Tag: M.W:100-200

271-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine, molecular formula is C7H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

PCC (45.7 g. 212 mmol) was compounded with silica gel (45.7 g. 100-200 mesh) and transferred to a 1 -L round-bottom flask containing DCE (400 mL). To the resulting orange suspension was added a solution of 1 -/-pyrrolo[2,3-b]pyridine (10.0 g, 84.7 mmol) in DCE (50 mL) and AICI3 (1 .5 g, 1 1 mmol). The mixture was stirred at 80C for 3 h, cooled to rt, filtered and the filter cake was washed with EA. The filtrate was concentrated and purified by FCC (PE:EA = 5: 1 ) to give compound P27a as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 271-63-6, 1H-Pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHENEX-FXR GMBH; GEGE, Christian; BIRKEL, Manfred; HAMBRUCH, Eva; DEUSCHLE, Ulrich; KREMOSER, Claus; (203 pag.)WO2019/16269; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-55-1, name is 3-Bromopyridine. This compound has unique chemical properties. The synthetic route is as follows. 626-55-1

Synthesis of 3-(4-Methoxyphenyl)pyridine (30) via Scheme 5; A mixture of 3-bromopyridine, (29, 190 mg, 1.20 mmol), 4- methoxyphenylboronic acid (152 mg, 1.00 mmol), Pd(PPh3 )4 (35.0 mg, 0.0300 mmol) and K3PO4 (430 mg, 2.00 mmol) in 1 ,4-dioxane (10 mL) was heated at 100 0C for 18 h. The solvent was removed under reduced pressure and ethyl acetate was added to the solid residue. The organic layer was washed sequentially with water, brine, and then dried over anhydrous Na2SO4. Concentration of the filtrate followed by chromatography [silica, hexanes/ethyl acetate (3: 1 )] gave 30 as a white solid (108 mg, 58% yield), mp 61-63 0C. 1 H NMR (500 MHz, CDCl3) delta 3.86 (s, 3H), 7.01 (d, J = 8.5 Hz, 2H), 7.33 (dd, J = 5.0, 8.0 Hz, 1 H), 7.52 (d, J = 8.5 Hz, 2H), 7.81-7.83 (m, 1 H), 8.54 (dd, J = 2.0, 5.0 Hz, 1 H), 8.81 (br s, 1 H).

Statistics shows that 626-55-1 is playing an increasingly important role. we look forward to future research findings about 3-Bromopyridine.

Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; WO2009/114180; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

6419-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

D56Pyridin-3-yI-acetic acid ethyl esterTo a solution of 3-pyridylacetic acid hydrochloride (40g, 230.41mmol) in ethanol (90 mL) was added sulfuric acid(73 g, 744.3 mmole, 98%) under N2. The reaction mixture was refluxed for 4 h, then cooled to rt. Ammonium hydroxide (250 mL, 25%) was added and extracted with DCM (500 mL) twice, dried over sodium sulfate, concentrated to afford the title product (33 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride.

Reference:
Patent; GLAXO GROUP LIMITED; WAN, Zehong; ZHANG, XIaomin; WANG, Jian; PENG, Cheng; JIN, Yun; HU, Yimin; WO2012/75917; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding some certain compound to certain chemical reactions, such as: 586-95-8, name is 4-Pyridinemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 586-95-8. 586-95-8

4-tert-Butyldimethylsilanyloxymethyl)pyridine (26B). To a solution of 4-pyridylcarbinol (26A) (40.0 g, 366.53 mmol) in 400 mL of anhydrous DMF under a nitrogen atmosphere was added imidazole (27.4 g, 403.18 mmol) and tert-butyldimethylchlorosilane (58.0 g, 384.86 mmol). The reaction was stirred overnight at room temperature. The solvent was removed in vacuo. The residue was partitioned between 750 mL EtOAc and 750 mL H2O. The layers were separated and the organic layer was washed with H2O, brine, dried over MgSO4, filtered and concentrated in vacuo to afford the title compound (26B) as a beige oil. 1H NMR (400 MHz, CDCl3) delta 8.4(m, 2H), 7.25(m, 2H), 4.74(s, 2H), 0.96 (s, 9H), 0.12(s, 6H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 586-95-8.

Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1003-68-5, Adding a certain compound to certain chemical reactions, such as: 1003-68-5, 5-Methylpyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1003-68-5, blongs to pyridine-derivatives compound.

A single-necked flask was charged with 0.1 g (1 mmol) of 5-methyl-2 (1H)one 0.14 g K2CO3, 0.17 g p-bromobenzaldehyde,0.05 g CuI, 5 ml DMF as solvent,The reflux reaction was carried out,TCL monitoring to the reaction is completed,Stop reaction, filter,The filtrate was extracted with EA (ethyl acetate)The organic layer was concentrated (PE: EA = 3: 1, volume ratio, PE was petroleum ether)To give a yellowish or white flake solid 0.08 g,That is compound 1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1003-68-5, its application will become more common.

Reference:
Patent; Sichuan University; Yin, Shufan; Li, Yong; Cao, Tingting; Yuan, Li; Song, Zhangwei; (16 pag.)CN106397408; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

609-71-2 , The common heterocyclic compound, 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of sodium hypobromide was made by adding Br2 (1.01 ml, 39.5 mmol, 1.1 eq) slowly over a period of 5 min to NaOH (5N, 40 ml) that was previously cooled to 0 C. in an ice bath. The solution was stirred for 10 min before adding 2-hydroxynicotinic acid (5.0 g, 35.9 mmol) and placed in a 50 C. oil bath and stirred. Concurrently, a second pot of sodium hypobromide solution was made by slowly adding Br2 (1.01 ml, 39.5 mmol, 1.1 eq) to a NaOH solution (5N, 40 ml) in an ice bath. The second pot of sodium hypobromide was added to the solution of 2-hydroxynicotinic acid after 24 h of heating then was stirred for an additional 24 h. The solution was cooled to RT, placed in an ice bath and acidified with concentrated HCl while stirring. The precipitate which formed was filtered, washed and dried to afford the desired compound as an off-white solid.

According to the analysis of related databases, 609-71-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Amgen Inc.; US2003/225106; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38875-53-5, name is 5-Bromo-2,3-diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 38875-53-5

To a soln of [BROMOACETALDEHYDE] diethyl acetal (2.37 mL, 15.4 [MMOL)] in [DIOXANE/H20] (2: 1/15 mL) at rt was added conc. [HCI] (0.3 mL) and the mixture was refluxed for 30 min. The mixture was cooled to rt whereupon [NAHCO3] (2.6 g, 30.8 [MMOL)] was carefully added followed by dropwise addition of diamino derivative (1.5 g, 7.7 [MMOL)] in [DIOXANE/H20] (2: [1/15] mL). The resultant mixture was stirred at reflux for 14 h and was cooled to rt. The mixture was diluted with 1 M [NAOH] (30 mL) and was extracted with [CH2CI2] (3 x 35 mL). The organic layers were combined, washed with brine [(1] x 20 mL), dried [(NA2SO4),] filtered and concentrated under reduced pressure to afford 1.5 g (92%) of the desired compound [[M +] H = 214. [0].]

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 38875-53-5, 5-Bromo-2,3-diaminopyridine.

Reference:
Patent; SCHERING CORPORATION; WO2004/26867; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

98-98-6 , The common heterocyclic compound, 98-98-6, name is Picolinic acid, molecular formula is C6H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Picolinic acid (20.0 mmol) and 1,2-diaminobenzene (20.0 mmol) were added to 28 g PPA (polyphosphric acid),and stirred at 160 C for 8 h. The resulting viscous solution was poured into 500 mL water, producing a solid which was collected by suction filtration. The solid was suspended in 500 mL of aqueous 0.5 M Na2CO3, and filtered giving a pale yellow powder. Recrystallization from methanol/water. Yield: 43%, m.p.: 219 C, chemical formula (mol.wt.): C12H9N3 (195.22 g/mol), elemental analysis, calc. (%): C, 73.83; H, 4.65; N, 21.52, found: C, 73.75; H, 4.54; N, 21.43, 1H NMR: 8.213 (d, 2H, H4′,5′ ), 8.169 (d, 1H, H6” ), 7.964 (dt, 1H, H4” ), 7.737 (d, 1H, H3” ), 7.699-7.592 (complex, 4H, H 3′,6′,1,5” ), 13C NMR: 159.36 (C2” ), 156.91 (C2), 146.76 (C6” ), 137.35 (C2′ ), 133.22 (C1′ ), 130.54 (C4” ), 129.50 (C5′ ), 129.09 (C4′ ), 128.55 (C3” ), 128.30 (C3′), 127.41 (C6′ ), 117.44 (C5” ), FT-IR (KBr, cm-1): nu(NH), 3399 (s); nu(C-H), 3055 (m); nu(C=C), 1545 (s); nu(C=N), 1532 (s); delta(C-H), 741 (s).

According to the analysis of related databases, 98-98-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Patel, Mohan N.; Dosi, Promise A.; Bhatt, Bhupesh S.; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 86; (2012); p. 508 – 514;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

13472-85-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13472-85-0, name is 5-Bromo-2-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 2. 5-Hydroxy-2-methoxypyridine To a stirred solution of 5-bromo-2-methoxypyridine (8.9 g, 47.9 mmol) in THF (175 mL) at -78 C. was added an n-butyllithium solution (2.5 M in hexane; 28.7 mL, 71.8 mmol) dropwise and the resulting mixture was allowed to stir at -78 C. for 45 min. Trimethyl borate (7.06 mL, 62.2 mmol) was added via syringe and the resulting mixture was stirred for an additional 2 h. The bright orange reaction mixture was warmed to 0 C. and was treated with a mixture of a 3 N NaOH solution (25 mL, 71.77 mmol) and a hydrogen peroxide solution (30%; approx. 50 mL). The resulting yellow and slightly turbid reaction mixture was warmed to room temp. for 30 min and then heated to the reflux temp. for 1 h. The reaction mixture was then allowed to cool to room temp. The squares layer was neutralized with a 1N HCl solution then extracted with Et2O (2*100 mL). The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure to give a viscous yellow oil (3.5 g, 60%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13472-85-0, 5-Bromo-2-methoxypyridine.

Reference:
Patent; BAYER CORPORATION; US2003/207914; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding some certain compound to certain chemical reactions, such as: 109-04-6, name is 2-Bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-04-6. 109-04-6

To a 250 mL flask were charged 2-bromopyridine (4.8 mL, 49 mmol), 2-bromophenylboronic acid (9.85 g, 49 mmol), triphenylphosphine (1.09 g, 4.17 mmol), and ethylene glycol dimethyl ether (55 mL). A homogeneous solution was formed. To this solution was added 2 M K2CO3 (60 mL, 120 mmol). The mixture was purged with nitrogen then Pd(OAc)2 (0.24 g, 1 mmol) was added. The mixture was refluxed for 5 h then cooled to room temperature. The reaction mixture was transferred into a separating funnel and the organic layer was separated and retained. The aqueous phase was extracted with ethyl acetate (EtOAc) (4¡Á100 mL). The combined organic layers were washed with water (200 mL) and brine (200 mL) and dried over MgSO4. Filtration and evaporation produced a dark brown oil, which was purified by chromatography on silica gel with CH2Cl2_heptane=2:1 and CH2Cl2 to provide a light yellow oil, 7.57 g, 65%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-04-6.

Reference:
Patent; Eastman Kodak Company; US6835835; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem