Tag: M.W=150-200

Li, Yu-Ling; Zhou, Bo-Wen; Cheng, Jie; Zhang, Fang; Zhang, Jing; Zhang, Li; Guo, Yin-Long published the artcile< Mass Spectrometry-Based Discovery of New Chemical Scaffold Rearrangement Ions: Aza-biphenylene as a Novel Potent Biradical Agent in Cancer Chemotherapy>, Recommanded Product: N-Phenylpyridin-4-amine, the main research area is azabiphenylene metabolite anticancer oxidative stress mass spectrometry.

Discovery of a new drug is time-consuming, laborious, and expensive. Herein, a novel integrative strategy for discovering potential new lead compounds has been developed, which was based on the characteristics of mass spectrometry (MS). MS was used to predict the potential forced degradation products (DPs) and metabolites of drugs by electrospray ionization and collision-induced dissociation (CID). Special rearrangement ions representing unique predicted DPs and metabolites were identified. The consistency between the predicted and the measured results was proven by in vitro metabolism and forced degradation of a com. drug, resp. From this, new chem. scaffold rearrangement ions named (aza)-biphenylenes, as potent anticancer agents, were discovered. As a representative aza-biphenylene analog, 2-azabiphenylene was proven in vitro to induce apoptosis and inhibit the growth of various human cancer cells in a dose-dependent manner. Surprisingly, 2-azabiphenylene exhibited the best comparable bioactivity with the pos. control sorafenib, but showed significantly lower in vitro cytotoxicity than sorafenib (at least a 5-fold decrease in cytotoxicity) because it could be targeted to the tumor microenvironment at low pH. A biradical mechanism accompanied by a mitochondrion-dependent oxidative stress mechanism was proposed to explore its anticancer mechanism. The highly reactive intermediate aza-biphenylenediyl worked as an active pharmaceutical ingredient and induced apoptosis of cancer cells. This provided the basis for the potential applications of CID-induced special rearrangement ions in developing new lead compounds

Analytical Chemistry (Washington, DC, United States) published new progress about Antitumor agents. 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Recommanded Product: N-Phenylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Basu, Sourav; Middya, Sandip; Banerjee, Monali; Ghosh, Rajib; Pryde, David C.; Yadav, Dharmendra B.; Shrivastava, Ritesh; Surya, Arjun published the artcile< The discovery of potent small molecule cyclic urea activators of STING>, Application In Synthesis of 387350-39-2, the main research area is cyclic urea preparation interferon stimulator activation; Immune oncology; Innate immunity; Interferon; STING; cGAS.

STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyclic STING ligands. We describe here the discovery of 3,4-dihydroquinazolin-2(1H)-one based 6,6-bicyclic heterocyclic agonists of human STING that activate all known human variants of STING with high potency.

European Journal of Medicinal Chemistry published new progress about Heterocyclic compounds, nitrogen Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 387350-39-2 belongs to class pyridine-derivatives, and the molecular formula is C7H7F3N2, Application In Synthesis of 387350-39-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tjosaas, Freddy; Fiksdahl, Anne published the artcile< A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution>, Product Details of C7H6FNO2, the main research area is fluoride nucleophilic aromatic substitution nitro group nitropyridinecarboxylate.

The nitro group of Me 3-nitropyridine-4-carboxylate has successfully been replaced by a fluoride anion via nucleophilic aromatic substitution to give the 3-fluoropyridine-4-carboxylate.

Molecules published new progress about 876919-08-3. 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Product Details of C7H6FNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tang, Yinghong; Zhai, Jingying; Chen, Qinghan; Xie, Xiaojiang published the artcile< Ruthenium bipyridine complexes as electrochemiluminescent transducers for ionophore-based ion-selective detection>, Synthetic Route of 366-18-7, the main research area is .

We report here a method to determine target ion concentrations (with Na+ as a model) based on ionophores and electrochemiluminescence (ECL). Ruthenium bipyridine complexes were released from thin polymeric films (plasticized poly(vinyl chloride) also containing a sodium ionophore) into the sample solution following an explicit ion-exchange process (between Na+ and the ruthenium complex). Two signal transducers, tris(2,2′-(pCF3)bipyridine)ruthenium(II) (Ru(p-CF3-bpy)32+) and tris(2,2′-bipyridyl)dichlororuthenium(II) (Ru(bpy)32+), were examined using the sensing film, with the latter providing a more sensitive detection range (ca. 1 to 100 μM) than that of the more hydrophobic one (0.01 to 1 mM). While the ionophore (Na+ ionophore X) offered excellent selectivity to the method, the ruthenium complexes made the measurements independent of the sample pH. Furthermore for complex biol. samples such as blood serum, an indirect approach of measuring the ECL of the remaining ruthenium complexes helps avoid background matrix interference to the ECL production at the working electrode, making the ECL method more attractive for real complex samples.

Analyst (Cambridge, United Kingdom) published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Caixia; Zhang, Zeyuan; Li, Danyang; Gong, Jian; Han, Xushuang; Liu, Xuan; Ma, Chen published the artcile< Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is nitrogen heterocycle fused quinoxaline green synthesis DMSO solvent reactant; pyrroloquinoxaline; indoloquinoxaline; pyrroloquinoline; benzimidazoquinazoline synthesis.

An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. DMSO was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinolines, and benzo[4,5]imidazo[1,2-c]quinazolines.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dalal, Anuj; Nehra, Kapeesha; Hooda, Anjli; Singh, Sitender; Singh, Devender; Kumar, Sumit published the artcile< Synthesis, Optoelectronic and Photoluminescent Characterizations of Green Luminous Heteroleptic Ternary Terbium Complexes>, Application In Synthesis of 366-18-7, the main research area is green luminous heteroleptic ternary terbium complexe optoelectronic photoluminescence property; 2,2’-Bipyridine; Color purity; Fluorescence; Tauc’s relation; Ternary terbium complexes.

This article presents four ternary terbium complexes based on fluorinated 2-thenoyltrifluoroacetone (TTFA) and N donor bidentate neutral ligands. The prepared complexes were examined by elemental study, electrochem. anal., spectroscopically and thermo-gravimetrically. Spectral anal. shows the bonding of Tb3+ ion with oxygen and nitrogen atom of diketone and neutral ligand resp. Upon excitation in UV region, synthesized terbium complexes show luminescence in green region of electromagnetic spectrum. Photoluminescence emission spectra of complexes do not show any ligand based peak suggesting the effective transferal of energy from ligand to metal ion. Green emanation by terbium complexes is owing to intense peak ∼547 nm (5D4 → 7F5). The outcome of emission data and CIE coordinates correlate with each other and affirms the utility of green luminous complexes as potential emissive material for optoelectronic gadgets applied in lighting system.

Journal of Fluorescence published new progress about Cyclic voltammetry. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application In Synthesis of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hussain, Afzal; AlAjmi, Mohamed Fahad; Rehman, Tabish Md.; Amir, Samira; Husain, Fohad Mabood; Alsalme, Ali; Siddiqui, Maqsood Ahmad; AlKhedhairy, Abdulaziz A.; Khan, Rais Ahmad published the artcile< Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies>, Electric Literature of 366-18-7, the main research area is copper complex anticancer nonsteroidal antiinflammatory agent breast cancer.

Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with benzimidazole-derived scaffolds, a biocompatible mol., and secondary ligands viz, 1-10-phenanthroline and 2,2′-bipyridyl. All the copper complexes have been designed, synthesized and adequately characterized using various spectroscopic techniques. In-vitro, human serum albumin (HSA) binding was also carried out using fluorescence technique and in-silico mol. modeling studies, which exhibited significant binding affinities of the complexes with HSA. Furthermore, copper complexes 1-3 were tested for biol. studies, i.e., anticancer as well as NSAIDS. In vitro cytotoxicity results were carried out on cultured MCF-7 cell lines. To get the insight over the mechanism of action, GSH depletion and change in lipid peroxidation were tested and thus confirmed the role of ROS generation, responsible for the cytotoxicity of the complexes 1-3. Moreover, the copper complexes 1-3 were tested for potential to act as NSAIDS on albino rats and mice in animal studies in-vivo. Addnl., we also predicted the mechanism of action of the copper complexes 1-3 using mol. modeling studies with COX-2 inhibitor.

Scientific Reports published new progress about Analgesics. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yakhontov, L. N.; Lapan, E. I. published the artcile< Azaindole derivatives. XLI. Synthesis of 3-substituted 5-azaindoles>, Application In Synthesis of 23612-36-4, the main research area is substitution azaindole electrophilic; nitration azaindole; bromination azaindole; cyanomethylation azaindole; Mannich reaction azaindole.

Bromination of 5-azaindole (I, R = H) with Br in dioxane gave 3-bromo-5-azaindole (II, R = H, R1 = Br) quant. Nitration of I (R = H) gave 3-nitro-5-azaindole (II, R = H, R1 = NO2) quant. 5-Azagramine (II, R = H, R1 = CH2NMe2) was obtained in 92% yield by a Mannich reaction with Me2NH and CH2O. Analogously 13% 1-phenyl-5-azagramine (II, R = Ph, R1 = CH2NMe2) was obtained. Cyanomethylation of I (R = H) yielded 23% azaindole III (R = H), which, when heated with KOH gave 31% acid II (R = H, R1 = CH2CO2H).

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Bromination. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Application In Synthesis of 23612-36-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Segawa, Yasutomo; Levine, David R.; Itami, Kenichiro published the artcile< Topologically Unique Molecular Nanocarbons>, Electric Literature of 366-18-7, the main research area is topol mol nanocarbon organic mol.

As new forms of carbon are unearthed, they invariably transform the scientific landscape. Numerous researchers have been inspired to discover the unique characteristics of these fascinating materials, consistently leading to the development of important technol. innovations in materials science. Recently, studies on the preparation of mol. nanocarbons (small mol. analogs of larger carbon nanostructures) by precision organic synthesis have attracted much attention. Cycloparaphenylene (CPP), the substructure of carbon nanotubes (CNTs), is the oldest of such organic mols., and since 2008 the successful synthesis of CPP dramatically advanced the synthetic chem. of mol. nanocarbons. In fact, as pioneering research, we succeeded in producing carbon nanotubes using seed CPP mols. in 2013. This method represented an important landmark in the quest for controlling the diameter of CNTs via utilization of a well-defined small mol. as a template. Other avenues of research on graphene nanoribbons and partial structures of fullerenes such as corannulene and sumanene are also highly active at the current time. On the other hand, carbon forms with nontrivial topologies, i.e., topol. nanocarbons, are virtually unexplored. In addition to the 3D network structures represented by the Mackay crystal, many topol. complex structures have been envisioned. To date, there is no rational approach toward the bottom-up synthesis of these carbon structures. As with the case of fullerenes and CNTs, access to these unique carbon structures should undoubtedly revolutionize a wide range of sciences. This Account highlights our efforts toward the synthesis of topol. unique mol. nanocarbons. Starting from CPP as the topol. simple subunit, we have successfully created novel mol. nanocarbons that have more complexed topologies. The first topic is carbon nanobelts, fully fused cylinder-shaped mol. nanocarbons representing the segment structure of armchair-type CNTs. The second topic is carbon nanocages, mol. nanocarbons having a “”three-holed”” topol. representing the joint unit of branched CNTs. The third and fourth topics are all-benzene catenanes consisting of two CPP rings and an all-benzene trefoil knot topol. related to a carbon nanotorus. The world of nanocarbon mols. is only limited by our imagination and creativity. As history has proved, the synthesis of new forms of carbon and topol. complex mols. has always subsequently led to new fields and applications associated with their unforeseen properties and functions.

Accounts of Chemical Research published new progress about Carbon nanotubes. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nagieva, I. T.; Ali-zadeh, N. I.; Nagiev, T. M. published the artcile< Coherent synchronization of pyridine dimerization reactions and decomposition of ""green oxidants""- H2O2 and N2O>, Synthetic Route of 366-18-7, the main research area is pyridine dimer preparation.

The reaction of pyridine oxidation by hydrogen peroxide and nitrous oxide under homogeneous conditions, in the gas phase, without the use of catalysts, at atm. pressure, was exptl. investigated. Areas of selective oxidation of pyridine with hydrogen peroxide and nitrous oxide were established, and optimal conditions were found for obtaining valuable raw materials required in the petrochem., chem., and pharmaceutical industries.

Azerbaidzhanskii Khimicheskii Zhurnal published new progress about Dimerization. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem