 mL) and washed with water (2×10 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford a crude product. The crude product was purified by CombiFlash using 25% EtOAc-hexane as eluent to obtain methyl 4-[[2-(5-chloro-2-fluoro-phenyl)-5-(l-methoxy-l-methyl- ethyl)-4-pyridyl]amino]pyridine-3-carboxylate (42 mg).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16135-36-7, Methyl 4-aminonicotinate.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; PUJALA, Brahmam; SHINDE, Bharat Uttam; NAYAK, Anjan Kumar; CHAKLAN, Naveen; AGARWAL, Anil Kumar; RAMACHANDRAN, Sreekanth A.; PHAM, Son; WO2015/103355; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 628-13-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 628-13-7, name is Pyridinehydrochloride. A new synthetic method of this compound is introduced below.

4-(5-Hydroxy-benzofuran-2-yl)-benzoic acid 128 A mixture of 4-(5-Methoxy-benzofuran-2-yl)-benzoic acid methyl ester (0.5 g, 1.8 mmol) and Pyridine HCl (5 g) was heated to 200 C. After 2 hr, the reaction was cooled and poured into water and exracted with EtOAc. The EtOAc layer was dried over MgSO4, concentrated and the product was purified by column chrmatography on silica gel (75% EtOAc/hex) to give a solid (0.21 g, 47%): 1H NMR (DMSO-d6) delta 13.07 (br s, 1H), 9.29 (br s, 1H), 8.02 (d, 2H, J=8.1 Hz), 7.97 (d, 2H, J=8.7 Hz), 7.46 (m, 2H), 6.97 (d, 1H, J=2.9 Hz), 6.79 (dd, 1H, J=9.3 Hz, 2.9 Hz); MS 253 (M-H)-

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,628-13-7, its application will become more common.

Reference:
Patent; Wyeth; US2003/171428; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 54127-30-9 ,Some common heterocyclic compound, 54127-30-9, molecular formula is C6H5Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 500 mL round-bottom flask, manganese oxide (43.5 g, 0.50 mol) was added to a solution of 2,3-dichloro-5-hydroxymethylpyridine (3, 8.10 g, 50.0 mmol, Sigma-Aldrich, St. Louis, Mo.) in anhydrous CH2Cl2 (150 mL). The reaction mixture was stirred at a temperature of about 25 C. for 48 h, filtered through CELITE, and concentrated under reduced pressure. The mixture was chromatographed by a silica gel chromatography column eluting with a gradient of ethyl acetate (0%-40%)/hexanes to provide 7.2 g of 4 (90% yield). 1H NMR (400 MHz, CDCl3) delta 10.08 (1H, s), 8.77 (1H, d, J=1.97 Hz), 8.25 (1H, d, J=1.97 Hz). LC/MS (M+1): 176.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 54127-30-9, (5,6-Dichloropyridin-3-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tafesse, Laykea; US2010/120862; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem