Tag: M.W:100-200

73583-39-8, A common compound: 73583-39-8, name is 3-Bromo-5-chloropyridine,molecular formula is C5H3BrClN, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Example 22: Synthesis of 2-Chloro-4-(5-chloro-4-hydroxymethyl-pyridin-3-yl)- b nzonitrileStep 1: 3-Bromo-5-chtoro-pyridine-4-carbaldehyde (22a)n-BuLi (11.25 ml_, 1.6 M, 18 mmol) was added dropwise to a solution of diisopropylamine (2.78 mL, 19.5 mmol) in THF(60mL) at -78C under N2. The resulting mixture was warmed up to -4CTC and stirred for 10 min and recooled to -78C. A solution of 3-bromo-5- chloropyridine (2.89 g, 15 mmol) in THF was added dropwise at this temperature. After 30 min, DMF was added dropwise and the resulting mixture was stirred for another 30 min. the reaction was quenched with saturated NH4CI solution, and warmed up to room temperature. After concentration, the residue was dissolved in EtOAc and washed with saturated NaHC03 solution. After dying over Na2S04, filtration and concentration, the residue was purified by I SCO (40g) column (0-30% EtOAc/Heptane) to give slightly yellow crystal (1.91g). ESI-MS m/z: 253.8 [M+1 +MeOH]+, Retention time 1.07min. -NMR (CDCI3, 400 MHz) delta 8.65 (s, 1 H), 8.76 (s, 1 H), 10.32 (s, 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 73583-39-8.

Reference:
Patent; NOVARTIS AG; ALLAN, Martin; CHAMOIN, Sylvie; HU, Qi-Ying; IMASE, Hidetomo; PAPILLON, Julien; WO2011/61168; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2637-34-5, name is 2-Mercaptopyridine. This compound has unique chemical properties. The synthetic route is as follows. 2637-34-5

A 1.0 M solution of HCI (45 mL) and DCM (45 mL) was cooled to -10 C and pyridine-2-thiol (1 .0 g, 9.0 mmol) added. After 10 min, NaOCI (6% solution, 47 mL, 3.3 eq.) was added drop-wise over 5 min and stirring continued at -10 C for 10 min. The organic phase was separated, dried using Na2S04 and filtered. The resulting solution was added drop-wise to a pre-cooled solution of sat. methanolic ammonia and DCM (1 : 1 , 40 mL) at 0 C then allowed to warm to ambient temperature and stirred until completion, typically 2 h. The solvent was removed in vacuo to give a white solid which was dissolved in hot EtOAc and filtered to remove solid impurities. The solvent was removed in vacuo and recrystallized with EtOAc-hexanes to give the titled compound as a yellow solid (0.5 g, 35%). 1 H NMR (300 MHz, DMSO-d6) delta = 8.70 (ddd, J = 4.7, 1 .7, 0.9 Hz, 1 H), 8.05 (td, J = 7.7, 1 .7 Hz, 1 H), 7.91 (dt, J = 7.9, 1 .1 Hz, 1 H), 7.62 (ddd, J = 7.6, 4.7, 1 .2 Hz, 1 H), 7.45 (s, 2H).

Statistics shows that 2637-34-5 is playing an increasingly important role. we look forward to future research findings about 2-Mercaptopyridine.

Reference:
Patent; THE UNIVERSITY OF QUEENSLAND; THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN; O’NEILL, Luke; COLL, Rebecca; COOPER, Matt; ROBERTSON, Avril; SCHRODER, Kate; (379 pag.)WO2016/131098; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5350-93-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5350-93-6, name is 6-Chloropyridin-3-amine, the common compound, a new synthetic route is introduced below.

Sodium nitrite (3.45g, 0.05mol) was added portion wise to a stirred solution of 6- chloro-pyridin-3-ylamine (6.4g, 0.05mol) in acetic acid (56ml) and HCl (cone)(9.92ml) while maintaining the temperature below 15¡ãC. This solution was then added drop wise to a stirred solution of sulfur dioxide (17.2g, 0.27mol), copper (II) chloride (1.85g, 0.01 lmol) and water (2.2ml) in acetic acid (37ml) at 5¡ãC. The reaction mixture was allowed to warm to room temperature and poured over ice water and stirred for a further 15min. The resultant precipitate was collected by filtration, washed with water and dried overnight in a vacuum oven to give 6- chloro-pyridine-3-sulfonyl chloride (6.41g, 60.5percent yield); (400 MHz; d6-DMSO) 8.54 (IH, d), 7.96 (IH, dd), 7.50 (IH, d).

Statistics shows that 5350-93-6 is playing an increasingly important role. we look forward to future research findings about 6-Chloropyridin-3-amine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/49605; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, Adding a certain compound to certain chemical reactions, such as: 108-48-5, 2,6-Dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-48-5, blongs to pyridine-derivatives compound.

General procedure: To a stirred solution of substituted indoline-2,3-diones (1.0 mmol) in dioxane (1 mL) was added lutidines/picolines (2.5 mmol) and Iodine (20 mol %). The resulting mixture was heated at reflux for 8 h. After completion of the reaction, poured EtOAc and then washed with an ice cold saturated aqueous Na2S2O3 solution (10 mL¡Á2). Organic layer washed sequentially with brine, ice water and dried over anhydrous MgSO4. Evaporation of the organic solvent afforded the crude products, which was purified by silica gel column chromatography using n-hexane/ethyl acetate (4:1-1:1) as eluent to give desired products.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-48-5, its application will become more common.

Reference:
Article; Vuppalapati, Srinivasu V.N.; Lee, Yong Rok; Tetrahedron; vol. 68; 39; (2012); p. 8286 – 8292;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

585-48-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 585-48-8, name is 2,6-Di-tert-butylpyridine, molecular formula is C13H21N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 16 1-(1-Naphthoyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S,R)-(ethoxymethyl)pyrrolidine To a solution of 0.033 g (0.074 mmol) of 1-(1-naphthoyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-hydroxymethylpyrrolidine and 0.057 g (0.22 mmol) of AgOTf in 2 mL of CH2Cl2 was added 0.058 mL (0.26 mmol) of 2,6-di-t-butylpyridine and 0.019 mL (0.24 mmol) of ethyl iodide and the reaction mixture was stirred at rt for 1.5 h. The reaction mixture was diluted with CH2Cl2 and filtered through a thin pad of Celite eluding with acetone:hexanes (1:2). The filtrate was concentrated and the residue was purified by chromatography (silica, acetone:hexanes, 1:3 to 1:2) to give the title compound. 1H NMR (CDCl3) delta (key peaks) 7.88-7.91 (M, 3H), 7.47-7.57 (M, 4H), 7.09-7.12 and 7.18-7.21 (M, 2H, 7.01 and 6.96 (t, 2H, J=8.5 Hz), 1.25 and 1.09 (t, 3H, J=7.0 Hz); Mass Spectrum (ESI) m/e=475 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 585-48-8, 2,6-Di-tert-butylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck & Co., Inc.; US6372764; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 97483-77-7, name is 5-Bromopicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. 97483-77-7

5-Bromo-2-tetrazol-5-ylpyridine. A mixture OF 3-bromo-6-cyano-pyridine (2 g, 10.9 mmol), sodium azide (0.85 g, 13 mmol), and ammonium chloride (0.59 g, 11 mmol) in N,N-dimethylformamide (20 mL) was heated for 1 h at 120 C. The reaction mixture was diluted with ethyl acetate (~ 100 mL) and the product was isolated by filtration and then washed with ethyl acetate to give the title compound, an off-white amorphous solid which was used in the next step without further purification.

Statistics shows that 97483-77-7 is playing an increasingly important role. we look forward to future research findings about 5-Bromopicolinonitrile.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/48350; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-04-6, name is 2-Bromopyridine. This compound has unique chemical properties. The synthetic route is as follows. 109-04-6

A solution of the Grignard reagent of 4-bromobenzaldehyde dimethyl acetal (63 g of solution, containing 0.074 mol), prepared analogously to Example 9, is added dropwise over a total of 6 hours to a solution of 2-bromopyridine (7.95 g, 0.050 mol), ZnCl2 (0.0071 g, 0.052 mmol) and palladium tetrakistriphenylphosphine (0.032 g, 0.028 mmol) in tetrahydrofuran (23.6 g) maintained at 50 C. with agitation under an inert atmosphere. The reaction mixture is maintained at 50 C. for 30 minutes and then cooled to 25 C. [00079] A solution constituted by water (28 g) and 30% hydrochloric acid (9 g) is added to the reaction mixture and the mixture is maintained under agitation for 2 hours at 25 C. 30 g of solvent are evaporated under vacuum and replaced by an equal amount of toluene and then the phases are separated. Toluene (30 g) and 30% ammonia (12 g) are added to the aqueous phase. After filtering over a panel of Celite the solid at the interphase and washing the panel with toluene, the phases are separated to give a solution of 4-(2′-pyridyl)benzaldehyde (73.53 g, HPLC strength 11.1%, equal to 8.16 g, 0.0446 mol; yield in moles relative to the 2-bromopyridine added 89%; turnover of catalyst (Pd): 1620; turnover of Zn: 890).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-04-6, 2-Bromopyridine.

Reference:
Patent; Euticals Prime European Therapeutical SpA; US6765097; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

13472-85-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13472-85-0, name is 5-Bromo-2-methoxypyridine, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Bromo-2-methoxypyridine (28.8 g, 150 mmol, 1 eq.) Was dissolved in 300 ml of anhydrous tetrahydrofuran and set aside.Diisopropylamine (17g, 165mmol, 1.1eq.) Was dissolved in 150ml of anhydrous tetrahydrofuran, cooled to -5C , under nitrogen,N-Butyllithium (66 ml, 165 mmol, 1.1 eq.) Was added dropwise to the above solution.After the dropwise addition, the mixture was stirred for 30 minutes.Reduce the temperature of the above reaction system to -78C ,A solution of 5-bromo-2-methoxypyridine in tetrahydrofuran was added dropwise.After the dropwise addition, the mixture was stirred for 1 hour.Then, N, N-dimethylformamide (16.8 g, 225 mmol, 1.5 eq.) Was added dropwise to the above reaction system, and reacted for 2 hours.After the reaction was completed, 150 ml of ammonium chloride solution was slowly added to the reaction solution.After extraction with n-hexane, the organic phase was dried over anhydrous sodium sulfate and concentrated.The resulting concentrate was slurried with n-hexane and filtered with suction,The filter cake was dried to obtain 25 g of white solid 5-bromo-2-methoxypyridine-4-carbaldehyde,The yield is 77%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13472-85-0, 5-Bromo-2-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ali Biological New Materials (Changzhou) Co., Ltd.; Shi Jianyun; Xu Yibo; Dai Hongsheng; Zhou Chao; (8 pag.)CN110734397; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-48-5, name is 2,6-Dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A 25 mL Schlenk tube equipped with a magneticstirring bar was charged with2,6-lutidine (0.75 mmol, 3equiv.), p-nitro-benzaldehyde(0.25 mmol), dioxane/water(1:1, 1ml) and [Hmim][H2PO4](1equiv.).The tube was sealed and heated at 100 for 24h. Aftercompletion of the reaction, the resulting solution was extracted with ether (3¡Á10 ml). The organic layer was dried with anhydrous Na2SO4,and concentrated under vacuum. The residue was chromatographed on a silica gelcolumn eluted with a mixture of petroleum ether and ethyl acetate (1:1) to givepure products (92%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 108-48-5, 2,6-Dimethylpyridine.

Reference:
Article; Zhang, Xue-Yan; Dong, Dao-Qing; Yue, Tao; Hao, Shuang-Hong; Wang, Zu-Li; Tetrahedron Letters; vol. 55; 40; (2014); p. 5462 – 5464;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5350-93-6, Adding a certain compound to certain chemical reactions, such as: 5350-93-6, 6-Chloropyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5350-93-6, blongs to pyridine-derivatives compound.

Step a: (6-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester To a mixture of 6-chloropyridin-3-amine (30.0 g, 0.23 mol), DMAP (1 g) and Et3N (41.7 g, 0.47 mol) in CH2Cl2 (200 mL) was added Boc2O (54.5 g, 0.25 mol) at 0 C. The mixture was allowed to warm to room temperature and stirred overnight. The mixture was washed with saturated NaHCO3 solution. The aqueous solution was extracted with dichloromethane. The combined organics were washed with brine (100 mL), dried over Na2SO4 and evaporated under vacuum to give tert-butyl 6-chloropyridin-3-ylcarbamate (50.0 g, 94%), which was used directly in the next reaction. 1H NMR (300 MHz, CDCl3) delta 8.23 (d, J=2.7 Hz, 1H), 7.97 (d, J=6.9 Hz, 1H), 7.27-7.24 (m, 1H), 6.58 (s, 1H), 1.52 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5350-93-6, its application will become more common.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; US2009/253736; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem