Tag: M.W:100-200

5470-18-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-18-8, name is 2-Chloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

1.a 3-Nitro-2-phenoxypyridine 3.6 g (150 mmol) of sodium hydride were added, a little at a time, to a mixture of 12 g (128 mmol) of phenol and 100 ml of dimethylformamide. After the evolution of gas had ceased, the resulting mixture was treated with 18 g (114 mmol) of 2-chloro-3-nitropyridine. After the reaction mixture had been stirred at room temperature (approximately 25 C.) for 3 hours, it was treated with water. Following extraction with tert-butyl methyl ether, washing and drying the organic phase and removal of the solvent under reduced pressure, the product crystallized out. It was purified further by stirring with tert-butyl methyl ether/n-pentane. This gave 6.6 g (27%) of the title compound. A further 3.0 g (12%) of the title compound were obtained from the mother liquor. 1 H NMR (CDCl3; delta in ppm): 7.1 (m,3H, phenyl); 7.2 (t,1H); 7.4 (t, br, 2H); 8.3 (m,2H, pyridyl).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-18-8, 2-Chloro-3-nitropyridine.

Reference:
Patent; BASF Aktiengesellschaft; US5977146; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

74115-13-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74115-13-2, name is 5-Bromo-3-pyridinol, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-bromopyridin-3-ol (100 mg, 0.575 mmol), silver carbonate (475 mg, 1.724 mmol), and benzyl bromide (68.4 muL, 0.575 mmol) were dissolved in CHCl3 (2874 muL) and stirred for 18 hours. The reaction mixture was filtered to remove the silver salts and concentrated in vacuo. The crude material was purified by column chromatography (ISCO, 12 g silica gel column, 19 minute gradient from 0 to 100% EtOAc in hexanes) to give Intermediate 14A (41.2 mg, 0.156 mmol, 27.1%) as a yellow oil: 1H NMR (0455) (400MHz, CHLOROFORM-d) delta 8.30 (dd, J=4.4, 2.4 Hz, 2H), 7.45-7.33 (m, 6H), 5.10 (s, 2H); LC^MS: Method H, RT = 0.99 min, MS (ESI) m/z: 264/266 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis 74115-13-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; RICHTER, Jeremy M.; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; (111 pag.)WO2018/13772; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-70-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-70-2, name is Methyl 6-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: PtO2 (3.00 g) was added to a methanol solution (200 mL) of methyl 6-methylpyridine-3-carboxylate(18.00g, 119.08 mmol), and then added with water (10mL) and hydrochloric acid (20mL); under H2 (50psi), the reaction solutionwas heated to 50C and stirred for 15 h. TLC showed that the reactants were completely consumed; then solid werefiltered, and the filtrate was concentrated under reduced pressure, residues were dissolved in toluol (100 mL), then thesolvent toluol was spin-dried to obtain methyl 6-methylpiperidyl-3-carboxylatewhich was yellow oily matter (18.00 g, yieldwas 96.15%). The value of C8H15NO2[M+H]+157 was calculated using MS ESI, was 157.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-70-2, Methyl 6-methylnicotinate.

Reference:
Patent; Wuxi Fortune Pharmaceutical Co., Ltd; WU, Hao; MAO, Weiwei; FAN, Lili; DING, Charles Z.; CHEN, Shuhui; WANG, Fei; HU, Guoping; LI, Jian; (85 pag.)EP3248980; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1003-68-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1003-68-5, name is 5-Methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

To a 25 mL round bottom flask was added 0.10 g (1 mmol, 1 quiv.) Of compound 3,0.17 g (1 mmol, 1 quiv.) Bromobenzene, 1.4 g (10 mmol, 10 equiv.) K2CO3,0.05 g (0.26 mmol, 0.25 equiv.) CuI,5 mL of DMF as solvent,Reflux stirring reaction 1h,TLC followed by reaction completion, cooling, adding 30 mL of water, 3 x 20 mL of ethyl acetate extraction, and an organic layer of anhydrous sulfuric acidSodium dry, spin dry, 300 mesh silica gel column chromatography, eluent petroleum ether: ethyl acetate = 1: 3 (v / v) to give pirfenidone,The yield was 76%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1003-68-5, 5-Methylpyridin-2(1H)-one.

Reference:
Patent; Sichuan Univeristy; Yi, Shufan; Li, Yong; Cao, Tingting; Yang, Ziyao; (17 pag.)CN106083702; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1121-60-4, name is Picolinaldehyde. A new synthetic method of this compound is introduced below., 1121-60-4

General procedure: Ce(NO3)3¡¤6H2O (0.15 mmol) was added to a mixture of the diamine 1 (0.5 mmol) and the appropriate aldehyde 2 (0.6 mmol) in DMF (3 mL). The reaction mixture was stirred at 80C. The reaction progress was monitored by TLC. After complete consumption of the starting materials, the reaction mixture was cooled to rt, water (15 mL) was added and the resulting mixture was extracted with EtOAc (3 10 mL). The combined organic phases were successively washed with water and brine, and dried over anhydrous MgSO4. After filtration, the solvent was removed under reduced pressure. The product was purified chromatographically (hexane- EtOAc, 70:30).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1121-60-4, Picolinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Martins, Guilherme M.; Puccinelli, Thiago; Gariani, Rogerio A.; Xavier, Fernando R.; Silveira, Claudio C.; Mendes, Samuel R.; Tetrahedron Letters; vol. 58; 20; (2017); p. 1969 – 1972;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5446-92-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5446-92-4, name is 2-Methoxy-5-nitropyridine. A new synthetic method of this compound is introduced below.

[0238] A mixture of 2-methoxy-5-nitropyridine (5.0 g,32.4 mmol) in HOAc (50 ml) was added iron powder (5 g,89.53 mmol). After the mixture was heated to 60 C. for 2 h,the mixture was filtered through celite, and the filtered cakewas washed with HOAc and then water. The filtrate wasconcentrate and the residue was neutralized with saturatedNaHC03 solution, the aqueous phase was extracted withDCM (1 00 ml), and insoluble materials were removed byfiltration. After the aqueous phase was extracted with DCM(100 mlx4), the combined organic phase was washed withbrine and concentrated to afford crude product, which waspurified by silica gel colunm chromatography (2% MeOH inDCM) to afford compound 22 (3.5 g, yield 86%) as a brownoil[0239] m/z: [M+Ht 125.2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5446-92-4, 2-Methoxy-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Gao, Daxin; Yang, Heping; Yu, Yajun; US2014/329800; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-48-5, name is 2,6-Dimethylpyridine, molecular formula is C7H9N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 250 mL flask, 2,6-lutidine (5 mL, 43 mmol), NBS (N-bromosuccinimide) (7.65 g, 43 mmol) and CCl4 (75 mL) were sequentially added and the mixture was heated under reflux in an oil bath.To the above reflux solution was added AIBN (azobisisobutyronitrile) (0.125g / time, once every 1h, plus 7 times), the reaction was filtered off to remove the white succinimide precipitation,The filtrate was stripped to remove the solvent to give a tan oil, which was isolated as a pink oil (5.4 g, 68%) by column chromatography using CH2Cl2 as eluent.

The chemical industry reduces the impact on the environment during synthesis 108-48-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Northwest University; Zhang Ronglan; Yang Weixing; Su Yuanyuan; Zhao Jianshe; (16 pag.)CN107312024; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

18368-63-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 18368-63-3 as follows.

2-Chloro-6-methylpyridine (1 10mg, Aldrich), N-bromosuccinimide (153mg) and AIBN (14.16mg) were dissolved in carbon tetrachloride (2ml) and the reaction mixture stirred at 80 0C under argon for three hours. The reaction mixture was allowed to cool to room temperature, filtered through Kieselguhr, washed with dichloromethane and evaporated to afford the title compound (98mg; crude material used directly in the next step), m/z [M+H]+: 205.9 / 207.9 / 210.1. Retention time 0.89 min (LC/MS method 3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18368-63-3, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; BLUNT, Richard; EATHERTON, Andrew John; GARZYA, Vincenzo; HEALY, Mark Patrick; MYATT, James; PORTER, Roderick Alan; WO2011/12622; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6304-16-1, name is (4-Pyridyl)acetone. A new synthetic method of this compound is introduced below., 6304-16-1

Step 1 Preparation of 4-(3-fluoro-4-methoxylphenyl)-3-pyridyl-3-butene-2-one A solution of 4-pyridylacetone (1.0 g, 7.4 mmol), 3-fluoro-p-anisaldehyde (1.25 g, 8.1 mmol), and piperidine (0.13 g, 1.5 mmol) in toluene (50 ml) was heated to reflux. After 18 hours, the reaction was cooled to room temperature and the solvent was removed under reduced pressure. The crude product (3.0 g) was purified by column chromatography (silica gel, 65:35 ethyl acetate/hexane) to give 4-(3-fluoro-4-methoxylphenyl)-3-pyridyl-3-butene-2-one as a pale yellow solid (1.60 g, 80%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6304-16-1, (4-Pyridyl)acetone, and friends who are interested can also refer to it.

Reference:
Patent; G. D. Searle & Company; US6423713; (2002); B1;; ; Patent; G.D. Searle & Company; US6514977; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

A solution of compound 23 (10 g, 59.9 mmol)Dissolved in methanol (lOOmL)In the ice bath slowly addedTo a solution of dichlorosulfoxide (28.5 mL, 239.5 mmol)The reaction was refluxed for 4 h, Followed by spin-drying to give compound 24 (11.4 g, 98.3percent).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Patent; Jiangnan University; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Wang Wenlong; Li Jia; Feng Bonian; Yang Donglin; Gao Lixin; Ye Huihua; Xu Haojie; Zhao Yanan; Zhang Siqi; (51 pag.)CN104418811; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem