Application of 141-86-6

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 141-86-6, 2,6-Diaminopyridine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141-86-6, name is 2,6-Diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 141-86-6

Preparation 44. N- (6-Amino-pyridin-2-yl) acetamide; Dissolve 2,6-diaminopyridine (9.822 g, 90 mmol) in dioxane (100 mL) and cool to 0C. Add acetyl chloride (2.355 g, 2.1 mL, 30 mmol) slowly and stir for 1 hr. at 0C. Remove the ice bath and stir at room temperature overnight. Quench the reaction mixture with saturated NaHCO3 solution, extract with ethylacetate three times. Combine the organic layers, dry over Na2S04, filter, and concentrate to give a solid. Chromatography on silica gel, eluting with a gradient of 60-70% ethylacetate in hexanes affords the title intermediate (3.45 g, 76%): mass spectrum (ion spray): m/z = 152. 1 (M+1) ; 1H NMR (CDC13, ppm): 7.49 (m, 3H), 6.28 (d, 1H), 4.31 (s, br, 2H), 2.19 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 141-86-6, 2,6-Diaminopyridine.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/35499; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The important role of 13472-85-0

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13472-85-0, 5-Bromo-2-methoxypyridine.

13472-85-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13472-85-0, name is 5-Bromo-2-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

Example 4: Synthesis of 3-(5-hydroxy-3-(2-methyl-2-propylthio)-l-[4[(2-methoxypyridin-5-yl)benzyl]- indol-2-yl-2,2-dimethyl-propionic acid ethyl ester (R = -CH2CH3; X = Br). Ethyl 3-(3-(tert-butylthio)-5-hydroxy-l-(4-(4,4J5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzyl)-lH- indol-2-yl)-2,2-dimethylpropionate (675g, 1.2 mol), 5-bromo-2-methoxypyridine (280.5g, 1.5 mol), Pd(PPh3)4(23.63g, 0.02 mol), and K2CO3 (412g) were added to a reactor containing 6.75 L of DME and 3.38 L of water and stirred. Nitrogen gas was bubbled into the mixture for about 20 minutes. The mixture was then heated to between 80 to 85 0C and stirred overnight. TLC analysis (EtO Ac/Petroleum ether = 1/5) showed the reaction had reached completion. The mixture was subsequently cooled to ambient temperature. Following cooling, the compound was extracted three times with EtOAc. The organic layer was then washed with water, followed by a brine wash. The organic layer was then dried with sodium sulfate, the solid removed by filtration and the organic layer was then concentrated in vacuo, affording 653 g of product in near quantitative yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13472-85-0, 5-Bromo-2-methoxypyridine.

Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; WO2009/55721; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 141-86-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 141-86-6, 2,6-Diaminopyridine, other downstream synthetic routes, hurry up and to see.

141-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 141-86-6, name is 2,6-Diaminopyridine, molecular formula is C5H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Diamine (1mmol), alcohol (2mmol), catalyst (1mol %), KOH (50mol %) and toluene (2mL) were placed in a 25mL round bottomed flask and stirred on a preheated oil bath (100C) for 12h. Upon completion (as monitored by TLC), the reaction mixture was cooled at ambient temperature, H2O (3mL) was added and the organic layer was extracted with ethyl acetate. The organic extract was separated, dried, and concentrated. The desired product was purified by column chromatography with CH2Cl2/EtOAc as eluent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 141-86-6, 2,6-Diaminopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ramachandran, Rangasamy; Prakash, Govindan; Nirmala, Muthukumaran; Viswanathamurthi, Periasamy; Malecki, Jan Grzegorz; Journal of Organometallic Chemistry; vol. 791; (2015); p. 130 – 140;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 1124-64-7

The synthetic route of 1124-64-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1124-64-7, name is 1-Butylpyridinium Chloride, the common compound, a new synthetic route is introduced below. 1124-64-7

General procedure: A mixture of pyridine (0.80g, 10mmol) and bromoethane (1.30g, 12mmol) was stirred ar rt for 43h, then the mixture was washed with ether twice and treated with active charcoal for 12h by stirring. After removing active charcoal by filtration and washed with ether, the filtrate was dried under reduced pressure at rt to give 1-ethylpyridin-1-ium bromide (0.60g, 3.2mmol) in 32% yield. Mp 120C, 1H NMR (500MHz, ppm, CDCl3 J=Hz) delta 1.75 (3H, t, J=7.5), 5.10 (2H, q, J=7.5), 8.15 (2H, t, J=7), 8.53 (1H, s), 9.63 (2H, d, J=6.5); 13C NMR (125MHz, ppm, CDCl3 J=Hz) delta 17.37, 57.12, 57.39, 128.48, 128.64, 144.74, 144.92, 145.08, 145.60. A mixture of 1-ethylpyridin-1-ium bromide (150mg, 0.80mmol) and ammonium cetyl-PEG10 sulfate [20] (624mg, 0.80mmol) in dichloromethane (CH2Cl2) (8.0ml) was stirred at rt for 24h to form the precipitate of ammonium bromide (NH4Br). The precipitate was removed by filtration and the extract was diluted with CH2Cl2 and cooled to-25C to form the precipitate of NH4Br which was removed by filtration. This process was repeated several times until no more precipitate was formed. The resulting filtrate was dried by lyophilization to give 666mg (0.77mmol) of PYET in 96% yield

The synthetic route of 1124-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kadotani, Shiho; Nokami, Toshiki; Itoh, Toshiyuki; Tetrahedron; vol. 75; 4; (2019); p. 441 – 447;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 1603-41-4

The chemical industry reduces the impact on the environment during synthesis 1603-41-4, I believe this compound will play a more active role in future production and life.

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1603-41-4 as follows., 1603-41-4

Water (20 mL),3-Chloro-4- (4-methylphenyl) -4-oxobutanoic acid(5.02 g, 0.022 mol),2-Amino-5-methylpyridine (3) (3.58 g, 0.033 mol)And sodium carbonate (2.33 g, 0.022 mol) were successively added to a 100 mL reaction flask,After mixing,Slowly warmed to 80 internal temperature, nitrogen protection,Insulation reaction 7h, stop the reaction.With 6N hydrochloric acid pH = 0.5 ~ 1, Stirred at room temperature for 30min,No change in pH after the test, adding an equal amount of ethyl acetate,Stir 15min, points to the reservoir,Water layer plus activated carbon 0.1g, 50 decolorization 30min, hot filtration,The filtrate was adjusted to pH = 3.0 ~ 3.5 with 6N aqueous sodium hydroxide solution to precipitate a solid,Cooling to 0 ~ 5 insulation 1h, suction filtration, the filter cake with 10mL ice water rinse,80 vacuum drying 6h,3.21 g of pale yellow solid (HPLC: 97.6%) was obtained in a yield of 52.0%.

The chemical industry reduces the impact on the environment during synthesis 1603-41-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; East China University of Science and Technology; Zhao Jianhong; Guan Yu; Liao Fan; Deng Weiping; Shi Xiaoxin; Zhao Jinyuan; Ma Lirong; Chen Chunyan; Yang Jun; Li Jie; Lei Qingyun; (11 pag.)CN107383005; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 271-63-6

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 271-63-6, 1H-Pyrrolo[2,3-b]pyridine.

271-63-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

10.0 g (84.65 mmol) of 7-azaindole was suspended in 300 ml of CCl 4 and 4.35 mL (84.65 mmol) of Br 2 slowly at room temperatureAnd stirred for 12 hours under a stream of nitrogen. After completion of the reaction, the resulting solid was filtered,The reaction mixture was dissolved in loromethane and extracted with Na2S2O3. The organic solvent was removed and dried to obtain 12.0 g (yield: 72%) of the intermediate product (A)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 271-63-6, 1H-Pyrrolo[2,3-b]pyridine.

Reference:
Patent; Cheil Industries Co., Ltd.; Hong, Jin Suk; Yu, Dong Gyu; Yu, Uhn Sun; Lee, Han Ir; Kang, Dong Min; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; (31 pag.)KR2015/15252; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: 1122-62-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-62-9, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 1122-62-9, 1-(Pyridin-2-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1122-62-9, blongs to pyridine-derivatives compound. 1122-62-9

General procedure: To a 25 mL Schlenk tube containing a solution of 1 in 2 mL of THF was added an aldehyde (1.0 mmol) and (EtO)3 SiH (0.20 g, 1.2 mmol). The reaction mixture was stirred at 50-55 C until there was no aldehyde left (monitored by TLC and GC-MS). The reaction was then quenched byMeOH (2mL) and a 10% aqueous solution of NaOH (5 mL) with vigorous stirring at 60 C for about 24 h.The organic product was extracted with diethyl ether (10 mL ¡Á 3), dried over anhydrous MgSO4, and concentrated under vacuum. The alcohol product was further purified using flash column chromatography (elute with 5-10% ethyl acetate in petroleum ether). The 1H NMR and 13C NMR spectra of the alcohol products are providedin Supporting information.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-62-9, its application will become more common.

Reference:
Article; Xue, Benjing; Sun, Hongjian; Niu, Qingfen; Li, Xiaoyan; Fuhr, Olaf; Fenske, Dieter; Catalysis Communications; vol. 94; (2017); p. 23 – 28;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: 115473-15-9

According to the analysis of related databases, 115473-15-9, the application of this compound in the production field has become more and more popular.

115473-15-9 , The common heterocyclic compound, 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, molecular formula is C7H10ClNOS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 5: Methyl(S)-2(2-chlorophenyl)-2-(2,4,5,6,7,7a-hexahydrothieno [3,2-c]-5- pyridin-2-one)acetate[0064] In a dry, 250-ml reaction flask, 5.94 gm (31.1 mmoles) of 5,6,7, 7a-tetrahydro-4H- thieno[3,2-c]pyridin-2-one hydrochloride, 39 ml of dichloromethane and 29.8 g of a 30% aqueous solution of potassium carbonate were mixed. After stirring for 10 minutes, 10 gm of (25.9 mmoles of Methyl (R)-2- (4-nitrophenylsulfonyloxy)-2(2-chlorophenyl)acetate as a solution in 13 ml of dichloromethane was added. The two-phase medium thus obtained was heated under reflux for 6 hrs. Then cooled to about 30C. Filtered the R.M. Filtrate was having two layers. MDC layer was washed with brine solution. Dried over anhydrous sodium sulfate. After concentration Methyl(S)-2(2-chlorophenyl)-2- (2,4,5,6,7,7a-hexhydrothieno[3,2-c]-5-pyridin-2-one)acetate [(S)-thiolactone of Formula II ] was obtained.

According to the analysis of related databases, 115473-15-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IPCA LABORATORIES LIMITED; KUMAR, Ashok; NELLITHANATH, Thankachen, Byju; WO2012/25942; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 7379-35-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7379-35-3, 4-Chloropyridine hydrochloride, other downstream synthetic routes, hurry up and to see.

7379-35-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7379-35-3, name is 4-Chloropyridine hydrochloride, molecular formula is C5H5Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-aminothiophenol (3.8 mL, 34 mmoles) in anh DMF (90mL) was added 4-chloropyridine hydrochloride (5.4 g, 35.6 mmoles) followed by K2CO3 (16.7 g, 121 mmoles). The reaction mixture was stirred at room temp. for 1.5 h, then diluted with EtOAc (100 mL) and water (100mL). The aqueous layer was back-extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with a saturated NaCl solution (100 mL), dried (MgSO4), and concentrated under reduced pressure. The residue was filtered through a pad of silica (gradient from 50percent EtOAc/50percent hexane to 70percent EtOAc/30percent hexane) and the resulting material was triturated with a Et2O/hexane solution to afford the desired product (4.6 g, 66percent): TLC (100 percent ethyl acetate) Rf 0.29; 1H-NMR (DMSO-d6) delta 5.41 (s, 2H), 6.64-6.74 (m, 3H), 7.01 (d, J=4.8, 2H), 7.14 (t, J=7.8 Hz, 1H), 8.32 (d, J=4.8, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7379-35-3, 4-Chloropyridine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Pharmaceuticals Corp.; EP1047418; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Share a compound : 1003-68-5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1003-68-5, 5-Methylpyridin-2(1H)-one.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1003-68-5, name is 5-Methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. 1003-68-5

1 (10.9 g, 0.1 mol) and 2 (31.6 g, 0.12 mol) were dissolved in dry DMF (200 mL) under N2 atmosphere, then anhydrous K2CO3 (27.6 g, 0.2 mol) and CuI (3.8 g, 0.02 mol) were added. The reaction mixture was refluxed for 10 h. After cooling, the mixture was quenched with saturated NaHCO3 (aq, 150 mL), and extracted with EtOAc (3¡Á50 mL), the organic layers were collected, dried over anhydrous Na2SO4, filtered and concentrated, crystallized from EtOAc /PE. The desired product 3 was obtained as a yellowish solid (21.5 g, 74%), mp: 123-124. 1HNMR (400MHz, CDCl3): delta 7.05-7.46 (m, 11H), 6.62 (d, J=9.2 Hz, 1H), 5.11 (s, 2H), 2.10 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1003-68-5, 5-Methylpyridin-2(1H)-one.

Reference:
Article; Ma, Zhen; Pan, Youlu; Huang, Wenhai; Yang, Yewei; Wang, Zunyuan; Li, Qin; Zhao, Yin; Zhang, Xinyue; Shen, Zhengrong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 220 – 223;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem