Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.113293-70-2, name is 2,6-Dichloroisonicotinaldehyde, molecular formula is C6H3Cl2NO, molecular weight is 176, as common compound, the synthetic route is as follows.Product Details of 113293-70-2

Exemplified dye D-2-9a was synthesized in the same manner as exemplified dye D-1-1a, except that compound d-1-8 for exemplified dye D-1-1a was changed to compound d-39-1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113293-70-2, 2,6-Dichloroisonicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; FUJIFILM Corporation; Tani, Yukio; Kobayashi, Katsumi; (63 pag.)US9953768; (2018); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 3430-21-5 ,Some common heterocyclic compound, 3430-21-5, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-Amino-5-methylnicotinonitrile. A mixture of 2-Amino-5-bromo-3-methylpyridine (15.49 g, 82.8 mmol) and Cu(I)CN (9.27 g, 103.5 mmol) in DMF (160 mL) was heated at 150 C. for 24 h. The reaction mixture was poured onto water and the solid which formed was extracted by using ethylacetate (600 mL, 3 times) from aq. NH4OH. The solvent was evaporated and the precipitate purified by chromatography (SiO2, hexanes/EtOAc 4:6). Yield 70%, mp 198-200 C., (Lit. mp 203-205 C.; see Dunn A. D. and Norrie R. J. Prakt. Chem./Chem.-Ztg, 338 (7), 663-666 (1996). Lit. melting point not reported via palladium-catalyzed cyanation; see Maligres, P. et al., Tetrahedron Lett., 40, 8193-8195 (1999).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3430-21-5, 5-Bromo-3-methylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boykin, David W.; Tidwell, Richard R.; Wilson, W. David; Ismail, Mohamed A.; US2005/282853; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 107867-51-6, name is 5-(Trifluoromethyl)pyridine-2,3-diamine, molecular formula is C6H6F3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H6F3N3

Production Example 59-4 6.1 g of sodium hydrogen sulfite was added to a mixture of 8.6 g of 5-trifluoromethyl-pyridine-2,3-diamine, 11 g of 2-formyl-5-trifluoromethylphenyl ethyl sulfide, and 67 mL of DMF at room temperature. After heating and stirring the mixture for 3 hours at 100C. 1 g of copper (II) chloride dihydrate was added thereto, and the mixture was heated and stirred for 1 hour at 100C. After allowing the mixture to cool to room temperature, the reaction mixture was added to water and was subjected to extraction using ethyl acetate. A combined organic layer was dried using sodium sulfate, and then, was condensed under reduced pressure. The residue was subjected to silicagel column chromatography to obtain yellow solid powder. The powder was washed with hexane to obtain 12 g of 2-(2-ethylsulfanyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (hereinafter, referred to as the present condensed heterocyclic compound 59).

With the rapid development of chemical substances, we look forward to future research findings about 107867-51-6.

Reference:
Patent; Sumitomo Chemical Company, Limited; SUZUKI, Tatsuya; IWATA, Atsushi; NOKURA, Yoshihiko; EP2865266; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1211517-76-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1211517-76-8, name is 3-Bromo-5-fluoro-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: A mixture of the intermediate of step 1 (150 mg, 475 pmol), 3-bromo-5-fluoro-4-methylpyridine(108 mg, 570 pL), Cu(l)l (6 mg, 24 pmol), K2C03 (132 mg, 964 pmol) and N,N?-dimethyl ethylendiamine(30 mg, 81 pmol) in toluene (0.5 mL) was heated in a sealed tube to 120 C under N2 atmosphereovernight. The volatiles were removed under reduced pressure and the residue was purified bychromatography (Interchim cartridge 5OSiHP /12 g, EtOAc/Cy) to yield the title compound of example17(111 mg,55%).LC-MS (Method 2): m/z [M-?-H] = 425.1(MW calc. = 424.76); R = 0.79 mm. Step 2: A mixture of the intermediate of step 1 (150 mg, 475 pmol), 3-bromo-5-fluoro-4-methylpyridine(108 mg, 570 pL), Cu(l)l (6 mg, 24 pmol), K2C03 (132 mg, 964 pmol) and N,N?-dimethyl ethylendiamine(30 mg, 81 pmol) in toluene (0.5 mL) was heated in a sealed tube to 120 C under N2 atmosphereovernight. The volatiles were removed under reduced pressure and the residue was purified bychromatography (Interchim cartridge 5OSiHP /12 g, EtOAc/Cy) to yield the title compound of example17(111 mg,55%).LC-MS (Method 2): m/z [M-?-H] = 425.1(MW calc. = 424.76); R = 0.79 mm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211517-76-8, 3-Bromo-5-fluoro-4-methylpyridine.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56057-19-3, name is 6-Chloro-5-nitro-2-picoline, the common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Chloro-5-nitro-2-picoline

Method B applied to 2-chloro-6-methyl-3-nitropyridine (86 mg, 0.5 mmol) and 5-phenylcarbamoyl-pentanoic acid methyl ester (141 mg, 0.6 mmol) afforded the title compound as viscous oil (61 mg, 38%). 1H NMR (DMSO) delta 1.52-1.73 (m, 4 H), 2.22 (t, J = 6.8 Hz, 2 H), 2.48 (s, 3 H), 2.75 (t, J = 6.8 Hz, 2 H), 3.53 (s, 3 H), 7.13 (d, J = 8.0 Hz), 7.47-7.63 (m, 5 H), 7.93 (d, J = 8.0 Hz).

The synthetic route of 56057-19-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; sanofi-aventis; EP1878724; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 81565-19-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 81565-19-7 as follows.

(3) The title compound was obtained from 3-chloro-4- trifluoromethylpyridine by the method described in Eur . J . Org . Chem., (2004), 3793.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81565-19-7, its application will become more common.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; WO2008/18639; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 850663-54-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 850663-54-6, name is 4-Chloro-5-nitropyridin-2(1H)-one, molecular formula is C5H3ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Chloro-2-hydroxy-5-nitropyridine (17.2 g, 98.6 mmol) was suspended in toluene (150 mL) before careful addition of phosphorus oxychloride (28 mL, 300 mmol) over 20 minutes. The reaction mixture was heated to reflux for 6 h before cooling to 60 C and stirring for a further 15 h. The reaction mixture was cooled to ambient temperature and then concentrated to dryness under vacuum to give a dark brown oil which was carefully basified at 0 C with sat. K2CO3 (?60 mL). The mixture was extracted with AcOEt (3 x 200 mL). The combined organic phases were quickly washed with water and then brine before drying over Na2SO4. The solvents were removed under vacuum to give a dark brown oil which was purified by passing through a plug of silica, (eluting with petrol ? 1:1, petrol: AcOEt) to give the product as a pale yellow powder (12.2 g, 64%). 1H NMR (400 MHz, CDCl3) delta (ppm): 9.0 (1 H, s), 7.6 (1 H, s). LC-MS: Rt = 2.44 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 850663-54-6, 4-Chloro-5-nitropyridin-2(1H)-one.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel (Prof. Dr.); Falcenberg, Mathias (Dr.); EP2818472; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1239880-00-2, name is 6-Bromoimidazo[1,5-a]pyridine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H5BrN2

Synthesis of 6-bromoimidazo[1,5-a]pyridine-1-carbaldehyde. A solution of 6-bromoimidazo[1,5-a]pyridine (1.7 g, 8.63 mmol) in dry DMF (944 mg, 12.9 mmol) was cooled in an ice bath to 0-5 C. Phosphorus oxychloride (1.98 g, 12.9 mmol, 1.5 eq) was added dropwise at 0-5 C. and the reaction mixture was subsequently stirred at 100 C. over 2 h. The reaction mixture was cooled and poured onto aqueous saturated sodium bicarbonate (200 mL), kept stirring for another 2 h, and extracted with ethyl acetate (50 mL*3). The combined organic phases were washed with brine and dried over sodium sulphate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ether/ethyl acetate=1/1) to afford 6-bromoimidazo[1,5-a]pyridine-1-carbaldehyde (500 mg, yield: 26%) as a yellow solid. ESI-MS [M+H]+: 226.0.

The synthetic route of 1239880-00-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 129768-95-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 129768-95-2, name is (4-Methylpyridin-2-yl)methanamine. A new synthetic method of this compound is introduced below.

4-methyl-2-(pyrrolidin-2-one-1-yl)methyl pyridine g 3.66 (0.03 moles) of 4-methyl-2-aminomethyl pyridine were dissolved in 60 ml of dry CHCl3, ml 16.8 of triethylamine were added and the resulting solution was cooled at -20C. g 4 (0.036 moles) of 4-chlorobutyrroylchloride were then dropped in, on stirring and cooling, at such a rate to keep the temperature at -20C. The reaction was completed by stirring at room temperature for 2 hours, TLC CHCl3/MeOH/NH3; 94.5/5/0.5. The reaction mixture was poured in 40 ml of 20% Na2CO3; the organic layer was separated and the aqueous layer was extracted twice with CH2Cl2. The collected organic phases were dried on Na2SO4, filtered and evaporated i.v. The crude oil obtained was dissolved in 300 ml THF dry and under nitrogen atmosphere, at 0C, g 1.3 of NaH 80% and ml 1 of HMPT were added.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,129768-95-2, (4-Methylpyridin-2-yl)methanamine, and friends who are interested can also refer to it.

Reference:
Patent; Smithkline Beecham Farmaceutici S.p.A.; EP447704; (1991); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 19346-44-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19346-44-2, name is 2-Fluoro-3-nitro-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

LiHMDS l.5M in THF (2.6 mL; 3.84 mmol) was added dropwise at 5C to a solutionof 4-methyl-3-(hydroxymethyl)morpholine (420 mg; 3.20 mmol) in Me-THF (12 mL).After 30 mi 2-fluoro-5-methyl-3-nitropyridine (500 mg; 3.20 mmol) was quickly added and the reaction mixture was allowed to warm to room temperature and stirredrt overnight. LiHMDS 1 .5M in THF (854 p1; 1.28 mmol) was added at 0C and the mixture was stirred at rt for 5h. The reaction mixture was poured onto iced water, a10% aqueous solution of K2C03 and extracted with EtOAc. The organic layer was decanted, washed with water, dried over MgSO4, filtered and evaporated to give 733 mg of crude. The crude was purified by chromatography over silica gel (SiOH, GraceResolv, 12 g, Mobile phase DCM/MeOH/NH4OH, Gradient from: 99% DCM, 1% MeOH, 0.1% NH4OH to 97% DCM, 3% MeOH, 0.3% NH4OH). The pure fractionswere collected and the solvent was evaporated to give 544 mg of intermediate 445 (64% yield, yellow solid).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19346-44-2, 2-Fluoro-3-nitro-5-methylpyridine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (476 pag.)WO2017/125534; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem