Tag: M.W=150-200

Meneses-Sanchez, Manuel; Turo-Cortes, Ruben; Bartual-Murgui, Carlos; da Silva, Ivan; Munoz, M. Carmen; Real, Jose Antonio published the artcile< Enhanced Interplay between Host-Guest and Spin-Crossover Properties through the Introduction of an N Heteroatom in 2D Hofmann Clathrates>, Formula: C10H8N2, the main research area is transition metal Hofmann clathrate preparation host guest spin crossover; crystal structure iron bipyridine palladium platinum cyano Hofmann clathrate.

Controlled modulation of the spin-crossover (SCO) behavior through the sorption-desorption of invited mols. is an extensively exploited topic because of its potential applications in mol. sensing. For this purpose, understanding the mechanisms by which the spin-switching properties are altered by guest mols. is of paramount importance. Here, the authors show an exptl. approach revealing a direct probe of how the interplay between SCO and host-guest chem. is noticeably activated by chem. tuning the host structure. Thus, the axial ligand 4-phenylpyridine (4-PhPy) in the 2-dimensional Hofmann clathrates {Fe(4-PhPy)2[M(CN)4]} (PhPyM; M = Pt, Pd) is replaced by 2,4-bipyridine (2,4-Bipy), resulting in the isomorphous compounds {Fe(2,4-Bipy)2[M(CN)4]} (BipyM; M = Pt, Pd), which basically differ from the former in that they have a noncoordinated N heteroatom in the ancillary aromatic substituent, i.e., 2-pyridyl instead of Ph. Chem., magnetic, calorimetric, and structural characterizations demonstrate that this subtle chem. composition change provokes outstanding modifications not only in the capability to adsorb small guests as H2O or MeOH but also in the extent to which these guests affect the SCO characteristics.

Inorganic Chemistry published new progress about Adsorption. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grozavu, Alexandru; Hepburn, Hamish B.; Smith, Philip J.; Potukuchi, Harish K.; Lindsay-Scott, Peter J.; Donohoe, Timothy J. published the artcile< The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation>, Category: pyridine-derivatives, the main research area is pyridinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; quinolinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; tetrahydropyridine preparation; tetrahydroquinoline preparation.

Aromatic rings are ubiquitous in organic chem. and form the basis of many com. products. Despite the numerous routes available for the preparation of aromatic compounds, there remain few methods that allow their conversion into synthetically useful partially saturated derivatives and even fewer that allow new C-C bonds to be formed at the same time. Here we set out to address this problem and uncover a unique catalytic partial reduction reaction that forms partially saturated azaheterocycles from aromatic precursors. In this reaction, methanol and formaldehyde are used for the reductive functionalization of pyridines and quinolines using catalytic iridium; thus, inexpensive and renewable feedstocks are utilized in the formation of complex N-heterocycles. By harnessing the formation of a nucleophilic enamine intermediate, the C-C bond-forming process reverses the normal pattern of reactivity and allows access to the C3 position of the arene. Mechanistic investigations using D-labeling experiments reveal the source of hydride added to the ring and show the reversible nature of the iridium-hydride addition

Nature Chemistry published new progress about C-C bond formation. 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ando, Shin; Hirota, Yurina; Matsunaga, Hirofumi; Ishizuka, Tadao published the artcile< Nickel-catalyzed N-arylation of amines with arylboronic acids under open air>, COA of Formula: C11H10N2, the main research area is arylamine preparation; amine arylboronic acid Chan Lam coupling nickel catalyst.

Novel NHC-Ni complex was developed and used for the synthesis of arylamines via Chan-Lam coupling of amines with arylboronic acids. This novel NHC-Ni complex in combination with 4,4′-dimethyl-2,2′-bipyridine, however, proved to be an effective catalyst that lowered the required catalyst loading to only 2.0 mol%. The robustness of NHC complexes toward oxidative conditions and high level of σ-donating ability of NHC ligands could be reason for catalysis.

Tetrahedron Letters published new progress about Arylation. 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, COA of Formula: C11H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Moreau, Robert J.; Skepper, Colin K.; Appleton, Brent A.; Blechschmidt, Anke; Balibar, Carl J.; Benton, Bret M.; Drumm, Joseph E.; Feng, Brian Y.; Geng, Mei; Li, Cindy; Lindvall, Mika K.; Lingel, Andreas; Lu, Yipin; Mamo, Mulugeta; Mergo, Wosenu; Polyakov, Valery; Smith, Thomas M.; Takeoka, Kenneth; Uehara, Kyoko; Wang, Lisha; Wei, Jun-Rong; Weiss, Andrew H.; Xie, Lili; Xu, Wenjian; Zhang, Qiong; de Vicente, Javier published the artcile< Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is triazolopyrimidinone preparation phosphopantetheine adenylyltransferase inhibitory activity; azabenzimidazole preparation phosphopantetheine adenylyltransferase inhibitory activity.

The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-neg. bacteria is a major challenge with fundamental importance to our global healthcare system. Part of our broad program at Novartis to address this urgent, unmet need includes the search for new agents that inhibit novel bacterial targets. Here we report the discovery and hit-to-lead optimization of new inhibitors of phosphopantetheine adenylyltransferase (PPAT) from Gram-neg. bacteria. Utilizing a fragment-based screening approach, we discovered a number of unique scaffolds capable of interacting with the pantetheine site of E. coli PPAT and inhibiting enzymic activity, including triazolopyrimidinone. Structure-based optimization resulted in the identification of two lead compounds as selective, small mol. inhibitors of bacterial PPAT: triazolopyrimidinone I and azabenzimidazole II efficiently inhibited E. coli and P. aeruginosa PPAT and displayed modest cellular potency against the efflux-deficient E. coli ΔtolC mutant strain.

Journal of Medicinal Chemistry published new progress about Antibiotics. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gurgul, Ilona; Janczy-Cempa, Ewelina; Mazuryk, Olga; Lekka, Malgorzata; Lomzik, Michal; Suzenet, Franck; Gros, Philippe C.; Brindell, Malgorzata published the artcile< Inhibition of Metastasis by Polypyridyl Ru(II) Complexes through Modification of Cancer Cell Adhesion - In Vitro Functional and Molecular Studies>, COA of Formula: C10H8N2, the main research area is polypyridyl ruthenium complex cancer metastasis cell adhesion.

The effect of polypyridyl Ru(II) complexes on the ability of cancer cells to migrate and invade, two features important in the formation of metastases, is evaluated. In vitro studies are carried out on breast cancer cell lines, MDA-MB-231 and MCF-7, as well as melanoma cell lines A2058 and A375. Three Ru(II) complexes comprising two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and as a third ligand 2,2′-bipyridine (bpy), or its derivative with either 4-[3-(2-nitro-1H-imidazol-1-yl)propyl] (bpy-NitroIm), or 5-(4-{4′-methyl-[2,2′-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (bpy-SC) moiety attached are examined The low sub-toxic doses of the studied compounds greatly affected the cancer cells by inhibiting cell detachment, migration, invasion, transmigration, and re-adhesion, as well as increasing cell elasticity. The mol. studies revealed that the Ru(II) polypyridyl complexes impact the activity of the selected integrins and upregulate the expression of focal adhesion components such as vinculin and paxillin, leading to an increased number of focal adhesion contacts.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ren, Linning; Wang, Manman; Fang, Benyao; Yu, Wenquan; Chang, Junbiao published the artcile< Iodine-mediated oxidative N-N coupling of secondary amines to hydrazines>, Product Details of C11H10N2, the main research area is aromatic secondary amine iodine mediator oxidative dimerization; diaryl hydrazine preparation.

An I2-mediated N-N coupling reaction was established for oxidative dimerization of N-aryl aminopyridines to a variety of novel hydrazine derivatives under mild conditions. This synthetic method does not required the use of transition metals and was conveniently carried out on a gram scale. It was also applicable to diphenylamine and N-alkyl aniline substrates.

Organic & Biomolecular Chemistry published new progress about Hydrazines Role: SPN (Synthetic Preparation), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Product Details of C11H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Meng; Mu, Yan-Fei; Yao, Shuang; Guo, Song; Guo, Xiang-Wei; Zhang, Zhi-Ming; Lu, Tong-Bu published the artcile< Photosensitizing single-site metal-organic framework enabling visible-light-driven CO2 reduction for syngas production>, Recommanded Product: 2,2′-Bipyridine, the main research area is photosensitizing MOF carbon reduction syngas.

Photocatalytic CO2 reduction into syngas (CO and H2) is one of sustainable strategies for recycling CO2 into value-added products. Herein, a simple and effective two-step self-assembly process was developed to functionalize phosphorescent metal-organic framework (MOF) with single site catalyst. The resulting (Co/Ru)n-UiO-67(bpydc) supplied mol. platform to enable fast multielectron injection from photosensitizers (PSs) to Co-catalyst, leading to the first MOF-based composite photocatalyst for efficient syngas production with a yield of 13,600μmol·g-1 (H2 : CO = 2 : 1) in 16 h, 29.2-fold higher than that of its homogeneous counterpart. The H2/CO ratios can be well controlled by carefully adjusting the molar ratio of PS/catalyst in the MOF platform and the water content in the photocatalytic system. This work provides a prospective strategy for recycling CO2 into H2-rich syngas by merging PSs and single-site catalysts into a MOF platform.

Applied Catalysis, B: Environmental published new progress about Photocatalysts. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Qi-Pin; Wang, Zhen-Feng; Tan, Ming-Xiong; Huang, Xiao-Ling; Zou, Hua-Hong; Zou, Bi-Qun; Shi, Bei-Bei; Zhang, Shu-Hua published the artcile< Complexes of lanthanides(III) with mixed 2,2'-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents>, Application of C10H8N2, the main research area is cervical ovarian cancer lanthanide III metal chelation.

Five novel lanthanides(III) complexes, [Lu(Me)(MBrQ)2NO3] (MeMBrQ-Lu), [Ho(MeO)(MBrQ)2NO3] (MeOMBrQ-Ho), [Ho(Me)(MBrQ)2NO3] (MeMBrQ-Ho), [La(Me)2(BrQ)2NO3] (MeBrQ-La) and [Sm(Me)(BrQ)2(CH3OH)NO3] (MeBrQ-Sm) were synthesized in which 2,2′-bipyridyl (4,4′-dimethyl-2,2′-bipyridyl (Me) and 4,4′-dimethoxy-2,2′-bipyridine (MeO)) and 5,7-dibromo-8-quinolinoline derivatives (5,7-dibromo-2-methyl-8-quinolinol (MBrQ-H) and 5,7-dibromo-8-quinolinol (BrQ-H)) act as chelating ligands. The in vitro cytotoxic activities of five Ln(III) complexes have been studied with SK-OV-3/DDP, NCI-H460 and HeLa cancer cells. MeMBrQ-Lu, MeOMBrQ-Ho, MeMBrQ-Ho, MeBrQ-La and MeBrQ-Sm show higher cytotoxicity against the HeLa cells than cisplatin (13.11 ± 0.53 μM). In particular, the MeOMBrQ-Ho and MeMBrQ-Ho complexes exhibit superior cytotoxic activity, with IC50 values at 1.00 ± 0.34 nM and 125.00 ± 1.08 nM. We further demonstrate that MeOMBrQ-Ho and MeMBrQ-Ho inhibit the proliferation of HeLa cells by inhibiting telomerase and targeting mitochondria to induce DNA damage-mediated apoptosis. In addition, MeOMBrQ-Ho significantly inhibits tumor growth with a tumor growth inhibition rate (IR) of 50.8% in a HeLa mouse xenograft model. Taken together, MeOMBrQ-Ho is a novel lanthanide(III) complex with promising antitumor activity.

Metallomics published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Impert, Olga; Kozakiewicz, Anna; Wrzeszcz, Grzegorz; Katafias, Anna; Bienko, Alina; van Eldik, Rudi; Ozarowski, Andrew published the artcile< Characterization of a Mixed-Valence Ru(II)/Ru(III) Ion-Pair Complex. Unexpected High-Frequency Electron Paramagnetic Resonance Evidence for Ru(III)-Ru(III) Dimer Coupling>, Name: 2,2′-Bipyridine, the main research area is ruthenium picolinate bipyridine complex preparation EPR DFT magnetic property; crystal structure ruthenium picolinate bipyridine.

In this contribution, we report the synthesis and full characterization of the first mixed-valence Ru(II)/Ru(III) ion-pair complex, [RuII(bipy)2(pic)]+[cis-RuIIICl2(pic)2]-, in the solid state and in aqueous solution, where bipy = 2,2′-bipyridine and pic- = picolinate. In addition, unexpected high-frequency ESR evidence for interactions between two neighboring Ru(III) ions, resulting in a triplet state, S = 1, was found.

Inorganic Chemistry published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Dongsheng; Lu, Jun; Xie, Jin; Cui, Junjun; Li, Teng-Fei; Wang, Yan-Chao; Chen, Yuan; Gong, Nian; Li, Xin-Yan; Fu, Lei; Wang, Yong-Xiang published the artcile< Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent D-amino acid oxidase inhibitor>, Formula: C5H4Cl2N2, the main research area is chlorodihydro pyridopyrazine dione preparation amino acid oxidase inhibitor; 5-Azaquinoxaline-2,3-diones; 8-Chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione; Analgesic effects; D-amino acid oxidase; DAAO inhibitors.

A series of 5-azaquinoxaline-2,3-dione derivatives were synthesized and evaluated on D-amino acid oxidase (DAAO) inhibition as potential α-hydroxylactam-based inhibitors. The potent inhibitory activities in vitro suggested that 5-nitrogen could significantly enhance the binding affinity by strengthening relevant hydrogen bond interactions. The analgesic effects of intrathecal and systemic injection of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione, a representative mol. of 5-azaquinoxaline-2,3-dione, were investigated in rodents. This research not only confirmed the analgesic effect of the DAAO inhibitors but provided a new class of chem. entities with oral application potential for the treatment of chronic pain and morphine analgesic tolerance.

European Journal of Medicinal Chemistry published new progress about Analgesics. 188577-68-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4Cl2N2, Formula: C5H4Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem