Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 499-51-4, 4-Hydroxypyridine-2,6-dicarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 4-Hydroxypyridine-2,6-dicarboxylic acid, blongs to pyridine-derivatives compound. Application In Synthesis of 4-Hydroxypyridine-2,6-dicarboxylic acid

Chelidamic acid (5 g, 27 mmol) was mixed with phosphorus pentabromide (58 g, 135 mmol) and heated to 80C for 2 h. The resulting mixture was cooled to room temperature, chloroform (50 ml_) was added and the mixture was filtered. The filtrate was cooled to 0C, methanol (90 ml_) was added in small portions and the resulting suspension was filtered off and dried under vacuum at 50C to afford dimethyl 4-bromopyridine-2,6-dicarboxylate (7 g, 93%). 1H NMR: dH (300 MHz, DMSO-d6) 8.43 (2H, s), 3.93 (6H, s).

The synthetic route of 499-51-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MIRONID LIMITED; ADAM, Julia Mary; ADAMS, David Roger; KULKARNI, Santosh Shripad; NANDURDIKAR, Rahul Shripad; (131 pag.)WO2019/193342; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 935466-69-6, name is 4-Chloro-1H-pyrrolo[2,3-b]pyridin-6-amine. A new synthetic method of this compound is introduced below., Product Details of 935466-69-6

The compound (11.0g, 65.6mmol) obtained in Step 2 was dissolved in pyridine (100ml) and cyclopropanecarbonyl chloride (7.5g, 72.2mmol) was slowly added dropwise at 0oC, followed by stirring at the same temperature for 1 hour. The reaction mixture was added to water (350 ml), and the resulting solid was filtered and dried under reduced pressure to obtain the title compound (12.7 g, 53.9 mmol)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 935466-69-6, 4-Chloro-1H-pyrrolo[2,3-b]pyridin-6-amine.

Reference:
Patent; H Kei Ino N Co., Ltd.; Ryu Ha-na; Kim Dong-gyu; Jeong Su-yeon; Ji Mi-gyeong; Lee Hyeok-u; Kim Seung-chan; Ki So-yeong; Kim Myeong-jung; Lee Ye-rim; Lee Ho-yeol; Park Ji-yeon; (334 pag.)KR102112336; (2020); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 7379-35-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7379-35-3, name is 4-Chloropyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of 5-nitro-1-(4-pyridinyl)-1H-indole To a solution of 5-nitroindole (7.0 g, 43.2 mmol) and 4-chloropyridine hydrochloride (7.8 g, 51.8 mmol) in DMF (43 mL) was added potassium tert-butoxide (12.1 g, 108.0 mmol), portionwise. The reaction was heated at 100¡ã C. for 48 h. The mixture was allowed to cool to room temperature and poured into water (400 mL). The resulting solid was removed by filtration and dried under vacuum. Desired compound (6.04 g, 25.3 mmol; 58percent yield); 1H NMR (DMSO-d6) delta 8.76 (dd, J=1.7, 4.5, 2H), 8.68 (d, J=2.2, 1H), 8.06-8.13 (m, 2H), 7.92 (d, J=9.2, 1H), 7.75 (dd, J=1.5, 4.6, 2H), 7.07 (dd, J=0.9, 3.5, 1H); ES MS [M+H]+=240.

According to the analysis of related databases, 7379-35-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER CORPORATION; US2004/2507; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16063-69-7, name is 2,4,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H2Cl3N

To a solution of 2,4,6-trichloro-pyridine (5.00 g) in tetrahydrofuran (anhydrous, 50,00 mL) at -78 00 under a nitrogen atmosphere was added n-butyl lithium (2.5M in hexane) (10,96 ml) dropwise. The mixture was stirred at -78 00 for 1 h and then piperidine-1- carbaldehyde (3.04 mL) was added drop wise. The reaction was stirred at -78 00 for 1 h. The reaction mixture was quenched with sat NH4CI aq (50 ml). The mixture was extracted with TBME (3 x 40 mL) and the organic phase washed successively with 1 M HCI (75 mL) and sat. ammonium carbonate (75 mL). The organic phase were dried (Na2504) and concentrated and the residue purified by Biotage Isolera FCC (5i02: 50 g) eluting with 10-50% TBME in cyclohexane to give 2.94 g of product as a yellow solid.Analysis: HPLC-MS: R1 = 1.27 mm (method P)1H NMR (DMSO, 250 MHz) 68.07 (1H, s), 10.28 (1H, s)

With the rapid development of chemical substances, we look forward to future research findings about 16063-69-7.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HOFFMANN, Matthias; DAHMANN, Georg; GNAMM, Christian; FANDRICK, Daniel; SCOTT, John; MCCARTHY, Clive; (149 pag.)WO2017/42100; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

13472-83-8, Adding a certain compound to certain chemical reactions, such as: 13472-83-8, 2-Methoxypyridin-3-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13472-83-8, blongs to pyridine-derivatives compound.

The starting material can be obtained as follows: A mixture of 15.4 g of 3-hydroxy-2-methoxy-pyridine, 16 g of potassium carbonate, 25 ml of epichlorohydrin and 150 ml of acetonitrile is refluxed for 7 hours. Cooling and filtering the mixture and evaporating the filtrate yields crude 3-(2,3-epoxy-propoxy)-2-methoxypyridine, which is used without further purification. In an analogous manner, 1-{1-[2-hydroxy-3-(2-methoxy-6-methyl-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one, which after recrystallisation from a mixture of methylene chloride and diethyl ether melts at 144-147, can be obtained by reacting 20 g of crude 3-(2,3-epoxy-propoxy)-2-methoxy-6-methyl-pyridine and 16.5 g of 1-(4-piperidyl)-imidazolidin-2-one.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13472-83-8, its application will become more common.

Reference:
Patent; Ciba-Geigy Corporation; US4264599; (1981); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1206979-33-0, Adding a certain compound to certain chemical reactions, such as: 1206979-33-0, 6-Chloro-1H-pyrazolo[4,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1206979-33-0, blongs to pyridine-derivatives compound.

A suspension of 6-chloro-lH-pyrazolo[4,3-c]pyridine (lg, 6.54mmol), l-(bromomethyl)-2- fluorobenzene (l . leq) and potassium carbonate (2eq) in acetonitrile (20mL) was heated at 60C for 18h. The resultant mixture was diluted with DCM and washed with H20. The organic phase was collected, dried (hydrophobic frit) and concentrated in vacuo. The resultant residue was purified by column chromatography (DCM:EtOAc) to give 6-chloro-l- (2-fluorobenzyl)-lH-pyrazolo[4,3-c]pyridine.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1206979-33-0, its application will become more common.

Reference:
Patent; CELLZOME LIMITED; OXENFORD, Sally; HOBSON, Andrew; OLIVER, Kathryn; RATCLIFFE, Andrew; RAMSDEN, Nigel; WO2013/17479; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

53234-55-2 , The common heterocyclic compound, 53234-55-2, name is 5-Cyanopicolinic acid, molecular formula is C7H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of I-72a (80 mg, 0.23 mmol) in MeOH (13 mL) at RT, was added HC1 (6M in 2-propanol, 57.41 jiL, 0.344 mmol) and the mixture was stirred for 5 mm.Then 5-cyanopyridine-2-carboxylic acid ([53234-55-2], 40.8 mg. 0.276 mmol) was added and 5 mm later, EDCI (57.22 mg, 0.299 mmol) was added. The reaction was finished in 30 mm. The solvent was removed under vacuo, the residue was dissolved in DCM and washed with aq. sol. Na2CO3. The organic layer was dried (MgSO4), filtered and evaporated. The residue was purified by flash chromatography (DCM : methanol,100:0 to 96:4). The product fractions were collected and evaporated. The residue was purified further via Prep HPLC (Stationary phase: RP XBridge Prep Cl 8 OBDl0jim,3Oxl5Omm; mobile phase: 0.25% NH4HCO3 solution in water, CH3CN) The product fractions were collected and the solvent was evaporated under reduced pressure. The crude product was triturated with DIPE, filtered off and then dried undervacuum at 50C to yield compound 21a (20 mg, 15%).

According to the analysis of related databases, 53234-55-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN BRANDT, Sven, Franciscus, Anna; GIJSEN, Henricus, Jacobus, Maria; ROMBOUTS, Frederik, Jan, Rita; (134 pag.)WO2018/83247; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

29681-38-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29681-38-7, name is Methyl 5-methylpicolinate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5-methylpyridirie-2-carboxylic acid methyl ester (140 mg, 0.93 mmol) in CCl4 (8 mL) was added NBS (181 mg, 1.02 mmol) and VAZO (23 mg, 0.09 mmol). The reaction was stirred at reflux for 18 h. Standard work-up and purification by flash chromatography on silica gel (10% ether in CH2Cl2) afforded 5-bromomethylpyridine-2- carboxylic acid methyl ester (107 mg, 50%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 29681-38-7, Methyl 5-methylpicolinate.

Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

18653-75-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine, molecular formula is C8H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 33 (1-33) A solution of iodine (6.99 g, 27.555 mmol) in DCM (29 mL) was added dropwise to a suspension of 2-(lH-imidazol-2-yl)pyridine (2g, 13.777 mmol) in NaOH (2M in water, 29 mL). The biphasic mixture was stirred vigorously at rt for 18 h. The aqueous layer was separated and neutralized with AcOH and then washed with sat. sol. Na2S203 was added until the solution remained colorless. The suspension was stirred for 10 min and the precipitate was filtered and dried in vacuo to yield 1-33 (4.45 g, 81%) as a solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALCAZAR-VACA, Manuel, Jesus; ALONSO-DE DIEGO, Sergio-Alvar; DE LUCAS OLIVARES, Ana, Isabel; (105 pag.)WO2016/87487; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16179-97-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16179-97-8, name is 2-(Pyridin-2-yl)acetic acid hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

[0187] To the solution of compound of Example 38 (40 mg, 0.05 mmol), catalytic amount of dimethylaminopyridine and 2-pyridylacetic acid hydrochloride (18 mg, 0.10 mmol) in CH2Cl2 (2 mL) was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (50 mg, 0.26 mmol). The reaction was stirred at room temperature for 16 h before being diluted with ethyl acetate (50 mL). The organic solution was washed with sat. aq. NH4Cl (5 mL), sat. aq. NaHCO3 (5 mL) and brine (5 mL), dried over MgSO4, and concentrated. The crude product was dissolved in methanol (5 mL) and stirred at room temperature for 72 h. Concentration and purification by chromatography (silica gel, 95:5:0.3 dichloromethane/methanol/conc. NH4OH) yielded 30 mg (68%) of the title compound. MS 906 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16179-97-8, 2-(Pyridin-2-yl)acetic acid hydrochloride.

Reference:
Patent; Henninger, Todd C.; Macielag, Mark J.; Marinelli, Brett A.; Zhu, Bin; US2004/18994; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem