Tag: M.W:100-200

Application of 98198-48-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98198-48-2, name is 2-Amino-5-bromo-4-methylpyridine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 2-amino-5-bromo-4-methylpyridine (1 g, 5.4 mmol) and 2,5-dihydroxytetrahydrofuran (2.8 g, 27 mmol) in acetic acid (10 mL) was heated at 90 C in a sealed tube for 2 h. The reaction mixture was concentrated and the residue was purified by silica gel chromatography using 4: 1 hexanes/ethyl acetate, providing 14a (900 mg, 71 % yield) as a light yellow oil.

According to the analysis of related databases, 98198-48-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; WO2005/63756; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 126553-00-2, name is 6-Ethylpyridin-3-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 126553-00-2

c) A mixture of 5-amino-2-ethylpyridine (17.6 g) and diethyl ethoxymethylenemalonate (23.25 g) was heated on a steam bath for 2.5 hours. The mixture was cooled in ice. The solid formed was ground up in petroleum ether, b.p. 60-80 C. and then filtered to give diethyl 2-(6-ethyl-3-pyridylaminomethylene)malonate, m.p. 55-57 C.

The synthetic route of 126553-00-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Knoll Aktiengesellschaft; US5780482; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 18437-58-6, Adding some certain compound to certain chemical reactions, such as: 18437-58-6, name is 4-Amino-2-picoline,molecular formula is C6H8N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18437-58-6.

General procedure: To a slurry of 6?-bromo-8?-methyl-2?H-spiro[cyclohexane-1,3?-imidazo[1,5-a]pyridine]-1?,5?-dione (12) and aromatic aminederivatives (1.2 eq) in 1,4-dioxane was added Cs2CO3 (3 eq). Themixture was stirred at room temperature for 20 min under nitrogen.To the mixture was then added Pd(OAc)2 (0.1 eq) and Xantphos(0.2 eq). After stirred at room temperature for additional 20 minunder nitrogen, the mixture was heated at 95 C for 12 h undernitrogen. The mixture was concentrated in vacuo, added with water,stirred and filtered. The filter cake was dried and purified by flashcolumn chromatography.

According to the analysis of related databases, 18437-58-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yuan, Xinrui; Wu, Hanshu; Bu, Hong; Zheng, Peiyuan; Zhou, Jinpei; Zhang, Huibin; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1211 – 1225;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 70298-88-3, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, blongs to pyridine-derivatives compound. Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Step 2 To a solution of 2,2-dimethyl-N-pyridin-3-yl-propionamide (3.0 g, 17.0 mmol) in dry THF (50 mL) was added t-BuLi in pentanes (28.0 mL, 1.5 M in pentanes) dropwise at -78 C. After the addition, the reaction was stirred at -50 C. for 1 hr. Then benzaldehyde (2.17 g, 20.5 mmol) was added at -78 C. The mixture was allowed to warm to room temperature and stirred overnight. The mixture was quenched with chilly saturated NH4Cl (60 mL) and extracted with EA (60 mL*3). The organic layers were washed with brine (100 mL), dried over anhydrous Na2SO4 and concentrated to give crude product, which was purified by silica gel column (PE) to afford N-[4-(hydroxy-phenyl-methyl)-pyridin-3-yl]-2,2-dimethyl-propionamide (1.60 g, yield: 33%) as a yellow solid. 1H NMR (300 MHz , CDCl3): delta=9.34 (s, 1H), 8.73 (brs, 1H), 8.25 (d, J=4.8 Hz, 1H), 7.36-7.28 (m, 5H), 7.05 (d, J=5.2 Hz, 1H), 5.89 (s, 1H), 1.31 (s, 9H) .

The synthetic route of 70298-88-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanford-Burnham Medical Research Institute; The Royal Institution for the Advancement of Learning / McGill University; The Government of the United States of America as Represented by the Secretary of the Department of; RONAI, Ze’ev; PINKERTON, Anthony B.; FENG, Yongmei; TOPISIROVIC, Ivan; BROWN, Kevin; HASSIG, Christian A.; (155 pag.)US2018/44324; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 865156-48-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 865156-48-5, name is 7-Bromoimidazo[1,5-a]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 7-bromoimidazo[1,5-a]pyridine-1-carbaldehyde. A solution of 7-bromoimidazo[1,5-a]pyridine (7.5 g, 38.1 mmol) in dry DMF (10 mL) was cooled with ice bath to 0-5 C. Phosphorus oxychloride (8.76 g, 57.1 mmol, 1.5 eq) was added dropwise at this temperature, and then the reaction mixture wassubsequently stirred at 100 C. for 2 h. After the reaction was completed, the reaction mixture was cooled to RT and poured into saturated aqueous sodium bicarbonate (200 mL) and kept stirring for another 2 h. The solution was extracted with ethyl acetate (200 mL*3). The combined organic phases were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuum to afford a residue which was purified by silica gel chromatography (petroleum ether/ethyl acetate=1/1) to afford 7-bromoimidazo[1,5-a]pyridine-1-carbaldehyde (5.5 g, 64%) as a yellow solid. ESI-MS [M+H]+: 224.9.

According to the analysis of related databases, 865156-48-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1480-65-5 ,Some common heterocyclic compound, 1480-65-5, molecular formula is C5H3ClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a microwave vial was combined M (18 mg, 0.062 mmol, 1 eq.), triethylamine (0.172 mL, 1.24 mmol, 20 eq.), 5-chloro-2-fluoropyridine (163 mg, 1.24 mmol, 20 eq.), and NMP (0.60 mL). The reaction was heated under microwave irradiation at 250¡ã C. for 20 minutes. The crude reaction mixture was purified directly on preparative HPLC. Fractions were neutralized with saturated NaHCO3, extracted with EtOAc. dried over Na2SO4, and concentrated under forced air with heat to afford the title compound (5.42 mg, 24percent yield) as a white solid. 1H NMR (400 MHz, CDCl3) delta 8.04 (d, J=2.5 Hz, 1H), 7.39 (dd, J=8.9, 2.6 Hz, 1H), 7.32-7.28 (m, 2H), 7.11 (t, J=8.3 Hz, 2H), 6.87 (s, 1H), 6.46 (d, J=8.5 Hz, 1H), 5.35 (bs, 1H), 4.50 (d, J=5.6 Hz), 4.51-4.48 (m, 2H), 4.16-4.13 (m, 2H). ES-MS [M+1]+: 356.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1480-65-5, its application will become more common.

Reference:
Patent; Vanderbilt University; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A.; Engers, Julie L.; Konkol, Leah C.; US2015/361081; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13534-97-9, name is 6-Bromopyridin-3-amine, molecular formula is C5H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 6-Bromopyridin-3-amine

Step 3: ethyl 4-(5-amino-2,3′-bipyridin-6′-yloxy)cyclohexanecarboxylate (B-33)To a solution of ethyl 4-(5-(4,4,5s5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridin-2- yloxy)cyclohexanecarboxylate (300 mg, 0.799 mmol) and 5-amino-2-bromopyridine (160 mg, 0.924 mmol) in 1,4 dioxane:3/40 (3:1, 20 mL) was addedtetrakis(triphenylphosphine)palladium(0) (194 mg, 0.168 mmol) and Na2C03 (267 mg, 2.52 mmol). The reaction mixture was heated to reflux and stirred for 15 h. The solution was filtered through celite, concentrated and purified by ISCO to yield ethyl 4-(5-amino-2,3′- bipyridin-6′-yloxy)cyclohexanecarboxylate as a brown oil (191 mg, 70percent yield 1 :1 trans is ratio). MS (M+l): 342.

With the rapid development of chemical substances, we look forward to future research findings about 13534-97-9.

Reference:
Patent; SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.; WO2011/31628; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1150617-54-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1150617-54-1, name is 6-Bromo-1H-pyrazolo[4,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

Into a microwave reaction tube, 300 mg compound a, 473 mg 1-methyl-1H-pyrazolo-4-borate pinacol ester and 628 mg potassium carbonate were disposed, 5 ml dioxane, 2.5 ml ethanol and 2.5 ml water were added into the microwave reaction tube, air was displaced for three times, under a nitrogen atmosphere, 62 mg complex of 1,1?-bis(diphenylphosphino) ferrocene palladium (II) dichloride and dichloromethane was added into the microwave tube, then the microwave tube was sealed, The microwave tube was placed into a microwave reactor, reaction was conducted at a temperature of 120 C. for 30 minutes, till the reaction was completed. The aforementioned reactant liquid was poured into 15 ml water, extracted three times with dichloromethane, the organic layer was dried over anhydrous sodium sulfate then concentrated, isolated by flash preparative chromatography to obtain compound n (m=275 mg, yield: 91%). (0192) 1H NMR (300 MHz, DMSO-d6) delta 13.29 (s, 1H), 8.80 (s, 1H), 8.36 (s, 1H), 8.24 (s, 1H), 8.07 (s, 2H), 3.90 (s, 3H).

According to the analysis of related databases, 1150617-54-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD.; Shen, Jingkang; Geng, Meiyu; Ding, Jian; Xiong, Bing; Al, Jing; Ma, Yuchi; Wang, Xin; Peng, Xia; Chen, Yuelei; Chen, Danqi; Meng, Tao; Ma, Lanping; Ji, Yinchun; (110 pag.)US2016/137640; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13466-38-1, 5-Bromopyridin-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Bromopyridin-2-ol, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Bromopyridin-2-ol

[00320] A round bottom flask was charged with 2-hydroxy-5-bromopyridine (1.0 g, 5.7 mmol) and 1,2-dimethoxy ethane (30 mL) and potassium tert-butoxide (0.65 g, 5.7 mmol) was added and the reaction mixture stirred at room temperature for 30 minutes, potassium carbonate (0.56 g, 4.0 mmol) and l-Boc-3-bromomethylazetidine (2.88 g, 11.5 mmol) were added and the reaction mixture heated to reflux overnight. The reaction mixture was cooled to room temperature and quenched with water and extracted with ethyl acetate (3X100 mL). The combined organics were washed with brine and dried over MgS04. The solvents were evaporated to dryness and the residue purified by flash chromatography (40 g silica, 0-100% ethyl acetate in hexanes) to give the product as white solid (1.65 g, 84%). LC/MS: [M+] 343.2; 1H MR (300 MHz, CDC13): delta 7.39-7.34 (m, 2H), 6.49 (d, J=9.3 Hz, IH), 4.08-3.97 (m, 4H), 3.72-3.67 (m, 2H), 3.07-3.05 (m, IH), 1.44 (s, 9H),

The synthetic route of 13466-38-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FGH BIOTECH, INC.; HUFF, Joel; UESUGI, Motonari; KINCAID, John; (213 pag.)WO2017/190086; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1594-58-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1594-58-7, name is N-Hydroxynicotinimidamide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of heteroaromatic amidoximes 7 (7mmol) and distilled triethylamine (7mmol) in anhydrous DCM (70mL), solutions of the aromatic and heteroaromatic hydroximoyl chlorides 6 (7mmol) in the same solvent (70mL) were added dropwise. After keeping the reaction mixtures for two days at room temperature, the organic phases were washed twice with brine and dried over anhydrous Na2SO4. Upon evaporation of the solvent, the residues were submitted to chromatographic separation to isolate the desired compounds. 1,2,4-Oxadiazole-4-oxides 5Aa, 5Bb, and 5Dd are known compounds.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1594-58-7, N-Hydroxynicotinimidamide.

Reference:
Article; Memeo, Misal Giuseppe; Dondi, Daniele; Mannucci, Barbara; Corana, Federica; Quadrelli, Paolo; Tetrahedron; vol. 69; 35; (2013); p. 7387 – 7394;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem