Tag: M.W:100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1210838-82-6, name is 5-Bromo-3-ethynylpyridin-2-ylamine. A new synthetic method of this compound is introduced below., Product Details of 1210838-82-6

Step 3: 5-Bromo-3-(3-(((tert-butyldimethylsilyl)oxy)methyl)isoxazol-5-yl)pyridin-2-amine To a suspension of 5-bromo-3-ethynylpyridin-2-amine (Intermediate C15) (500 mg, 2.54 mmol) and sodium ascorbate (0.254 ml, 0.254 mmol) in t-BuOH (10 ml) and water (10ml) under N2 was added copper(ll) sulfate pentahydrate (13mg, 0.051 mmol, 2mol%) and NaHCOs (853mg, 10.15mmol) followed by 2-((tert-butyldimethylsilyl)oxy)-N- hydroxyacetimidoyl chloride (step 3) (1.7g, 7.61 mmol, 3eq) slowly over 15mins. The mixture was stirred at RT overnight. The resulting mixture was extracted into DCM, washed with water, brine, the organic layer separated, dried over MgS04, filtered and the solvent removed under reduced pressure. The crude product was purified by flash column chromatography elution with iso-hexane:ethyl acetate (0-30%) on a 24g silica cartridge. The required fractions were combined and the solvent removed under reduced pressure to afford the title compound; LCMS: Rt = 1.62mins MS m/z 384.4 [M+H]+; Method 2minl_owpHv03.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1210838-82-6, 5-Bromo-3-ethynylpyridin-2-ylamine.

Reference:
Patent; NOVARTIS AG; BELLENIE, Benjamin Richard; BLOOMFIELD, Graham Charles; BRUCE, Ian; CULSHAW, Andrew James; HALL, Edward Charles; HOLLINGWORTH, Gregory; NEEF, James; SPENDIFF, Matthew; WATSON, Simon James; WO2015/162456; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 133081-24-0, 6-Hydrazinylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H7N3O2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H7N3O2

General procedure: A 0.5M solution of 2-chloropyridine-5-carboxylic acid (15 mmol) was treated with hydrazine hydrate (150 mmol, added at once) and heated at reflux for 72 h. The suspension was concentrated to dryness. The residue was dissolved in water and acidified (pH = 3) with acetic acid. The precipitate of 2-hydrazinopyridine-5-carboxylic acid that formed in 15 min was filtered off, washed with water and air-dried. It was dissolved in the respective aliphatic carboxylic acid and the solution (0.5M) was heated at reflux for 48 h. Upon cooling to room temperature, the volatiles were removed in vacuo and the residue was triturated with 1M aqueous sodium bicarbonate. The precipitate thus formed was filtered off, washed with water and air dried. The resulting 1,2,4-triazolo[4,3-a]pyridine 12 was dissolved in methanol (0.25M and was hydrogenated over Pd(OH)2 catalyst (0.1 equiv.) at 100 atm and 100 C over 24 hours. The mixture was filtered while still hot and concentrated in vacuo. The residue was crystallized from isopropyl alcohol to provide analytically pure carboxylic acids 11a-d.

The synthetic route of 133081-24-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mishchuk, Alexander; Shtil, Natalia; Poberezhnyk, Mykola; Nazarenko, Konstiantyn; Savchenko, Timur; Tolmachev, Andrey; Krasavin, Mikhail; Tetrahedron Letters; vol. 57; 9; (2016); p. 1056 – 1059;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1597-32-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1597-32-6, name is 2-Amino-6-fluoropyridine, molecular formula is C5H5FN2, molecular weight is 112.11, as common compound, the synthetic route is as follows.

General procedure: To the solution of Acid SM-IX (750 mg, 2.i8 mmol, iOO mol-%) in dry DCM (iO ml) under nitrogen atmosphere was added 3-amino-5- methylisoxazole (427 mg, 4.36 mmol, 200 mol-%) and pyridine (526 p1, 6.53mmol, 300 mol-%). T3P (50 w-% in EtOAc) (2.6 ml, 4.36 mmol, 200 mol-%) was added dropwise and the reaction mixture stirred at rt for four hours. DCM (i 0 ml) and i 0 % NaH 003 (30 ml) were added. The water phase was extracted twice with DCM (2 x iO ml). The organic phases were combined and washed with 0.i N HCI solution (3 x 30 ml), water (3 x 30 ml) and finally withbrine (3 x 30 ml) and dried with sodium sulfate. The crude yield of compound i was 95 % (875 mg).1H NMR (200 MHz, DMSO-d6): 0.97 (5, 3 H), i.24 -2.46 (m, i6 H),2.37 (5, 3H), 2.58 – 3.Oi (m, 2 H), 6.64 (5, i H), 6.88-7.06 (m, i H), 7.07 – 7.25 (m, 2 H), iO.88 (5, i H).

The chemical industry reduces the impact on the environment during synthesis 1597-32-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; FORENDO PHARMA LTD; HIRVELAe, Leena; HAKOLA, Marjo; LINNANEN, Tero; KOSKIMIES, Pasi; STJERNSCHANTZ, Camilla; (182 pag.)WO2018/224736; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 271-73-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-73-8, name is 1H-Pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A. 3-lodo-I H-pyrazolo[3,4-b]pyridineTo a solution of iH-pyrazolo[3,4-b]pyridine (2.00 g, i6.8 mmol) in DMF (35 mL) were added iodine (6.39 g, 25.2 mmol) and potassium hydroxide (2.35 g, 42.0 mmol). The reaction mixture was stirred at RT for i6 h. The mixture was diluted with iO% sodium thiosulfate and water and the resulting suspension was filtered to give the title compound as a yellow powder. TLC, R (EtOAc) = 0.8; MS (UPLCMS): 246.0 [M+H]+, 243.9 [M-H]-; tR (HPLC conditions f): i .3i mm.

According to the analysis of related databases, 271-73-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; RANDL, Stefan Andreas; VULPETTI, Anna; WO2014/2057; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 18653-75-3, Adding some certain compound to certain chemical reactions, such as: 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine,molecular formula is C8H7N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18653-75-3.

Chromium(III) chloride hexahydrate (0.266 g, 1 mmol) and pyim(0.145 g, 1 mmol) were disolved in 50 cm3 of water and refluxed for onehour at 80 C under continuous stirring. An aqueous solution of lithiumoxalate (2 mmol, 20 cm3) [generated in situ by reaction of stoichiometricamounts of oxalic acid and lithium hydroxide] was added andthe reflux was continued to 1.5 h. During this time, the initial greensolution turned deep violet. The resulting solution was filtered to discardany small solid particle and allowed to evaporate at room temperature.Reddish brown chunky crystals separated in several crops asfar as the volume was reduced during two weeks. They were collected by filtration and dried on filter paper. The recrystallization in methanol afforded X-ray quality crystals of 1 as reddish brown prisms. The yield is ca. 80%. Anal. Calc. for C13H11CrLiN3O9 (1): C, 37.89; H, 2.67; N,10.19. Found: C, 37.68; H, 2.58; N, 10.08%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fortea-Perez, Francisco Ramon; Pasan, Jorge; Pascual-Alvarez, Alejandro; Ruiz-Perez, Catalina; Julve, Miguel; Lloret, Francesc; Inorganica Chimica Acta; vol. 486; (2019); p. 150 – 157;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54189-82-1, name is 6-Chloro-N-methylnicotinamide, molecular formula is C7H7ClN2O, molecular weight is 170.6, as common compound, the synthetic route is as follows.category: pyridine-derivatives

6-({2-[(2/?,5/?)-2>5-dimethyl-1-pyrrolidinyl]-2,3-dihydro-1H-inden-5-yl}oxy)-yV-methyl- 3-pyridinecarboxamide (E9) Sodium hydride (22mg, 0.55mmol, 60% in mineral oil) was added to a solution of 2-[(2f?,5R)-2,5-dimethyl-1-pyrrolidinyl]-2,3-dihydro-1H-inden-5-ol (may be prepared as described in Description 8) (105mg, 0.45mmol) in dimethylformamide (4ml) and the resulting mixture was stirred at room temperature for 20 minutes. 6-Chloro-Lambda/-methyl-3- pyridinecarboxamide (93mg, 0.55mmol; may be prepared as described in Description 10 of WO2004056369) was added and the mixture heated at 9O0C under argon for 21 hours. The mixture was then cooled to room temperature, applied to an sex ion exchange column and eluted with methanol and then a solution of ammonia in methanol (2M). The basic fractions were evaporated under reduced pressure and the residue purified on the mass directed autoprep to afford the title compound (E9); MS (ES+) m/e 366 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54189-82-1, 6-Chloro-N-methylnicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/61193; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 105170-27-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105170-27-2, name is 2-Bromo-5-methoxypyridine, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 2-Bromo-5-methoxypyridine 1 (2.82 g, 15 mmol), copper iodide (286mg, 1.5 mmol, 10 mol%), diisopropylethylamine (3.14 ml, 18 mmol) and bis(triphenylphosphine) palladium chloride (316 mg, 0.45 mmol, 3 mol%) in dimethylformamide (30 ml) at r.t. was evacuated then back filled with nitrogen. Triethylsilylacetylene(3.22 ml, 18 mmol) was added and the resulting mixture was stirred at r.t. for 24 hours. The crude reaction mixture was then diluted with ethyl acetate (100ml) and washed with water (2×30 ml), brine (30 ml), dried over sodium sulfate, filtered and concentrated to an oil. The oil was purified by flash chromatography using an ISCO 80g column eluting with a gradient of 0 to 30% EtOAc in heptane to give 3.53 g of 5-methoxy-2-triethylsilanylethynylpyridine 2 as an amber oil. LCMS-ESI(+): [MH]+=248;1H NMR (400MHz, CHLOROFORM-d) d= 8.27 (d, J=3.0 Hz, 1H), 7.42 (d, J=8.6 Hz, 1H), 7.13 (dd, J=3.0,8.6 Hz, 1H), 3.87 (s, 3H), 1.06 (t, J=7.8 Hz, 9H), 0.70 (q, J=7.8Hz, 6H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 105170-27-2, 2-Bromo-5-methoxypyridine.

Reference:
Article; Braganza, John F.; Bernier, Louise; Botrous, Iriny; Collins, Michael R.; Li, Baohua; McAlpine, Indrawan; Ninkovic, Sacha; Ren, Shijian; Sach, Neal; Tran-Dube, Michelle; Zeng, Qingbin; Zheng, Baojiang; Tetrahedron Letters; vol. 56; 42; (2015); p. 5757 – 5760;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141-86-6, name is 2,6-Diaminopyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 2,6-Diaminopyridine

Example 1 N, /V’-(pyridine-2, 6-diyl) dibenzamid 1) Synthetic Procedure: In a round bottom flask 2, 6-diaminopyridine (lg, 9.163 mmol) was dissolved in 40mL of dry dichloromethane and triethylamine (2.8mL, 27.72mmol) was added. Then, benzoyl chloride (2.5mL, 17.98 mmol) was added drop by drop and this mixture was stirred under inert atmosphere at room temperature for 15h. Reaction mixture was poured in water. Crude product was extracted in dichloromethane, organic layer was washed with water and dried over anhydrous sodium sulphate. The solvent was evaporated on rotary evaporator and crude product was purified by column chromatography on silica gel by eluting with ethyl acetate: hexane (40:60) mixture. The product was further purified by recrystallization using a methanol. Yield: 2.60 g (89%). NMR (200MHz, CDC13): delta ppm 7.54 (m, 6H), 7.90 (d, 4H, J=6Hz), 7.82 (t, 1H, J=8Hz), 8.10 (d, 2H, J=8Hz), 8.39 (s, 2H).

The synthetic route of 141-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; AMBADE, Ashootosh Vasant; PESALA, Bala; JOSHI, Kavita; BASUTKAR, Nitin Bapurao; RAY, Shaumik; DASH, Jyotirmayee; VILASRAO, Kaware Vaibhav; WO2015/104722; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19828-20-7, name is 2-Amino-5-acetylpyridine, molecular formula is C7H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-Amino-5-acetylpyridine

Step A: 2-(6-Aminopyridin-3-yl)-6-chloroquinoline-4-carboxylic acid (27) [00392] A solution of l-(6-aminopyridin-3-yl)ethanone 16, example 8, step A) (1.5 g, 11.0 mmol) in ethanol (10 mL) was added slowly to a solution of 5-chloroindoline-2,3-dione (9) (1.66 g, 9.17mmol) in 6M aqueous KOH (lOmL) at 100C. The reaction was monitored by LCMS until the staring material consumed. Then the reaction mixture was concentrated to remove ethanol, the residue was diluted with water (10 mL), the pH value of the mixture was acidified to 5 by adding 1M aqueous HCl solution. The precipitate was filtered to give the desired product (1.2 g, 44%) as an orange solid. LC-MS: (M + H)+ 300.1

With the rapid development of chemical substances, we look forward to future research findings about 19828-20-7.

Reference:
Patent; NEW YORK UNIVERSITY; UNIVERSITY OF ALBANY; SCHMIDT, Ann, Marie; RAMASAMY, Ravichandran; SHEKHTMAN, Alexander; RAI, Vivek; MANIGRASSO, Michaele, B.; (179 pag.)WO2017/184547; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-28-8, name is 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H8N2O

Add 5.0g (0.034mol) to a 500mL single-mouth bottle4,6-dimethyl-3-cyanopyrimidin-2-one,250mL of methanol, not fully soluble,25mL 25% ammonia water,About 5.0g of nickel, replaced by argon three times,The hydrogen was replaced three times, and the temperature was raised to 50 C. After 11 h of reaction, the TLC reaction was complete.Stop the reaction and filter the solution through diatomaceous earth.The filtrate was evaporated to dryness to give 6.3 g, m.Dissolve the product with methanol,Placed in an ice salt bath,20mL of 4N hydrochloric acid ethanol solution was added dropwise with stirring.After the drop,After stirring for 1 h in an ice bath, a large amount of white solid was precipitated, which was filtered with suction to give a white solid.Wash twice with ethanol, suction filtration,Dry to give 5.0 g of a white solid.The yield was 96.9%.

With the rapid development of chemical substances, we look forward to future research findings about 769-28-8.

Reference:
Patent; Shenyang Pharmaceutical University; Chen Guoliang; Wang Lihui; Zhou Qifan; Du Fangyu; Dong Xiaoyu; Yang Jingyu; Wu Chunfu; (48 pag.)CN109320499; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem