Tag: M.W=150-200

Hikawa, Hidemasa; Nakayama, Taku; Nakamura, Shunki; Kikkawa, Shoko; Azumaya, Isao published the artcile< Dehydrative amination of benzhydrols with electron-withdrawing group-substituted 2-aminopyridines utilizing Au(III)/TPPMS catalyst system in water>, HPLC of Formula: 21901-29-1, the main research area is benzyl aminopyridine preparation; benzhydrol aminopyridine dehydrative amination gold sodium diphenylphosphinobenzene sulfonate water.

Authors report a method for gold(III)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS)-catalyzed direct amination of benzhydrols using 2-aminopyridines with poor nucleophilic character in water. Various functional groups such as electron-withdrawing nitro, cyano and halogen groups were tolerated well to form the desired N-benzylated 2-aminopyridine compounds On the basis of mechanistic studies including kinetic profiles, Hammett study and isotope effects, authors propose a pathway in which a Lewis acidic gold cation species activates the sp3 C-O bond of the alc. in the rate-determining step.

Organic & Biomolecular Chemistry published new progress about Amination (dehydrative). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Yin; Li, Yilin; Guo, Kaimeng; Tang, Huabiao; Hou, Lifen; Li, Gang published the artcile< Water-assisted proton conductivity of two highly stable imidazole multi-carboxylate-based MOFs>, Safety of 2,2′-Bipyridine, the main research area is crystal structure manganese zinc carboxylimidazoledicarboxylate bipyridine metal organic framework; manganese zinc carboxylimidazoledicarboxylate bipyridine MOF preparation proton conductivity.

Two new chain-like metal-organic frameworks (MOFs), {[Mn(o-CPhH2IDC)(4.4′-bipy)0.5(H2O)2]·3H2O}n (1) (o-CPhH4IDC = 2-phenyl(2-carboxyl)-1-H-imidazole-4,5-dicarboxylic acid; 4,4′-bipy = 4,4′-bipyridine) and {[Zn5(o-CPhH2IDC)2(o-CPhHIDC)2(2,2′-bipy)5]·5H2O}n (2) (2,2′-bipy = 2,2′-bipyridine) were designed and solvothermally or hydrothermally synthesized and structurally characterized. By SEM determinations and PXRD analyses, the high H2O stability and acid and alkali resistance of both MOFs were determined The affluent H-bond networks inside the frameworks formed by imidazole multi-carboxylate ligands and H2O mols. would favor the transfer of protons. Also, the temperature- and humidity-dependent proton conduction properties of the two MOFs were demonstrated. Also, the proton conducting mechanisms will be highlighted herein.

New Journal of Chemistry published new progress about Activation energy (proton conductivity). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Malvinder P.; Joseph, Tomi; Kumar, Surat; Bathini, Yadagiri; Lown, J. William published the artcile< Synthesis and sequence-specific DNA binding of a topoisomerase inhibitory analog of Hoechst 33258 designed for altered base and sequence recognition>, COA of Formula: C6H7N3O2, the main research area is topoisomerase inhibitor DNA binding preparation; DNA binding Hoechst 33258 analog sequence; safety benzoyl peroxide explosive; health hazard methoxymethyl chloride nitrobenzene.

The preparation and DNA binding characteristics of a structural analog of Hoechst 33258 bearing 2 pyridine N atoms are described. The 1H NMR signals of the complex formed between the new ligand I and decadeoxyribonucleotide d(CATGGCCATG)2 were assigned by employing 1- and 2-dimensional NMR techniques. Intermol. nuclear Overhauser effects (NOE) between the ligand and the DNA receptor fragment confirm that the ligand binds in the minor groove of the DNA, interacting with the centrally located 5′-GGCCA segment. In contrast to the steric interaction between the benzimidazole rings of the parent Hoechst 33258 mol. and the guanine 2-NH2 groups, which renders it G·C avoiding and thus A·T base pair preferring, the ligand I described here overcomes these unfavorable interactions and instead exhibits a marked preference for G·C base pairs. This behavior appears to arise from addnl. stabilization due to H-bonding with the guanine 2-NH2 groups. Although a ligand-induced distortion at the binding site is qual. assessable, the overall B-type conformation of the DNA fragment is retained upon complexation. The structural conclusions drawn from the NOE-NMR evidence were confirmed by mol. mechanics and mol. modeling studies. Safety in the use of methoxymethyl chloride and nitrobenzene, suspected toxins and benzyl peroxide, a potential explosive, is emphasized.

Chemical Research in Toxicology published new progress about DNA, complexes Role: BIOL (Biological Study). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, COA of Formula: C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oyamada, Nobuaki; Minamimoto, Hiro; Murakoshi, Kei published the artcile< Room-Temperature Molecular Manipulation via Plasmonic Trapping at Electrified Interfaces>, Safety of 2,2′-Bipyridine, the main research area is plasmonic trapping electrified interface Raman spectra optical tweezers.

For the motion control of individual mols. at room temperature, optical tweezers could be one of the best approaches to realize desirable selectivity with high resolution in time and space. Because of phys. limitations due to the thermal fluctuation, optical manipulation of small mols. at room temperature is still a challenging subject. The difficulty of the manipulation also emerged from the variation of mol. polarizability depending on the choice of mols. as well as the mol. orientation to the optical field. In this article, we have demonstrated plasmonic optical trapping of small size mols. with less than 1 nm at the gap of a single metal nanodimer immersed in an electrolyte solution In situ electrochem. surface-enhanced Raman scattering measurements prove that a plasmonic structure under electrochem. potential control realizes not only the selective mol. condensation but also the formation of unique mixed mol. phases which is distinct from those under a thermodn. equilibrium Through detailed analyses of optical trapping behavior, we established the methodol. of plasmonic optical trapping to create the novel adsorption isotherm under applying an optical force at electrified interfaces.

Journal of the American Chemical Society published new progress about Chemical potential. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halevas, Eleftherios; Pekou, Anna; Papi, Rigini; Mavroidi, Barbara; Hatzidimitriou, Antonios G.; Zahariou, Georgia; Litsardakis, George; Sagnou, Marina; Pelecanou, Maria; Pantazaki, Anastasia A. published the artcile< Synthesis, physicochemical characterization and biological properties of two novel Cu(II) complexes based on natural products curcumin and quercetin>, Formula: C10H8N2, the main research area is copper curcumin quercetin bipyridine complex preparation crystal mol structure; antioxidant antiinflammatory DNA binding cleavage copper curcumin quercetin complex; Antioxidant activity; Copper complexes; Curcumin; DNA plasmid binding; Quercetin.

Curcumin and quercetin are two of the most prominent natural polyphenols with a diverse spectrum of beneficial properties, including antioxidant, anti-inflammatory, chemopreventive and chemotherapeutic activity. The complexation of these natural products with bioactive transition metal ions can lead to the generation of novel metallodrugs with enhanced biochem. and pharmacol. activities. Within this framework, the synthesis and detailed structural and physicochem. characterization of two novel complex assemblies of Cu(II) with curcumin and quercetin and the ancillary aromatic chelator 2,2′-bipyridine is presented. The two complexes represent the only crystallog. characterized structures with Cu(II) as the central metal ion and curcumin or quercetin as the ligands. The new complexes were biol. evaluated in vitro for their antioxidant potential, both exhibiting strong scavenging activity in the 2,2-diphenyl-1-picrylhydrazyl assay, and their plasmid DNA binding/cleavage properties. Both complexes appear to be non-toxic in the eukaryotic exptl. model Saccharomyces cerevisiae and merit further investigation of their pharmacol. profile.

Journal of Inorganic Biochemistry published new progress about Anti-inflammatory agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aramesh-Boroujeni, Zahra; Bordbar, Abdol-Khalegh; Khorasani-Motlagh, Mozhgan; Sattarinezhad, Elham; Fani, Najme; Noroozifar, Meissam published the artcile< Synthesis, characterization, and binding assessment with human serum albumin of three bipyridine lanthanide(III) complexes>, HPLC of Formula: 366-18-7, the main research area is bipyridine lanthanide complex HAS mol docking binding affinity; Bpy, 2,2′-bipyridine; BpyDy, bipyridine dysprosium(III); BpyLn, bipyridine lanthanide; BpyTb, bipyridine terbium(III); binding interaction; fluorescence spectroscopy; human serum albumin; lanthanide complex; molecular docking.

In this work, the terbium(III), dysprosium(III), and ytterbium(III) complexes containing 2, 2′-bipyridine (bpy) ligand have been synthesized and characterized using CHN elemental anal., FT-IR, UV-Vis and 1H-NMR techniques and their binding behavior with human serum albumin (HSA) was studied by UV-Vis, fluorescence and mol. docking examinations The exptl. data indicated that all three lanthanide complexes have high binding affinity to HSA with effective quenching of HSA fluorescence via static mechanism. The binding parameters, the type of interaction, the value of resonance energy transfer, and the binding distance between complexes and HSA were estimated from the anal. of fluorescence measurements and Forster theory. The thermodn. parameters suggested that van der Waals interactions and hydrogen bonds play an important role in the binding mechanism. While, the energy transfer from HSA mols. to all these complexes occurs with high probability, the order of binding constants (BpyTb > BpyDy > BpyYb) represents the importance of radius of Ln3+ ion in the complex-HSA interaction. The results of mol. docking calculation and competitive experiments assessed site 3 of HSA, located in subdomain IB, as the most probable binding site for these ligands and also indicated the microenvironment residues around the bound mentioned complexes. The computational results kept in good agreement with exptl. data.

Journal of Biomolecular Structure and Dynamics published new progress about Binding energy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cotton, Simon A.; Raithby, Paul R.; Schiffers, Stephanie; Teat, Simon J.; Warren, John E. published the artcile< The Synthesis and Structure of a Scandium Nitrate Hydroxy-Bridged Dimeric Complex Supported by Bipyridyl Ligands †>, Application of C10H8N2, the main research area is crystal structure; eight coordinate complex; hydroxy group; nitrate complex; scandium complex.

The current discussion on whether scandium, yttrium and lanthanum should represent Group 3 in the Periodic Table or whether lutetium should replace lanthanum in the group has prompted us to further explore the structural chem. of the Group 3 elements and compare the coordination numbers and coordination geometries adopted. The steric and electronic properties of the coordinated ligands have a major influence on the structures adopted. We report the synthesis and crystal structure determination of an unusual dinuclear scandium complex [(bipy)(NO3)2Sc(μ-OH)2Sc(NO3)2(bipy)] obtained by the reaction of hydrated scandium nitrate with 2,2′-bipyridyl (bipy) in either ethanol or nitromethane. The crystal structure of the complex shows that the scandium centers are eight coordinate, and the structure obtained contrasts with related complexes found in the lanthanide series [Ln(bipy)2(NO3)3] and [Ln(phen)2(NO3)3] (phen = phenanthroline) and in [M(terpy)(NO3)3] (M = Sc, Er-Lu), where these complexes are all mononuclear.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N. published the artcile< Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning>, SDS of cas: 22280-62-2, the main research area is fluorinated pyridinealdoxime preparation treatment organophosphorus nerve agent poisoning; sarin poisoning fluorinated pyridinealdoxime preparation treatment.

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime and 3-fluoropyridine-2- and -4-aldoxime were synthesized. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4-aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pKa nearer to 8 and enhance their therapeutic potential.

Journal of Fluorine Chemistry published new progress about Antidotes. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, SDS of cas: 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nisbet, Matthew L.; Hiralal, Emily; Poeppelmeier, Kenneth R. published the artcile< Crystal structures of three copper(II)-2,2′-bipyridine (bpy) compounds, [Cu(bpy)2(H2O)]-[SiF6]·4H2O, [Cu(bpy)2(TaF6)2] and [Cu(bpy)3][TaF6]2 and a related coordination polymer,[Cu(bpy)(H2O)2SnF6]n>, COA of Formula: C10H8N2, the main research area is copper bipyridine compound coordination polymer crystal structure; copper; crystal structure; d0 early transition metal; hydro­thermal synthesis; main group; racemic compounds.

We report the hydrothermal syntheses and crystal structures of aquabis(2,2′-bipyridine-κ2N,N′)copper(II) hexafluoridosilicate tetrahydrate, [Cu(bpy)2(H2O)]-[SiF6]·4H2O (bpy is 2,2′-bipyridine, C10H8N2), (I), bis(2,2′-bipyridine-3κ2N,N′)-di-μ-fluorido-1:3κ2F:F;2:3κ2F:F-decafluorido-1κ5F,2κ5F-ditantalum(V)copper(II),[Cu(bpy)2(TaF6)2], (II), tris(2,2′-bipyridine-κ2N,N′)copper(II) bis[hexafluoridotantalate(V)], [Cu(bpy)3][TaF6]2, (III), and catena-poly[[diaqua(2,2′-bipyridine-κ2N,N′)copper(II)]-μ-fluorido-tetrafluoridotin-μ-fluorido], [Cu(bpy)(H2O)2SnF6]n, (IV). Compounds (I), (II) and (III) contain locally chiral copper coordination complexes with C2, D2, and D3 symmetry, resp. The extended structures of (I) and (IV) are consolidated by O-H····F and O-H····O hydrogen bonds. The structure of (III) was found to be a merohedral (racemic) twin.

Acta Crystallographica, Section E: Crystallographic Communications published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gomes, Emmanuel M.; Franco, Douglas F.; Scarpari, Sergio L.; Colaco, Marcos V.; Ferreira, Monica S.; Freire, Ricardo O.; Marques, Lippy F. published the artcile< Study of energy transfer mechanism in the EuIII and GdIII homobimetallic complexes containing the anti-inflammatory drug naproxen and N,N-donors ligands>, Safety of 2,2′-Bipyridine, the main research area is naproxen homobimetallic complex donors ligand antiinflammatory agent energy transfer.

In this work, we present the synthesis, solid state characterization and complete photoluminescence study of new important homobimetallic lanthanide complexes containing the non-steroidal anti-inflammatory drug (NSAID) naproxen. The anal. and spectroscopic techniques reveals the formation of eight compounds of general formula [Ln2(nap)6(H2O)4] (Eu 1 and Gd 2), [Ln2(nap)6(bpy)2] (Eu 3 and Gd 4), [Ln2(nap)6(4,4′-dmbpy)2] (Eu 5 and Gd 6) and [Ln2(nap)6(phen)2] (Eu 7 and Gd 8), where: nap = naproxen ligand, bpy =2,2′-bipyridine, 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine and phen = 1,10-phenanthroline. Using the RM1 model, the mol. structures of the EuIII complexes were calculated, with your optimized ground state geometries used to obtain all details involved in the energy transfer process. From the resp. GdIII complexes were obtained the lowest ligand triplet states, proving that the photoluminescence in the EuIII naproxen complexes is proposed to be a ligand sensitized luminescence process. On the other hand, the position of the triplet states also explains the non-effective energy transfer in the TbIII naproxen complexes. The presence of N,N-donors ligands (bpy, 4,4′-dmbpy and phen) results in an 3-4-fold increase in the quantum efficiency when compared with the EuIII complex without nitrogen ligands. The high values of emission quantum efficiency (η ∼ 70 – 98%) show the EuIII complexes can be potential candidates as emitters in biol. assays.

Journal of Luminescence published new progress about Anti-inflammatory agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem