Tag: M.W:100-200

5350-93-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5350-93-6, name is 6-Chloropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: Preparation of ( 6-chloro-pyridin-3-yl) -carbamic acid tert-butyl ester; 6-Chloro-pyridin-3-ylamine (10.0 g) were dissolved in tert- butanol (140 mL) , di-tert-butyl dicarbonate (18.7 g) were added and the solution was stirred at 500C for 4 h. Di- tert-butyl dicarbonate (3.40 g) was added and the reaction mixture was stirred for another 8 h at 5O0C. Most of the solvent was removed in vacuum and the residue was dissolved in ethyl acetate and washed 3x with water, washed with brine, dried over magnesium sulfate and concentrated in vacuum. The residue was purified by column chromatography (silica 60, chloroform/ethyl acetate 10:1, Rf = 0.30) to afford 16.5 g of the title compound of the formulaas a white solid .1H-NMR (CDCl3, TMS) delta (ppm) : 1.52 (9H, s), 6.54 (IH, br s), 7.27 (IH, d, J = 3 Hz), 7.96 (IH, s), 8.23 (IH, d, J = 3 Hz) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5350-93-6, 6-Chloropyridin-3-amine.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2008/130021; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

97483-77-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 97483-77-7, name is 5-Bromopicolinonitrile, molecular formula is C6H3BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 5-bromopyridine-2-carbonitrile (6.3 g, 34.43 mmol, 1 .00 equiv), 3 ,5-difluorobenzene- 1 -thiol (5 g, 34.21 mmol, 0.99 equiv ), and cesium carbonate (22.3 g, 68.23 mmol, 1 .98 equiv) in 1 -methylpyrrolidin-2-one (70 mL) was stirred under nitrogen at 1 00 “C for 1 .5 h. The reaction was then quenched by the addition of 200 mL of water. The precipitated product (4 6 g) was collected by filtration. The filtrate was extracted with 3×200 mL of ethyl acetate. The combined organic layers was washed with 3×200 mL of brine, dried over anhydrous sodium sulfate, and concentrated under vacuum to give in total 7.6 y (89%) of 5-[(3 ,5-difluorophenyl)sulfanyl]pyridine-2- carbonitrile as a brown solid. LC/MS (Method J, ESI): RT = 1 .62 min, m z = 249.0 [M+H]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 97483-77-7, 5-Bromopicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; GOSSELIN, Francis; YUEN, Po-Wai; ZAK, Mark; ZHENG, Xiaozhang; WO2013/127267; (2013); A1;,
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16867-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16867-03-1, name is 2-Amino-3-hydroxypyridine, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Polyphosphoric acid (10 g) was added to the mixture of 2-aminophenols(or 2-aminothiols or 2-phenylenediamines) 2 (7-9 mmol,1.0 eq) and carboxylic acids 3 (1.0 eq) at room temperature and heatedto 170 C (dissolution of reactants in polyphosphoric acid and effectivestirring was observed at elevated temperatures). The reaction mixturewas stirred at 170 C for 3 h and was then allowed to cool to roomtemperature. The viscous reaction mixture was slowly diluted by icewater(200 mL), neutralized (to pH 7) by saturated solution of NaHCO3and extracted with multiple portions of ethyl acetate (3¡Á50 mL). Thecombined organic extracts were washed with brine (50 mL), dried oversodium sulfate (30 g), filtered and concentrated to yield compounds 4in 24-91% yields as colored solids.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16867-03-1, 2-Amino-3-hydroxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ankenbruck, Nicholas; Kumbhare, Rohan; Naro, Yuta; Thomas, Meryl; Gardner, Laura; Emanuelson, Cole; Deiters, Alexander; Bioorganic and Medicinal Chemistry; vol. 27; 16; (2019); p. 3735 – 3743;,
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Pyridine | C5H5N – PubChem

1121-60-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: to a solution of 2-pyridinecarbaldehyde 1 (54 mg, 0.5 mmol) and ammonium acetate (385mg, 5.0 mmol) in MeCN )6ml), was added trimethylphenylammonium tribromide (376 mg, 1.0 mmol) at room temperature. after stirring for 21 h at rt, the reaction mixture was treated with 0.5 M aq Na2S2O3(10 ml), 1.0 M NaHCO3 )15 ml) and extracted with EtOAc (60 mL). The organic layer was washed with 0.5 M Na2S2O3 and successively washed with saturated aq.NaCl, and dried over MgSO4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1121-60-4, Picolinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sayama, Shinsei; Heterocycles; vol. 92; 10; (2016); p. 1796 – 1802;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74115-13-2, name is 5-Bromo-3-pyridinol, molecular formula is C5H4BrNO, molecular weight is 174, as common compound, the synthetic route is as follows.74115-13-2

Step 1) Formation of3-bromo-5-(2-methoxyethoxy)pyridineTo a solution of 3-bromo-5-hydroxypyridine (2 g, 11.4 mmol) in dry DMF (10 mL) was added potassium carbonate (2.3 g, 17.2 mmol) at once and stirred for 20 min under inert atmosphere at RT before dropwise addition of 2-bromomethyl ethyl ether. After 4 h the reaction mixture was filtered and water (100 mL) was added to the filtrate which was extracted with EtOAc (2 x 15 mL). The organic layer was washed with aq. sodium hydroxide (10% solution, 15 mL), water, brine then dried over Na2SO4 and concentrated under vacuum to afford the title compound (2 g, 75%) as a brown liquid. LC/MS, M+(ESI): 234.0. HPLC, Rt: 2.33 min (purity: 96.3%). 1H NMR (CDCI3, 400 MHz) delta 8.25 (S, 2H), 7.37 (t, J = 2.4 Hz, 1 H), 4.13-4.11 (m, 2H), 3.73-3.71 (m, 2H), 3.41 (S, 3H).

Statistics shows that 74115-13-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-3-pyridinol.

Reference:
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 117519-09-2 as follows., 117519-09-2

2-Chloro-6-(trifluoromethyl)pyridin-3-amine (3 g, 15.263 mmol, 1.000 equiv) was added into a mixture of CuBr2 (6.8 g, 30.445 mmol, 2.000 equiv) and t-BuONO (3.1 g, 30.062 mmol, 2.000 equiv) in CH3CN (100 mL). The resulting solution was stirred for 2 h at room temperature. The reaction mixture was diluted with water, extracted with diethyl ether, dried over sodium sulfate, and concentrated under vacuum. This resulted in the title compound (3 g, 75%) as a brown liquid.

The chemical industry reduces the impact on the environment during synthesis 117519-09-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; CHEN, Huifen; CHU, Yanyan; DO, Steven; ESTRADA, Anthony; HU, Baihua; KOLESNIKOV, Aleksandr; LIN, Xingyu; LYSSIKATOS, Joseph P.; SHORE, Daniel; VERMA, Vishal; WANG, Lan; WU, Guosheng; YUEN, Po-wai; WO2015/52264; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

932-35-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 932-35-4, name is 3-Hydroxypicolinonitrile. A new synthetic method of this compound is introduced below.

Example 4: At room temperature, 2-cyano-3-hydroxypyridine 0.46 g was added to a three-necked flask. Under a nitrogen atmosphere, 3.0 ml of toluene and 1.31 g of phosphorus pentachloride were added at a bath temperature of 120 C for 10 hours. The mixture was allowed to cool to 70 C and water was added to the solution and the aqueous layer was extracted with toluene. The organic layer thus obtained was washed with saturated aqueous sodium hydrogencarbonate solution and concentrated under reduced pressure to obtain 8.28 g of a solution containing 0.27 g of 2-cyano-3-chloropyridine. The yield of 2-cyano-3-chloropyridine was 50% based on 2-cyano-3-hydroxypyridine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-35-4, 3-Hydroxypicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WAKAMATSU, TAKAYUKI; NAGASHIMA, YUTA; IMOTO, RIKA; (24 pag.)TW2016/510; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5350-93-6 , The common heterocyclic compound, 5350-93-6, name is 6-Chloropyridin-3-amine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

b) Preparation of 5 -bromo-2-chloro-pyridine. 6-Chloro-pyridin-3-ylamine (15 g, 117 mmol) was dissolved slowly with constant stirring in 48percent HBr solution (50 mL) at r.t. and then the solution was chilled to -10 ¡ãC. A solution of sodium nitrite (8.9 g, 129 mmol) in cold water (25 mL) was added dropwise at -10 ¡ãC with constant stirring over 2 h, followed by a solution of copper (I) bromide (25 g, 176 mmol) in 48percent HBr (40 mL) dropwise. The mixture was- then stirred at r.t. until complete. The mixture was neutralised with sodium carbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over soldium sulfate and concentrated. The residue was purified by column chromatography on silica gel (60-120 mesh) eluting with 1percent ethyl acetate/petroleum ether to afford 5- bromo-2-chloro-pyridine (ll.l g, 49percent).

According to the analysis of related databases, 5350-93-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F2G LTD; WO2008/62182; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

16063-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16063-70-0, name is 2,3,5-Trichloropyridine. A new synthetic method of this compound is introduced below.

Step 1 : In a sealed tube, 2,3,5-trichloro pyridine (8.0 g, 44mmol), 4-chloro aniline (6.17 g, 49 mmol), triphenyl phosphine (1.16 g, 44 mmol) and sodium-te/t-butoxide (5.09 g, 53mmol) were mixed in c-xylene (80 mL). The resulting mixture was purged with argon, added Pd(OAc)2 (0.49 g, 2.2mmol) and heated at 110 C for 12 h. After completion of the reaction, the reaction mixture was filtered through celite bed and concentrated under vacuum. The residue obtained was diluted with ethyl acetate (200 mL), washed with water, brine solution and dried over anhydrous Na2S04. The organic phase was concentrated and purified by the column chromatography (60-120 size mesh) to get the yellow solid 3,5-dichloro-//-(4-chlorophenyl)pyridin-2-amine (7.0 g, 58.23%). LCMS: (Method B) 275 (M+H), RT. 3.69 min, 1H NMR (400 MHz, DMSO-d6) : delta 8.68 (s, 1H), 8.14 (d, J = 2.28 Hz, 1H), 8.04 (d, J = 2.32 Hz, 1H), 7.68-7.66 (m, 2H), 7.34-7.32 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16063-70-0, 2,3,5-Trichloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; SPANGENBERG, Thomas; (129 pag.)WO2016/827; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2942-59-8, name is 2-Chloronicotinic acid, molecular formula is C6H4ClNO2, molecular weight is 157.55, as common compound, the synthetic route is as follows.2942-59-8

To a solution of 2-chloronicotinic acid (B-1) (7.88 g, 50.0 mmol) in THF (100 mL) was added methyl magnesium bromide (42 mL, 3M ethyl ether solution) dropwise under 0 ¡ãC. Upon completion of the addition, the reaction mixture was stirred at 0 ¡ãC for 0.5 h and then at room temperature overnight. The reaction mixture was added into ice/water (150 mL), and extracted with ethyl acetate. The combined organic layers were dried over Na2S04 and concentrated to afford the title compound 1 -(2-chloropyridin-3-yl)ethanone (B-2). MS (m/z): 156 (M+1 )+.

Statistics shows that 2942-59-8 is playing an increasingly important role. we look forward to future research findings about 2-Chloronicotinic acid.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; WO2011/79804; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem